A protein kinase involved in the regulation of inflammatory cytokine biosynthesis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-12

AUTHORS

J C Lee, J T Laydon, P C McDonnell, T F Gallagher, S Kumar, D Green, D McNulty, M J Blumenthal, J R Heys, S W Landvatter, J E Strickler, M M McLaughlin, I R Siemens, S M Fisher, G P Livi, J R White, J L Adams, P R Young

ABSTRACT

Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated protein kinase homologues, termed CSBPs. Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production. More... »

PAGES

739-746

Journal

TITLE

Nature

ISSUE

6508

VOLUME

372

Author Affiliations

Related Patents

  • Methods For Treating Polycystic Kidney Disease (Pkd) Or Other Cyst Forming Diseases
  • Mapkap Kinase 2-Inhibitors And The Use Thereof In Anti-Inflammatory Therapy
  • Method Of Inhibiting Photoaging Of Skin
  • A Human Map Kinase Homolog
  • Methods Of Designing Inhibitors For Jnk Kinases
  • Polynucleotides Encoding Anti-Amyloid Beta Monoclonal Antibodies
  • Human Map Kinase Homolog
  • Drug Binding Protein
  • Compounds
  • Antibody To Tnf Receptor-Like Molecules
  • Monoclonal Antibody
  • Compounds And Methods For Treating Inflammatory And Fibrotic Disorders
  • Nucleic Acids Encoding Mk61 Receptors
  • Methods For Identifying Agents That Interact With Map Kinase Activated Protein Kinase 2
  • Synthesis Of Imidazooxazole And Imidazothiazole Inhibitors Of P38 Map Kinase
  • Methods Of Treating Ocular Disease Associated With Amyloid-Beta-Related Pathology Using An Anti-Amyloid-Beta Antibody
  • Treatment Of Oncostatin M Receptor Β Mediated Heart Failure
  • Thieno-Pyridinone Derivatives As Kinase Inhibitors
  • Substituted Indolin-2-One Derivatives And Their Use As P38 Mitogen-Activated Kinase Inhibitors
  • Inhibitors Of Gsk-3 And Crystal Structures Of Gsk-3Β Protein And Protein Complexes
  • Arylamine Substituted Bicyclic Heteroaromatic Compounds As P38 Kinase Inhibitors
  • Gene Therapy In Coronary Angioplasty And Bypass
  • 3,4-Dihydro-(1h)Quinazolin-2-One Compounds As Csbp/P38 Kinase Inhibitors
  • 3,4-Dihydro-(1h)Quinazolin-2-One Compounds As Csbp/P38 Kinase Inhibitors
  • Max-Interacting Proteins And Related Molecules And Methods
  • Mitogen-Activated Protein Kinase P38-2 And Methods Of Use Therefor
  • Human Map Kinase Homolog
  • Crystalline Forms Of 3-[5-Chloro-4-[(2,4-Difluorobenzyl) Oxy]-6-Oxopyrimidin-1(6h)-Yl]-N-(2-Hydroxyethyl)-4-Methylbenzamide
  • Method For Achieving Desired Glial Growth Factor 2 Plasma Levels
  • 2,4,5-Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents
  • 2,4,5-Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents
  • 4,8-Diphenyl-Polyazanaphthalene Derivatives
  • Method For Achieving Desired Glial Growth Factor 2 Plasma Levels
  • Eef2/Eef2k As Therapeutic Target For Treating Tnf-Alpha-Related Diseases
