Acetylcholine receptor channel imaged in the open state View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1995-01

AUTHORS

N Unwin

ABSTRACT

The structure of the open-channel form of the acetylcholine receptor has been determined from electron images of Torpedo ray postsynaptic membranes activated by brief (< 5 ms) mixing with droplets containing acetylcholine. Comparison with the closed-channel form shows that acetylcholine initiates small rotations of the subunits in the extracellular domain, which trigger a change in configuration of alpha-helices lining the membrane-spanning pore. The open pore tapers towards the intracellular membrane face, where it is shaped by a 'barrel' of alpha-helices having a pronounced right-handed twist. More... »

PAGES

37-43

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/373037a0

DOI

http://dx.doi.org/10.1038/373037a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050150805

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7800037


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