Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-07

AUTHORS

James A. Johnston, Masaru Kawamura, Robert A. Kirken, Yi-Qing Chen, Trevor B. Blake, Kyoichi Shibuya, John R. Ortaldo, Daniel W. McVicar, John J. O'Shea

ABSTRACT

INTERLEUKIN-2 is an autocrine growth factor for T cells1,2 which also activates other cells including B cells3 and natural killer cells4. The subunits of the interleukin-2 receptor (IL-2R) lack intrinsic enzymatic activity, but protein tyrosine phosphorylation is a critical event following ligand binding and src family kinases, such as Lck, are known to be activated by IL-2 (refs 5–9). However, IL- 2 signalling can occur in the absence of receptor interaction with Lck, suggesting that other protein tyrosine kinases might be important10. Here we report that a new member of the Janus family of kinases (Jak-3) is coupled to the IL-2R in human peripheral blood T cells and natural killer cells. More... »

PAGES

151-153

Journal

TITLE

Nature

ISSUE

6485

VOLUME

370

Related Patents

  • Janus Family Kinases And Identification Of Immune Modulators
  • Jak-3 Inhibitors For Treating Allergic Disorders
  • Pyrrolo[2,3-D]Pyrimidine Compounds
  • Nucleotide Sequences Coding Binding Polypeptide; For Monitorin Interleukin Induced Signal Transduction; For Diagnosis And Treatment Of Interleukin Defects
  • Therapeutic Use Of Jak-3 Inhibitors
  • Pyrrolo[2,3-D]Pyrimidine Compounds
  • Jak-3 Inhibitors For Treating Allergic Disorders
  • Jak-3 Inhibitors For Treating Allergic Disorders
  • Pyrrolo[2,3-D]Pyrimidine Compounds
  • Pyrrolo[2,3-D]Pyrimidine Compounds
  • Azaindole Derivatives As Tyrosine Kinase Inhibitors
  • Azaindole Derivatives As Jak3 Inhibitors
  • Jak-3 Inhibitors For Treating Allergic Disorders
  • Method Of Treatment Of Transplant Rejection
  • Protein Kinase Inhibitors, Useful Therapy As Immunosuppressive Agents For Organ Transplants, Xeno Transplation, Lupus, Multiple Sclerosis, Rheumatoid Arthritis, Psoriasis, Type I Diabetes And Complications From Diabetes, Cancer, Asthma, Atopic Dermatitis, Autoimmune Thyroid Disorders, Ulcerative Colitis
  • Jak-3 Inhibitors For Treating Allergic Disorders
  • Administering 3-{4-Methyl-3-[Methyl-(7h-Pyrrolo[2,3-D]Pyrimidin-4-Yl)-Amino]-Piperidin-1-Yl}-3-Oxo-Propionitrile Or Salts, For The Treatment Of Dermatitis, Crohn's Disease, Inflammatory Bowel Disease, Transplant Rejection, Lupus, Multiple Sclerosis, Arthritis, Psoriasis, Diabetes And Autoimmune Diseases
  • Pyrrolo[2,3-D]Pyrimidine Compounds
  • Pyrrolo[2,3-D]Pyrimidine Compounds
  • Janus Kinase 3 (Jak3); Such As 4-(3'-5'-Dibromo-4'-Hydroxyphenyl)-Amino-6,7-Dimethoxyquinazoline For Inhibiting Proinflamatory Mediator Release
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/370151a0

    DOI

    http://dx.doi.org/10.1038/370151a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010238294

