Structure of influenza haemagglutinin at the pH of membrane fusion View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-09

AUTHORS

P A Bullough, F M Hughson, J J Skehel, D C Wiley

ABSTRACT

Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered. More... »

PAGES

37-43

Journal

TITLE

Nature

ISSUE

6492

VOLUME

371

Author Affiliations

Related Patents

  • Trimerizing Polypeptides
  • Inhibitors Of Hiv Membrane Fusion
  • Targeted Delivery Of Drugs, Therapeutic Nucleic Acids And Functional Nucleic Acids To Mammalian Cells Via Intact Killed Bacterial Cells
  • Matriptase Inhibitors And Uses Thereof Against Orthomyxoviridae Infections
  • Influenza Virus Vaccine And Uses Thereof
  • Vaccines For Use In The Prophylaxis And Treatment Of Influenza Virus Disease
  • Influenza Virus Vaccines And Uses Thereof
  • Targeted Delivery Of Drugs, Therapeutic Nucleic Acids And Functional Nucleic Acids To Mammalian Cells Via Intact Killed Bacterial Cells
  • Dps Fusion Proteins For Use In Vaccines And Diagnostics
  • Antibodies Against Influenza Virus Hemagglutinin And Uses Thereof
  • Controlling Uptake By Cells
  • Method For Production Of Ph Stable Enveloped Viruses
  • Long Lasting Fusion Peptide Inhibitors For Hiv Infection
  • Five-Helix Protein
  • Core Structure Of Gp41 From The Hiv Envelope Glycoprotein
  • Five-Helix Protein
  • Method For Production Of Ph Stable Enveloped Viruses
  • Targeted Delivery Of Drugs, Therapeutic Nucleic Acids And Functional Nucleic Acids To Mammalian Cells Via Intact Killed Bacterial Cells
  • Synthetic Peptides Capable Of Binding To Influenza Hemagglutinin Protein
  • Synthetic Peptides Capable Of Binding To Influenza Hemagglutinin Protein
  • Inhibitors Of Hiv Membrane Fusion
  • Five-Helix Protein
  • Inhibitors Of Hiv Membrane Fusion
  • Peptide Inhibitors Of Hiv Entry
  • Constrained Helical Peptides And Methods Of Making Same
  • Method For Production Of Ph Stable Enveloped Viruses
  • Covalently Stabilized Chimeric Coiled-Coil Hiv Gp41 N-Peptides With Improved Antiviral Activity
  • Conserved Influenza Hemagglutinin Epitope And Antibodies Thereto
  • Synthetic Peptides Capable Of Binding To Influenza Hemagglutinin Protein
  • Soluble Chimeric Peptide Inhibitors Of Hiv Entry Comprising An Iz Trimeric Coiled-Coil Peptide And Hiv Gp41 N-Helix Coiled-Coil Peptide
  • Trimerizing Polypeptides
  • Antibodies Against Influenza Virus And Methods Of Use Thereof
  • Antibodies Against Influenza Virus And Methods Of Use Thereof
  • Core Structure Of Gp41 From The Hiv Envelope Glycoprotein
  • Peptide Inhibitors Of Hiv Entry
  • Dps Fusion Proteins For Use In Vaccines And Diagnostics
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/371037a0

    DOI

    http://dx.doi.org/10.1038/371037a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1046282624

