pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-09

AUTHORS

Gregory J. Hannon, David Beach

ABSTRACT

TRANSFORMING growth factor-beta (TGF-β) inhibits cell proliferation by inducing a Gl-phase cell cycle arrest1. Normal progression through Gl is promoted by the activity of the cyclin-dependent protein kinases CDK4 and CDK6 (ref. 2), which are inhibited by the protein p16INK4. We have isolated a new member of the p16INK4 family, p15INK4B. p15 expression is induced ∼30-fold in human keratinocytes by treatment with TGF-β, suggesting that pi5 may act as an effector of TGF-β-mediated cell cycle arrest. The gene encoding p15 is located on chromosome 9 adjacent to the p16 gene at a frequent site of chromosomal abnormality in human tumours (9p21). More... »

PAGES

257-261

Journal

TITLE

Nature

ISSUE

6494

VOLUME

371

Related Patents

  • Ink4c-P18 And Ink4d-P19, Inhibitors Of Cyclin-Depedent Kinases Cdk4 And Cdk6, And Uses Thereof
  • Agent For Treating Tumours And Other Hyperplasia
  • Mts1 Gene
  • Ink4c-P18 And Ink4d-P19, Inhibitors Of Cyclin-Dependent Kinases Cdk4 And Cdk6, And Uses Thereof
  • Arf-P19, A Novel Regulator Of The Mammalian Cell Cycle
  • Mammalian Checkpoint Proteins Polypeptides And Encoding Sequences Thereof
  • Compositions And Methods For The Treatment And Diagnosis Of Cardiovascular Disease
  • Kit For Detecting The Level Of Cyclin-Dependent Kinase Inhibitor P16 Gene Expression
  • Mts2 Gene
  • Mts2 Gene
  • P19: A Cell Cycle Inhibitor
  • Cyclin Dependent Kinase Binding Peptides
  • Cell-Cycle Regulatory Proteins, And Uses Related Thereto
  • Cell-Cycle Regulatory Proteins, And Uses Related Thereto
  • Inhibitors Of Cell-Cycle Progression, And Uses Related Thereto
  • Cell-Cycle Regulatory Proteins, And Uses Related Thereto
  • Antibodies To Arf-P19
  • Arf-P19, A Novel Regulator Of The Mammalian Cell Cycle
  • Compositions And Methods For The Detection And Treatment Of Methylthioadenosine Phosphorylase Deficient Cancers
  • Mts2 Gene
  • Mammalian Checkpoint Genes And Proteins
  • Arf-P19, A Novel Regulator Of The Mammalian Cell Cycle
  • Cyclin Dependent Kinase Mutants, And Diagnostic And Therapeutic Uses Related Thereto
  • Arf-P19, A Novel Regulator Of The Mammalian Cell Cycle
  • Cell-Cycle Regulatory Proteins, And Uses Related Thereto
  • Antibodies To The Cell Cycle Regulatory Protein P16
  • Isolated Nucleic Acid Molecules Encoding P57kip2
  • Purine And Pyrimidine Cdk Inhibitors And Their Use For The Treatment Of Autoimmune Diseases
  • Probes For Mts1 Gene And Polynucleotides Encoding Mutant Mts1 Genes
  • Vector Containing Mts1e1Β Gene
  • Antibodies Specific For Mts2 Polypeptide
  • Stimulation Of Cellular Regeneration And Differentiation In The Inner Ear
  • Stimulation Of Cellular Regeneration And Differentiation In The Inner Ear
  • Mts1e1Β Gene
  • Germline Mutations In The Mts Gene
  • Methods For Detecting Predisposition To Cancer At The Mts Gene
  • Signatures Of Clinical Outcome In Gastro Intestinal Stromal Tumors And Method Of Treatment Of Gastroinstestinal Stromal Tumors
  • P16ink4 Polypeptides
  • Method Of Screening Ink4 Family Gene Expression Controller And P19 Gene Promoter
  • Cell-Cycle Regulatory Proteins, And Uses Related Thereto
  • Nucleic Acid Encoding Arf-19, A Novel Regulator Of The Mammalian Cell Cycle
  • Compositions And Methods For Increasing Animal Size Growth Rate
  • Mouse Mtsi Gene
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/371257a0

    DOI

    http://dx.doi.org/10.1038/371257a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045553304

