Regulation of embryonic growth and lysosomal targeting by the imprintedIgf2/Mpr gene View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-12

AUTHORS

Zhao-Qi Wang, Marion R. Fung, Denise P. Barlow, Erwin F. Wagner

ABSTRACT

THE receptor for insulin-like growth factor type 2, also known as the cation-independent mannose-6-phosphate receptor (Igf2/Mpr), is a multifunctional receptor thought to play a role in lysosomal targeting, cell growth and signal transduction1–8. Igf2/Mpr has been mapped to the mouse Tme9 locus and shown to be an imprinted gene10, which further suggests a role in embryonic growth regulation. To define the functions of Igf2/Mpr, we have generated mice lacking this gene. We report here that maternal inheritance of an Igf2/Mpr null allele (−/+) as well as homo-zygosity for the inactive allele (−/−) is generally lethal at birth and mutants are about 30% larger, indicating that maternal expression of Igf2/Mpr is essential for late embryonic development and growth regulation. The phenotype is probably caused by an excess of Igf 2 because the introduction of anIgf2 null allele rescued the Igf2/Mpr mutant mice. Mutant mice also have organ and skeletal abnormalities and missort mannose-6-phosphate-tagged proteins. A few (−/+) mice reactivated their paternal Igf2/Mpr allele in some tissues and survived to adults. But no (−/−) mice survived, indicating a role for the reactivated paternal allele in postnatal survival. More... »

PAGES

464-467

Journal

TITLE

Nature

ISSUE

6505

VOLUME

372

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/372464a0

DOI

http://dx.doi.org/10.1038/372464a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030652086

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7984240


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biological Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Embryonic and Fetal Development", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endocytosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomic Imprinting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lysosomes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, IGF Type 2", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Research Institute for Molecular Pathology (I.M.P.), Dr Bohr-Gasse 7, A-1030, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.14826.39", 
          "name": [
            "Research Institute for Molecular Pathology (I.M.P.), Dr Bohr-Gasse 7, A-1030, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Zhao-Qi", 
        "id": "sg:person.07505334664.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07505334664.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute for Molecular Pathology (I.M.P.), Dr Bohr-Gasse 7, A-1030, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.14826.39", 
          "name": [
            "Research Institute for Molecular Pathology (I.M.P.), Dr Bohr-Gasse 7, A-1030, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fung", 
        "givenName": "Marion R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute for Molecular Pathology (I.M.P.), Dr Bohr-Gasse 7, A-1030, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.14826.39", 
          "name": [
            "Research Institute for Molecular Pathology (I.M.P.), Dr Bohr-Gasse 7, A-1030, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barlow", 
        "givenName": "Denise P.", 
        "id": "sg:person.01003563726.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003563726.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute for Molecular Pathology (I.M.P.), Dr Bohr-Gasse 7, A-1030, Vienna, Austria", 
          "id": "http://www.grid.ac/institutes/grid.14826.39", 
          "name": [
            "Research Institute for Molecular Pathology (I.M.P.), Dr Bohr-Gasse 7, A-1030, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wagner", 
        "givenName": "Erwin F.", 
        "id": "sg:person.010726523645.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010726523645.29"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/360741a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006209157", 
          "https://doi.org/10.1038/360741a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/345078a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033319950", 
