A family of transcriptional adaptor proteins targeted by the E1A oncoprotein View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-03

AUTHORS

Zoltan Arany, David Newsome, Elizabeth Oldread, David M. Livingston, Richard Eckner

ABSTRACT

THE cellular protein p300 is a target of the adenoviral El A oncoprotein and is thought to participate in preventing the GO/G1 transition in the cell cycle, activating certain enhancers and stimulating differentiation pathways1. CBP is a protein that is associated with and coactivates the transcription factor CREB, mediating the induction by cyclic AMP of certain responsive promoters2–4. The sequences of p300 and CBP are highly related4,5. We show here that p300, like CBP2, can stimulate transcription. This activity is directly and specifically inhibited by E1A. We also find that CBP exists in a DNA-bound complex containing a member of the CREB family and that El A and CBP interact with one another in vivo. In keeping with the idea that El A functionally targets CBP, cAMP-dependent transcription is repressed by El A. Thus, p300 and CBP define a family of transcriptional adaptor proteins that are specifically targeted by the El A oncoprotein. More... »

PAGES

81-84

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/374081a0

DOI

http://dx.doi.org/10.1038/374081a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050930677

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7870178


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenovirus E1A Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CREB-Binding Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclic AMP", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcriptional Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Cells, Cultured", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arany", 
        "givenName": "Zoltan", 
        "id": "sg:person.014014372367.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014014372367.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Newsome", 
        "givenName": "David", 
        "id": "sg:person.01146577062.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146577062.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oldread", 
        "givenName": "Elizabeth", 
        "id": "sg:person.0633161350.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633161350.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Livingston", 
        "givenName": "David M.", 
        "id": "sg:person.011172773572.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011172773572.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eckner", 
        "givenName": "Richard", 
        "id": "sg:person.01032350462.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032350462.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/365855a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012014177", 
          "https://doi.org/10.1038/365855a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/370223a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048791872", 
          "https://doi.org/10.1038/370223a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/370226a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042384968", 
          "https://doi.org/10.1038/370226a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1995-03", 
    "datePublishedReg": "1995-03-01", 
    "description": "THE cellular protein p300 is a target of the adenoviral El A oncoprotein and is thought to participate in preventing the GO/G1 transition in the cell cycle, activating certain enhancers and stimulating differentiation pathways1. CBP is a protein that is associated with and coactivates the transcription factor CREB, mediating the induction by cyclic AMP of certain responsive promoters2\u20134. The sequences of p300 and CBP are highly related4,5. We show here that p300, like CBP2, can stimulate transcription. This activity is directly and specifically inhibited by E1A. We also find that CBP exists in a DNA-bound complex containing a member of the CREB family and that El A and CBP interact with one another in vivo. In keeping with the idea that El A functionally targets CBP, cAMP-dependent transcription is repressed by El A. Thus, p300 and CBP define a family of transcriptional adaptor proteins that are specifically targeted by the El A oncoprotein.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/374081a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6517", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "374"
      }
    ], 
    "keywords": [
      "transcriptional adaptor proteins", 
      "adaptor protein", 
      "cAMP-dependent transcription", 
      "DNA-binding complex", 
      "transcription factor CREB", 
      "El A", 
      "certain enhancers", 
      "CREB family", 
      "protein p300", 
      "cell cycle", 
      "G1 transition", 
      "CBP", 
      "protein", 
      "transcription", 
      "p300", 
      "oncoprotein", 
      "cyclic AMP", 
      "family", 
      "CBP2", 
      "E1A.", 
      "E1A", 
      "pathways1", 
      "CREB", 
      "enhancer", 
      "sequence", 
      "induction", 
      "vivo", 
      "complexes", 
      "members", 
      "target", 
      "Thus", 
      "AMP", 
      "activity", 
      "cycle", 
      "transition", 
      "Functionally", 
      "idea"
    ], 
    "name": "A family of transcriptional adaptor proteins targeted by the E1A oncoprotein", 
    "pagination": "81-84", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1050930677"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/374081a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7870178"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/374081a0", 
      "https://app.dimensions.ai/details/publication/pub.1050930677"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-05-10T09:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_292.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/374081a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/374081a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/374081a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/374081a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/374081a0'


 

This table displays all metadata directly associated to this object as RDF triples.

