Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-05

AUTHORS

Mario B. Marrero, Bernhard Schieffer, William G. Paxton, Lauri Heerdt, Bradford C. Berk, Patrick Delafontaine, Kenneth E. Bernstein

ABSTRACT

THE peptide angiotensin II is the effector molecule of the renin-angiotensin system. All the haemodynamic effects of angiotensin II, including vasoconstriction and adrenal aldosterone release, are mediated through a single class of cell-surface receptors known as AT1 (refs 1, 2). These receptors contain the structural features of the G-protein-coupled receptor superfamily3. We show here that angiotensin II induces the rapid phosphorylation of tyrosine in the intracellular kinases Jak2 and Tyk2 in rat aortic smooth-muscle cells and that this phosphorylation is associated with increased activity of Jak2. The Jak family substrates STAT1 and STAT2 (for signal transducers and activators of transcription) are rapidly tyrosine-phosphorylated in response to angiotensin II. We also find that Jak2 co-precipitates with the AT1, receptor, indicating that G-protein-coupled receptors may be able to signal through the intracellular phosphorylation pathways used by cytokine receptors4,5. More... »

PAGES

247-250

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/375247a0

DOI

http://dx.doi.org/10.1038/375247a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037354896

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7746328


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensin II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aorta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Janus Kinase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscle, Smooth, Vascular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Angiotensin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "STAT1 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "STAT2 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tyrosine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Laboratory Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA", 
          "id": "http://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marrero", 
        "givenName": "Mario B.", 
        "id": "sg:person.0655015541.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655015541.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Laboratory Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA", 
          "id": "http://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schieffer", 
        "givenName": "Bernhard", 
        "id": "sg:person.01075113266.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075113266.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Laboratory Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA", 
          "id": "http://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paxton", 
        "givenName": "William G.", 
        "id": "sg:person.0667124402.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667124402.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Santa Cruz Biotechnology Inc., 95060, Santa Cruz, California, USA", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Santa Cruz Biotechnology Inc., 95060, Santa Cruz, California, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heerdt", 
        "givenName": "Lauri", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Division of Cardiology, University of Washington, 98195, Seattle, Washington, USA", 
          "id": "http://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Medicine, Division of Cardiology, University of Washington, 98195, Seattle, Washington, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berk", 
        "givenName": "Bradford C.", 
        "id": "sg:person.012523312277.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012523312277.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA", 
          "id": "http://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Delafontaine", 
        "givenName": "Patrick", 
        "id": "sg:person.011150175304.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011150175304.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology and Laboratory Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA", 
          "id": "http://www.grid.ac/institutes/grid.189967.8", 
          "name": [
            "Department of Pathology and Laboratory Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bernstein", 
        "givenName": "Kenneth E.", 
        "id": "sg:person.01240003301.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240003301.55"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/296613a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035034012", 
          "https://doi.org/10.1038/296613a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/366583a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046404612", 
          "https://doi.org/10.1038/366583a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/227680a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010419937", 
          "https://doi.org/10.1038/227680a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/351233a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035923039", 
          "https://doi.org/10.1038/351233a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/366580a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029168623", 
          "https://doi.org/10.1038/366580a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/366166a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003119860", 
          "https://doi.org/10.1038/366166a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-05", 
    "datePublishedReg": "1995-05-01", 
    "description": "THE peptide angiotensin II is the effector molecule of the renin-angiotensin system. All the haemodynamic effects of angiotensin II, including vasoconstriction and adrenal aldosterone release, are mediated through a single class of cell-surface receptors known as AT1 (refs 1, 2). These receptors contain the structural features of the G-protein-coupled receptor superfamily3. We show here that angiotensin II induces the rapid phosphorylation of tyrosine in the intracellular kinases Jak2 and Tyk2 in rat aortic smooth-muscle cells and that this phosphorylation is associated with increased activity of Jak2. The Jak family substrates STAT1 and STAT2 (for signal transducers and activators of transcription) are rapidly tyrosine-phosphorylated in response to angiotensin II. We also find that Jak2 co-precipitates with the AT1, receptor, indicating that G-protein-coupled receptors may be able to signal through the intracellular phosphorylation pathways used by cytokine receptors4,5.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/375247a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6528", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "375"
      }
    ], 
    "keywords": [
      "angiotensin II", 
      "angiotensin II AT1 receptor", 
      "adrenal aldosterone release", 
      "renin-angiotensin system", 
      "rat aortic smooth muscle cells", 
      "aortic smooth muscle cells", 
      "II AT1 receptors", 
      "smooth muscle cells", 
      "peptide angiotensin II", 
      "G protein-coupled receptors", 
      "haemodynamic effects", 
      "intracellular phosphorylation pathways", 
      "aldosterone release", 
      "AT1 receptor", 
      "direct stimulation", 
      "cell surface receptors", 
      "receptors", 
      "JAK/", 
      "effector molecules", 
      "AT1", 
      "JAK2", 
      "single class", 
      "rapid phosphorylation", 
      "kinase JAK2", 
      "phosphorylation pathway", 
      "activity of JAK2", 
      "vasoconstriction", 
      "cytokines", 
      "pathway", 
      "phosphorylation", 
      "JAK family", 
      "stimulation", 
      "STAT1", 
      "cells", 
      "STAT2", 
      "release", 
      "response", 
      "activity", 
      "effect", 
      "tyrosine", 
      "family", 
      "features", 
      "molecules", 
      "structural features", 
      "system", 
      "class"
    ], 
    "name": "Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor", 
    "pagination": "247-250", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037354896"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/375247a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7746328"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/375247a0", 
      "https://app.dimensions.ai/details/publication/pub.1037354896"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_284.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/375247a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/375247a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/375247a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/375247a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/375247a0'


