Structure of the NF-κB p50 homodimer bound to DNA View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-01

AUTHORS

C W Müller, F A Rey, M Sodeoka, G L Verdine, S C Harrison

ABSTRACT

The structure of a large fragment of the p50 subunit of the human transcription factor NF-kappa B, bound as a homodimer to DNA, reveals that the Rel-homology region has two beta-barrel domains that grip DNA in the major groove. Both domains contact the DNA backbone. The amino-terminal specificity domain contains a recognition loop that interacts with DNA bases; the carboxy-terminal dimerization domain bears the site of I-kappa B interaction. The folds of these domains are related to immunoglobulin-like modules. The amino-terminal domain also resembles the core domain of p53. More... »

PAGES

311-317

Journal

TITLE

Nature

ISSUE

6512

VOLUME

373

Author Affiliations

Related Patents

  • Inhibitors Of Type 2 Vascular Endothelial Growth Factor Receptors
  • Compositions And Methods For Determining The Activity Of Dna-Binding Proteins And Of Initiation Of Transcription
  • Composition And Methods For Determining The Activity Of Dna-Binding Proteins And Of Initiation Of Trascription
  • Serum Albumin Binding Molecules
  • Therapeutic Curcumin Derivatives
  • Methods Of Inhibiting Type 2 Vascular Endothelial Growth Factor Receptors Using Polypeptides
  • Protein Scaffolds For Antibody Mimics And Other Binding Proteins
  • Protein Scaffolds For Antibody Mimics And Other Binding Proteins
  • Serum Albumin Binding Molecules
  • Bispecific Egfr/Igfir Binding Molecules
  • Multivalent Fibronectin Based Scaffold Domain Proteins
  • Artificial Antibody Polypeptides
  • Artificial Antibody Polypeptides
  • Inhibitors Of Type 2 Vascular Endothelial Growth Factor Receptors
  • Fibronectin Based Scaffold Proteins Having Improved Stability
  • Protein Scaffolds For Antibody Mimics And Other Binding Proteins
  • Targeted Therapeutics Based On Engineered Proteins That Bind Egfr
  • Method Of Treating Cancer By Administering Egfr And Egfr/Igfir Binding Molecules
  • Nucleic Acid Encoding 10fn3 Polypeptide Inhibitors Of Type 2 Vascular Endothelial Growth Factor Receptors
  • Artificial Antibody Polypeptides
  • Targeted Therapeutics Based On Engineered Proteins That Bind Egfr
  • Artificial Antibody Polypeptides
  • Inhibitors Of Type 2 Vascular Endothelial Growth Factor Receptors
  • Reconstituted Polypeptides
  • Pharmacokinetic Modulation And Compositions For Modified Fn3 Polypeptides
  • Artificial Antibody Polypeptides
  • Compositions And Methods For Determining The Activity Of Dna-Binding Proteins And Of Initiation Of Transcription
  • Therapeutic Curcumin Derivatives
  • Multivalent Fibronectin Based Scaffold Domain Proteins
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/373311a0

    DOI

    http://dx.doi.org/10.1038/373311a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026631071