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8022485


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Enzyme Activation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Growth Hormone", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "In Vitro Techniques", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Interleukin-2", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Janus Kinase 3", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leukocytes, Mononuclear", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Phosphorylation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein-Tyrosine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Signal Transduction", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Cells, Cultured", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.48336.3a", 
              "name": [
                "Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Johnston", 
            "givenName": "James A.", 
            "id": "sg:person.015231163517.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015231163517.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.48336.3a", 
              "name": [
                "Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kawamura", 
            "givenName": "Masaru", 
            "id": "sg:person.010543047252.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010543047252.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory of Molecular Immunoregulation, Biological Response Modifier Program, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.48336.3a", 
              "name": [
                "Laboratory of Molecular Immunoregulation, Biological Response Modifier Program, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kirken", 
            "givenName": "Robert A.", 
            "id": "sg:person.01217710714.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217710714.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Biological Carcinogenesis and Development Program, PRI/DynCorp, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.48336.3a", 
              "name": [
                "Biological Carcinogenesis and Development Program, PRI/DynCorp, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Chen", 
            "givenName": "Yi-Qing", 
            "id": "sg:person.01006704366.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006704366.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Biological Carcinogenesis and Development Program, PRI/DynCorp, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.48336.3a", 
              "name": [
                "Biological Carcinogenesis and Development Program, PRI/DynCorp, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Blake", 
            "givenName": "Trevor B.", 
            "id": "sg:person.01055017566.68", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055017566.68"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Advanced BioSciences Laboratories Inc., National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.48336.3a", 
              "name": [
                "Advanced BioSciences Laboratories Inc., National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shibuya", 
            "givenName": "Kyoichi", 
            "id": "sg:person.01123132766.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123132766.51"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.48336.3a", 
              "name": [
                "Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ortaldo", 
            "givenName": "John R.", 
            "id": "sg:person.0106370345.65", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0106370345.65"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.48336.3a", 
              "name": [
                "Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "McVicar", 
            "givenName": "Daniel W.", 
            "id": "sg:person.01322126054.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322126054.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA", 
              "id": "http://www.grid.ac/institutes/grid.48336.3a", 
              "name": [
                "Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "O'Shea", 
            "givenName": "John J.", 
            "id": "sg:person.0611511210.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611511210.03"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/366583a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046404612", 
              "https://doi.org/10.1038/366583a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/366166a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003119860", 
              "https://doi.org/10.1038/366166a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/291335a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036146781", 
              "https://doi.org/10.1038/291335a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/366129a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053037655", 
              "https://doi.org/10.1038/366129a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/370153a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036067090", 
              "https://doi.org/10.1038/370153a0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1994-07", 
        "datePublishedReg": "1994-07-01", 
        "description": "INTERLEUKIN-2 is an autocrine growth factor for T cells1,2 which also activates other cells including B cells3 and natural killer cells4. The subunits of the interleukin-2 receptor (IL-2R) lack intrinsic enzymatic activity, but protein tyrosine phosphorylation is a critical event following ligand binding and src family kinases, such as Lck, are known to be activated by IL-2 (refs 5\u20139). However, IL- 2 signalling can occur in the absence of receptor interaction with Lck, suggesting that other protein tyrosine kinases might be important10. Here we report that a new member of the Janus family of kinases (Jak-3) is coupled to the IL-2R in human peripheral blood T cells and natural killer cells.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/370151a0", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6485", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "370"
