Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-12

AUTHORS

Irma Sánchez, Rowland T. Hughes, Bruce J. Mayer, Karen Yee, James R. Woodgett, Joseph Avruch, John M. Kyriakls, Leonard I. Zon

ABSTRACT

THE stress-activated protein kinases (SAPKs), which are distantly related to the MAP kinases, are the dominant c-Jun amino-termi-nal protein kinases activated in response to a variety of cellular stresses, including treatment with tumour-necrosis factor-α and interleukin-β (refs 1, 2). SAPK phosphorylation of c-Jun probably activates the c-Jun transactivation function3. SAPKs are part of a signal transduction cascade related to, but distinct from, the MAPK pathway1. We have now identified a novel protein kinase, called SAPK/ERK kinase-1 (SEK1), which is structurally related to the MAP kinase kinases (MEKs)4. SEK1 is a potent activator of the SAPKs in vitro and in vivo. An inactive SEK1 mutant blocks SAPK activation by extracellular stimuli without interfering with the MAPK pathway. Although alternative mechanisms of SAPK activation may exist, as an immediate upstream activator of the SAPKs, SEK1 further defines a signalling cascade that couples cellular stress agonists to the c-Jun transcription factor. More... »

PAGES

794-798

Journal

TITLE

Nature

ISSUE

6508

VOLUME

372

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/372794a0

DOI

http://dx.doi.org/10.1038/372794a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1012539120

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7997269


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Base Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cloning, Molecular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Complementary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heat-Shock Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Kinase 4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Kinase Kinase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Muscles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-jun", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sequence Homology, Amino Acid", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Substrate Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital East, and Department of Medicine Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital East, and Department of Medicine Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "S\u00e1nchez", 
        "givenName": "Irma", 
        "id": "sg:person.0671571352.95", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671571352.95"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology/Oncology, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Hematology/Oncology, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hughes", 
        "givenName": "Rowland T.", 
        "id": "sg:person.0673156416.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673156416.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute, Children's Hospital and \u00b6 Dana-Farber Cancer Institute, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Department of Microbiology and Molecular Genetics, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA", 
            "Howard Hughes Medical Institute, Children's Hospital and \u00b6 Dana-Farber Cancer Institute, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mayer", 
        "givenName": "Bruce J.", 
        "id": "sg:person.01244537451.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244537451.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Hematology/Oncology, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Division of Hematology/Oncology, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yee", 
        "givenName": "Karen", 
        "id": "sg:person.0665115156.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665115156.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ontario Cancer Institute, Princess Margaret Hospital, 500 Sherbourne Street, M4X 1K9, Toronto, Ontario, Canada", 
          "id": "http://www.grid.ac/institutes/grid.415224.4", 
          "name": [
            "Ontario Cancer Institute, Princess Margaret Hospital, 500 Sherbourne Street, M4X 1K9, Toronto, Ontario, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Woodgett", 
        "givenName": "James R.", 
        "id": "sg:person.0731233037.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731233037.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital East, and Department of Medicine Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital East, and Department of Medicine Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Avruch", 
        "givenName": "Joseph", 
