Ontology type: schema:ScholarlyArticle
1994-09
AUTHORSNicholas C. Nicolaides, Nickolas Papadopoulos, Bo Liu, Ying-Fei Weit, Kenneth C. Carter, Steven M. Ruben, Craig A. Rosen, William A. Haseltine, Robert D. Fleischmann, Claire M. Fraser, Mark D. Adams, J. Craig Venter, Malcolm G. Dunlop, Stanley R. Hamilton, Gloria M. Petersen, Albert de la Chapelle, Bert Vogelstein, Kenneth W. Kinzler
ABSTRACTHEREDITARY nonpolyposis colorectal cancer (HNPCC) is one of man's commonest hereditary diseases1. Several studies have implicated a defect in DNA mismatch repair in the pathogenesis of this disease2–8. In particular, hMSH2 and hMLHl homologues of the bacterial DNA mismatch repair genes mutS and mutL, respectively, were shown to be mutated in a subset of HNPCC cases9–16. Here we report the nucleotide sequence, chromosome localization and mutational analysis of hPMSl and hPMS2, two additional homologues of the prokaryotic mutL gene. Both hPMSl and hPMS2 were found to be mutated in the germline of HNPCC patients. This doubles the number of genes implicated in HNPCC and may help explain the relatively high incidence of this disease. More... »
PAGES75-80
http://scigraph.springernature.com/pub.10.1038/371075a0
DOIhttp://dx.doi.org/10.1038/371075a0
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/8072530
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