Male–female differences in fertility and blood pressure in ACE-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-05

AUTHORS

John H. Krege, Simon W. M. John, Laura L. Langenbach, Jeffrey B. Hodgin, John R. Hagaman, Eric S. Bachman, J. Charles Jennette, Deborah A. O'Brien, Oliver Smithies

ABSTRACT

ANGIOTENSIN-CONVERTING enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide bradykinin1. The gene encoding ACE is composed of two homologous regions and codes for both a somatic and testis isoenzyme2–4. Experiments with hypertensive rats5,6 and some7–9, but not other10–13, studies of humans suggest that sequences at or linked to the gene influence blood pressure. The testis-specific form of ACE has its own promoter within intron 12 (ref. 14), is encoded by the 3′ region of the gene, and is found only in postmeiotic spermatogenic cells and sperm15. Its function is unknown16. Here we investigate the role of the Ace gene in blood pressure control and reproduction using mice generated to carry an insertional mutation that is designed to inactivate both forms of ACE. All homozygous female mutants were found to be fertile, but the fertility of homozygous male mutants was greatly reduced. Heterozygous males but not females had blood pressures that were 15–20 mm Hg less than normal, although both male and female heterozygotes had reduced serum ACE activity. More... »

PAGES

146-148

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/375146a0

DOI

http://dx.doi.org/10.1038/375146a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031952418

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7753170


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chimera", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fertility", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Targeting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutagenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptidyl-Dipeptidase A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sex Characteristics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Department of Internal Medicine, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA", 
            "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krege", 
        "givenName": "John H.", 
        "id": "sg:person.01102236366.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102236366.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "John", 
        "givenName": "Simon W. M.", 
        "id": "sg:person.010360505452.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010360505452.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Langenbach", 
        "givenName": "Laura L.", 
        "id": "sg:person.0711732114.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711732114.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hodgin", 
        "givenName": "Jeffrey B.", 
        "id": "sg:person.01233735433.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233735433.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hagaman", 
        "givenName": "John R.", 
        "id": "sg:person.01134725371.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134725371.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bachman", 
        "givenName": "Eric S.", 
        "id": "sg:person.01074273714.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074273714.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jennette", 
        "givenName": "J. Charles", 
        "id": "sg:person.0730025123.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730025123.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics and Cell Biology and Anatomy, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Department of Pediatrics and Cell Biology and Anatomy, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "O'Brien", 
        "givenName": "Deborah A.", 
        "id": "sg:person.0751622065.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751622065.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA", 
          "id": "http://www.grid.ac/institutes/grid.10698.36", 
          "name": [
            "Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smithies", 
        "givenName": "Oliver", 
        "id": "sg:person.0606267652.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606267652.09"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/326292a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050105118", 
          "https://doi.org/10.1038/326292a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/353521a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040415481", 
          "https://doi.org/10.1038/353521a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0492-72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015521261", 
          "https://doi.org/10.1038/ng0492-72"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00484623", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036109235", 
          "https://doi.org/10.1007/bf00484623"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-05", 
    "datePublishedReg": "1995-05-01", 
    "description": "ANGIOTENSIN-CONVERTING enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide bradykinin1. The gene encoding ACE is composed of two homologous regions and codes for both a somatic and testis isoenzyme2\u20134. Experiments with hypertensive rats5,6 and some7\u20139, but not other10\u201313, studies of humans suggest that sequences at or linked to the gene influence blood pressure. The testis-specific form of ACE has its own promoter within intron 12 (ref. 14), is encoded by the 3\u2032 region of the gene, and is found only in postmeiotic spermatogenic cells and sperm15. Its function is unknown16. Here we investigate the role of the Ace gene in blood pressure control and reproduction using mice generated to carry an insertional mutation that is designed to inactivate both forms of ACE. All homozygous female mutants were found to be fertile, but the fertility of homozygous male mutants was greatly reduced. Heterozygous males but not females had blood pressures that were 15\u201320 mm Hg less than normal, although both male and female heterozygotes had reduced serum ACE activity.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/375146a0", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2524503", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6527", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "375"
      }
    ], 
    "keywords": [
      "angiotensin converting enzyme", 
      "blood pressure", 
      "ACE-deficient mice", 
      "influence blood pressure", 
      "blood pressure control", 
      "serum ACE activity", 
      "peptide angiotensin II", 
      "angiotensin II", 
      "ACE activity", 
      "ACE gene", 
      "pressure control", 
      "male-female differences", 
      "studies of humans", 
      "female heterozygotes", 
      "postmeiotic spermatogenic cells", 
      "spermatogenic cells", 
      "mice", 
      "carboxy-peptidase", 
      "female mutants", 
      "male mutants", 
      "testis-specific form", 
      "genes", 
      "heterozygous males", 
      "males", 
      "fertility", 
      "females", 
      "pressure", 
      "intron 12", 
      "cells", 
      "heterozygotes", 
      "humans", 
      "mutations", 
      "peptides", 
      "homologous regions", 
      "differences", 
      "control", 
      "activity", 
      "study", 
      "role", 
      "insertional mutation", 
      "enzyme", 
      "promoter", 
      "function", 
      "mutants", 
      "region", 
      "form", 
      "own promoter", 
      "reproduction", 
      "sequence", 
      "experiments", 
      "code"
    ], 
    "name": "Male\u2013female differences in fertility and blood pressure in ACE-deficient mice", 
    "pagination": "146-148", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031952418"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/375146a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7753170"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/375146a0", 
      "https://app.dimensions.ai/details/publication/pub.1031952418"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_284.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/375146a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/375146a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/375146a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/375146a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/375146a0'