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8072525


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Computer Graphics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Crystallography, X-Ray", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hemagglutinin Glycoproteins, Influenza Virus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hemagglutinins, Viral", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hydrogen-Ion Concentration", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Fusion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mutation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Orthomyxoviridae", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Peptide Fragments", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Conformation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Folding", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Harvard University", 
              "id": "https://www.grid.ac/institutes/grid.38142.3c", 
              "name": [
                "Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bullough", 
            "givenName": "P A", 
            "id": "sg:person.01306221564.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306221564.47"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Hughson", 
            "givenName": "F M", 
            "id": "sg:person.01354334764.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354334764.06"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Skehel", 
            "givenName": "J J", 
            "id": "sg:person.0744102055.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744102055.80"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Wiley", 
            "givenName": "D C", 
            "id": "sg:person.01104357451.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104357451.72"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90260-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005067432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0108767386099622", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006433158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.105.6.2887", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008233068"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2836(94)90027-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010230057"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0108767383001592", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010523045"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/newbio238145a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011911255", 
              "https://doi.org/10.1038/newbio238145a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/newbio238145a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011911255", 
              "https://doi.org/10.1038/newbio238145a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/newbio238145a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011911255", 
              "https://doi.org/10.1038/newbio238145a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(80)80457-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012418044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0108767390010224", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014210169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0021889891004399", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014885043"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/289366a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016242659", 
              "https://doi.org/10.1038/289366a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/356083a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017646872", 
              "https://doi.org/10.1038/356083a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0567739476001691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020146113"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(92)90140-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021073929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.bi.56.070187.002053", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022942674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0263-7855(87)80010-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023336895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0021889887086783", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025485987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/342555a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025994605", 
              "https://doi.org/10.1038/342555a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2836(83)90053-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027813648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(94)90344-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028334480"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1107/s0365110x53001964", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029987264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0969-2126(00)00025-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030969156"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0022-2836(90)90234-d", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032143632"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.102.1.11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034707516"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90376-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037094317"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0042-6822(83)80015-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037568983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0042-6822(83)90465-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038575472"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0042-6822(81)90030-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038677160"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0042-6822(86)90210-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038750627"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1083/jcb.89.3.674", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040327611"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/325084a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040333133", 
