pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-09

AUTHORS

G J Hannon, D Beach

ABSTRACT

Transforming growth factor-beta (TGF-beta) inhibits cell proliferation by inducing a G1-phase cell cycle arrest. Normal progression through G1 is promoted by the activity of the cyclin-dependent protein kinases CDK4 and CDK6 (ref. 2), which are inhibited by the protein p16INK4. We have isolated a new member of the p16INK4 family, p15INK4B. p15 expression is induced approximately 30-fold in human keratinocytes by treatment with TGF-beta, suggesting that p15 may act as an effector of TGF-beta-mediated cell cycle arrest. The gene encoding p15 is located on chromosome 9 adjacent to the p16 gene at a frequent site of chromosomal abnormality in human tumours (9p21). More... »

PAGES

257-261

Journal

TITLE

Nature

ISSUE

6494

VOLUME

371

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/371257a0

    DOI

    http://dx.doi.org/10.1038/371257a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045553304

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8078588


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