        "id": "sg:person.01074100404.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074100404.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital East, and Department of Medicine Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital East, and Department of Medicine Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kyriakls", 
        "givenName": "John M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Howard Hughes Medical Institute, Children's Hospital and \u00b6 Dana-Farber Cancer Institute, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.65499.37", 
          "name": [
            "Division of Hematology/Oncology, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA", 
            "Howard Hughes Medical Institute, Children's Hospital and \u00b6 Dana-Farber Cancer Institute, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zon", 
        "givenName": "Leonard I.", 
        "id": "sg:person.015341736157.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015341736157.56"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/369156a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029771272", 
          "https://doi.org/10.1038/369156a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/353670a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030142073", 
          "https://doi.org/10.1038/353670a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372798a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022511929", 
          "https://doi.org/10.1038/372798a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-12", 
    "datePublishedReg": "1994-12-01", 
    "description": "THE stress-activated protein kinases (SAPKs), which are distantly related to the MAP kinases, are the dominant c-Jun amino-termi-nal protein kinases activated in response to a variety of cellular stresses, including treatment with tumour-necrosis factor-\u03b1 and interleukin-\u03b2 (refs 1, 2). SAPK phosphorylation of c-Jun probably activates the c-Jun transactivation function3. SAPKs are part of a signal transduction cascade related to, but distinct from, the MAPK pathway1. We have now identified a novel protein kinase, called SAPK/ERK kinase-1 (SEK1), which is structurally related to the MAP kinase kinases (MEKs)4. SEK1 is a potent activator of the SAPKs in vitro and in vivo. An inactive SEK1 mutant blocks SAPK activation by extracellular stimuli without interfering with the MAPK pathway. Although alternative mechanisms of SAPK activation may exist, as an immediate upstream activator of the SAPKs, SEK1 further defines a signalling cascade that couples cellular stress agonists to the c-Jun transcription factor.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/372794a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7137801", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6508", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "372"
      }
    ], 
    "keywords": [
      "stress-activated protein kinase", 
      "SAPK/ERK kinase 1", 
      "ERK kinase 1", 
      "protein kinase", 
      "SAPK activation", 
      "kinase 1", 
      "novel protein kinase", 
      "MAP kinase kinase", 
      "signal transduction cascade", 
      "immediate upstream activator", 
      "stress-activated pathways", 
      "Jun transcription factor", 
      "transcription factor c", 
      "extracellular stimuli", 
      "kinase kinase", 
      "transduction cascade", 
      "transcription factors", 
      "cellular stress", 
      "upstream activator", 
      "SAPK phosphorylation", 
      "MAP kinase", 
      "MAPK pathway", 
      "kinase", 
      "factor C", 
      "potent activator", 
      "alternative mechanism", 
      "activator", 
      "pathway", 
      "cascade", 
      "activation", 
      "phosphorylation", 
      "pathway1", 
      "function3", 
      "tumor necrosis factor", 
      "vitro", 
      "vivo", 
      "mechanism", 
      "role", 
      "stress", 
      "factors", 
      "variety", 
      "response", 
      "stimuli", 
      "agonists", 
      "interleukin", 
      "part", 
      "treatment"
    ], 
    "name": "Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun", 
    "pagination": "794-798", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1012539120"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/372794a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7997269"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/372794a0", 
      "https://app.dimensions.ai/details/publication/pub.1012539120"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-06-01T22:00", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_234.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/372794a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/372794a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/372794a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/372794a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/372794a0'


