Major expansion of CD8+ T cells with a predominant Vβ usage during the primary immune response to HIV View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-08-11

AUTHORS

Giuseppe Pantaleo, James F. Demarest, Hugo Soudeyns, Cecilia Graziosi, François Denis, Joseph W. Adelsberger, Persephone Borrow, Michael S. Saag, George M. Shaw, Rafick P. Sekalytt, Anthony S. Fauci

ABSTRACT

A SIGNIFICANT proportion (up to 70%) of individuals experience an acute clinical syndrome of varying severity associated with primary infection with the human immunodeficiency virus (HIV)1–4. We report here studies on six individuals who showed an acute HIV syndrome which generally resolved within four weeks, concomitant with a dramatic downregulation of viraemia2–5. To characterize the T-cell-mediated primary immune response to HIV, we used combined semiquantitative polymerase chain reaction assay and cytofluorometry to analyse the T-cell antigen receptor repertoire in sequential peripheral blood mononuclear cells from the patients. We found major oligoclonal expansions in a restricted set of variable-domain β-chain (Vβ) families. Cells expressing the expanded Vβs predominantly expressed the CDS T-cell differentiation antigen and mediated HlV-specific cytotoxicity. Major oligoclonal expansions of these CD8+ T lymphocytes may represent an important component of the primary immune response to viral infections and may help to clarify both the immunopathogenic and the protective mechanisms of HIV infection. More... »

PAGES

463-467

Journal

TITLE

Nature

ISSUE

6489

VOLUME

370

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/370463a0

DOI

http://dx.doi.org/10.1038/370463a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030115200

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8047166


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