  • Mitogen-Activated Protein Kinase Kinase Mek6 And Variants Thereof
  • Crystallization Of C-Jun N-Terminal Kinase 3 (Jnk3)
  • Substituted Pyrimidinone And Pyridone Compounds And Methods Of Use
  • Tpl2 Transgenic Knockout Mice
  • Guanylhydrazones Useful For Treating Diseases Associated With T Cell Activation
  • Methods For Identifying Safe And Functional Humanized Antibodies
  • Substituted Spiro[Cycloalkyl-1,3′-Indo]-2′(1′H)-One Derivatives And Their Use As P38 Mitogen-Activated Kinase Inhibitors
  • Polynucleotides Encoding An Anti-Beta-Amyloid Monoclonal Antibody
  • Monoclonal Antibody
  • Mitogen-Activated Protein Kinase P38-2 And Methods Of Use Therefor
  • 2-Indolyl Imidazo [4,5-D] Phenanthroline Derivatives And Their Use In The Treatment Of Cancer
  • Guanylhydrazones Useful For Treating Diseases Associated With T Cell Activation
  • 3-Arylamino Pyridine Derivatives
  • P38 Mapk Pathway Predicts Endocrine-Resistant Growth Of Human Breast Cancer And Provides A Novel Diagnostic And Treatment Target
  • Inhibitors Of Gsk-3 And Crystal Structures Of Gsk-3Β Protein And Protein Complexes
  • 3-Arylamino Pyridine Derivatives
  • Bicyclic Heteroaromatic Compounds As Kinase Inhibitors
  • Aryl Imidazoles And Their Use As Anti-Cancer Agents
  • Nitrogen-Containing Heterocyclic Compound And Pharmaceutical Application Thereof
  • Inhibitors Of Gsk-3 And Crystal Structures Of Gsk-3Β Protein And Protein Complexes
  • 1,4-Disubstituted Naphthalenes As Inhibitors Of P38 Map Kinase
  • Treatment Of Oncostatin M Receptor ß Mediated Heart Failure
  • Mitogen-Activated Protein Kinase P38-2 And Methods Of Use Therefor
  • Human Map Kinase Homolog
  • Aryl Imidazoles And Their Use As Anti-Cancer Agents
  • Bicyclic Oxopyridine And Oxopyrimidine Derivatives
  • Pyridine And Pyrimidine Derivatives
  • 1,7-Naphthyridine Derivatives As P38 Map Kinase Inhibitors
  • Inhibitors Of Gsk-3 And Crystal Structures Of Gsk-3Β Protein And Protein Complexes
  • 3-Arylamino Pyridine Derivatives
  • Site-Specific Labeling Of Affinity Tags In Fusion Proteins
  • Use Of Pirfenidone In Therapeutic Regimens
  • Mitogen-Activated Protein Kinase P38-2 And Methods Of Use Therefor
  • Inhibitors Of P38 And Methods Of Using The Same
  • Substituted Pyridone Compounds And Methods Of Use
  • 3-Arylamino Pyridine Derivatives
  • 2,4,5-Trisubstituted Imidazoles And Their Use As Anti-Microbial Agents
  • 1,4-Disubstituted Naphthalenes As Inhibitors Of P38 Map Kinase
  • Nucleic Acid Molecules Encoding A Humanized Antibody
  • 2-Substituted Imidazo[4,5-D]Phenanthroline Derivatives And Their Use In The Treatment Of Cancer
  • Thienopyridone Derivatives As Kinase Inhibitors
  • Two Sterile-20 Kinase-Like Proteins And Methods Of Use Thereof
  • 3-([1,2,4]Triazolo[4,3-A]Pyridin-7-Yl)Benzamide Derivatives
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/372739a0