 

This table displays all metadata directly associated to this object as RDF triples.

270 TRIPLES      22 PREDICATES      99 URIs      88 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/372794a0 schema:about N036bef75c77240fd9fd886ae1429e328
2 N05157ca9f0804fd4bc7f8fae2cca074f
3 N0656dd27f0c64eaaa0bcaddb96205eda
4 N09c3a037651d41ab95a799b70aa03760
5 N0c6be12b6c6a4be99d6a62eaf4161aa7
6 N164200300fe24499b85d10c33c137a09
7 N22f33c510ee24e0f9875a01ee56eb796
8 N3eb94d3ae9c2433abc25fd418bffa288
9 N55147176d0e44f18989a180171b22d7d
10 N586f28f47250487a83ba994490387703
11 N6ea9e181ee014a6f9032873cd65806d1
12 N709a8342c53942d5996550fed45b675c
13 N82a74217ed14451eab40c55d46e900b5
14 N8d4929a68bc5425eacc555078b087091
15 Nc82b580edcd24c23be542fdceeb903ce
16 Nd8193f927cb04e0aaeb0e8c4129e426f
17 Nd8476c6588054c829378713189697323
18 Ne1a8e9986eea4784a0033cbb9084214a
19 Ne94a2a35d31747c1a31b11f2350c07b9
20 Nf1e20661089d4caa9464e984fb9a5eb1
21 Nf225270d6ab04bf58de93c21a7c15b22
22 Nfc0c0ac59dc04bbfbbdfc394144d5b4f
23 anzsrc-for:06
24 anzsrc-for:0601
25 schema:author N5a8346b09a574fbcb8de7332443e4b1b
26 schema:citation sg:pub.10.1038/353670a0
27 sg:pub.10.1038/369156a0
28 sg:pub.10.1038/372798a0
29 schema:datePublished 1994-12
30 schema:datePublishedReg 1994-12-01
31 schema:description THE stress-activated protein kinases (SAPKs), which are distantly related to the MAP kinases, are the dominant c-Jun amino-termi-nal protein kinases activated in response to a variety of cellular stresses, including treatment with tumour-necrosis factor-α and interleukin-β (refs 1, 2). SAPK phosphorylation of c-Jun probably activates the c-Jun transactivation function3. SAPKs are part of a signal transduction cascade related to, but distinct from, the MAPK pathway1. We have now identified a novel protein kinase, called SAPK/ERK kinase-1 (SEK1), which is structurally related to the MAP kinase kinases (MEKs)4. SEK1 is a potent activator of the SAPKs in vitro and in vivo. An inactive SEK1 mutant blocks SAPK activation by extracellular stimuli without interfering with the MAPK pathway. Although alternative mechanisms of SAPK activation may exist, as an immediate upstream activator of the SAPKs, SEK1 further defines a signalling cascade that couples cellular stress agonists to the c-Jun transcription factor.
32 schema:genre article
33 schema:inLanguage en
34 schema:isAccessibleForFree false
35 schema:isPartOf Na671a1dc1a7f4d0a94005ee4a0e10d8f
36 Nc1372d5c583f4d5c998bf19c3a4c6b93
37 sg:journal.1018957
38 schema:keywords ERK kinase 1
39 Jun transcription factor
40 MAP kinase
41 MAP kinase kinase
42 MAPK pathway
43 SAPK activation
44 SAPK phosphorylation
45 SAPK/ERK kinase 1
46 activation
47 activator
48 agonists
49 alternative mechanism
50 cascade
51 cellular stress
52 extracellular stimuli
53 factor C
54 factors
55 function3
56 immediate upstream activator
57 interleukin
58 kinase
59 kinase 1
60 kinase kinase
61 mechanism
62 novel protein kinase
63 part
64 pathway
65 pathway1
66 phosphorylation
67 potent activator
68 protein kinase
69 response
70 role
71 signal transduction cascade
72 stimuli
73 stress
74 stress-activated pathways
75 stress-activated protein kinase
76 transcription factor c
77 transcription factors
78 transduction cascade
79 treatment
80 tumor necrosis factor
81 upstream activator
82 variety
83 vitro
84 vivo
85 schema:name Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
86 schema:pagination 794-798
87 schema:productId N696af82050d448b4b9a4571c0ace87a7
88 N71d9e6fb652f42b182b27a4222d5c719
89 Nf02b9cc602884abba8529ecb38ff9eae
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012539120
91 https://doi.org/10.1038/372794a0
92 schema:sdDatePublished 2022-06-01T22:00
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N55dd627157c0494087ecfaf25b0c7c9e
95 schema:url https://doi.org/10.1038/372794a0
96 sgo:license sg:explorer/license/
97 sgo:sdDataset articles
98 rdf:type schema:ScholarlyArticle
99 N036bef75c77240fd9fd886ae1429e328 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Transcription, Genetic
101 rdf:type schema:DefinedTerm
102 N05157ca9f0804fd4bc7f8fae2cca074f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Heat-Shock Proteins
104 rdf:type schema:DefinedTerm
105 N0656dd27f0c64eaaa0bcaddb96205eda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Muscles
107 rdf:type schema:DefinedTerm