 

This table displays all metadata directly associated to this object as RDF triples.

245 TRIPLES      21 PREDICATES      95 URIs      83 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/375146a0 schema:about N431be7f8c1af4f4aaac9d1bae7d8fd56
2 N457580f515cd430395700c112633494e
3 N63cda863984043c781a67bd4769998d3
4 N674b2cec81b5470f897ae4b36c340a9f
5 N8e4a496e093c49328ae59b93e3b89599
6 N8f0f956bca804802a8b27a1ec8ba8ef9
7 Na21c92c38a2b44b2adc26a899de164f4
8 Na260a410dcd34dcfa7f8387300d6f5d5
9 Nc3e04c5dab5d4bff82f3bb7d3baf40a6
10 Nccad5f86548a43389de85aa01ea27339
11 Nd39f27b95688416a82fb88f0228f50a8
12 Nd7965bb6e5324577b2b95e6c0b67f66a
13 Nfa24be10be6949d3aee3296fd90e23d9
14 Nfab492f3ad2a428a8bad210217e7dabc
15 anzsrc-for:06
16 anzsrc-for:0604
17 schema:author N708f0b3daca14d2c959090fbf70c1fe6
18 schema:citation sg:pub.10.1007/bf00484623
19 sg:pub.10.1038/326292a0
20 sg:pub.10.1038/353521a0
21 sg:pub.10.1038/ng0492-72
22 schema:datePublished 1995-05
23 schema:datePublishedReg 1995-05-01
24 schema:description ANGIOTENSIN-CONVERTING enzyme (ACE) is a dipeptidyl carboxy-peptidase that generates the vasoconstricting peptide angiotensin II and inactivates the vasodilating peptide bradykinin1. The gene encoding ACE is composed of two homologous regions and codes for both a somatic and testis isoenzyme2–4. Experiments with hypertensive rats5,6 and some7–9, but not other10–13, studies of humans suggest that sequences at or linked to the gene influence blood pressure. The testis-specific form of ACE has its own promoter within intron 12 (ref. 14), is encoded by the 3′ region of the gene, and is found only in postmeiotic spermatogenic cells and sperm15. Its function is unknown16. Here we investigate the role of the Ace gene in blood pressure control and reproduction using mice generated to carry an insertional mutation that is designed to inactivate both forms of ACE. All homozygous female mutants were found to be fertile, but the fertility of homozygous male mutants was greatly reduced. Heterozygous males but not females had blood pressures that were 15–20 mm Hg less than normal, although both male and female heterozygotes had reduced serum ACE activity.
25 schema:genre article
26 schema:isAccessibleForFree false
27 schema:isPartOf N950080bd809546d1914aa862834d3cda
28 Ne4f3225e224c4651aa9c2ffaee33ce82
29 sg:journal.1018957
30 schema:keywords ACE activity
31 ACE gene
32 ACE-deficient mice
33 activity
34 angiotensin II
35 angiotensin converting enzyme
36 blood pressure
37 blood pressure control
38 carboxy-peptidase
39 cells
40 code
41 control
42 differences
43 enzyme
44 experiments
45 female heterozygotes
46 female mutants
47 females
48 fertility
49 form
50 function
51 genes
52 heterozygotes
53 heterozygous males
54 homologous regions
55 humans
56 influence blood pressure
57 insertional mutation
58 intron 12
59 male mutants
60 male-female differences
61 males
62 mice
63 mutants
64 mutations
65 own promoter
66 peptide angiotensin II
67 peptides
68 postmeiotic spermatogenic cells
69 pressure
70 pressure control
71 promoter
72 region
73 reproduction
74 role
75 sequence
76 serum ACE activity
77 spermatogenic cells
78 studies of humans
79 study
80 testis-specific form
81 schema:name Male–female differences in fertility and blood pressure in ACE-deficient mice
82 schema:pagination 146-148
83 schema:productId N6d46c2958e73404f96d559a706617d97
84 N9821aac4bbfd4193beed6bd6440e2d1f
85 N999d9ff8268d420eaaf830c521bf0c1b
86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031952418
87 https://doi.org/10.1038/375146a0
88 schema:sdDatePublished 2022-12-01T06:21
89 schema:sdLicense https://scigraph.springernature.com/explorer/license/
90 schema:sdPublisher N26264faebbe643f0ba4e74eed3a954d5
91 schema:url https://doi.org/10.1038/375146a0