191 TRIPLES      22 PREDICATES      80 URIs      69 LITERALS      20 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/374081a0 schema:about N127b9f203d2b4534bc63c4917a1d9605
2 N2a7a6f5ca2014400b9ffa13ab2f3ab40
3 N2ee52c27dee7426e9ccf0e1c6376f324
4 N438097e3c9334bd7a9571f505d6253ad
5 N52ab29b953c645a78ccd8e6277a94fe5
6 N54618c6093bd4bbf9f793118f05e0216
7 N5d7dd7085ab6440c8138ebbeadf4783f
8 N770b8121851e40e2bd79ad36e64f9176
9 N96a3537cf41a4b8c99d601c180d84707
10 Na09656088a7f4df2bc8d4ed7c29a7c3b
11 Na28425461b0e44b7ae283632f8526cc0
12 Na68fc130fb0048e4a7e55513a21c4ddb
13 Nb6774ffcd37a499e8f43653d15f7e445
14 anzsrc-for:06
15 anzsrc-for:0601
16 schema:author N7901b995173345b18e25bfb406713e50
17 schema:citation sg:pub.10.1038/365855a0
18 sg:pub.10.1038/370223a0
19 sg:pub.10.1038/370226a0
20 schema:datePublished 1995-03
21 schema:datePublishedReg 1995-03-01
22 schema:description THE cellular protein p300 is a target of the adenoviral El A oncoprotein and is thought to participate in preventing the GO/G1 transition in the cell cycle, activating certain enhancers and stimulating differentiation pathways1. CBP is a protein that is associated with and coactivates the transcription factor CREB, mediating the induction by cyclic AMP of certain responsive promoters2–4. The sequences of p300 and CBP are highly related4,5. We show here that p300, like CBP2, can stimulate transcription. This activity is directly and specifically inhibited by E1A. We also find that CBP exists in a DNA-bound complex containing a member of the CREB family and that El A and CBP interact with one another in vivo. In keeping with the idea that El A functionally targets CBP, cAMP-dependent transcription is repressed by El A. Thus, p300 and CBP define a family of transcriptional adaptor proteins that are specifically targeted by the El A oncoprotein.
23 schema:genre article
24 schema:inLanguage en
25 schema:isAccessibleForFree false
26 schema:isPartOf N8ae9a84ecd7e4013bd06576e7c91beb3
27 Nff2d7cbd39364b189fbae5d825f2b0a3
28 sg:journal.1018957
29 schema:keywords AMP
30 CBP
31 CBP2
32 CREB
33 CREB family
34 DNA-binding complex
35 E1A
36 E1A.
37 El A
38 Functionally
39 G1 transition
40 Thus
41 activity
42 adaptor protein
43 cAMP-dependent transcription
44 cell cycle
45 certain enhancers
46 complexes
47 cycle
48 cyclic AMP
49 enhancer
50 family
51 idea
52 induction
53 members
54 oncoprotein
55 p300
56 pathways1
57 protein
58 protein p300
59 sequence
60 target
61 transcription
62 transcription factor CREB
63 transcriptional adaptor proteins
64 transition
65 vivo
66 schema:name A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
67 schema:pagination 81-84
68 schema:productId N403727d88ac34ccaaf8eaa699be04090
69 N90390add3ec24397884936c8b22c3410
70 N9b458d4936a84003bacc5e541fdef533
71 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050930677
72 https://doi.org/10.1038/374081a0
73 schema:sdDatePublished 2022-05-10T09:45
74 schema:sdLicense https://scigraph.springernature.com/explorer/license/
75 schema:sdPublisher N0cf74dd4023e490b80d1df814bbeaef6
76 schema:url https://doi.org/10.1038/374081a0
77 sgo:license sg:explorer/license/
78 sgo:sdDataset articles
79 rdf:type schema:ScholarlyArticle
80 N0cf74dd4023e490b80d1df814bbeaef6 schema:name Springer Nature - SN SciGraph project
81 rdf:type schema:Organization
82 N127b9f203d2b4534bc63c4917a1d9605 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Transcription Factors
84 rdf:type schema:DefinedTerm
85 N1fe8673db0a346ae8e8adf93857c20fb rdf:first sg:person.0633161350.38
86 rdf:rest N7ebb8b7f1a784cff9f02455681f20450
87 N2a7a6f5ca2014400b9ffa13ab2f3ab40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Humans
89 rdf:type schema:DefinedTerm
90 N2ee52c27dee7426e9ccf0e1c6376f324 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name DNA
92 rdf:type schema:DefinedTerm
93 N403727d88ac34ccaaf8eaa699be04090 schema:name dimensions_id
94 schema:value pub.1050930677
95 rdf:type schema:PropertyValue
96 N438097e3c9334bd7a9571f505d6253ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Transcriptional Activation
98 rdf:type schema:DefinedTerm
99 N52ab29b953c645a78ccd8e6277a94fe5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Adenovirus E1A Proteins
101 rdf:type schema:DefinedTerm