108 N09c3a037651d41ab95a799b70aa03760 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Brain
110 rdf:type schema:DefinedTerm
111 N0c6be12b6c6a4be99d6a62eaf4161aa7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name DNA, Complementary
113 rdf:type schema:DefinedTerm
114 N164200300fe24499b85d10c33c137a09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Molecular Sequence Data
116 rdf:type schema:DefinedTerm
117 N22f33c510ee24e0f9875a01ee56eb796 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Proto-Oncogene Proteins c-jun
119 rdf:type schema:DefinedTerm
120 N3e55d417e25d42f5bff888dd94eb389f rdf:first sg:person.0731233037.88
121 rdf:rest N96ba1a2368e44499a79223ad9967991a
122 N3eb94d3ae9c2433abc25fd418bffa288 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Amino Acid Sequence
124 rdf:type schema:DefinedTerm
125 N55147176d0e44f18989a180171b22d7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Signal Transduction
127 rdf:type schema:DefinedTerm
128 N55dd627157c0494087ecfaf25b0c7c9e schema:name Springer Nature - SN SciGraph project
129 rdf:type schema:Organization
130 N586f28f47250487a83ba994490387703 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name MAP Kinase Kinase 4
132 rdf:type schema:DefinedTerm
133 N5a8346b09a574fbcb8de7332443e4b1b rdf:first sg:person.0671571352.95
134 rdf:rest Ne4f8ea8f17cc4af3ab17c5608dd72472
135 N5ba4b53eaef94aae863ef4796412ade3 rdf:first sg:person.0665115156.33
136 rdf:rest N3e55d417e25d42f5bff888dd94eb389f
137 N696af82050d448b4b9a4571c0ace87a7 schema:name dimensions_id
138 schema:value pub.1012539120
139 rdf:type schema:PropertyValue
140 N6ea9e181ee014a6f9032873cd65806d1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Mitogen-Activated Protein Kinase Kinases
142 rdf:type schema:DefinedTerm
143 N6edc01bc1aac44418f28338deda70766 rdf:first sg:person.01244537451.59
144 rdf:rest N5ba4b53eaef94aae863ef4796412ade3
145 N6f5125335d5d4208ac679b33b6cb4e24 rdf:first sg:person.015341736157.56
146 rdf:rest rdf:nil
147 N709a8342c53942d5996550fed45b675c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Sequence Homology, Amino Acid
149 rdf:type schema:DefinedTerm
150 N71d9e6fb652f42b182b27a4222d5c719 schema:name doi
151 schema:value 10.1038/372794a0
152 rdf:type schema:PropertyValue
153 N7aa473c03a7a4b17a8a2e2cd4feb1d2b rdf:first Ne46dac88a8be4625b1b9e025a5f93817
154 rdf:rest N6f5125335d5d4208ac679b33b6cb4e24
155 N82a74217ed14451eab40c55d46e900b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Protein Kinases
157 rdf:type schema:DefinedTerm
158 N8d4929a68bc5425eacc555078b087091 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Animals
160 rdf:type schema:DefinedTerm
161 N96ba1a2368e44499a79223ad9967991a rdf:first sg:person.01074100404.77
162 rdf:rest N7aa473c03a7a4b17a8a2e2cd4feb1d2b
163 Na671a1dc1a7f4d0a94005ee4a0e10d8f schema:issueNumber 6508
164 rdf:type schema:PublicationIssue
165 Nc1372d5c583f4d5c998bf19c3a4c6b93 schema:volumeNumber 372
166 rdf:type schema:PublicationVolume
167 Nc82b580edcd24c23be542fdceeb903ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Gene Expression Regulation
169 rdf:type schema:DefinedTerm
170 Nd8193f927cb04e0aaeb0e8c4129e426f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Mice
172 rdf:type schema:DefinedTerm
173 Nd8476c6588054c829378713189697323 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name MAP Kinase Kinase Kinase 1
175 rdf:type schema:DefinedTerm
176 Ne1a8e9986eea4784a0033cbb9084214a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Base Sequence
178 rdf:type schema:DefinedTerm
179 Ne46dac88a8be4625b1b9e025a5f93817 schema:affiliation grid-institutes:grid.32224.35
180 schema:familyName Kyriakls
181 schema:givenName John M.
182 rdf:type schema:Person
183 Ne4f8ea8f17cc4af3ab17c5608dd72472 rdf:first sg:person.0673156416.35
184 rdf:rest N6edc01bc1aac44418f28338deda70766
185 Ne94a2a35d31747c1a31b11f2350c07b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Cloning, Molecular
187 rdf:type schema:DefinedTerm
188 Nf02b9cc602884abba8529ecb38ff9eae schema:name pubmed_id
189 schema:value 7997269
190 rdf:type schema:PropertyValue
191 Nf1e20661089d4caa9464e984fb9a5eb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Cell Line
193 rdf:type schema:DefinedTerm
194 Nf225270d6ab04bf58de93c21a7c15b22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Protein Serine-Threonine Kinases
196 rdf:type schema:DefinedTerm