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8078588


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Carrier Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Cycle Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cloning, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclin-Dependent Kinase 4", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclin-Dependent Kinase 6", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclin-Dependent Kinase Inhibitor p15", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclin-Dependent Kinase Inhibitor p16", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cyclin-Dependent Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gene Expression", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Keratinocytes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein-Serine-Threonine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proto-Oncogene Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Transforming Growth Factor beta", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Suppressor Proteins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 11724, Cold Spring Harbor, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.225279.9", 
              "name": [
                "Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 11724, Cold Spring Harbor, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hannon", 
            "givenName": "Gregory J.", 
            "id": "sg:person.015076500737.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015076500737.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 11724, Cold Spring Harbor, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.225279.9", 
              "name": [
                "Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 11724, Cold Spring Harbor, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Beach", 
            "givenName": "David", 
            "id": "sg:person.0657713656.56", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657713656.56"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/366704a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015821919", 
              "https://doi.org/10.1038/366704a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/366701a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020218634", 
              "https://doi.org/10.1038/366701a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/368753a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045854758", 
              "https://doi.org/10.1038/368753a0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1994-09", 
        "datePublishedReg": "1994-09-01", 
        "description": "TRANSFORMING growth factor-beta (TGF-\u03b2) inhibits cell proliferation by inducing a Gl-phase cell cycle arrest1. Normal progression through Gl is promoted by the activity of the cyclin-dependent protein kinases CDK4 and CDK6 (ref. 2), which are inhibited by the protein p16INK4. We have isolated a new member of the p16INK4 family, p15INK4B. p15 expression is induced \u223c30-fold in human keratinocytes by treatment with TGF-\u03b2, suggesting that pi5 may act as an effector of TGF-\u03b2-mediated cell cycle arrest. The gene encoding p15 is located on chromosome 9 adjacent to the p16 gene at a frequent site of chromosomal abnormality in human tumours (9p21).", 
        "genre": "article", 
        "id": "sg:pub.10.1038/371257a0", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6494", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "371"
          }
        ], 
        "keywords": [
          "effector of TGF", 
          "cell cycle arrest", 
          "cycle arrest", 
          "inhibits cell proliferation", 
          "frequent site", 
          "p15 expression", 
          "chromosomal abnormalities", 
          "human tumors", 
          "cell proliferation", 
          "TGF", 
          "human keratinocytes", 
          "p16 gene", 
          "arrest", 
          "normal progression", 
          "cyclin-dependent protein", 
          "effectors", 
          "tumors", 
          "abnormalities", 
          "progression", 
          "CDK4", 
          "keratinocytes", 
          "treatment", 
          "CDK6", 
          "p15", 
          "proliferation", 
          "genes", 
          "p16INK4", 
          "expression", 
          "activity", 
          "new member", 
          "protein", 
          "family", 
          "members", 
          "sites", 
          "GL", 
          "adjacent", 
          "Pi5", 
          "TRANSFORMING growth factor-beta (TGF-\u03b2) inhibits cell proliferation", 
          "growth factor-beta (TGF-\u03b2) inhibits cell proliferation", 
          "factor-beta (TGF-\u03b2) inhibits cell proliferation", 
          "Gl-phase cell cycle arrest1", 
          "cell cycle arrest1", 
          "cycle arrest1", 
          "arrest1", 
          "protein p16INK4", 
          "p16INK4 family", 
          "chromosome 9 adjacent", 
          "pl5INK4B"
        ], 
        "name": "pl5INK4B is a potentia| effector of TGF-\u03b2-induced cell cycle arrest", 
        "pagination": "257-261", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1045553304"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/371257a0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "8078588"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/371257a0", 
