Ontology type: schema:ScholarlyArticle
1995-03
AUTHORSJames R. Lundblad, Roland P. S. Kwok, Megan E. Laurance, Marian L. Harter, Richard H. Goodman
ABSTRACTTHE 265K nuclear protein CBP was initially identified as a co-activator for the protein kinase A (PKA)-phosphorylated form of the transcription factor CREB1. The domains in CBP that are involved in CREB binding and transcriptional activation are highly related to the adenoviral ElA-associated cellular protein p300 (refs 2, 3), and to two hypothetical proteins from Caenorhabditiselegans, R10E11.1 and K03H1.10 (refs 4 and 5, respectively), whose functions are unknown. Here, we show that CBP and p300 have similar binding affinity for the PKA-phosphorylated form of CREB, and that p300 can substitute for CBP in potentiating CREB-activated gene expression. We find that E1A binds to CBP through a domain conserved with p300 and represses the CREB-dependent co-activator functions of both CBP and p300. Our results indicate that the gene repression and cell immortalization functions associated with El A involve the inactivation of a family of related proteins that normally participate in second-messenger-regulated gene expression. More... »
PAGES85-88
http://scigraph.springernature.com/pub.10.1038/374085a0
DOIhttp://dx.doi.org/10.1038/374085a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1030959005
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/7870179
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adenovirus E1A Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amino Acid Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "CREB-Binding Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclic AMP Response Element-Binding Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cyclic AMP-Dependent Protein Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "E1A-Associated p300 Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Sequence Data",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nuclear Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphorylation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein Binding",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sequence Homology, Amino Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Trans-Activators",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transcription Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Transcriptional Activation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Cells, Cultured",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, Oregon, USA",
"id": "http://www.grid.ac/institutes/grid.5288.7",
"name": [
"Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, Oregon, USA"
],
"type": "Organization"
},
"familyName": "Lundblad",
"givenName": "James R.",
"id": "sg:person.01015523150.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01015523150.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, Oregon, USA",
"id": "http://www.grid.ac/institutes/grid.5288.7",
"name": [
"Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, Oregon, USA"
],
"type": "Organization"
},
"familyName": "Kwok",
"givenName": "Roland P. S.",
"id": "sg:person.01065622225.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065622225.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, Oregon, USA",
"id": "http://www.grid.ac/institutes/grid.5288.7",
"name": [
"Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, Oregon, USA"
],
"type": "Organization"
},
"familyName": "Laurance",
"givenName": "Megan E.",
"id": "sg:person.0737173524.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737173524.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, Oregon, USA",
"id": "http://www.grid.ac/institutes/grid.5288.7",
"name": [
"Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, Oregon, USA"
],
"type": "Organization"
},
"familyName": "Harter",
"givenName": "Marian L.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, Oregon, USA",
"id": "http://www.grid.ac/institutes/grid.5288.7",
"name": [
"Vollum Institute, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201, Portland, Oregon, USA"
],
"type": "Organization"
},
"familyName": "Goodman",
"givenName": "Richard H.",
"id": "sg:person.01364155143.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01364155143.92"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/370223a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048791872",
"https://doi.org/10.1038/370223a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/370226a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042384968",
"https://doi.org/10.1038/370226a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/364548a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039351996",
"https://doi.org/10.1038/364548a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/365855a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012014177",
"https://doi.org/10.1038/365855a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/368032a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010019915",
"https://doi.org/10.1038/368032a0"
],
"type": "CreativeWork"
}
],
"datePublished": "1995-03",
"datePublishedReg": "1995-03-01",
"description": "THE 265K nuclear protein CBP was initially identified as a co-activator for the protein kinase A (PKA)-phosphorylated form of the transcription factor CREB1. The domains in CBP that are involved in CREB binding and transcriptional activation are highly related to the adenoviral ElA-associated cellular protein p300 (refs 2, 3), and to two hypothetical proteins from Caenorhabditiselegans, R10E11.1 and K03H1.10 (refs 4 and 5, respectively), whose functions are unknown. Here, we show that CBP and p300 have similar binding affinity for the PKA-phosphorylated form of CREB, and that p300 can substitute for CBP in potentiating CREB-activated gene expression. We find that E1A binds to CBP through a domain conserved with p300 and represses the CREB-dependent co-activator functions of both CBP and p300. Our results indicate that the gene repression and cell immortalization functions associated with El A involve the inactivation of a family of related proteins that normally participate in second-messenger-regulated gene expression.",
"genre": "article",
"id": "sg:pub.10.1038/374085a0",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6517",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "374"
}
],
"keywords": [
"protein p300",
"gene expression",
"transcriptional co-activator CBP",
"co-activator function",
"co-activator CBP",
"PKA-phosphorylated form",
"protein kinase A",
"transcription factor CREB1",
"E1A binds",
"gene repression",
"hypothetical proteins",
"functional homologue",
"El A",
"protein CBP",
"transcriptional activation",
"related proteins",
"kinase A",
"similar binding affinities",
"CBP",
"p300",
"CREB",
"protein",
"binding affinities",
"expression",
"Caenorhabditiselegans",
"repression",
"homologues",
"CREB1",
"domain",
"binds",
"inactivation",
"function",
"activation",
"family",
"affinity",
"form",
"ELA",
"results"
],
"name": "Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP",
"pagination": "85-88",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1030959005"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/374085a0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"7870179"
]
}
],
"sameAs": [
"https://doi.org/10.1038/374085a0",
"https://app.dimensions.ai/details/publication/pub.1030959005"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T09:47",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_276.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/374085a0"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/374085a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/374085a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/374085a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/374085a0'
This table displays all metadata directly associated to this object as RDF triples.
211 TRIPLES
22 PREDICATES
86 URIs
72 LITERALS
22 BLANK NODES