Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-07

AUTHORS

Kendall M. Mohler, Paul R. Sleath, Jeffrey N. Fitzner, Douglas Pat Cerretti, Mark Alderson, Suresh S. Kerwar, Dauphine S. Torranee, Carol Otten-Evans, Teresa Greenstreet, Kumudini Weerawarna, Shirley R. Kronheim, Melissa Petersen, Mary Gerhart, Carl J. Kozlosky, Carl J. March, Roy A. Black

ABSTRACT

TUMOUR necrosis factor (tumour necrosis factor-α/cachectin) plays a critical role in certain physiological defensive responses but causes severe damage to the host organism when produced in excess1. There are two forms of tumour necrosis factor, a type II membrane protein of relative molecular mass 26,000 (26K) and a soluble, 17K form generated from the cell-bound protein by proteolytic cleavage2,3. The two forms of tumour necrosis factor and lymphotoxin-α (tumour necrosis factor-β/lymphotoxin), a related protein, have similar but apparently not identical biological activities4–6. A therapeutic agent which inhibited the release of tumour necrosis factor, but did not reduce the cell-associated activity or the level of lymphotoxin-α, might preserve the benefits of these cytokines while preventing tumour necrosis factor-induced damage. Here we describe a potent inhibitor of tumour necrosis factor processing and report that it protects mice from a lethal dose of endotoxin. More... »

PAGES

218-220

Journal

TITLE

Nature

ISSUE

6486

VOLUME

370

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/370218a0

    DOI

    http://dx.doi.org/10.1038/370218a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1022969551

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8028669


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