In vitro evolution of a self-alkylatlng ribozyme View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-04

AUTHORS

C Wilson, J W Szostak

ABSTRACT

RNA enzymes are postulated to have catalysed all chemical reactions in the earliest living cells. This idea is now investigated in a search for alkyl transferases from a pool of random sequence RNAs. Selection for self-biotinylation yields a transfer RNA-like ribozyme that efficiently catalyses carbon-nitrogen bond formation. Ribozymes can thus promote reactions other than those involving the RNA sugar-phosphate backbone, suggesting that RNA may be capable of a broad range of catalytic activities. More... »

PAGES

777-782

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/374777a0

DOI

http://dx.doi.org/10.1038/374777a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024355677

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7723823


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