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7830764


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Computer Graphics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Crystallography, X-Ray", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "NF-kappa B", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "NF-kappa B p50 Subunit", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nucleic Acid Conformation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Conformation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins c-rel", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recombinant Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute", 
              "id": "https://www.grid.ac/institutes/grid.413575.1", 
              "name": [
                "Howard Hughes Medical Institute, Cambridge, Massachusetts 02138."
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00fcller", 
            "givenName": "C W", 
            "id": "sg:person.01010124250.90", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010124250.90"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Rey", 
            "givenName": "F A", 
            "id": "sg:person.0772757574.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772757574.18"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Sodeoka", 
            "givenName": "M", 
            "id": "sg:person.01304431560.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304431560.00"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Verdine", 
            "givenName": "G L", 
            "id": "sg:person.0716610205.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716610205.05"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Harrison", 
            "givenName": "S C", 
            "id": "sg:person.013635370377.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013635370377.53"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1084/jem.169.4.1309", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000261339"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0021889888007903", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002264445"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90554-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004608030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.3.908", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004691234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/362219a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006902089", 
              "https://doi.org/10.1038/362219a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(05)80070-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007110256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(05)80070-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007110256"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90275-j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007165723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.73.3.804", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008317328"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/jmbi.1994.1582", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010002758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.7.1.305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010892055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(91)90320-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014027684"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0108767390010224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014210169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0021889891004399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014885043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373257a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016951914", 
              "https://doi.org/10.1038/373257a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-894x(00)80294-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018315488"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0567739476001691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020146113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0021889891007240", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021179039"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/354395a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023837651", 
              "https://doi.org/10.1038/354395a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.5.1529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025367325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1074-5521(94)90040-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027611552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1101/gad.6.10.1899", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027727502"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.340040202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037619816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/prot.340040202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037619816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90276-k", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039149433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.12.10.4412", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040059281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-419x(91)90007-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043133559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0304-419x(91)90007-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043133559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.12.7.3094", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044761952"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.15.6948", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046393740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/357089a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046499813", 
              "https://doi.org/10.1038/357089a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/355472a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048571716", 