          "https://doi.org/10.1038/345078a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-197707000-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038369538", 
          "https://doi.org/10.1203/00006450-197707000-00007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/369414a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014650330", 
          "https://doi.org/10.1038/369414a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/349084a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036969301", 
          "https://doi.org/10.1038/349084a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0693-110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037893950", 
          "https://doi.org/10.1038/ng0693-110"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-12", 
    "datePublishedReg": "1994-12-01", 
    "description": "THE receptor for insulin-like growth factor type 2, also known as the cation-independent mannose-6-phosphate receptor (Igf2/Mpr), is a multifunctional receptor thought to play a role in lysosomal targeting, cell growth and signal transduction1\u20138. Igf2/Mpr has been mapped to the mouse Tme9 locus and shown to be an imprinted gene10, which further suggests a role in embryonic growth regulation. To define the functions of Igf2/Mpr, we have generated mice lacking this gene. We report here that maternal inheritance of an Igf2/Mpr null allele (\u2212/+) as well as homo-zygosity for the inactive allele (\u2212/\u2212) is generally lethal at birth and mutants are about 30% larger, indicating that maternal expression of Igf2/Mpr is essential for late embryonic development and growth regulation. The phenotype is probably caused by an excess of Igf 2 because the introduction of anIgf2 null allele rescued the Igf2/Mpr mutant mice. Mutant mice also have organ and skeletal abnormalities and missort mannose-6-phosphate-tagged proteins. A few (\u2212/+) mice reactivated their paternal Igf2/Mpr allele in some tissues and survived to adults. But no (\u2212/\u2212) mice survived, indicating a role for the reactivated paternal allele in postnatal survival.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/372464a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6505", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "372"
      }
    ], 
    "keywords": [
      "lysosomal targeting", 
      "null alleles", 
      "growth regulation", 
      "insulin-like growth factor type 2", 
      "cation-independent mannose-6-phosphate receptor", 
      "mannose-6-phosphate receptor", 
      "functions of IGF2", 
      "late embryonic development", 
      "mutant mice", 
      "mpr gene", 
      "maternal inheritance", 
      "maternal expression", 
      "embryonic development", 
      "paternal IGF2", 
      "paternal allele", 
      "multifunctional receptor", 
      "factor type 2", 
      "inactive alleles", 
      "embryonic growth", 
      "IGF2", 
      "cell growth", 
      "growth factor type 2", 
      "alleles", 
      "genes", 
      "regulation", 
      "skeletal abnormalities", 
      "IGF-2", 
      "receptors", 
      "targeting", 
      "postnatal survival", 
      "missort", 
      "mutants", 
      "mice", 
      "protein", 
      "growth", 
      "role", 
      "phenotype", 
      "inheritance", 
      "expression", 
      "MPR", 
      "tissue", 
      "organs", 
      "survival", 
      "function", 
      "type 2", 
      "development", 
      "excess", 
      "abnormalities", 
      "introduction", 
      "adults", 
      "birth"
    ], 
    "name": "Regulation of embryonic growth and lysosomal targeting by the imprintedIgf2/Mpr gene", 
    "pagination": "464-467", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030652086"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/372464a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7984240"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/372464a0", 
      "https://app.dimensions.ai/details/publication/pub.1030652086"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_221.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/372464a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/372464a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/372464a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/372464a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/372464a0'