    DOI

    http://dx.doi.org/10.1038/372739a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1047199166

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7997261


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Calcium-Calmodulin-Dependent Protein Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chromosomes, Human, Pair 6", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cloning, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA, Complementary", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Imidazoles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Inflammation Mediators", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-1", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mitogen-Activated Protein Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Monocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Peptide Fragments", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pyridines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Radioligand Assay", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recombinant Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Necrosis Factor-alpha", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "p38 Mitogen-Activated Protein Kinases", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "GlaxoSmithKline (United States)", 
              "id": "https://www.grid.ac/institutes/grid.418019.5", 
              "name": [
                "Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lee", 
            "givenName": "J C", 
            "id": "sg:person.01152534221.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152534221.45"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Laydon", 
            "givenName": "J T", 
            "id": "sg:person.01104421021.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104421021.06"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "McDonnell", 
            "givenName": "P C", 
            "id": "sg:person.01271237413.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271237413.27"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Gallagher", 
            "givenName": "T F", 
            "id": "sg:person.0653744021.84", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653744021.84"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Kumar", 
            "givenName": "S", 
            "id": "sg:person.01025435766.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025435766.47"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Green", 
            "givenName": "D", 
            "type": "Person"
          }, 
          {
            "familyName": "McNulty", 
            "givenName": "D", 
            "id": "sg:person.0665202112.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665202112.19"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Blumenthal", 
            "givenName": "M J", 
            "id": "sg:person.01151155152.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151155152.15"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Heys", 
            "givenName": "J R", 
            "id": "sg:person.01023715343.00", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023715343.00"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Landvatter", 
            "givenName": "S W", 
            "id": "sg:person.01050253121.62", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050253121.62"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Strickler", 
            "givenName": "J E", 
            "id": "sg:person.0737157077.85", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737157077.85"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "McLaughlin", 
            "givenName": "M M", 
            "id": "sg:person.01346237722.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346237722.38"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Siemens", 
            "givenName": "I R", 
            "type": "Person"
          }, 
          {
            "familyName": "Fisher", 
            "givenName": "S M", 
            "id": "sg:person.01261430413.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261430413.27"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Livi", 
            "givenName": "G P", 
            "id": "sg:person.01132653606.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132653606.49"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "White", 
            "givenName": "J R", 
            "id": "sg:person.01201455045.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201455045.83"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Adams", 
            "givenName": "J L", 
            "id": "sg:person.0657605121.97", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657605121.97"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Young", 
            "givenName": "P R", 
            "id": "sg:person.01046214662.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046214662.87"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/s0952-7915(05)80018-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002098729"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.171.2.465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004016552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0959-437x(94)90095-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005855842"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.171.1.35", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006900923"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/9.1.213-b", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008858312"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.82.6.1585", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011796587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.177.4.1071", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014311577"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nbt1188-1321", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014460051", 
