Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-01

AUTHORS

David D. Ho, Avidan U. Neumann, Alan S. Perelson, Wen Chen, John M. Leonard, Martin Markowitz

ABSTRACT

Treatment of infected patients with ABT-538, an inhibitor of the protease of human immuno-deficiency virus type 1 (HIV-1), causes plasma HIV-1 levels to decrease exponentially (mean half-life, 2.1 ±0.4 days) and CD4 lymphocyte counts to rise substantially. Minimum estimates of HIV-1 production and clearance and of CD4 lymphocyte turnover indicate that replication of HIV-1 in vivo is continuous and highly productive, driving the rapid turnover of CD4 lymphocytes. More... »

PAGES

123-126

Journal

TITLE

Nature

ISSUE

6510

VOLUME

373

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/373123a0

    DOI

    http://dx.doi.org/10.1038/373123a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1014949926

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7816094


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