In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-04

AUTHORS

Jon H. Condra, William A. Schleif, Olga M. Blahy, Lori J. Gabryelski, Donald J. Graham, Julio Quintero, Audrey Rhodes, Helen L. Robbins, Elizabeth Roth, Malathi Shivaprakash, Donna Titus, Tao Yang, Hedy Tepplert, Kathleen E. Squires, Paul J. Deutsch, Emilio A. Emini

ABSTRACT

Inhibitors of the human immunodeficiency virus type 1 (HIV-1) protease have entered clinical study as potential therapeutic agents for HIV-1 infection. The clinical efficacy of HIV-1 reverse transcriptase inhibitors has been limited by the emergence of resistant viral variants. Similarly, variants expressing resistance to protease inhibitors have been derived in cell culture. We now report the characterization of resistant variants isolated from patients undergoing therapy with the protease inhibitor MK-639 (formerly designated L-735,524). Five of these variants, isolated from four patients, exhibited cross-resistance to all members of a panel of six structurally diverse protease inhibitors. This suggests that combination therapy with multiple protease inhibitors may not prevent loss of antiviral activity resulting from resistance selection. In addition, previous therapy with one compound may abrogate the benefit of subsequent treatment with a second inhibitor. More... »

PAGES

569-571

Journal

TITLE

Nature

ISSUE

6522

VOLUME

374

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/374569a0

    DOI

    http://dx.doi.org/10.1038/374569a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012077404

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7700387


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