              "https://doi.org/10.1038/nbt1188-1321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0959-437x(94)90096-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016001029"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.2.673", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017323159"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1749-6632.1993.tb17149.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019788557"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/367704a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021424273", 
              "https://doi.org/10.1038/367704a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0008-8749(92)90233-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022551302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.176.3.897", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024564672"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90666-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026425060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.13.12.7652", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028021305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0968-0004(88)90131-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029699682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0968-0004(88)90131-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029699682"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/369156a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029771272", 
              "https://doi.org/10.1038/369156a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/353670a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030142073", 
              "https://doi.org/10.1038/353670a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.21.9930", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031213692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/mcb.10.6.2678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031764548"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90278-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034501049"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90277-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046738899"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(91)90098-j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048724889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01972723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051172763", 
              "https://doi.org/10.1007/bf01972723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01972723", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051172763", 
              "https://doi.org/10.1007/bf01972723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90380-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051907375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3291115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062604905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.3754653", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062621372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7681220", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062648382"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7914033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062650632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.7939721", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062650740"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8047888", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062652077"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8191285", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062653073"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05492.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075602119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075835884", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1991.tb04978.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077347873"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077414559", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078035395", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078474349", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082468384", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082701492", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082719519", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1994-12", 
        "datePublishedReg": "1994-12-01", 
        "description": "Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated protein kinase homologues, termed CSBPs. Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/372739a0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6508", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "372"
          }
        ], 
        "name": "A protein kinase involved in the regulation of inflammatory cytokine biosynthesis", 