92 sgo:license sg:explorer/license/
93 sgo:sdDataset articles
94 rdf:type schema:ScholarlyArticle
95 N123d74e45ae54c9998f6e665f5600a1c rdf:first sg:person.0711732114.26
96 rdf:rest N8180bb5625ef49ba8c1bb3d86198dda0
97 N26264faebbe643f0ba4e74eed3a954d5 schema:name Springer Nature - SN SciGraph project
98 rdf:type schema:Organization
99 N431be7f8c1af4f4aaac9d1bae7d8fd56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Animals
101 rdf:type schema:DefinedTerm
102 N457580f515cd430395700c112633494e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Pregnancy
104 rdf:type schema:DefinedTerm
105 N594aa412ff2847b3989d3ee57fdcdf02 rdf:first sg:person.0730025123.97
106 rdf:rest N95c83c8edab6443d94156e0416f70702
107 N63cda863984043c781a67bd4769998d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Fertility
109 rdf:type schema:DefinedTerm
110 N674b2cec81b5470f897ae4b36c340a9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Gene Targeting
112 rdf:type schema:DefinedTerm
113 N6d46c2958e73404f96d559a706617d97 schema:name dimensions_id
114 schema:value pub.1031952418
115 rdf:type schema:PropertyValue
116 N708f0b3daca14d2c959090fbf70c1fe6 rdf:first sg:person.01102236366.49
117 rdf:rest Nbca6685b39084c30b347ccf7cb630779
118 N8180bb5625ef49ba8c1bb3d86198dda0 rdf:first sg:person.01233735433.84
119 rdf:rest Ndc4d7ddfe3054c08b2baf952c2327350
120 N8950f37c78a6453d9d311cc7ea9a1d64 rdf:first sg:person.0606267652.09
121 rdf:rest rdf:nil
122 N8e4a496e093c49328ae59b93e3b89599 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Peptidyl-Dipeptidase A
124 rdf:type schema:DefinedTerm
125 N8f0f956bca804802a8b27a1ec8ba8ef9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Male
127 rdf:type schema:DefinedTerm
128 N950080bd809546d1914aa862834d3cda schema:volumeNumber 375
129 rdf:type schema:PublicationVolume
130 N95c83c8edab6443d94156e0416f70702 rdf:first sg:person.0751622065.22
131 rdf:rest N8950f37c78a6453d9d311cc7ea9a1d64
132 N9821aac4bbfd4193beed6bd6440e2d1f schema:name doi
133 schema:value 10.1038/375146a0
134 rdf:type schema:PropertyValue
135 N999d9ff8268d420eaaf830c521bf0c1b schema:name pubmed_id
136 schema:value 7753170
137 rdf:type schema:PropertyValue
138 Na21c92c38a2b44b2adc26a899de164f4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Kidney
140 rdf:type schema:DefinedTerm
141 Na260a410dcd34dcfa7f8387300d6f5d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Female
143 rdf:type schema:DefinedTerm
144 Nbb17da6d843a44a3bf8efaec53cc3f0a rdf:first sg:person.01074273714.47
145 rdf:rest N594aa412ff2847b3989d3ee57fdcdf02
146 Nbca6685b39084c30b347ccf7cb630779 rdf:first sg:person.010360505452.66
147 rdf:rest N123d74e45ae54c9998f6e665f5600a1c
148 Nc3e04c5dab5d4bff82f3bb7d3baf40a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Mutagenesis
150 rdf:type schema:DefinedTerm
151 Nccad5f86548a43389de85aa01ea27339 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Mice, Inbred C57BL
153 rdf:type schema:DefinedTerm
154 Nd39f27b95688416a82fb88f0228f50a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Blood Pressure
156 rdf:type schema:DefinedTerm
157 Nd7965bb6e5324577b2b95e6c0b67f66a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Mice
159 rdf:type schema:DefinedTerm
160 Ndc4d7ddfe3054c08b2baf952c2327350 rdf:first sg:person.01134725371.42
161 rdf:rest Nbb17da6d843a44a3bf8efaec53cc3f0a
162 Ne4f3225e224c4651aa9c2ffaee33ce82 schema:issueNumber 6527
163 rdf:type schema:PublicationIssue
164 Nfa24be10be6949d3aee3296fd90e23d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Chimera
166 rdf:type schema:DefinedTerm
167 Nfab492f3ad2a428a8bad210217e7dabc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Sex Characteristics
169 rdf:type schema:DefinedTerm
170 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
