A protein kinase involved in the regulation of inflammatory cytokine biosynthesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-12

AUTHORS

J C Lee, J T Laydon, P C McDonnell, T F Gallagher, S Kumar, D Green, D McNulty, M J Blumenthal, J R Heys, S W Landvatter, J E Strickler, M M McLaughlin, I R Siemens, S M Fisher, G P Livi, J R White, J L Adams, P R Young

ABSTRACT

Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated protein kinase homologues, termed CSBPs. Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production. More... »

PAGES

739-746

Journal

TITLE

Nature

ISSUE

6508

VOLUME

372

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/372739a0

    DOI

    http://dx.doi.org/10.1038/372739a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047199166

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7997261


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