        "pagination": "739-746", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "e0d76208ced065be065fbfa2307a9937c0eff4f8602fcb01450f03cca281ca04"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "7997261"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/372739a0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1047199166"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/372739a0", 
          "https://app.dimensions.ai/details/publication/pub.1047199166"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000426.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/nature/journal/v372/n6508/full/372739a0.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/372739a0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/372739a0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/372739a0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/372739a0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    377 TRIPLES      21 PREDICATES      92 URIs      42 LITERALS      30 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/372739a0 schema:about N122dbe4220cc4d1aa92e737dd14af825
    2 N191da4fa1d6d4f56b65331ec3b776039
    3 N1c0746ef194349c982950d3b2a349292
    4 N32f07103621048e197d1f7ce450fc47d
    5 N469b830b36c644798b6e5246d5aebe4d
    6 N4bb822345d114ae3be178901e21fc61b
    7 N610475a2367c4e76a2935a96d94fb387
    8 N68bf7f749a8b438091e766959043b630
    9 N6a55293c49ef457394f94f0cb8e5e71b
    10 N6aa9767fa3a94a498374e1d5e2419d49
    11 N6fa0ee4718f94e048b9a2f52d4817a68
    12 N89335c0d93864b068d45b1e9cf6c6170
    13 N9436e29e3f3d470e80d957a51368e9b5
    14 N984ea2e6d6c24799bd98f03148eb5797
    15 Nb04c526f5733428abf0404c48e68cd00
    16 Nb2c31e57b5794d21b54ad5e5352ca134
    17 Nb6812fc336b348fbb427f9a552ebd4c2
    18 Nb83f18c445284c49b473da4e0dae977d
    19 Nd7171769f82343e18e11f056d739f9fc
    20 Ned88b94f993941f094063292d0132b68
    21 Nf46ddf5b751945bf8a55d31e634aa704
    22 anzsrc-for:06
    23 anzsrc-for:0601
    24 schema:author Nafd1d5c62006438d918aecc2ca5436cb
    25 schema:citation sg:pub.10.1007/bf01972723
    26 sg:pub.10.1038/353670a0
    27 sg:pub.10.1038/367704a0
    28 sg:pub.10.1038/369156a0
    29 sg:pub.10.1038/nbt1188-1321
    30 https://app.dimensions.ai/details/publication/pub.1075835884
    31 https://app.dimensions.ai/details/publication/pub.1077414559
    32 https://app.dimensions.ai/details/publication/pub.1078035395
    33 https://app.dimensions.ai/details/publication/pub.1078474349
    34 https://app.dimensions.ai/details/publication/pub.1082468384
    35 https://app.dimensions.ai/details/publication/pub.1082701492
    36 https://app.dimensions.ai/details/publication/pub.1082719519
    37 https://doi.org/10.1002/j.1460-2075.1991.tb04978.x
    38 https://doi.org/10.1002/j.1460-2075.1992.tb05492.x
    39 https://doi.org/10.1016/0008-8749(92)90233-f
    40 https://doi.org/10.1016/0092-8674(91)90098-j
    41 https://doi.org/10.1016/0092-8674(93)90666-e
    42 https://doi.org/10.1016/0092-8674(94)90277-1
    43 https://doi.org/10.1016/0092-8674(94)90278-x
    44 https://doi.org/10.1016/0092-8674(94)90380-8
    45 https://doi.org/10.1016/0959-437x(94)90095-7
    46 https://doi.org/10.1016/0959-437x(94)90096-5
    47 https://doi.org/10.1016/0968-0004(88)90131-4
    48 https://doi.org/10.1016/s0952-7915(05)80018-4
    49 https://doi.org/10.1073/pnas.82.6.1585
    50 https://doi.org/10.1073/pnas.89.2.673
    51 https://doi.org/10.1073/pnas.90.21.9930
    52 https://doi.org/10.1084/jem.171.1.35
    53 https://doi.org/10.1084/jem.171.2.465
    54 https://doi.org/10.1084/jem.176.3.897
    55 https://doi.org/10.1084/jem.177.4.1071
    56 https://doi.org/10.1093/nar/9.1.213-b
    57 https://doi.org/10.1111/j.1749-6632.1993.tb17149.x
    58 https://doi.org/10.1126/science.3291115
    59 https://doi.org/10.1126/science.3754653
    60 https://doi.org/10.1126/science.7681220
    61 https://doi.org/10.1126/science.7914033
    62 https://doi.org/10.1126/science.7939721
    63 https://doi.org/10.1126/science.8047888
    64 https://doi.org/10.1126/science.8191285
    65 https://doi.org/10.1128/mcb.10.6.2678
    66 https://doi.org/10.1128/mcb.13.12.7652
    67 schema:datePublished 1994-12
    68 schema:datePublishedReg 1994-12-01
    69 schema:description Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated protein kinase homologues, termed CSBPs. Binding of the pyridinyl-imidazole compounds inhibited CSBP kinase activity and could be directly correlated with their ability to inhibit cytokine production, suggesting that the CSBPs are critical for cytokine production.
    70 schema:genre research_article
    71 schema:inLanguage en
    72 schema:isAccessibleForFree false
    73 schema:isPartOf N2a8157421ea94d639852a5f474e23f40
    74 Ne81e14d2e0644505a03deace331d2157
    75 sg:journal.1018957
    76 schema:name A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    77 schema:pagination 739-746
    78 schema:productId N0962d913dd204ac7b02f16c282d017cf
    79 N2e94663a9fa04abeb160f063150f9814
    80 N75d822b11a4f4def82cf51fa6116c113
    81 N7b66ee4e15ae4966b14922bc39958ae1
    82 Nb82c45bafad54769a9fdd3f683cf66f6
    83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047199166
    84 https://doi.org/10.1038/372739a0
    85 schema:sdDatePublished 2019-04-10T15:39
    86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    87 schema:sdPublisher N5d41d99691b1488db901457e28e89a7e
    88 schema:url http://www.nature.com/nature/journal/v372/n6508/full/372739a0.html
