TGF-β signalling from cell membrane to nucleus through SMAD proteins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-12

AUTHORS

C H Heldin, K Miyazono, P ten Dijke

ABSTRACT

The recent identification of the SMAD family of signal transducer proteins has unravelled the mechanisms by which transforming growth factor-beta (TGF-beta) signals from the cell membrane to the nucleus. Pathway-restricted SMADs are phosphorylated by specific cell-surface receptors that have serine/threonine kinase activity, then they oligomerize with the common mediator Smad4 and translocate to the nucleus where they direct transcription to effect the cell's response to TGF-beta. Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADs. More... »

PAGES

465-471

References to SciGraph publications

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  • Journal

    TITLE

    Nature

    ISSUE

    6659

    VOLUME

    390

    Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/37284

    DOI

    http://dx.doi.org/10.1038/37284

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1001112208

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9393997


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