              "https://doi.org/10.1038/355472a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0074-7696(08)61873-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049014477"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/07391102.1988.10506483", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049015027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(86)90346-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052016317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/373303a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053068417", 
              "https://doi.org/10.1038/373303a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00693a025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055185558"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1279805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062471450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2006423", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062518047"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2028256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062518816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3118464", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062591696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3140380", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062594099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8023157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062652004"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1990.tb08287.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1078435826"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1995-01", 
        "datePublishedReg": "1995-01-01", 
        "description": "The structure of a large fragment of the p50 subunit of the human transcription factor NF-kappa B, bound as a homodimer to DNA, reveals that the Rel-homology region has two beta-barrel domains that grip DNA in the major groove. Both domains contact the DNA backbone. The amino-terminal specificity domain contains a recognition loop that interacts with DNA bases; the carboxy-terminal dimerization domain bears the site of I-kappa B interaction. The folds of these domains are related to immunoglobulin-like modules. The amino-terminal domain also resembles the core domain of p53.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/373311a0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6512", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "373"
          }
        ], 
        "name": "Structure of the NF-\u03baB p50 homodimer bound to DNA", 
        "pagination": "311-317", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "7ede2288e271edd63a6f099f70cc317d192d7d97edb1918d72be187a7f98c043"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "7830764"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/373311a0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1026631071"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/373311a0", 
          "https://app.dimensions.ai/details/publication/pub.1026631071"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nature/journal/v373/n6512/full/373311a0.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/373311a0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/373311a0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/373311a0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/373311a0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    282 TRIPLES      21 PREDICATES      85 URIs      36 LITERALS      24 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/373311a0 schema:about N1a923247bda64e42802bf79d794d2996
    2 N21735093056c4b43a298b7b4287c6d53
    3 N2bfec9419d184f0e830587eeaf3c34d5
    4 N3049e68fc49340e7a9c2e121d9f82d88
    5 N3824a0c8ac5c49a1b538c3d62826fa97
    6 N867eb10b894c4122a6eac92ca71cc146
    7 N8877d45754064cff88be1f8960c3369c
    8 Na3a37953a4e44f52af3bcfa6fd8475b8
    9 Na9bce876b9a8485197f10102525f0525
    10 Nbe2c9d6dd64f451f9f44d5f3c258c613
    11 Nc682f6d31de34a9ab8d655000cc384c3
    12 Nc719f7fdba404e12a413451ab1db6ab7
    13 Nd178d784ae5d495fa5ca299ff245b78e
    14 Nd6d0eb118d8042acb2d942c8a9cf0a15
    15 Nf997a51905694bd29306e8caab3a3fb1
    16 anzsrc-for:06
    17 anzsrc-for:0601
    18 schema:author N50867b24de254cc082898ec6ebf30d58
    19 schema:citation sg:pub.10.1038/354395a0
    20 sg:pub.10.1038/355472a0
    21 sg:pub.10.1038/357089a0
    22 sg:pub.10.1038/362219a0
    23 sg:pub.10.1038/373257a0
    24 sg:pub.10.1038/373303a0
    25 https://doi.org/10.1002/j.1460-2075.1990.tb08287.x
    26 https://doi.org/10.1002/prot.340040202
    27 https://doi.org/10.1006/jmbi.1994.1582
    28 https://doi.org/10.1016/0092-8674(86)90346-6
    29 https://doi.org/10.1016/0092-8674(90)90275-j
    30 https://doi.org/10.1016/0092-8674(90)90276-k
    31 https://doi.org/10.1016/0092-8674(91)90320-x
    32 https://doi.org/10.1016/0092-8674(92)90554-p
    33 https://doi.org/10.1016/0304-419x(91)90007-8
    34 https://doi.org/10.1016/1074-5521(94)90040-x
    35 https://doi.org/10.1016/s0074-7696(08)61873-2
    36 https://doi.org/10.1016/s0092-8674(05)80070-4
    37 https://doi.org/10.1016/s0960-894x(00)80294-2
    38 https://doi.org/10.1021/bi00693a025
    39 https://doi.org/10.1073/pnas.73.3.804
    40 https://doi.org/10.1073/pnas.89.5.1529
    41 https://doi.org/10.1073/pnas.91.15.6948
    42 https://doi.org/10.1073/pnas.91.3.908
    43 https://doi.org/10.1080/07391102.1988.10506483
    44 https://doi.org/10.1084/jem.169.4.1309
    45 https://doi.org/10.1101/gad.6.10.1899
    46 https://doi.org/10.1107/s0021889888007903
    47 https://doi.org/10.1107/s0021889891004399
    48 https://doi.org/10.1107/s0021889891007240
    49 https://doi.org/10.1107/s0108767390010224
    50 https://doi.org/10.1107/s0567739476001691
    51 https://doi.org/10.1126/science.1279805
    52 https://doi.org/10.1126/science.2006423
    53 https://doi.org/10.1126/science.2028256
    54 https://doi.org/10.1126/science.3118464
    55 https://doi.org/10.1126/science.3140380
    56 https://doi.org/10.1126/science.8023157
    57 https://doi.org/10.1128/mcb.12.10.4412
    58 https://doi.org/10.1128/mcb.12.7.3094
    59 https://doi.org/10.1128/mcb.7.1.305
    60 schema:datePublished 1995-01
    61 schema:datePublishedReg 1995-01-01
    62 schema:description The structure of a large fragment of the p50 subunit of the human transcription factor NF-kappa B, bound as a homodimer to DNA, reveals that the Rel-homology region has two beta-barrel domains that grip DNA in the major groove. Both domains contact the DNA backbone. The amino-terminal specificity domain contains a recognition loop that interacts with DNA bases; the carboxy-terminal dimerization domain bears the site of I-kappa B interaction. The folds of these domains are related to immunoglobulin-like modules. The amino-terminal domain also resembles the core domain of p53.