    89 sgo:license sg:explorer/license/
    90 sgo:sdDataset articles
    91 rdf:type schema:ScholarlyArticle
    92 N0962d913dd204ac7b02f16c282d017cf schema:name nlm_unique_id
    93 schema:value 0410462
    94 rdf:type schema:PropertyValue
    95 N0a38995d51ae406498d787feefc574b8 rdf:first sg:person.01023715343.00
    96 rdf:rest N327395085d4a4002b8b2f10c797b4f0b
    97 N0ec0dae788d7455caf44eb7ee33cc6f9 rdf:first sg:person.0665202112.19
    98 rdf:rest Nf407de2f73ae4e2496e412e766ea88fa
    99 N122dbe4220cc4d1aa92e737dd14af825 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Mitogen-Activated Protein Kinases
    101 rdf:type schema:DefinedTerm
    102 N191da4fa1d6d4f56b65331ec3b776039 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Cell Line
    104 rdf:type schema:DefinedTerm
    105 N1c0746ef194349c982950d3b2a349292 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Peptide Fragments
    107 rdf:type schema:DefinedTerm
    108 N1dca814595884ab7b8bc771e99c58f63 schema:familyName Green
    109 schema:givenName D
    110 rdf:type schema:Person
    111 N2a8157421ea94d639852a5f474e23f40 schema:issueNumber 6508
    112 rdf:type schema:PublicationIssue
    113 N2e94663a9fa04abeb160f063150f9814 schema:name pubmed_id
    114 schema:value 7997261
    115 rdf:type schema:PropertyValue
    116 N327395085d4a4002b8b2f10c797b4f0b rdf:first sg:person.01050253121.62
    117 rdf:rest Nc44c70c783684a8fb6fee27c263b829b
    118 N32f07103621048e197d1f7ce450fc47d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Interleukin-1
    120 rdf:type schema:DefinedTerm
    121 N32f2cdfee96d4f8c9bd197cb1b03c931 rdf:first sg:person.01025435766.47
    122 rdf:rest N8cc11ed762784357af01df247e23d975
    123 N377f2e47ece749f0a042b437512aff24 rdf:first sg:person.01046214662.87
    124 rdf:rest rdf:nil
    125 N469b830b36c644798b6e5246d5aebe4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Cloning, Molecular
    127 rdf:type schema:DefinedTerm
    128 N4bb822345d114ae3be178901e21fc61b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Base Sequence
    130 rdf:type schema:DefinedTerm
    131 N5d41d99691b1488db901457e28e89a7e schema:name Springer Nature - SN SciGraph project
    132 rdf:type schema:Organization
    133 N610475a2367c4e76a2935a96d94fb387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Amino Acid Sequence
    135 rdf:type schema:DefinedTerm
    136 N66c17382e55f4026991f4cba5b80f97b rdf:first sg:person.0653744021.84
    137 rdf:rest N32f2cdfee96d4f8c9bd197cb1b03c931
    138 N68bf7f749a8b438091e766959043b630 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Inflammation Mediators
    140 rdf:type schema:DefinedTerm
    141 N6a55293c49ef457394f94f0cb8e5e71b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Humans
    143 rdf:type schema:DefinedTerm
    144 N6aa9767fa3a94a498374e1d5e2419d49 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name p38 Mitogen-Activated Protein Kinases
    146 rdf:type schema:DefinedTerm
    147 N6fa0ee4718f94e048b9a2f52d4817a68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Monocytes
    149 rdf:type schema:DefinedTerm
    150 N75d822b11a4f4def82cf51fa6116c113 schema:name dimensions_id
    151 schema:value pub.1047199166
    152 rdf:type schema:PropertyValue
    153 N7b66ee4e15ae4966b14922bc39958ae1 schema:name readcube_id
    154 schema:value e0d76208ced065be065fbfa2307a9937c0eff4f8602fcb01450f03cca281ca04
    155 rdf:type schema:PropertyValue
    156 N89335c0d93864b068d45b1e9cf6c6170 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Tumor Necrosis Factor-alpha
    158 rdf:type schema:DefinedTerm
    159 N8cc11ed762784357af01df247e23d975 rdf:first N1dca814595884ab7b8bc771e99c58f63
    160 rdf:rest N0ec0dae788d7455caf44eb7ee33cc6f9
    161 N9436e29e3f3d470e80d957a51368e9b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Radioligand Assay
    163 rdf:type schema:DefinedTerm
    164 N96cbe4fdec624c57baddd2f21a6c17a9 rdf:first sg:person.01346237722.38
    165 rdf:rest Ndc7cd70d798f4e50b5a1cf306a990784
    166 N984ea2e6d6c24799bd98f03148eb5797 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    167 schema:name Calcium-Calmodulin-Dependent Protein Kinases
    168 rdf:type schema:DefinedTerm
    169 Na4a07265510b45ae802d86943c7647dc rdf:first sg:person.01271237413.27
    170 rdf:rest N66c17382e55f4026991f4cba5b80f97b
    171 Nadd1a6f474a54b4e9942325809b418b0 rdf:first sg:person.0657605121.97
    172 rdf:rest N377f2e47ece749f0a042b437512aff24
    173 Nafd1d5c62006438d918aecc2ca5436cb rdf:first sg:person.01152534221.45
    174 rdf:rest Nd2fcda2d02224260ae9ef067ac226e37
    175 Nb04c526f5733428abf0404c48e68cd00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Pyridines
    177 rdf:type schema:DefinedTerm
    178 Nb2c31e57b5794d21b54ad5e5352ca134 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Imidazoles
    180 rdf:type schema:DefinedTerm
    181 Nb6812fc336b348fbb427f9a552ebd4c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Cytokines
    183 rdf:type schema:DefinedTerm
    184 Nb82c45bafad54769a9fdd3f683cf66f6 schema:name doi
    185 schema:value 10.1038/372739a0
    186 rdf:type schema:PropertyValue
    187 Nb83f18c445284c49b473da4e0dae977d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Molecular Sequence Data
    189 rdf:type schema:DefinedTerm
    190 Nbdeeeba9c7f64bde8bb767af54f5d7ba rdf:first sg:person.01201455045.83
    191 rdf:rest Nadd1a6f474a54b4e9942325809b418b0