171 schema:name Biological Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
174 schema:name Genetics
175 rdf:type schema:DefinedTerm
176 sg:grant.2524503 http://pending.schema.org/fundedItem sg:pub.10.1038/375146a0
177 rdf:type schema:MonetaryGrant
178 sg:journal.1018957 schema:issn 0028-0836
179 1476-4687
180 schema:name Nature
181 schema:publisher Springer Nature
182 rdf:type schema:Periodical
183 sg:person.010360505452.66 schema:affiliation grid-institutes:grid.10698.36
184 schema:familyName John
185 schema:givenName Simon W. M.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010360505452.66
187 rdf:type schema:Person
188 sg:person.01074273714.47 schema:affiliation grid-institutes:grid.10698.36
189 schema:familyName Bachman
190 schema:givenName Eric S.
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074273714.47
192 rdf:type schema:Person
193 sg:person.01102236366.49 schema:affiliation grid-institutes:grid.10698.36
194 schema:familyName Krege
195 schema:givenName John H.
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102236366.49
197 rdf:type schema:Person
198 sg:person.01134725371.42 schema:affiliation grid-institutes:grid.10698.36
199 schema:familyName Hagaman
200 schema:givenName John R.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134725371.42
202 rdf:type schema:Person
203 sg:person.01233735433.84 schema:affiliation grid-institutes:grid.10698.36
204 schema:familyName Hodgin
205 schema:givenName Jeffrey B.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233735433.84
207 rdf:type schema:Person
208 sg:person.0606267652.09 schema:affiliation grid-institutes:grid.10698.36
209 schema:familyName Smithies
210 schema:givenName Oliver
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606267652.09
212 rdf:type schema:Person
213 sg:person.0711732114.26 schema:affiliation grid-institutes:grid.10698.36
214 schema:familyName Langenbach
215 schema:givenName Laura L.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0711732114.26
217 rdf:type schema:Person
218 sg:person.0730025123.97 schema:affiliation grid-institutes:grid.10698.36
219 schema:familyName Jennette
220 schema:givenName J. Charles
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730025123.97
222 rdf:type schema:Person
223 sg:person.0751622065.22 schema:affiliation grid-institutes:grid.10698.36
224 schema:familyName O'Brien
225 schema:givenName Deborah A.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751622065.22
227 rdf:type schema:Person
228 sg:pub.10.1007/bf00484623 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036109235
229 https://doi.org/10.1007/bf00484623
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/326292a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050105118
232 https://doi.org/10.1038/326292a0
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/353521a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040415481
235 https://doi.org/10.1038/353521a0
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/ng0492-72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015521261
238 https://doi.org/10.1038/ng0492-72
239 rdf:type schema:CreativeWork
240 grid-institutes:grid.10698.36 schema:alternateName Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA
241 Department of Pediatrics and Cell Biology and Anatomy, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA
242 schema:name Department of Internal Medicine, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA
243 Department of Pathology, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA
244 Department of Pediatrics and Cell Biology and Anatomy, University of North Carolina at Chapel Hill, 27599-7525, Chapel Hill, North Carolina, USA
245 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...