Serial triggering of many T-cell receptors by a few peptide–MHC complexes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-05

AUTHORS

S Valitutti, S Müller, M Cella, E Padovan, A Lanzavecchia

ABSTRACT

T lymphocytes can recognize and be activated by a very small number of complexes of peptide with major histocompatibility complex (MHC) molecules displayed on the surface of antigen-presenting cells (APCs). The interaction between the T-cell receptor (TCR) and its ligand has low affinity and high off-rate. Both findings suggest that an extremely small number of TCRs must be engaged in interaction with APCs and raise the question of how so few receptors can transduce an activation signal. Here we show that a small number of peptide-MHC complexes can achieve a high TCR occupancy, because a single complex can serially engage and trigger up to approximately 200 TCRs. Furthermore, TCR occupancy is proportional to the T cell's biological response. Our findings suggest that the low affinity of the TCR can be instrumental in enabling a small number of antigenic complexes to be detected. More... »

PAGES

148-151

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/375148a0

DOI

http://dx.doi.org/10.1038/375148a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047610851

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7753171


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