 

This table displays all metadata directly associated to this object as RDF triples.

260 TRIPLES      21 PREDICATES      98 URIs      84 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/375247a0 schema:about N07d4aa8c66644e61b89486690a96fedd
2 N0b88d8f8e9dd4e83ba14fb52284c6502
3 N26012ccbafcf42e18e6e62cfc3535320
4 N26e9b98baee742b290a704ea4a995733
5 N33c8de50cd3d400fbd2f5278c72fbeda
6 N380b6befabbb4abca2defdb3dfc22995
7 N3f12707cfb394d33a6bc61101fecc135
8 N3f5c93ae0555441dac1ae47f6ba47e71
9 N423b1e070ef440acb193099712900c7c
10 N7688a6f0509e4cd8a6378ea95be1f827
11 N76a6a5c67e0542d9ad243d2f486e2386
12 N7eef14aa433347d4859efd1915892327
13 Na8b6a4c27e3a430a9d193e03e0493527
14 Nacdb918cba754744b9d6b84e51f9a108
15 Nba06ee92c17640f7ae80d87e7f38e1ca
16 Nbf9a4fb890e94089a95c2a878220cde7
17 Nc1c926b6b0af49d7bf5c15878a6a6088
18 Nc494b78c9cb8443ba244908bb4c98195
19 Nd20b8c6d22a049deaf83324633c71dae
20 Neafe1418b73e4ac29af3ef2945a05700
21 anzsrc-for:11
22 anzsrc-for:1115
23 schema:author N849215a6c1c84c3e9a891f9768024996
24 schema:citation sg:pub.10.1038/227680a0
25 sg:pub.10.1038/296613a0
26 sg:pub.10.1038/351233a0
27 sg:pub.10.1038/366166a0
28 sg:pub.10.1038/366580a0
29 sg:pub.10.1038/366583a0
30 schema:datePublished 1995-05
31 schema:datePublishedReg 1995-05-01
32 schema:description THE peptide angiotensin II is the effector molecule of the renin-angiotensin system. All the haemodynamic effects of angiotensin II, including vasoconstriction and adrenal aldosterone release, are mediated through a single class of cell-surface receptors known as AT1 (refs 1, 2). These receptors contain the structural features of the G-protein-coupled receptor superfamily3. We show here that angiotensin II induces the rapid phosphorylation of tyrosine in the intracellular kinases Jak2 and Tyk2 in rat aortic smooth-muscle cells and that this phosphorylation is associated with increased activity of Jak2. The Jak family substrates STAT1 and STAT2 (for signal transducers and activators of transcription) are rapidly tyrosine-phosphorylated in response to angiotensin II. We also find that Jak2 co-precipitates with the AT1, receptor, indicating that G-protein-coupled receptors may be able to signal through the intracellular phosphorylation pathways used by cytokine receptors4,5.
33 schema:genre article
34 schema:isAccessibleForFree false
35 schema:isPartOf N80b5b2c311ac479b8568e8b603910c17
36 Na0d420de418b4cb1aede8604f2811a32
37 sg:journal.1018957
38 schema:keywords AT1
39 AT1 receptor
40 G protein-coupled receptors
41 II AT1 receptors
42 JAK family
43 JAK/
44 JAK2
45 STAT1
46 STAT2
47 activity
48 activity of JAK2
49 adrenal aldosterone release
50 aldosterone release
51 angiotensin II
52 angiotensin II AT1 receptor
53 aortic smooth muscle cells
54 cell surface receptors
55 cells
56 class
57 cytokines
58 direct stimulation
59 effect
60 effector molecules
61 family
62 features
63 haemodynamic effects
64 intracellular phosphorylation pathways
65 kinase JAK2
66 molecules
67 pathway
68 peptide angiotensin II
69 phosphorylation
70 phosphorylation pathway
71 rapid phosphorylation
72 rat aortic smooth muscle cells
73 receptors
74 release
75 renin-angiotensin system
76 response
77 single class
78 smooth muscle cells
79 stimulation
80 structural features
81 system
82 tyrosine
83 vasoconstriction
84 schema:name Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor
85 schema:pagination 247-250
86 schema:productId N1813481ff6e94c239deec52662800e10
87 N808036517de74e3dbb0e18517124ea53
88 Nee9503a568b745feba26221df5857426
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037354896
90 https://doi.org/10.1038/375247a0
91 schema:sdDatePublished 2022-10-01T06:30
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher Nde2887d6032e41d8a4767b362f744653
94 schema:url https://doi.org/10.1038/375247a0
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N07d4aa8c66644e61b89486690a96fedd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Animals
100 rdf:type schema:DefinedTerm
