The inositol trisphosphate calcium channel is inactivated by inositol trisphosphate View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-08

AUTHORS

György Hajnóczky, Andrew P. Thomas

ABSTRACT

ACTIVATION of intracellular Ca2+ channels by inositol 1,4,5-tris-phosphate (Ins(l,4,5)P3) represents the initial Ca2+ mobilization step in response to many extracellular signals1. Here we report that Ins(l,4,5)P3-induced channel activation in permeabilized hepatocytes is followed by a time-dependent inactivation, which is a direct consequence of ligand binding. The inactivation by Ins(l,4,5)P3 parallels the quantal character of channel opening, giving rise to a unique process of incremental inactivation whereby discrete channel populations are inhibited at each Ins(l,4,5)P3 dose. Ins(l,4,5)P3 can induce inactivation in the absence of stored Ca2+, but the inactivation rate is enhanced by increases of cytosolic Ca2+. The inhibitory effect of Ins(l,4,5)P3 can be reversed by Ins(l,4,5)P3 washout, or by chelation of cytosolic Ca2+. Thus, Ins(l,4,5)P3 and Ca2+ act as coinhibitors of the Ins(l,4,5)P3-sensitive Ca2+ channel. Inactivation is an inherent consequence of Ins(l,4,5)P3-induced channel opening which can terminate increases of cytosolic Ca2+. More... »

PAGES

474-477

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/370474a0

DOI

http://dx.doi.org/10.1038/370474a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038361570

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8047168


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