    192 Nc44c70c783684a8fb6fee27c263b829b rdf:first sg:person.0737157077.85
    193 rdf:rest N96cbe4fdec624c57baddd2f21a6c17a9
    194 Nc8c1788222324582a17673ff0a424464 schema:familyName Siemens
    195 schema:givenName I R
    196 rdf:type schema:Person
    197 Nd2fcda2d02224260ae9ef067ac226e37 rdf:first sg:person.01104421021.06
    198 rdf:rest Na4a07265510b45ae802d86943c7647dc
    199 Nd7171769f82343e18e11f056d739f9fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Recombinant Proteins
    201 rdf:type schema:DefinedTerm
    202 Ndbe2029c3976425cb582af1ece9d3201 rdf:first sg:person.01261430413.27
    203 rdf:rest Nf9e309334d7b46358512e7f46edc4c95
    204 Ndc7cd70d798f4e50b5a1cf306a990784 rdf:first Nc8c1788222324582a17673ff0a424464
    205 rdf:rest Ndbe2029c3976425cb582af1ece9d3201
    206 Ne81e14d2e0644505a03deace331d2157 schema:volumeNumber 372
    207 rdf:type schema:PublicationVolume
    208 Ned88b94f993941f094063292d0132b68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    209 schema:name Chromosomes, Human, Pair 6
    210 rdf:type schema:DefinedTerm
    211 Nf407de2f73ae4e2496e412e766ea88fa rdf:first sg:person.01151155152.15
    212 rdf:rest N0a38995d51ae406498d787feefc574b8
    213 Nf46ddf5b751945bf8a55d31e634aa704 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    214 schema:name DNA, Complementary
    215 rdf:type schema:DefinedTerm
    216 Nf9e309334d7b46358512e7f46edc4c95 rdf:first sg:person.01132653606.49
    217 rdf:rest Nbdeeeba9c7f64bde8bb767af54f5d7ba
    218 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    219 schema:name Biological Sciences
    220 rdf:type schema:DefinedTerm
    221 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    222 schema:name Biochemistry and Cell Biology
    223 rdf:type schema:DefinedTerm
    224 sg:journal.1018957 schema:issn 0090-0028
    225 1476-4687
    226 schema:name Nature
    227 rdf:type schema:Periodical
    228 sg:person.01023715343.00 schema:familyName Heys
    229 schema:givenName J R
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023715343.00
    231 rdf:type schema:Person
    232 sg:person.01025435766.47 schema:familyName Kumar
    233 schema:givenName S
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025435766.47
    235 rdf:type schema:Person
    236 sg:person.01046214662.87 schema:familyName Young
    237 schema:givenName P R
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046214662.87
    239 rdf:type schema:Person
    240 sg:person.01050253121.62 schema:familyName Landvatter
    241 schema:givenName S W
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050253121.62
    243 rdf:type schema:Person
    244 sg:person.01104421021.06 schema:familyName Laydon
    245 schema:givenName J T
    246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104421021.06
    247 rdf:type schema:Person
    248 sg:person.01132653606.49 schema:familyName Livi
    249 schema:givenName G P
    250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132653606.49
    251 rdf:type schema:Person
    252 sg:person.01151155152.15 schema:familyName Blumenthal
    253 schema:givenName M J
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01151155152.15
    255 rdf:type schema:Person
    256 sg:person.01152534221.45 schema:affiliation https://www.grid.ac/institutes/grid.418019.5
    257 schema:familyName Lee
    258 schema:givenName J C
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152534221.45
    260 rdf:type schema:Person
    261 sg:person.01201455045.83 schema:familyName White
    262 schema:givenName J R
    263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201455045.83
    264 rdf:type schema:Person
    265 sg:person.01261430413.27 schema:familyName Fisher
    266 schema:givenName S M
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261430413.27
    268 rdf:type schema:Person
    269 sg:person.01271237413.27 schema:familyName McDonnell
    270 schema:givenName P C
    271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01271237413.27
    272 rdf:type schema:Person
    273 sg:person.01346237722.38 schema:familyName McLaughlin
    274 schema:givenName M M
    275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346237722.38
    276 rdf:type schema:Person
    277 sg:person.0653744021.84 schema:familyName Gallagher
    278 schema:givenName T F
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653744021.84
    280 rdf:type schema:Person
    281 sg:person.0657605121.97 schema:familyName Adams
    282 schema:givenName J L
    283 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657605121.97
    284 rdf:type schema:Person
    285 sg:person.0665202112.19 schema:familyName McNulty
    286 schema:givenName D
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0665202112.19
    288 rdf:type schema:Person
    289 sg:person.0737157077.85 schema:familyName Strickler
    290 schema:givenName J E
    291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737157077.85
    292 rdf:type schema:Person
    293 sg:pub.10.1007/bf01972723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051172763
    294 https://doi.org/10.1007/bf01972723
    295 rdf:type schema:CreativeWork
    296 sg:pub.10.1038/353670a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030142073
    297 https://doi.org/10.1038/353670a0
    298 rdf:type schema:CreativeWork
    299 sg:pub.10.1038/367704a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021424273
    300 https://doi.org/10.1038/367704a0