 

This table displays all metadata directly associated to this object as RDF triples.

216 TRIPLES      21 PREDICATES      98 URIs      83 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/372464a0 schema:about N123fa7d81ae94b60b890f44ca83e85a9
2 N26eaba9538f448729f011b322c239589
3 N45e38cbb8f7346dda4dcea5975901144
4 N59e4d832a0e24c8e9ebb57c701040c7b
5 N66b327bf2b7843fead7ff531a33eb550
6 N7a48ecfae43e42b68ca782c2ae2f5680
7 N89fb6aed61ff4c8395460b0d3bb58064
8 Nb71614224fbd4574bb8ab40abf423915
9 Nc28e5fec2ff04a858b76775110538d0f
10 Nc68f808dd7a448e8ab153811d451d075
11 Nc9ee0ef1ae284f6b882d2a27a3b1a3f0
12 Nd16e2c9d063b4125ae6069c65e59ad46
13 Nda8ec829b13a4e7fb79b78b82ae06aa1
14 Nf53c7ae31a4f48dfaa63eb6ca4a02da1
15 anzsrc-for:06
16 anzsrc-for:0601
17 anzsrc-for:0604
18 schema:author N75b439d231cf4d8da22d7239ea4decb7
19 schema:citation sg:pub.10.1038/345078a0
20 sg:pub.10.1038/349084a0
21 sg:pub.10.1038/360741a0
22 sg:pub.10.1038/369414a0
23 sg:pub.10.1038/ng0693-110
24 sg:pub.10.1203/00006450-197707000-00007
25 schema:datePublished 1994-12
26 schema:datePublishedReg 1994-12-01
27 schema:description THE receptor for insulin-like growth factor type 2, also known as the cation-independent mannose-6-phosphate receptor (Igf2/Mpr), is a multifunctional receptor thought to play a role in lysosomal targeting, cell growth and signal transduction1–8. Igf2/Mpr has been mapped to the mouse Tme9 locus and shown to be an imprinted gene10, which further suggests a role in embryonic growth regulation. To define the functions of Igf2/Mpr, we have generated mice lacking this gene. We report here that maternal inheritance of an Igf2/Mpr null allele (−/+) as well as homo-zygosity for the inactive allele (−/−) is generally lethal at birth and mutants are about 30% larger, indicating that maternal expression of Igf2/Mpr is essential for late embryonic development and growth regulation. The phenotype is probably caused by an excess of Igf 2 because the introduction of anIgf2 null allele rescued the Igf2/Mpr mutant mice. Mutant mice also have organ and skeletal abnormalities and missort mannose-6-phosphate-tagged proteins. A few (−/+) mice reactivated their paternal Igf2/Mpr allele in some tissues and survived to adults. But no (−/−) mice survived, indicating a role for the reactivated paternal allele in postnatal survival.
28 schema:genre article
29 schema:isAccessibleForFree false
30 schema:isPartOf N08d16aa007f64546b6e8c3e4a0711c87
31 Nab1adb39de7045f5a74d321b5a1a6a3e
32 sg:journal.1018957
33 schema:keywords IGF-2
34 IGF2
35 MPR
36 abnormalities
37 adults
38 alleles
39 birth
40 cation-independent mannose-6-phosphate receptor
41 cell growth
42 development
43 embryonic development
44 embryonic growth
45 excess
46 expression
47 factor type 2
48 function
49 functions of IGF2
50 genes
51 growth
52 growth factor type 2
53 growth regulation
54 inactive alleles
55 inheritance
56 insulin-like growth factor type 2
57 introduction
58 late embryonic development
59 lysosomal targeting
60 mannose-6-phosphate receptor
61 maternal expression
62 maternal inheritance
63 mice
64 missort
65 mpr gene
66 multifunctional receptor
67 mutant mice
68 mutants
69 null alleles
70 organs
71 paternal IGF2
72 paternal allele
73 phenotype
74 postnatal survival
75 protein
76 receptors
77 regulation
78 role
79 skeletal abnormalities
80 survival
81 targeting
82 tissue
83 type 2
84 schema:name Regulation of embryonic growth and lysosomal targeting by the imprintedIgf2/Mpr gene
85 schema:pagination 464-467
86 schema:productId N4f4966b6494743529ac50060e67c43df
87 N768b79b4c3e649b898f0d2c46bf334aa
88 Nce2be8fe72d44991adb5b035d5499f48
89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030652086
90 https://doi.org/10.1038/372464a0
91 schema:sdDatePublished 2022-11-24T20:46
92 schema:sdLicense https://scigraph.springernature.com/explorer/license/
93 schema:sdPublisher Nda1c78e9f3724867872d72f5dfb9dca1
94 schema:url https://doi.org/10.1038/372464a0
95 sgo:license sg:explorer/license/
96 sgo:sdDataset articles
97 rdf:type schema:ScholarlyArticle
98 N08d16aa007f64546b6e8c3e4a0711c87 schema:issueNumber 6505
99 rdf:type schema:PublicationIssue
100 N123fa7d81ae94b60b890f44ca83e85a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Male
102 rdf:type schema:DefinedTerm
103 N26eaba9538f448729f011b322c239589 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Receptor, IGF Type 2
105 rdf:type schema:DefinedTerm
106 N45e38cbb8f7346dda4dcea5975901144 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Genomic Imprinting
108 rdf:type schema:DefinedTerm
109 N4f4966b6494743529ac50060e67c43df schema:name pubmed_id
110 schema:value 7984240
111 rdf:type schema:PropertyValue
112 N59e4d832a0e24c8e9ebb57c701040c7b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Endocytosis
114 rdf:type schema:DefinedTerm
115 N5f3b49cf3bda4cba8491ffa9f52a30e7 rdf:first sg:person.010726523645.29
