A B-cell coactivator of octamer-binding transcription factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1995-01

AUTHORS

M Gstaiger, L Knoepfel, O Georgiev, W Schaffner, C M Hovens

ABSTRACT

The octamer motif (ATGCAAAT) paradoxically plays a central role in mediating the activity of both B-cell specific and ubiquitous promoters. It has been widely assumed that the predominantly lymphoid-restricted octamer-binding factor Oct-2 mediates tissue-specific promoter activity, whereas the ubiquitously expressed Oct-1 mediates general promoter activity, but this view has been challenged. Here we use a modified yeast one-hybrid assay to isolate a B-cell factor, Bob1, which associates with either Oct-2 or Oct-1. In transfection experiments, this factor boosts Oct-1-mediated promoter activity and to a lesser extent, that of Oct-2. This coactivation is strictly dependent on the specific interaction with Oct-1 or Oct-2 because deletion of the octamer motif abolishes coactivation. We conclude that Bob1 could represent a new tissue-specific transcriptional coactivator which may convert a ubiquitously expressed transcription factor to a cell-type-specific activator. More... »

PAGES

360

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/373360a0

DOI

http://dx.doi.org/10.1038/373360a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050104470

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7779176


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