Phosphatidylinositol-3-OH kinase direct target of Ras View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-08

AUTHORS

Pablo Rodriguez-Viciana, Patricia H. Warne, Ritu Dhand, Bart Vanhaesebroeck, Ivan Gout, Michael J. Fry, Michael D. Waterfield, Julian Downward

ABSTRACT

Ras (p21ras) interacts directly with the catalytic subunit of phosphatidylinositol-3-OH kinase in a GTP-dependent manner through the Ras effector site. In vivo, dominant negative Ras mutant N17 inhibits growth factor induced production of 3′ hosphorylated phosphoinositides in PC12 cells, and transfection of Ras, but not Raf, into COS cells results in a large elevation in the level of these lipids. Therefore Ras can probably regulate phosphatidylinositol-3-OH kinase, providing a point of divergence in signalling pathways downstream of Ras. More... »

PAGES

527-532

Journal

TITLE

Nature

ISSUE

6490

VOLUME

370

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/370527a0

    DOI

    http://dx.doi.org/10.1038/370527a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052561899

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8052307


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