101 N0b88d8f8e9dd4e83ba14fb52284c6502 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cell Line
103 rdf:type schema:DefinedTerm
104 N1813481ff6e94c239deec52662800e10 schema:name doi
105 schema:value 10.1038/375247a0
106 rdf:type schema:PropertyValue
107 N26012ccbafcf42e18e6e62cfc3535320 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Phosphorylation
109 rdf:type schema:DefinedTerm
110 N26e9b98baee742b290a704ea4a995733 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Interferon-gamma
112 rdf:type schema:DefinedTerm
113 N33c8de50cd3d400fbd2f5278c72fbeda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name STAT2 Transcription Factor
115 rdf:type schema:DefinedTerm
116 N380b6befabbb4abca2defdb3dfc22995 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Rats
118 rdf:type schema:DefinedTerm
119 N3f12707cfb394d33a6bc61101fecc135 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name DNA-Binding Proteins
121 rdf:type schema:DefinedTerm
122 N3f5c93ae0555441dac1ae47f6ba47e71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Protein-Tyrosine Kinases
124 rdf:type schema:DefinedTerm
125 N423b1e070ef440acb193099712900c7c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Aorta
127 rdf:type schema:DefinedTerm
128 N5be3010cf84c45d095cc94013444eae4 rdf:first Nfaf8f13f74724841877f35a3e9e6f33e
129 rdf:rest N97fdcf7205e44ac6998fcf20a4f44161
130 N7688a6f0509e4cd8a6378ea95be1f827 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Janus Kinase 2
132 rdf:type schema:DefinedTerm
133 N76a6a5c67e0542d9ad243d2f486e2386 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Tyrosine
135 rdf:type schema:DefinedTerm
136 N7eef14aa433347d4859efd1915892327 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Trans-Activators
138 rdf:type schema:DefinedTerm
139 N808036517de74e3dbb0e18517124ea53 schema:name dimensions_id
140 schema:value pub.1037354896
141 rdf:type schema:PropertyValue
142 N80b5b2c311ac479b8568e8b603910c17 schema:volumeNumber 375
143 rdf:type schema:PublicationVolume
144 N849215a6c1c84c3e9a891f9768024996 rdf:first sg:person.0655015541.06
145 rdf:rest Nb3bff873eaed4e1298ce530b4ca76b07
146 N911faede657d41a688b818cd260a9c31 rdf:first sg:person.0667124402.19
147 rdf:rest N5be3010cf84c45d095cc94013444eae4
148 N97fdcf7205e44ac6998fcf20a4f44161 rdf:first sg:person.012523312277.63
149 rdf:rest Ndd909cbdb4254a8a95dd0f3060e00d99
150 Na0d420de418b4cb1aede8604f2811a32 schema:issueNumber 6528
151 rdf:type schema:PublicationIssue
152 Na1dc473a854e4423a80b623b61d894a6 rdf:first sg:person.01240003301.55
153 rdf:rest rdf:nil
154 Na8b6a4c27e3a430a9d193e03e0493527 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Enzyme Activation
156 rdf:type schema:DefinedTerm
157 Nacdb918cba754744b9d6b84e51f9a108 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name STAT1 Transcription Factor
159 rdf:type schema:DefinedTerm
160 Nb3bff873eaed4e1298ce530b4ca76b07 rdf:first sg:person.01075113266.30
161 rdf:rest N911faede657d41a688b818cd260a9c31
162 Nba06ee92c17640f7ae80d87e7f38e1ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Epidermal Growth Factor
164 rdf:type schema:DefinedTerm
165 Nbf9a4fb890e94089a95c2a878220cde7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Angiotensin II
167 rdf:type schema:DefinedTerm
168 Nc1c926b6b0af49d7bf5c15878a6a6088 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Proto-Oncogene Proteins
170 rdf:type schema:DefinedTerm
171 Nc494b78c9cb8443ba244908bb4c98195 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Muscle, Smooth, Vascular
173 rdf:type schema:DefinedTerm
174 Nd20b8c6d22a049deaf83324633c71dae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Receptors, Angiotensin
176 rdf:type schema:DefinedTerm
177 Ndd909cbdb4254a8a95dd0f3060e00d99 rdf:first sg:person.011150175304.01
178 rdf:rest Na1dc473a854e4423a80b623b61d894a6
179 Nde2887d6032e41d8a4767b362f744653 schema:name Springer Nature - SN SciGraph project
180 rdf:type schema:Organization
181 Neafe1418b73e4ac29af3ef2945a05700 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Humans