          }
        ], 
        "keywords": [
          "protein tyrosine kinases", 
          "Src family kinases", 
          "intrinsic enzymatic activity", 
          "protein tyrosine phosphorylation", 
          "family kinases", 
          "tyrosine phosphorylation", 
          "Janus family", 
          "IL-2 signaling", 
          "Janus kinase", 
          "ligand binding", 
          "tyrosine kinase", 
          "kinase", 
          "human peripheral blood T cells", 
          "B cells3", 
          "enzymatic activity", 
          "new member", 
          "receptor interaction", 
          "autocrine growth factor", 
          "interleukin-2", 
          "Lck", 
          "phosphorylation", 
          "peripheral blood T cells", 
          "growth factor", 
          "natural killer cells", 
          "blood T cells", 
          "critical events", 
          "cells", 
          "killer cells", 
          "IL-2", 
          "IL-2R", 
          "T cells", 
          "subunits", 
          "signaling", 
          "cells3", 
          "cells4", 
          "binding", 
          "activation", 
          "family", 
          "members", 
          "interaction", 
          "activity", 
          "absence", 
          "response", 
          "events", 
          "factors"
        ], 
        "name": "Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2", 
        "pagination": "151-153", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1010238294"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/370151a0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "8022485"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/370151a0", 
          "https://app.dimensions.ai/details/publication/pub.1010238294"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T15:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_237.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/370151a0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/370151a0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/370151a0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/370151a0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/370151a0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    248 TRIPLES      21 PREDICATES      91 URIs      76 LITERALS      20 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/370151a0 schema:about N155ee3055fdc48d6ab2c4687dd4a7f35
    2 N1677926eb2494377b4555eb8b0641f23
    3 N2ad9e3f2a1994edb99662ce9a57b5187
    4 N3fb8754e77924007bda3a4a5557cf399
    5 N584f7b22e81f4980982db6b1e8922f45
    6 N7811892e102646629f213128cd391211
    7 N7d6691757ab84b3cbd7f256079b693bd
    8 N8fcf7196d851439e9d11552a692cb1c0
    9 Nb7eb14f7c17147e6a14a9581f6c415d5
    10 Nbdc1d43663d945d08f36c1b0b4ad3470
    11 Nc5535f9600da469789bbf8d4fc3b1dcf
    12 Nea18e042f66f45d897edca7bb84ebb34
    13 Nf8a60b28e05a4296b0f61b656d50eb3e
    14 anzsrc-for:06
    15 anzsrc-for:0601
    16 anzsrc-for:11
    17 anzsrc-for:1107
    18 schema:author Nfe92659047554265863732ad87476747
    19 schema:citation sg:pub.10.1038/291335a0
    20 sg:pub.10.1038/366129a0
    21 sg:pub.10.1038/366166a0
    22 sg:pub.10.1038/366583a0
    23 sg:pub.10.1038/370153a0
    24 schema:datePublished 1994-07
    25 schema:datePublishedReg 1994-07-01
    26 schema:description INTERLEUKIN-2 is an autocrine growth factor for T cells1,2 which also activates other cells including B cells3 and natural killer cells4. The subunits of the interleukin-2 receptor (IL-2R) lack intrinsic enzymatic activity, but protein tyrosine phosphorylation is a critical event following ligand binding and src family kinases, such as Lck, are known to be activated by IL-2 (refs 5–9). However, IL- 2 signalling can occur in the absence of receptor interaction with Lck, suggesting that other protein tyrosine kinases might be important10. Here we report that a new member of the Janus family of kinases (Jak-3) is coupled to the IL-2R in human peripheral blood T cells and natural killer cells.
    27 schema:genre article
    28 schema:isAccessibleForFree true
    29 schema:isPartOf N7e4a040ee0284d35bf24f0dd68fb5d30
    30 Nd431cf8bfa9b425c9d7d2641aa6d0c9f
    31 sg:journal.1018957
    32 schema:keywords B cells3
    33 IL-2
    34 IL-2 signaling
    35 IL-2R
    36 Janus family
    37 Janus kinase
    38 Lck
    39 Src family kinases
    40 T cells
    41 absence
    42 activation
    43 activity
    44 autocrine growth factor
    45 binding
    46 blood T cells
    47 cells
    48 cells3
    49 cells4
    50 critical events
    51 enzymatic activity
    52 events
    53 factors
    54 family
    55 family kinases
    56 growth factor
    57 human peripheral blood T cells
    58 interaction
    59 interleukin-2
    60 intrinsic enzymatic activity
    61 killer cells
    62 kinase
    63 ligand binding
    64 members
    65 natural killer cells
    66 new member
    67 peripheral blood T cells
    68 phosphorylation
    69 protein tyrosine kinases
    70 protein tyrosine phosphorylation
    71 receptor interaction
    72 response
    73 signaling
    74 subunits
    75 tyrosine kinase
    76 tyrosine phosphorylation
    77 schema:name Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2
    78 schema:pagination 151-153
    79 schema:productId N8433d5f3716141aab9737b5d46709dd2
    80 Nbcbefd7783784e3994ed89a37e861ef1
    81 Nc8bd8a97f1f54728b3056093defa1fb7
    82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010238294
    83 https://doi.org/10.1038/370151a0
    84 schema:sdDatePublished 2022-09-02T15:46
    85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    86 schema:sdPublisher N9a0b3356c1fc46e3a6cabebcf6a00f12
    87 schema:url https://doi.org/10.1038/370151a0
    88 sgo:license sg:explorer/license/
    89 sgo:sdDataset articles
    90 rdf:type schema:ScholarlyArticle
    91 N155ee3055fdc48d6ab2c4687dd4a7f35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name Cytokines
    93 rdf:type schema:DefinedTerm
    94 N1677926eb2494377b4555eb8b0641f23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Humans