          "https://app.dimensions.ai/details/publication/pub.1045553304"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:06", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_256.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/371257a0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/371257a0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/371257a0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/371257a0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/371257a0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    213 TRIPLES      22 PREDICATES      99 URIs      88 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/371257a0 schema:about N07e6180c2ba445329011b059aa3ed12f
    2 N0d1dd2eec7004566a0ce43d4880ee15d
    3 N0e12a6b8a85b47eba1abd834db34b768
    4 N13f8157c040d434b89dae09d3537a27d
    5 N22008c4478e846ac87a9c2f0c6e7e292
    6 N393726aa3f274292956f73ed3cbc5489
    7 N39712e7a39634676b7dd0249e2dce9cf
    8 N3a0ba41257a04617a12098cc14220dfc
    9 N3f783e3671a84c78bc169bd3dff622a3
    10 N45840a26373448f1bd7da5eb57636d42
    11 N4b1b9bbd8b804ac5abe03c4be0dc45ee
    12 N658305694c474dba8b167d0c32e09b42
    13 Nace2ddbcec5f42609d2e05005b74e9df
    14 Nb4508976d1e449afb66e996ea9864e1c
    15 Ncbe13e6d0fc34715b76d3a104692134d
    16 Ndc571e2aab6b4d73aa6b66869133cbbf
    17 Ne35dfeedae864f1483e10cf43f2c6281
    18 Ne576258a907d4033950877f14ac3dd14
    19 Nef09a361e63b47068d761a892559f3f8
    20 Nfcb4cf6071214d17b163e163931147f2
    21 Nff6b3eddbda146c69a4eb366bf8bda6b
    22 anzsrc-for:06
    23 anzsrc-for:0601
    24 schema:author N2fbb3154f6774cac89780530b2673f9f
    25 schema:citation sg:pub.10.1038/366701a0
    26 sg:pub.10.1038/366704a0
    27 sg:pub.10.1038/368753a0
    28 schema:datePublished 1994-09
    29 schema:datePublishedReg 1994-09-01
    30 schema:description TRANSFORMING growth factor-beta (TGF-β) inhibits cell proliferation by inducing a Gl-phase cell cycle arrest1. Normal progression through Gl is promoted by the activity of the cyclin-dependent protein kinases CDK4 and CDK6 (ref. 2), which are inhibited by the protein p16INK4. We have isolated a new member of the p16INK4 family, p15INK4B. p15 expression is induced ∼30-fold in human keratinocytes by treatment with TGF-β, suggesting that pi5 may act as an effector of TGF-β-mediated cell cycle arrest. The gene encoding p15 is located on chromosome 9 adjacent to the p16 gene at a frequent site of chromosomal abnormality in human tumours (9p21).
    31 schema:genre article
    32 schema:inLanguage en
    33 schema:isAccessibleForFree false
    34 schema:isPartOf N9a63e0e39aca41c99c737c5a803d2f71
    35 Ne7f2a87d8fdc497095069d912012c95e
    36 sg:journal.1018957
    37 schema:keywords CDK4
    38 CDK6
    39 GL
    40 Gl-phase cell cycle arrest1
    41 Pi5
    42 TGF
    43 TRANSFORMING growth factor-beta (TGF-β) inhibits cell proliferation
    44 abnormalities
    45 activity
    46 adjacent
    47 arrest
    48 arrest1
    49 cell cycle arrest
    50 cell cycle arrest1
    51 cell proliferation
    52 chromosomal abnormalities
    53 chromosome 9 adjacent
    54 cycle arrest
    55 cycle arrest1
    56 cyclin-dependent protein
    57 effector of TGF
    58 effectors
    59 expression
    60 factor-beta (TGF-β) inhibits cell proliferation
    61 family
    62 frequent site
    63 genes
    64 growth factor-beta (TGF-β) inhibits cell proliferation
    65 human keratinocytes
    66 human tumors
    67 inhibits cell proliferation
    68 keratinocytes
    69 members
    70 new member
    71 normal progression
    72 p15
    73 p15 expression
    74 p16 gene
    75 p16INK4
    76 p16INK4 family
    77 pl5INK4B
    78 progression
    79 proliferation
    80 protein
    81 protein p16INK4
    82 sites
    83 treatment
    84 tumors
    85 schema:name pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
    86 schema:pagination 257-261
    87 schema:productId N00f4ffeae54b47a683aef2a2367c9c6c
    88 N44a6ef1eafd94e1fb16761aa27d3adf3
    89 N9ce3a1cdf32644188b3f1815caa17292
    90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045553304
    91 https://doi.org/10.1038/371257a0
    92 schema:sdDatePublished 2022-01-01T18:06
    93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    94 schema:sdPublisher N8a624290e520449e86c5a767d773410e
    95 schema:url https://doi.org/10.1038/371257a0
    96 sgo:license sg:explorer/license/
    97 sgo:sdDataset articles
    98 rdf:type schema:ScholarlyArticle
    99 N00f4ffeae54b47a683aef2a2367c9c6c schema:name dimensions_id
    100 schema:value pub.1045553304
    101 rdf:type schema:PropertyValue
    102 N07e6180c2ba445329011b059aa3ed12f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name RNA, Messenger
    104 rdf:type schema:DefinedTerm
    105 N0d1dd2eec7004566a0ce43d4880ee15d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    106 schema:name Proto-Oncogene Proteins
    107 rdf:type schema:DefinedTerm
    108 N0e12a6b8a85b47eba1abd834db34b768 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Cyclin-Dependent Kinase 6
    110 rdf:type schema:DefinedTerm
    111 N13f8157c040d434b89dae09d3537a27d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Keratinocytes
    113 rdf:type schema:DefinedTerm
