Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-12-29

AUTHORS

Irma Sánchez, Rowland T. Hughes, Bruce J. Mayer, Karen Yee, James R. Woodgett, Joseph Avruch, John M. Kyriakls, Leonard I. Zon

ABSTRACT

THE stress-activated protein kinases (SAPKs), which are distantly related to the MAP kinases, are the dominant c-Jun amino-termi-nal protein kinases activated in response to a variety of cellular stresses, including treatment with tumour-necrosis factor-α and interleukin-β (refs 1, 2). SAPK phosphorylation of c-Jun probably activates the c-Jun transactivation function3. SAPKs are part of a signal transduction cascade related to, but distinct from, the MAPK pathway1. We have now identified a novel protein kinase, called SAPK/ERK kinase-1 (SEK1), which is structurally related to the MAP kinase kinases (MEKs)4. SEK1 is a potent activator of the SAPKs in vitro and in vivo. An inactive SEK1 mutant blocks SAPK activation by extracellular stimuli without interfering with the MAPK pathway. Although alternative mechanisms of SAPK activation may exist, as an immediate upstream activator of the SAPKs, SEK1 further defines a signalling cascade that couples cellular stress agonists to the c-Jun transcription factor. More... »

PAGES

794-798

Journal

TITLE

Nature

ISSUE

6508

VOLUME

372

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/372794a0

    DOI

    http://dx.doi.org/10.1038/372794a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012539120

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7997269


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