197 Nfc0c0ac59dc04bbfbbdfc394144d5b4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Substrate Specificity
199 rdf:type schema:DefinedTerm
200 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
201 schema:name Biological Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
204 schema:name Biochemistry and Cell Biology
205 rdf:type schema:DefinedTerm
206 sg:grant.7137801 http://pending.schema.org/fundedItem sg:pub.10.1038/372794a0
207 rdf:type schema:MonetaryGrant
208 sg:journal.1018957 schema:issn 0028-0836
209 1476-4687
210 schema:name Nature
211 schema:publisher Springer Nature
212 rdf:type schema:Periodical
213 sg:person.01074100404.77 schema:affiliation grid-institutes:grid.32224.35
214 schema:familyName Avruch
215 schema:givenName Joseph
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074100404.77
217 rdf:type schema:Person
218 sg:person.01244537451.59 schema:affiliation grid-institutes:grid.65499.37
219 schema:familyName Mayer
220 schema:givenName Bruce J.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244537451.59
222 rdf:type schema:Person
223 sg:person.015341736157.56 schema:affiliation grid-institutes:grid.65499.37
224 schema:familyName Zon
225 schema:givenName Leonard I.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015341736157.56
227 rdf:type schema:Person
228 sg:person.0665115156.33 schema:affiliation grid-institutes:grid.38142.3c
229 schema:familyName Yee
230 schema:givenName Karen
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665115156.33
232 rdf:type schema:Person
233 sg:person.0671571352.95 schema:affiliation grid-institutes:grid.32224.35
234 schema:familyName Sánchez
235 schema:givenName Irma
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671571352.95
237 rdf:type schema:Person
238 sg:person.0673156416.35 schema:affiliation grid-institutes:grid.38142.3c
239 schema:familyName Hughes
240 schema:givenName Rowland T.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673156416.35
242 rdf:type schema:Person
243 sg:person.0731233037.88 schema:affiliation grid-institutes:grid.415224.4
244 schema:familyName Woodgett
245 schema:givenName James R.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0731233037.88
247 rdf:type schema:Person
248 sg:pub.10.1038/353670a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030142073
249 https://doi.org/10.1038/353670a0
250 rdf:type schema:CreativeWork
251 sg:pub.10.1038/369156a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029771272
252 https://doi.org/10.1038/369156a0
253 rdf:type schema:CreativeWork
254 sg:pub.10.1038/372798a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022511929
255 https://doi.org/10.1038/372798a0
256 rdf:type schema:CreativeWork
257 grid-institutes:grid.32224.35 schema:alternateName Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital East, and Department of Medicine Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA
258 schema:name Diabetes Research Laboratory, Medical Services, Massachusetts General Hospital East, and Department of Medicine Harvard Medical School, 149 13th Street, 02129, Charlestown, Massachusetts, USA
259 rdf:type schema:Organization
260 grid-institutes:grid.38142.3c schema:alternateName Division of Hematology/Oncology, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA
261 schema:name Division of Hematology/Oncology, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA
262 rdf:type schema:Organization
263 grid-institutes:grid.415224.4 schema:alternateName Ontario Cancer Institute, Princess Margaret Hospital, 500 Sherbourne Street, M4X 1K9, Toronto, Ontario, Canada
264 schema:name Ontario Cancer Institute, Princess Margaret Hospital, 500 Sherbourne Street, M4X 1K9, Toronto, Ontario, Canada
265 rdf:type schema:Organization
266 grid-institutes:grid.65499.37 schema:alternateName Howard Hughes Medical Institute, Children's Hospital and ¶ Dana-Farber Cancer Institute, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA
267 schema:name Department of Microbiology and Molecular Genetics, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA
268 Division of Hematology/Oncology, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA
269 Howard Hughes Medical Institute, Children's Hospital and ¶ Dana-Farber Cancer Institute, Harvard Medical School, 300 Longwood Avenue, Enders 650, 02115, Boston, Massachusetts, USA
270 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...