    301 rdf:type schema:CreativeWork
    302 sg:pub.10.1038/369156a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029771272
    303 https://doi.org/10.1038/369156a0
    304 rdf:type schema:CreativeWork
    305 sg:pub.10.1038/nbt1188-1321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014460051
    306 https://doi.org/10.1038/nbt1188-1321
    307 rdf:type schema:CreativeWork
    308 https://app.dimensions.ai/details/publication/pub.1075835884 schema:CreativeWork
    309 https://app.dimensions.ai/details/publication/pub.1077414559 schema:CreativeWork
    310 https://app.dimensions.ai/details/publication/pub.1078035395 schema:CreativeWork
    311 https://app.dimensions.ai/details/publication/pub.1078474349 schema:CreativeWork
    312 https://app.dimensions.ai/details/publication/pub.1082468384 schema:CreativeWork
    313 https://app.dimensions.ai/details/publication/pub.1082701492 schema:CreativeWork
    314 https://app.dimensions.ai/details/publication/pub.1082719519 schema:CreativeWork
    315 https://doi.org/10.1002/j.1460-2075.1991.tb04978.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1077347873
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1002/j.1460-2075.1992.tb05492.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1075602119
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1016/0008-8749(92)90233-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1022551302
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1016/0092-8674(91)90098-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1048724889
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1016/0092-8674(93)90666-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1026425060
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1016/0092-8674(94)90277-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046738899
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1016/0092-8674(94)90278-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1034501049
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1016/0092-8674(94)90380-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051907375
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1016/0959-437x(94)90095-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005855842
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1016/0959-437x(94)90096-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016001029
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.1016/0968-0004(88)90131-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029699682
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1016/s0952-7915(05)80018-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002098729
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.1073/pnas.82.6.1585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011796587
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.1073/pnas.89.2.673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017323159
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.1073/pnas.90.21.9930 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031213692
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.1084/jem.171.1.35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006900923
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.1084/jem.171.2.465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004016552
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.1084/jem.176.3.897 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024564672
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.1084/jem.177.4.1071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014311577
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.1093/nar/9.1.213-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1008858312
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.1111/j.1749-6632.1993.tb17149.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019788557
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.1126/science.3291115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062604905
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.1126/science.3754653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062621372
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.1126/science.7681220 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062648382
    362 rdf:type schema:CreativeWork
    363 https://doi.org/10.1126/science.7914033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650632
    364 rdf:type schema:CreativeWork
    365 https://doi.org/10.1126/science.7939721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062650740
    366 rdf:type schema:CreativeWork
    367 https://doi.org/10.1126/science.8047888 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062652077
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1126/science.8191285 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653073
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1128/mcb.10.6.2678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031764548
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1128/mcb.13.12.7652 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028021305
    374 rdf:type schema:CreativeWork
    375 https://www.grid.ac/institutes/grid.418019.5 schema:alternateName GlaxoSmithKline (United States)
    376 schema:name Department of Cellular Biochemistry, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406.
    377 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...