              "https://doi.org/10.1038/325084a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(85)90157-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042655360"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pro.5560020916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046701730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/355472a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048571716", 
              "https://doi.org/10.1038/355472a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1071/bi9800441", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052065046"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00155a013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055162956"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/bi00493a027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055178198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/0022-1317-69-11-2785", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060356609"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079696826", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1987.tb02387.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079848966"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1986.tb04175.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1080052798"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080060636", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081612209", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1994-09", 
        "datePublishedReg": "1994-09-01", 
        "description": "Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/371037a0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6492", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "371"
          }
        ], 
        "name": "Structure of influenza haemagglutinin at the pH of membrane fusion", 
        "pagination": "37-43", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "dc77e82ff74b69bd21566fd0bb36041a7dd54893f22b638ce06886d427593503"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "8072525"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/371037a0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1046282624"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/371037a0", 
          "https://app.dimensions.ai/details/publication/pub.1046282624"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:39", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000426.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/371037a0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/371037a0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/371037a0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/371037a0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/371037a0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    268 TRIPLES      21 PREDICATES      84 URIs      34 LITERALS      22 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/371037a0 schema:about N1aa8c698f41a40e4b25554acf396cbe3
    2 N1d770260d0d1476f9afcb3a8cfa81de3
    3 N2032a57a84df40be8ab42ab74d0adcdb
    4 N26604c0208634c188901e003f1abe979
    5 N29567e0650684a52a6c9a0d865df86f2
    6 N47177cda259144aead58130cf7a06265
    7 N476ccb6312ed46f8988c991f0b1099f2
    8 N62f3c7d398d243dda20d2f7b56692274
    9 N889b34577b8647e39752401847c797b9
    10 N9af25c3281f342328755b532e0640e65
    11 N9d8fdeadb4954baeb7b7b5345cb4d905
    12 Na91571cd2cae41469cf35fafa37f69cf
    13 Nd8974f739063406981cad8bd7f2e9916
    14 anzsrc-for:06
    15 anzsrc-for:0601
    16 schema:author N7ac57b4d7d0e4402bf77a75d71c78636
    17 schema:citation sg:pub.10.1038/289366a0
    18 sg:pub.10.1038/325084a0
    19 sg:pub.10.1038/342555a0
    20 sg:pub.10.1038/355472a0
    21 sg:pub.10.1038/356083a0
    22 sg:pub.10.1038/newbio238145a0
    23 https://app.dimensions.ai/details/publication/pub.1079696826
    24 https://app.dimensions.ai/details/publication/pub.1080060636
    25 https://app.dimensions.ai/details/publication/pub.1081612209
    26 https://doi.org/10.1002/j.1460-2075.1986.tb04175.x
    27 https://doi.org/10.1002/j.1460-2075.1987.tb02387.x
    28 https://doi.org/10.1002/pro.5560020916
    29 https://doi.org/10.1016/0014-5793(80)80457-1
    30 https://doi.org/10.1016/0022-2836(83)90053-0
    31 https://doi.org/10.1016/0022-2836(90)90234-d
    32 https://doi.org/10.1016/0022-2836(94)90027-2
    33 https://doi.org/10.1016/0042-6822(81)90030-1
    34 https://doi.org/10.1016/0042-6822(83)90465-8
    35 https://doi.org/10.1016/0042-6822(86)90210-2
    36 https://doi.org/10.1016/0092-8674(85)90157-6
    37 https://doi.org/10.1016/0092-8674(92)90140-8
    38 https://doi.org/10.1016/0092-8674(93)90260-w
    39 https://doi.org/10.1016/0092-8674(93)90376-2
    40 https://doi.org/10.1016/0092-8674(94)90344-1
    41 https://doi.org/10.1016/0263-7855(87)80010-3
    42 https://doi.org/10.1016/s0042-6822(83)80015-4
    43 https://doi.org/10.1016/s0969-2126(00)00025-3
    44 https://doi.org/10.1021/bi00155a013
    45 https://doi.org/10.1021/bi00493a027
    46 https://doi.org/10.1071/bi9800441
    47 https://doi.org/10.1083/jcb.102.1.11
    48 https://doi.org/10.1083/jcb.105.6.2887
    49 https://doi.org/10.1083/jcb.89.3.674
    50 https://doi.org/10.1099/0022-1317-69-11-2785
    51 https://doi.org/10.1107/s0021889887086783
    52 https://doi.org/10.1107/s0021889891004399
    53 https://doi.org/10.1107/s0108767383001592
    54 https://doi.org/10.1107/s0108767386099622
    55 https://doi.org/10.1107/s0108767390010224
    56 https://doi.org/10.1107/s0365110x53001964
    57 https://doi.org/10.1107/s0567739476001691
    58 https://doi.org/10.1146/annurev.bi.56.070187.002053
    59 schema:datePublished 1994-09
    60 schema:datePublishedReg 1994-09-01
