Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-04

AUTHORS

M C Kiefer, M J Brauer, V C Powers, J J Wu, S R Umansky, L D Tomei, P J Barr

ABSTRACT

Members of the Bcl-2 family of proteins are characterized by their ability to modulate cell death. Bcl-2 and some of its homologues inhibit apoptosis, whereas other family members, such as Bax, will accelerate apoptosis under certain conditions. Here we describe the identification and characterization of a complementary DNA that encodes a previously unknown Bcl-2 homologue designated Bak. Like Bax, the bak gene product primarily enhances apoptotic cell death following an appropriate stimulus. Unlike Bax, however, Bak can inhibit cell death in an Epstein-Barr-virus-transformed cell line. The widespread tissue distribution of Bak messenger RNA, including those containing long-lived, terminally differentiated cell types, suggests that cell-death-inducing activity is broadly distributed, and that tissue-specific modulation of apoptosis is controlled primarily by regulation of molecules that inhibit apoptosis. More... »

PAGES

736-739

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/374736a0

DOI

http://dx.doi.org/10.1038/374736a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021818446

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7715731


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