A protein kinase involved in the regulation of inflammatory cytokine biosynthesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-12

AUTHORS

John C. Lee, Jeffrey T. Laydon, Peter C. McDonnell, Timothy F. Gallagher, Sanjay Kumar, David Green, Dean McNulty, Mary Jane Blumenthal, J. Richard Keys, Scott W. Land vatter, James E. Strickler, Megan M. McLaughlin, Ivo R. Siemens, Seth M. Fisher, George P. Livi, John R. White, Jerry L. Adams, Peter R. Young

ABSTRACT

Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated protein kinase homologues, termed CSBPs. Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production. More... »

PAGES

739-746

Journal

TITLE

Nature

ISSUE

6508

VOLUME

372

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/372739a0

    DOI

    http://dx.doi.org/10.1038/372739a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047199166

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7997261


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