    63 schema:genre research_article
    64 schema:inLanguage en
    65 schema:isAccessibleForFree false
    66 schema:isPartOf N11d8e1257b0e4cec89f8977d90d355a1
    67 Nafd8f70e20a642d3b5c730922dc4ffaa
    68 sg:journal.1018957
    69 schema:name Structure of the NF-κB p50 homodimer bound to DNA
    70 schema:pagination 311-317
    71 schema:productId N3e9bf8920a8c4f6ab0be1436addb633d
    72 N7d9e2749fd3c4939838cffc4df69bd2c
    73 N99fe7ddafd9641a0b6079cd408a88c53
    74 N9ec531d778d6468d9e986feceaeff754
    75 Nd883e8b40b1d4eb79291087b6d2befa8
    76 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026631071
    77 https://doi.org/10.1038/373311a0
    78 schema:sdDatePublished 2019-04-10T17:19
    79 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    80 schema:sdPublisher N8f533e070a35443692d5f25fc6750ec0
    81 schema:url http://www.nature.com/nature/journal/v373/n6512/full/373311a0.html
    82 sgo:license sg:explorer/license/
    83 sgo:sdDataset articles
    84 rdf:type schema:ScholarlyArticle
    85 N0ad3cdfb76e04626bdc9ebc9f099e52a rdf:first sg:person.01304431560.00
    86 rdf:rest N724b1b59cbb243b2a810cb662b6383ba
    87 N11d8e1257b0e4cec89f8977d90d355a1 schema:volumeNumber 373
    88 rdf:type schema:PublicationVolume
    89 N1a923247bda64e42802bf79d794d2996 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Molecular Sequence Data
    91 rdf:type schema:DefinedTerm
    92 N21735093056c4b43a298b7b4287c6d53 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Protein Conformation
    94 rdf:type schema:DefinedTerm
    95 N2bfec9419d184f0e830587eeaf3c34d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Protein Binding
    97 rdf:type schema:DefinedTerm
    98 N3049e68fc49340e7a9c2e121d9f82d88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Base Sequence
    100 rdf:type schema:DefinedTerm
    101 N3824a0c8ac5c49a1b538c3d62826fa97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name DNA
    103 rdf:type schema:DefinedTerm
    104 N3e9bf8920a8c4f6ab0be1436addb633d schema:name readcube_id
    105 schema:value 7ede2288e271edd63a6f099f70cc317d192d7d97edb1918d72be187a7f98c043
    106 rdf:type schema:PropertyValue
    107 N4d50766c3f3b4283b28b422b1f9ed5a3 rdf:first sg:person.0772757574.18
    108 rdf:rest N0ad3cdfb76e04626bdc9ebc9f099e52a
    109 N50867b24de254cc082898ec6ebf30d58 rdf:first sg:person.01010124250.90
    110 rdf:rest N4d50766c3f3b4283b28b422b1f9ed5a3
    111 N724b1b59cbb243b2a810cb662b6383ba rdf:first sg:person.0716610205.05
    112 rdf:rest Nac772a0ad66c4ac2a946cd9faeeeb7fa
    113 N7d9e2749fd3c4939838cffc4df69bd2c schema:name pubmed_id
    114 schema:value 7830764
    115 rdf:type schema:PropertyValue
    116 N867eb10b894c4122a6eac92ca71cc146 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Humans
    118 rdf:type schema:DefinedTerm
    119 N8877d45754064cff88be1f8960c3369c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    120 schema:name Proto-Oncogene Proteins c-rel
    121 rdf:type schema:DefinedTerm
    122 N8f533e070a35443692d5f25fc6750ec0 schema:name Springer Nature - SN SciGraph project
    123 rdf:type schema:Organization
    124 N99fe7ddafd9641a0b6079cd408a88c53 schema:name doi
    125 schema:value 10.1038/373311a0
    126 rdf:type schema:PropertyValue
    127 N9ec531d778d6468d9e986feceaeff754 schema:name nlm_unique_id
    128 schema:value 0410462
    129 rdf:type schema:PropertyValue
    130 Na3a37953a4e44f52af3bcfa6fd8475b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Recombinant Proteins
    132 rdf:type schema:DefinedTerm
    133 Na9bce876b9a8485197f10102525f0525 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name NF-kappa B
    135 rdf:type schema:DefinedTerm
    136 Nac772a0ad66c4ac2a946cd9faeeeb7fa rdf:first sg:person.013635370377.53
    137 rdf:rest rdf:nil
    138 Nafd8f70e20a642d3b5c730922dc4ffaa schema:issueNumber 6512
    139 rdf:type schema:PublicationIssue
    140 Nbe2c9d6dd64f451f9f44d5f3c258c613 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Nucleic Acid Conformation
    142 rdf:type schema:DefinedTerm
    143 Nc682f6d31de34a9ab8d655000cc384c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Crystallography, X-Ray
    145 rdf:type schema:DefinedTerm
    146 Nc719f7fdba404e12a413451ab1db6ab7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    147 schema:name Computer Graphics
    148 rdf:type schema:DefinedTerm
    149 Nd178d784ae5d495fa5ca299ff245b78e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    150 schema:name NF-kappa B p50 Subunit
    151 rdf:type schema:DefinedTerm
    152 Nd6d0eb118d8042acb2d942c8a9cf0a15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Amino Acid Sequence
    154 rdf:type schema:DefinedTerm
    155 Nd883e8b40b1d4eb79291087b6d2befa8 schema:name dimensions_id
    156 schema:value pub.1026631071
    157 rdf:type schema:PropertyValue
    158 Nf997a51905694bd29306e8caab3a3fb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Proto-Oncogene Proteins
    160 rdf:type schema:DefinedTerm
    161 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    162 schema:name Biological Sciences
    163 rdf:type schema:DefinedTerm
    164 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    165 schema:name Biochemistry and Cell Biology
    166 rdf:type schema:DefinedTerm
    167 sg:journal.1018957 schema:issn 0090-0028
    168 1476-4687
    169 schema:name Nature
    170 rdf:type schema:Periodical
    171 sg:person.01010124250.90 schema:affiliation https://www.grid.ac/institutes/grid.413575.1
    172 schema:familyName Müller
    173 schema:givenName C W
    174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010124250.90
    175 rdf:type schema:Person
    176 sg:person.01304431560.00 schema:familyName Sodeoka
    177 schema:givenName M
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304431560.00
    179 rdf:type schema:Person
    180 sg:person.013635370377.53 schema:familyName Harrison
    181 schema:givenName S C
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013635370377.53
    183 rdf:type schema:Person
    184 sg:person.0716610205.05 schema:familyName Verdine
