Positional cloning of the mouse obese gene and its human homologue View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-12

AUTHORS

Y Zhang, R Proenca, M Maffei, M Barone, L Leopold, J M Friedman

ABSTRACT

The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation of ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot. More... »

PAGES

425-432

Journal

TITLE

Nature

ISSUE

6505

VOLUME

372

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/372425a0

    DOI

    http://dx.doi.org/10.1038/372425a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052657184

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7984236


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    RDF/XML is a standard XML format for linked data.

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