Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-12

AUTHORS

C M Fraser, S Casjens, W M Huang, G G Sutton, R Clayton, R Lathigra, O White, K A Ketchum, R Dodson, E K Hickey, M Gwinn, B Dougherty, J F Tomb, R D Fleischmann, D Richardson, J Peterson, A R Kerlavage, J Quackenbush, S Salzberg, M Hanson, R van Vugt, N Palmer, M D Adams, J Gocayne, J Weidman, T Utterback, L Watthey, L McDonald, P Artiach, C Bowman, S Garland, C Fuji, M D Cotton, K Horst, K Roberts, B Hatch, H O Smith, J C Venter

ABSTRACT

The genome of the bacterium Borrelia burgdorferi B31, the aetiologic agent of Lyme disease, contains a linear chromosome of 910,725 base pairs and at least 17 linear and circular plasmids with a combined size of more than 533,000 base pairs. The chromosome contains 853 genes encoding a basic set of proteins for DNA replication, transcription, translation, solute transport and energy metabolism, but, like Mycoplasma genitalium, it contains no genes for cellular biosynthetic reactions. Because B. burgdorferi and M. genitalium are distantly related eubacteria, we suggest that their limited metabolic capacities reflect convergent evolution by gene loss from more metabolically competent progenitors. Of 430 genes on 11 plasmids, most have no known biological function; 39% of plasmid genes are paralogues that form 47 gene families. The biological significance of the multiple plasmid-encoded genes is not clear, although they may be involved in antigenic variation or immune evasion. More... »

PAGES

580-586

Journal

TITLE

Nature

ISSUE

6660

VOLUME

390

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/37551

    DOI

    http://dx.doi.org/10.1038/37551

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016222704

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9403685


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