102 N54618c6093bd4bbf9f793118f05e0216 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Trans-Activators
104 rdf:type schema:DefinedTerm
105 N5d7dd7085ab6440c8138ebbeadf4783f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Tumor Cells, Cultured
107 rdf:type schema:DefinedTerm
108 N770b8121851e40e2bd79ad36e64f9176 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Recombinant Fusion Proteins
110 rdf:type schema:DefinedTerm
111 N788b0a046c1f4ac28834aa8c15b90919 rdf:first sg:person.01032350462.01
112 rdf:rest rdf:nil
113 N7901b995173345b18e25bfb406713e50 rdf:first sg:person.014014372367.34
114 rdf:rest Nce49d7961eca48a88d2e3763ab2fddf0
115 N7ebb8b7f1a784cff9f02455681f20450 rdf:first sg:person.011172773572.68
116 rdf:rest N788b0a046c1f4ac28834aa8c15b90919
117 N8ae9a84ecd7e4013bd06576e7c91beb3 schema:volumeNumber 374
118 rdf:type schema:PublicationVolume
119 N90390add3ec24397884936c8b22c3410 schema:name pubmed_id
120 schema:value 7870178
121 rdf:type schema:PropertyValue
122 N96a3537cf41a4b8c99d601c180d84707 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Nuclear Proteins
124 rdf:type schema:DefinedTerm
125 N9b458d4936a84003bacc5e541fdef533 schema:name doi
126 schema:value 10.1038/374081a0
127 rdf:type schema:PropertyValue
128 Na09656088a7f4df2bc8d4ed7c29a7c3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Transfection
130 rdf:type schema:DefinedTerm
131 Na28425461b0e44b7ae283632f8526cc0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cyclic AMP
133 rdf:type schema:DefinedTerm
134 Na68fc130fb0048e4a7e55513a21c4ddb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Protein Binding
136 rdf:type schema:DefinedTerm
137 Nb6774ffcd37a499e8f43653d15f7e445 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name CREB-Binding Protein
139 rdf:type schema:DefinedTerm
140 Nce49d7961eca48a88d2e3763ab2fddf0 rdf:first sg:person.01146577062.06
141 rdf:rest N1fe8673db0a346ae8e8adf93857c20fb
142 Nff2d7cbd39364b189fbae5d825f2b0a3 schema:issueNumber 6517
143 rdf:type schema:PublicationIssue
144 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
145 schema:name Biological Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
148 schema:name Biochemistry and Cell Biology
149 rdf:type schema:DefinedTerm
150 sg:journal.1018957 schema:issn 0028-0836
151 1476-4687
152 schema:name Nature
153 schema:publisher Springer Nature
154 rdf:type schema:Periodical
155 sg:person.01032350462.01 schema:affiliation grid-institutes:grid.38142.3c
156 schema:familyName Eckner
157 schema:givenName Richard
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032350462.01
159 rdf:type schema:Person
160 sg:person.011172773572.68 schema:affiliation grid-institutes:grid.38142.3c
161 schema:familyName Livingston
162 schema:givenName David M.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011172773572.68
164 rdf:type schema:Person
165 sg:person.01146577062.06 schema:affiliation grid-institutes:grid.38142.3c
166 schema:familyName Newsome
167 schema:givenName David
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146577062.06
169 rdf:type schema:Person
170 sg:person.014014372367.34 schema:affiliation grid-institutes:grid.38142.3c
171 schema:familyName Arany
172 schema:givenName Zoltan
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014014372367.34
174 rdf:type schema:Person
175 sg:person.0633161350.38 schema:affiliation grid-institutes:grid.38142.3c
176 schema:familyName Oldread
177 schema:givenName Elizabeth
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633161350.38
179 rdf:type schema:Person
180 sg:pub.10.1038/365855a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012014177
181 https://doi.org/10.1038/365855a0
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/370223a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048791872
184 https://doi.org/10.1038/370223a0
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/370226a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042384968
187 https://doi.org/10.1038/370226a0
188 rdf:type schema:CreativeWork
189 grid-institutes:grid.38142.3c schema:alternateName The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA
190 schema:name The Dana Farber Cancer Institute and Harvard Medical School, 44 Binney Street, 02115, Boston, Massachusetts, USA
191 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...