183 rdf:type schema:DefinedTerm
184 Nee9503a568b745feba26221df5857426 schema:name pubmed_id
185 schema:value 7746328
186 rdf:type schema:PropertyValue
187 Nfaf8f13f74724841877f35a3e9e6f33e schema:affiliation grid-institutes:None
188 schema:familyName Heerdt
189 schema:givenName Lauri
190 rdf:type schema:Person
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
195 schema:name Pharmacology and Pharmaceutical Sciences
196 rdf:type schema:DefinedTerm
197 sg:journal.1018957 schema:issn 0028-0836
198 1476-4687
199 schema:name Nature
200 schema:publisher Springer Nature
201 rdf:type schema:Periodical
202 sg:person.01075113266.30 schema:affiliation grid-institutes:grid.189967.8
203 schema:familyName Schieffer
204 schema:givenName Bernhard
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075113266.30
206 rdf:type schema:Person
207 sg:person.011150175304.01 schema:affiliation grid-institutes:grid.189967.8
208 schema:familyName Delafontaine
209 schema:givenName Patrick
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011150175304.01
211 rdf:type schema:Person
212 sg:person.01240003301.55 schema:affiliation grid-institutes:grid.189967.8
213 schema:familyName Bernstein
214 schema:givenName Kenneth E.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01240003301.55
216 rdf:type schema:Person
217 sg:person.012523312277.63 schema:affiliation grid-institutes:grid.34477.33
218 schema:familyName Berk
219 schema:givenName Bradford C.
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012523312277.63
221 rdf:type schema:Person
222 sg:person.0655015541.06 schema:affiliation grid-institutes:grid.189967.8
223 schema:familyName Marrero
224 schema:givenName Mario B.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655015541.06
226 rdf:type schema:Person
227 sg:person.0667124402.19 schema:affiliation grid-institutes:grid.189967.8
228 schema:familyName Paxton
229 schema:givenName William G.
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667124402.19
231 rdf:type schema:Person
232 sg:pub.10.1038/227680a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010419937
233 https://doi.org/10.1038/227680a0
234 rdf:type schema:CreativeWork
235 sg:pub.10.1038/296613a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035034012
236 https://doi.org/10.1038/296613a0
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/351233a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035923039
239 https://doi.org/10.1038/351233a0
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/366166a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003119860
242 https://doi.org/10.1038/366166a0
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/366580a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029168623
245 https://doi.org/10.1038/366580a0
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/366583a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046404612
248 https://doi.org/10.1038/366583a0
249 rdf:type schema:CreativeWork
250 grid-institutes:None schema:alternateName Santa Cruz Biotechnology Inc., 95060, Santa Cruz, California, USA
251 schema:name Santa Cruz Biotechnology Inc., 95060, Santa Cruz, California, USA
252 rdf:type schema:Organization
253 grid-institutes:grid.189967.8 schema:alternateName Department of Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA
254 Department of Pathology and Laboratory Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA
255 schema:name Department of Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA
256 Department of Pathology and Laboratory Medicine, Division of Cardiology, Emory University, 30322, Atlanta, Georgia, USA
257 rdf:type schema:Organization
258 grid-institutes:grid.34477.33 schema:alternateName Department of Medicine, Division of Cardiology, University of Washington, 98195, Seattle, Washington, USA
259 schema:name Department of Medicine, Division of Cardiology, University of Washington, 98195, Seattle, Washington, USA
260 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...