Ontology type: schema:ScholarlyArticle
1994-07
AUTHORSBruce A. Witthuhn, Olli Silvennoinen, Osamu Miura, Koon Siew Lai, Christopher Cwik, Edison T. Liu, James N. Ihle
ABSTRACTMANY cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies1–10 have shown that one or more of the Janus kinase family members (Jaks) associate with cytokine receptors and are tyrosine phosphorylated and activated following ligand binding. Here we describe a new Jak family kinase, Jak-3, and demonstrate that Jak-3, and to a lesser extent Jak-1, are tyrosine phosphorylated and Jak-3 is activated in the responses to interleukin-2 and interleukin–4 in T cells and myeloid cells. Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor β-chain, but does not require the acidic domain that is required for association and activation of Src family kinases. More... »
PAGES153-157
http://scigraph.springernature.com/pub.10.1038/370153a0
DOIhttp://dx.doi.org/10.1038/370153a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1036067090
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/8022486
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amino Acid Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Marrow",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Bone Marrow Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cytokines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Enzyme Activation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Interleukin-2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Interleukin-4",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Janus Kinase 3",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Mice",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Sequence Data",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Organ Specificity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Precipitin Tests",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein-Tyrosine Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sequence Homology, Amino Acid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Signal Transduction",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, 38105, Memphis, Tennessee, USA",
"id": "http://www.grid.ac/institutes/grid.240871.8",
"name": [
"Department of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, 38105, Memphis, Tennessee, USA"
],
"type": "Organization"
},
"familyName": "Witthuhn",
"givenName": "Bruce A.",
"id": "sg:person.014716143024.04",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014716143024.04"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, 38105, Memphis, Tennessee, USA",
"id": "http://www.grid.ac/institutes/grid.240871.8",
"name": [
"Department of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, 38105, Memphis, Tennessee, USA"
],
"type": "Organization"
},
"familyName": "Silvennoinen",
"givenName": "Olli",
"id": "sg:person.01164700021.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164700021.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of First Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan",
"id": "http://www.grid.ac/institutes/grid.265073.5",
"name": [
"Department of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, 38105, Memphis, Tennessee, USA",
"Department of First Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan"
],
"type": "Organization"
},
"familyName": "Miura",
"givenName": "Osamu",
"id": "sg:person.0600241142.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600241142.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599-7295, Chapel Hill, North Carolina, USA",
"id": "http://www.grid.ac/institutes/grid.10698.36",
"name": [
"Department of Biology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599-7295, Chapel Hill, North Carolina, USA"
],
"type": "Organization"
},
"familyName": "Lai",
"givenName": "Koon Siew",
"id": "sg:person.0744432266.02",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744432266.02"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, 38105, Memphis, Tennessee, USA",
"id": "http://www.grid.ac/institutes/grid.240871.8",
"name": [
"Department of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, 38105, Memphis, Tennessee, USA"
],
"type": "Organization"
},
"familyName": "Cwik",
"givenName": "Christopher",
"type": "Person"
},
{
"affiliation": {
"alternateName": "School of Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599-7295, Chapel Hill, North Carolina, USA",
"id": "http://www.grid.ac/institutes/grid.10698.36",
"name": [
"School of Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599-7295, Chapel Hill, North Carolina, USA"
],
"type": "Organization"
},
"familyName": "Liu",
"givenName": "Edison T.",
"id": "sg:person.01244760140.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244760140.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, 38105, Memphis, Tennessee, USA",
"id": "http://www.grid.ac/institutes/grid.240871.8",
"name": [
"Department of Biochemistry, St Jude Children's Research Hospital, 332 North Lauderdale, 38105, Memphis, Tennessee, USA"
],
"type": "Organization"
},
"familyName": "Ihle",
"givenName": "James N.",
"id": "sg:person.01146753706.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146753706.54"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/366129a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053037655",
"https://doi.org/10.1038/366129a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/370151a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010238294",
"https://doi.org/10.1038/370151a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/366166a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003119860",
"https://doi.org/10.1038/366166a0"
],
"type": "CreativeWork"
}
],
"datePublished": "1994-07",
"datePublishedReg": "1994-07-01",
"description": "MANY cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies1\u201310 have shown that one or more of the Janus kinase family members (Jaks) associate with cytokine receptors and are tyrosine phosphorylated and activated following ligand binding. Here we describe a new Jak family kinase, Jak-3, and demonstrate that Jak-3, and to a lesser extent Jak-1, are tyrosine phosphorylated and Jak-3 is activated in the responses to interleukin-2 and interleukin\u20134 in T cells and myeloid cells. Jak-3 activation requires the serine-rich, membrane-proximal domain of the interleukin-2 receptor \u03b2-chain, but does not require the acidic domain that is required for association and activation of Src family kinases.",
"genre": "article",
"id": "sg:pub.10.1038/370153a0",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6485",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "370"
}
],
"keywords": [
"JAK-3",
"Janus kinase (JAK) family members",
"cytokine receptors",
"kinase family members",
"membrane-proximal domain",
"JAK family kinases",
"protein tyrosine phosphorylation",
"interleukin-2 receptor \u03b2",
"couple ligand",
"acidic domain",
"myeloid cells",
"Src family",
"catalytic domain",
"family kinases",
"tyrosine phosphorylation",
"Janus kinase",
"ligand binding",
"JAK-1",
"kinase",
"receptor \u03b2",
"cells",
"family members",
"receptors",
"domain",
"activation",
"phosphorylation",
"binding",
"interleukin-2",
"induction",
"family",
"interleukin-4",
"members",
"ligands",
"interaction",
"cytokines",
"response",
"chain",
"involvement",
"association"
],
"name": "Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells",
"pagination": "153-157",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1036067090"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/370153a0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"8022486"
]
}
],
"sameAs": [
"https://doi.org/10.1038/370153a0",
"https://app.dimensions.ai/details/publication/pub.1036067090"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:19",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_242.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/370153a0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/370153a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/370153a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/370153a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/370153a0'
This table displays all metadata directly associated to this object as RDF triples.
235 TRIPLES
22 PREDICATES
87 URIs
76 LITERALS
25 BLANK NODES