    114 N144f896d1fe24e6093daa53b037eaeff rdf:first sg:person.0657713656.56
    115 rdf:rest rdf:nil
    116 N22008c4478e846ac87a9c2f0c6e7e292 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    117 schema:name Cell Line
    118 rdf:type schema:DefinedTerm
    119 N2fbb3154f6774cac89780530b2673f9f rdf:first sg:person.015076500737.82
    120 rdf:rest N144f896d1fe24e6093daa53b037eaeff
    121 N393726aa3f274292956f73ed3cbc5489 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Cell Cycle Proteins
    123 rdf:type schema:DefinedTerm
    124 N39712e7a39634676b7dd0249e2dce9cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Gene Expression
    126 rdf:type schema:DefinedTerm
    127 N3a0ba41257a04617a12098cc14220dfc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Cell Cycle
    129 rdf:type schema:DefinedTerm
    130 N3f783e3671a84c78bc169bd3dff622a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Molecular Sequence Data
    132 rdf:type schema:DefinedTerm
    133 N44a6ef1eafd94e1fb16761aa27d3adf3 schema:name doi
    134 schema:value 10.1038/371257a0
    135 rdf:type schema:PropertyValue
    136 N45840a26373448f1bd7da5eb57636d42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Cyclin-Dependent Kinase Inhibitor p16
    138 rdf:type schema:DefinedTerm
    139 N4b1b9bbd8b804ac5abe03c4be0dc45ee schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Humans
    141 rdf:type schema:DefinedTerm
    142 N658305694c474dba8b167d0c32e09b42 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Cyclin-Dependent Kinase 4
    144 rdf:type schema:DefinedTerm
    145 N8a624290e520449e86c5a767d773410e schema:name Springer Nature - SN SciGraph project
    146 rdf:type schema:Organization
    147 N9a63e0e39aca41c99c737c5a803d2f71 schema:volumeNumber 371
    148 rdf:type schema:PublicationVolume
    149 N9ce3a1cdf32644188b3f1815caa17292 schema:name pubmed_id
    150 schema:value 8078588
    151 rdf:type schema:PropertyValue
    152 Nace2ddbcec5f42609d2e05005b74e9df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    153 schema:name Cyclin-Dependent Kinases
    154 rdf:type schema:DefinedTerm
    155 Nb4508976d1e449afb66e996ea9864e1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    156 schema:name Cloning, Molecular
    157 rdf:type schema:DefinedTerm
    158 Ncbe13e6d0fc34715b76d3a104692134d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name Cyclin-Dependent Kinase Inhibitor p15
    160 rdf:type schema:DefinedTerm
    161 Ndc571e2aab6b4d73aa6b66869133cbbf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    162 schema:name Protein-Serine-Threonine Kinases
    163 rdf:type schema:DefinedTerm
    164 Ne35dfeedae864f1483e10cf43f2c6281 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Base Sequence
    166 rdf:type schema:DefinedTerm
    167 Ne576258a907d4033950877f14ac3dd14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Tumor Suppressor Proteins
    169 rdf:type schema:DefinedTerm
    170 Ne7f2a87d8fdc497095069d912012c95e schema:issueNumber 6494
    171 rdf:type schema:PublicationIssue
    172 Nef09a361e63b47068d761a892559f3f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Transforming Growth Factor beta
    174 rdf:type schema:DefinedTerm
    175 Nfcb4cf6071214d17b163e163931147f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Amino Acid Sequence
    177 rdf:type schema:DefinedTerm
    178 Nff6b3eddbda146c69a4eb366bf8bda6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Carrier Proteins
    180 rdf:type schema:DefinedTerm
    181 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    182 schema:name Biological Sciences
    183 rdf:type schema:DefinedTerm
    184 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    185 schema:name Biochemistry and Cell Biology
    186 rdf:type schema:DefinedTerm
    187 sg:journal.1018957 schema:issn 0028-0836
    188 1476-4687
    189 schema:name Nature
    190 schema:publisher Springer Nature
    191 rdf:type schema:Periodical
    192 sg:person.015076500737.82 schema:affiliation grid-institutes:grid.225279.9
    193 schema:familyName Hannon
    194 schema:givenName Gregory J.
    195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015076500737.82
    196 rdf:type schema:Person
    197 sg:person.0657713656.56 schema:affiliation grid-institutes:grid.225279.9
    198 schema:familyName Beach
    199 schema:givenName David
    200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657713656.56
    201 rdf:type schema:Person
    202 sg:pub.10.1038/366701a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020218634
    203 https://doi.org/10.1038/366701a0
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/366704a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015821919
    206 https://doi.org/10.1038/366704a0
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/368753a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045854758
    209 https://doi.org/10.1038/368753a0
    210 rdf:type schema:CreativeWork
    211 grid-institutes:grid.225279.9 schema:alternateName Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 11724, Cold Spring Harbor, New York, USA
    212 schema:name Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 11724, Cold Spring Harbor, New York, USA
    213 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...