    61 schema:description Low pH induces a conformational change in the influenza virus haemagglutinin, which then mediates fusion of the viral and host cell membranes. The three-dimensional structure of a fragment of the haemagglutinin in this conformation reveals a major refolding of the secondary and tertiary structure of the molecule. The apolar fusion peptide moves at least 100 A to one tip of the molecule. At the other end a helical segment unfolds, a subdomain relocates reversing the chain direction, and part of the structure becomes disordered.
    62 schema:genre research_article
    63 schema:inLanguage en
    64 schema:isAccessibleForFree false
    65 schema:isPartOf N7dabe20121bb406e8a59d7abed8c6acf
    66 Nb785d2d601eb4ce2a9f08e46dd374c40
    67 sg:journal.1018957
    68 schema:name Structure of influenza haemagglutinin at the pH of membrane fusion
    69 schema:pagination 37-43
    70 schema:productId N15026d44cee4450eaf9998ace5b4d480
    71 N2b67cb86f59242deaa3350e7901ea222
    72 N407ac7512d9143949d9ec4057751060a
    73 N85c4af578e37474b9af85550a14dc319
    74 Ncff53fc085314b4d9d270521eeec829b
    75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046282624
    76 https://doi.org/10.1038/371037a0
    77 schema:sdDatePublished 2019-04-10T15:39
    78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    79 schema:sdPublisher Nfcb73b61d30f48908fa60dcff13123f8
    80 schema:url http://www.nature.com/articles/371037a0
    81 sgo:license sg:explorer/license/
    82 sgo:sdDataset articles
    83 rdf:type schema:ScholarlyArticle
    84 N06704bd88e41432aac77348f27aa0240 rdf:first sg:person.0744102055.80
    85 rdf:rest N5da6cd80e6084285a91f494f58eb2ff8
    86 N15026d44cee4450eaf9998ace5b4d480 schema:name doi
    87 schema:value 10.1038/371037a0
    88 rdf:type schema:PropertyValue
    89 N1aa8c698f41a40e4b25554acf396cbe3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Peptide Fragments
    91 rdf:type schema:DefinedTerm
    92 N1d770260d0d1476f9afcb3a8cfa81de3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    93 schema:name Orthomyxoviridae
    94 rdf:type schema:DefinedTerm
    95 N2032a57a84df40be8ab42ab74d0adcdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    96 schema:name Hydrogen-Ion Concentration
    97 rdf:type schema:DefinedTerm
    98 N26604c0208634c188901e003f1abe979 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Molecular Sequence Data
    100 rdf:type schema:DefinedTerm
    101 N29567e0650684a52a6c9a0d865df86f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Hemagglutinins, Viral
    103 rdf:type schema:DefinedTerm
    104 N2b67cb86f59242deaa3350e7901ea222 schema:name nlm_unique_id
    105 schema:value 0410462
    106 rdf:type schema:PropertyValue
    107 N407ac7512d9143949d9ec4057751060a schema:name pubmed_id
    108 schema:value 8072525
    109 rdf:type schema:PropertyValue
    110 N47177cda259144aead58130cf7a06265 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Mutation
    112 rdf:type schema:DefinedTerm
    113 N476ccb6312ed46f8988c991f0b1099f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Protein Folding
    115 rdf:type schema:DefinedTerm
    116 N5da6cd80e6084285a91f494f58eb2ff8 rdf:first sg:person.01104357451.72
    117 rdf:rest rdf:nil
    118 N62f3c7d398d243dda20d2f7b56692274 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Membrane Fusion
    120 rdf:type schema:DefinedTerm
    121 N7ac57b4d7d0e4402bf77a75d71c78636 rdf:first sg:person.01306221564.47
    122 rdf:rest Na5160b29a7a84786b698e79347619102
    123 N7dabe20121bb406e8a59d7abed8c6acf schema:volumeNumber 371
    124 rdf:type schema:PublicationVolume
    125 N85c4af578e37474b9af85550a14dc319 schema:name readcube_id
    126 schema:value dc77e82ff74b69bd21566fd0bb36041a7dd54893f22b638ce06886d427593503
    127 rdf:type schema:PropertyValue
    128 N889b34577b8647e39752401847c797b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Amino Acid Sequence
    130 rdf:type schema:DefinedTerm
    131 N9af25c3281f342328755b532e0640e65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    132 schema:name Computer Graphics
    133 rdf:type schema:DefinedTerm
    134 N9d8fdeadb4954baeb7b7b5345cb4d905 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Protein Conformation
    136 rdf:type schema:DefinedTerm
    137 Na5160b29a7a84786b698e79347619102 rdf:first sg:person.01354334764.06
    138 rdf:rest N06704bd88e41432aac77348f27aa0240
    139 Na91571cd2cae41469cf35fafa37f69cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Hemagglutinin Glycoproteins, Influenza Virus
    141 rdf:type schema:DefinedTerm
    142 Nb785d2d601eb4ce2a9f08e46dd374c40 schema:issueNumber 6492
    143 rdf:type schema:PublicationIssue
    144 Ncff53fc085314b4d9d270521eeec829b schema:name dimensions_id
    145 schema:value pub.1046282624
    146 rdf:type schema:PropertyValue
    147 Nd8974f739063406981cad8bd7f2e9916 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Crystallography, X-Ray
    149 rdf:type schema:DefinedTerm
    150 Nfcb73b61d30f48908fa60dcff13123f8 schema:name Springer Nature - SN SciGraph project
    151 rdf:type schema:Organization
    152 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    153 schema:name Biological Sciences
    154 rdf:type schema:DefinedTerm
    155 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    156 schema:name Biochemistry and Cell Biology
    157 rdf:type schema:DefinedTerm
    158 sg:journal.1018957 schema:issn 0090-0028
    159 1476-4687
    160 schema:name Nature
    161 rdf:type schema:Periodical
    162 sg:person.01104357451.72 schema:familyName Wiley
    163 schema:givenName D C
    164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104357451.72
    165 rdf:type schema:Person
    166 sg:person.01306221564.47 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
    167 schema:familyName Bullough
    168 schema:givenName P A
    169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306221564.47
    170 rdf:type schema:Person
    171 sg:person.01354334764.06 schema:familyName Hughson
    172 schema:givenName F M
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354334764.06
    174 rdf:type schema:Person
    175 sg:person.0744102055.80 schema:familyName Skehel
    176 schema:givenName J J
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744102055.80
    178 rdf:type schema:Person