116 rdf:rest rdf:nil
117 N66b327bf2b7843fead7ff531a33eb550 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Cell Line
119 rdf:type schema:DefinedTerm
120 N6c05ea6a783847149bca12f73c5e829d schema:affiliation grid-institutes:grid.14826.39
121 schema:familyName Fung
122 schema:givenName Marion R.
123 rdf:type schema:Person
124 N752bdf2f32f8465fb9ec0f6530a9293d rdf:first sg:person.01003563726.07
125 rdf:rest N5f3b49cf3bda4cba8491ffa9f52a30e7
126 N75b439d231cf4d8da22d7239ea4decb7 rdf:first sg:person.07505334664.47
127 rdf:rest Nb81b069b88ef425083033fc42626784f
128 N768b79b4c3e649b898f0d2c46bf334aa schema:name doi
129 schema:value 10.1038/372464a0
130 rdf:type schema:PropertyValue
131 N7a48ecfae43e42b68ca782c2ae2f5680 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Lysosomes
133 rdf:type schema:DefinedTerm
134 N89fb6aed61ff4c8395460b0d3bb58064 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Female
136 rdf:type schema:DefinedTerm
137 Nab1adb39de7045f5a74d321b5a1a6a3e schema:volumeNumber 372
138 rdf:type schema:PublicationVolume
139 Nb71614224fbd4574bb8ab40abf423915 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Biological Transport
141 rdf:type schema:DefinedTerm
142 Nb81b069b88ef425083033fc42626784f rdf:first N6c05ea6a783847149bca12f73c5e829d
143 rdf:rest N752bdf2f32f8465fb9ec0f6530a9293d
144 Nc28e5fec2ff04a858b76775110538d0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Mice
146 rdf:type schema:DefinedTerm
147 Nc68f808dd7a448e8ab153811d451d075 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Animals
149 rdf:type schema:DefinedTerm
150 Nc9ee0ef1ae284f6b882d2a27a3b1a3f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Mice, Knockout
152 rdf:type schema:DefinedTerm
153 Nce2be8fe72d44991adb5b035d5499f48 schema:name dimensions_id
154 schema:value pub.1030652086
155 rdf:type schema:PropertyValue
156 Nd16e2c9d063b4125ae6069c65e59ad46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Alleles
158 rdf:type schema:DefinedTerm
159 Nda1c78e9f3724867872d72f5dfb9dca1 schema:name Springer Nature - SN SciGraph project
160 rdf:type schema:Organization
161 Nda8ec829b13a4e7fb79b78b82ae06aa1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Embryonic and Fetal Development
163 rdf:type schema:DefinedTerm
164 Nf53c7ae31a4f48dfaa63eb6ca4a02da1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Phenotype
166 rdf:type schema:DefinedTerm
167 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
168 schema:name Biological Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
171 schema:name Biochemistry and Cell Biology
172 rdf:type schema:DefinedTerm
173 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
174 schema:name Genetics
175 rdf:type schema:DefinedTerm
176 sg:journal.1018957 schema:issn 0028-0836
177 1476-4687
178 schema:name Nature
179 schema:publisher Springer Nature
180 rdf:type schema:Periodical
181 sg:person.01003563726.07 schema:affiliation grid-institutes:grid.14826.39
182 schema:familyName Barlow
183 schema:givenName Denise P.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003563726.07
185 rdf:type schema:Person
186 sg:person.010726523645.29 schema:affiliation grid-institutes:grid.14826.39
187 schema:familyName Wagner
188 schema:givenName Erwin F.
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010726523645.29
190 rdf:type schema:Person
191 sg:person.07505334664.47 schema:affiliation grid-institutes:grid.14826.39
192 schema:familyName Wang
193 schema:givenName Zhao-Qi
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07505334664.47
195 rdf:type schema:Person
196 sg:pub.10.1038/345078a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033319950
197 https://doi.org/10.1038/345078a0
198 rdf:type schema:CreativeWork
199 sg:pub.10.1038/349084a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036969301
200 https://doi.org/10.1038/349084a0
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/360741a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006209157
203 https://doi.org/10.1038/360741a0
204 rdf:type schema:CreativeWork
205 sg:pub.10.1038/369414a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014650330
206 https://doi.org/10.1038/369414a0
207 rdf:type schema:CreativeWork
208 sg:pub.10.1038/ng0693-110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037893950
209 https://doi.org/10.1038/ng0693-110
210 rdf:type schema:CreativeWork
211 sg:pub.10.1203/00006450-197707000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038369538
212 https://doi.org/10.1203/00006450-197707000-00007
213 rdf:type schema:CreativeWork
214 grid-institutes:grid.14826.39 schema:alternateName Research Institute for Molecular Pathology (I.M.P.), Dr Bohr-Gasse 7, A-1030, Vienna, Austria
215 schema:name Research Institute for Molecular Pathology (I.M.P.), Dr Bohr-Gasse 7, A-1030, Vienna, Austria
216 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...