    185 schema:givenName G L
    186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716610205.05
    187 rdf:type schema:Person
    188 sg:person.0772757574.18 schema:familyName Rey
    189 schema:givenName F A
    190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0772757574.18
    191 rdf:type schema:Person
    192 sg:pub.10.1038/354395a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023837651
    193 https://doi.org/10.1038/354395a0
    194 rdf:type schema:CreativeWork
    195 sg:pub.10.1038/355472a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048571716
    196 https://doi.org/10.1038/355472a0
    197 rdf:type schema:CreativeWork
    198 sg:pub.10.1038/357089a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046499813
    199 https://doi.org/10.1038/357089a0
    200 rdf:type schema:CreativeWork
    201 sg:pub.10.1038/362219a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006902089
    202 https://doi.org/10.1038/362219a0
    203 rdf:type schema:CreativeWork
    204 sg:pub.10.1038/373257a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016951914
    205 https://doi.org/10.1038/373257a0
    206 rdf:type schema:CreativeWork
    207 sg:pub.10.1038/373303a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053068417
    208 https://doi.org/10.1038/373303a0
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1002/j.1460-2075.1990.tb08287.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1078435826
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1002/prot.340040202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037619816
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1006/jmbi.1994.1582 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010002758
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/0092-8674(86)90346-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052016317
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/0092-8674(90)90275-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1007165723
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/0092-8674(90)90276-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1039149433
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/0092-8674(91)90320-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014027684
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/0092-8674(92)90554-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1004608030
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/0304-419x(91)90007-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043133559
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/1074-5521(94)90040-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027611552
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1016/s0074-7696(08)61873-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049014477
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1016/s0092-8674(05)80070-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007110256
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1016/s0960-894x(00)80294-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018315488
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1021/bi00693a025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055185558
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1073/pnas.73.3.804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008317328
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1073/pnas.89.5.1529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025367325
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1073/pnas.91.15.6948 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046393740
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1073/pnas.91.3.908 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004691234
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1080/07391102.1988.10506483 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049015027
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1084/jem.169.4.1309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000261339
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1101/gad.6.10.1899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027727502
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1107/s0021889888007903 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002264445
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1107/s0021889891004399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014885043
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1107/s0021889891007240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021179039
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1107/s0108767390010224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014210169
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1107/s0567739476001691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020146113
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1126/science.1279805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062471450
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1126/science.2006423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062518047
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1126/science.2028256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062518816
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1126/science.3118464 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062591696
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1126/science.3140380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062594099
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1126/science.8023157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652004
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1128/mcb.12.10.4412 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040059281
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1128/mcb.12.7.3094 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044761952
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1128/mcb.7.1.305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010892055
    279 rdf:type schema:CreativeWork
    280 https://www.grid.ac/institutes/grid.413575.1 schema:alternateName Howard Hughes Medical Institute
    281 schema:name Howard Hughes Medical Institute, Cambridge, Massachusetts 02138.
    282 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...