    179 sg:pub.10.1038/289366a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016242659
    180 https://doi.org/10.1038/289366a0
    181 rdf:type schema:CreativeWork
    182 sg:pub.10.1038/325084a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040333133
    183 https://doi.org/10.1038/325084a0
    184 rdf:type schema:CreativeWork
    185 sg:pub.10.1038/342555a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025994605
    186 https://doi.org/10.1038/342555a0
    187 rdf:type schema:CreativeWork
    188 sg:pub.10.1038/355472a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048571716
    189 https://doi.org/10.1038/355472a0
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1038/356083a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017646872
    192 https://doi.org/10.1038/356083a0
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1038/newbio238145a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011911255
    195 https://doi.org/10.1038/newbio238145a0
    196 rdf:type schema:CreativeWork
    197 https://app.dimensions.ai/details/publication/pub.1079696826 schema:CreativeWork
    198 https://app.dimensions.ai/details/publication/pub.1080060636 schema:CreativeWork
    199 https://app.dimensions.ai/details/publication/pub.1081612209 schema:CreativeWork
    200 https://doi.org/10.1002/j.1460-2075.1986.tb04175.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1080052798
    201 rdf:type schema:CreativeWork
    202 https://doi.org/10.1002/j.1460-2075.1987.tb02387.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079848966
    203 rdf:type schema:CreativeWork
    204 https://doi.org/10.1002/pro.5560020916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046701730
    205 rdf:type schema:CreativeWork
    206 https://doi.org/10.1016/0014-5793(80)80457-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012418044
    207 rdf:type schema:CreativeWork
    208 https://doi.org/10.1016/0022-2836(83)90053-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027813648
    209 rdf:type schema:CreativeWork
    210 https://doi.org/10.1016/0022-2836(90)90234-d schema:sameAs https://app.dimensions.ai/details/publication/pub.1032143632
    211 rdf:type schema:CreativeWork
    212 https://doi.org/10.1016/0022-2836(94)90027-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010230057
    213 rdf:type schema:CreativeWork
    214 https://doi.org/10.1016/0042-6822(81)90030-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038677160
    215 rdf:type schema:CreativeWork
    216 https://doi.org/10.1016/0042-6822(83)90465-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038575472
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1016/0042-6822(86)90210-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038750627
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1016/0092-8674(85)90157-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042655360
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1016/0092-8674(92)90140-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021073929
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/0092-8674(93)90260-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1005067432
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/0092-8674(93)90376-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037094317
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/0092-8674(94)90344-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028334480
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1016/0263-7855(87)80010-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023336895
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1016/s0042-6822(83)80015-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037568983
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1016/s0969-2126(00)00025-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030969156
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1021/bi00155a013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055162956
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1021/bi00493a027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055178198
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1071/bi9800441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052065046
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1083/jcb.102.1.11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034707516
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1083/jcb.105.6.2887 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008233068
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1083/jcb.89.3.674 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040327611
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1099/0022-1317-69-11-2785 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060356609
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1107/s0021889887086783 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025485987
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1107/s0021889891004399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014885043
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1107/s0108767383001592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010523045
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1107/s0108767386099622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006433158
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1107/s0108767390010224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014210169
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1107/s0365110x53001964 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029987264
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1107/s0567739476001691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020146113
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1146/annurev.bi.56.070187.002053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022942674
    265 rdf:type schema:CreativeWork
    266 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
    267 schema:name Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.
    268 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...