    96 rdf:type schema:DefinedTerm
    97 N273948f7f5454feba99a0ca54dc59573 rdf:first sg:person.01217710714.91
    98 rdf:rest N550786050c8c4b9a993c539915b5579b
    99 N2ad9e3f2a1994edb99662ce9a57b5187 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    100 schema:name Janus Kinase 3
    101 rdf:type schema:DefinedTerm
    102 N308fb248b1c34215baf27462ec0da0dc rdf:first sg:person.01123132766.51
    103 rdf:rest Nf50bb74cb83043adbb6b529e8b83d954
    104 N3dd96f3e3f034277b330e2b983ce9b1c rdf:first sg:person.01055017566.68
    105 rdf:rest N308fb248b1c34215baf27462ec0da0dc
    106 N3fb8754e77924007bda3a4a5557cf399 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    107 schema:name Leukocytes, Mononuclear
    108 rdf:type schema:DefinedTerm
    109 N550786050c8c4b9a993c539915b5579b rdf:first sg:person.01006704366.15
    110 rdf:rest N3dd96f3e3f034277b330e2b983ce9b1c
    111 N584f7b22e81f4980982db6b1e8922f45 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Cell Line
    113 rdf:type schema:DefinedTerm
    114 N7811892e102646629f213128cd391211 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Growth Hormone
    116 rdf:type schema:DefinedTerm
    117 N7d6691757ab84b3cbd7f256079b693bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Tumor Cells, Cultured
    119 rdf:type schema:DefinedTerm
    120 N7e4a040ee0284d35bf24f0dd68fb5d30 schema:volumeNumber 370
    121 rdf:type schema:PublicationVolume
    122 N8433d5f3716141aab9737b5d46709dd2 schema:name doi
    123 schema:value 10.1038/370151a0
    124 rdf:type schema:PropertyValue
    125 N8fcf7196d851439e9d11552a692cb1c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Protein-Tyrosine Kinases
    127 rdf:type schema:DefinedTerm
    128 N9a0b3356c1fc46e3a6cabebcf6a00f12 schema:name Springer Nature - SN SciGraph project
    129 rdf:type schema:Organization
    130 Na0b1254ecf2a4e29869de40aac78e02d rdf:first sg:person.010543047252.14
    131 rdf:rest N273948f7f5454feba99a0ca54dc59573
    132 Na9aa349693fe485fa9acb9e80d1be1a9 rdf:first sg:person.01322126054.05
    133 rdf:rest Nbacf090b959444288642dd8f839671b1
    134 Nb7eb14f7c17147e6a14a9581f6c415d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    135 schema:name Phosphorylation
    136 rdf:type schema:DefinedTerm
    137 Nbacf090b959444288642dd8f839671b1 rdf:first sg:person.0611511210.03
    138 rdf:rest rdf:nil
    139 Nbcbefd7783784e3994ed89a37e861ef1 schema:name pubmed_id
    140 schema:value 8022485
    141 rdf:type schema:PropertyValue
    142 Nbdc1d43663d945d08f36c1b0b4ad3470 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Enzyme Activation
    144 rdf:type schema:DefinedTerm
    145 Nc5535f9600da469789bbf8d4fc3b1dcf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Interleukin-2
    147 rdf:type schema:DefinedTerm
    148 Nc8bd8a97f1f54728b3056093defa1fb7 schema:name dimensions_id
    149 schema:value pub.1010238294
    150 rdf:type schema:PropertyValue
    151 Nd431cf8bfa9b425c9d7d2641aa6d0c9f schema:issueNumber 6485
    152 rdf:type schema:PublicationIssue
    153 Nea18e042f66f45d897edca7bb84ebb34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    154 schema:name Signal Transduction
    155 rdf:type schema:DefinedTerm
    156 Nf50bb74cb83043adbb6b529e8b83d954 rdf:first sg:person.0106370345.65
    157 rdf:rest Na9aa349693fe485fa9acb9e80d1be1a9
    158 Nf8a60b28e05a4296b0f61b656d50eb3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    159 schema:name In Vitro Techniques
    160 rdf:type schema:DefinedTerm
    161 Nfe92659047554265863732ad87476747 rdf:first sg:person.015231163517.86
    162 rdf:rest Na0b1254ecf2a4e29869de40aac78e02d
    163 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    164 schema:name Biological Sciences
    165 rdf:type schema:DefinedTerm
    166 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    167 schema:name Biochemistry and Cell Biology
    168 rdf:type schema:DefinedTerm
    169 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    170 schema:name Medical and Health Sciences
    171 rdf:type schema:DefinedTerm
    172 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    173 schema:name Immunology
    174 rdf:type schema:DefinedTerm
    175 sg:journal.1018957 schema:issn 0028-0836
    176 1476-4687
    177 schema:name Nature
    178 schema:publisher Springer Nature
    179 rdf:type schema:Periodical
    180 sg:person.01006704366.15 schema:affiliation grid-institutes:grid.48336.3a
    181 schema:familyName Chen
    182 schema:givenName Yi-Qing
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006704366.15
    184 rdf:type schema:Person
    185 sg:person.010543047252.14 schema:affiliation grid-institutes:grid.48336.3a
    186 schema:familyName Kawamura
    187 schema:givenName Masaru
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010543047252.14
    189 rdf:type schema:Person
    190 sg:person.01055017566.68 schema:affiliation grid-institutes:grid.48336.3a
    191 schema:familyName Blake
    192 schema:givenName Trevor B.
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055017566.68
    194 rdf:type schema:Person
    195 sg:person.0106370345.65 schema:affiliation grid-institutes:grid.48336.3a
    196 schema:familyName Ortaldo
    197 schema:givenName John R.
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0106370345.65
    199 rdf:type schema:Person
    200 sg:person.01123132766.51 schema:affiliation grid-institutes:grid.48336.3a
    201 schema:familyName Shibuya
    202 schema:givenName Kyoichi
    203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01123132766.51
    204 rdf:type schema:Person
    205 sg:person.01217710714.91 schema:affiliation grid-institutes:grid.48336.3a
    206 schema:familyName Kirken
    207 schema:givenName Robert A.
    208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01217710714.91
    209 rdf:type schema:Person
    210 sg:person.01322126054.05 schema:affiliation grid-institutes:grid.48336.3a
    211 schema:familyName McVicar
    212 schema:givenName Daniel W.
    213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322126054.05
    214 rdf:type schema:Person
    215 sg:person.015231163517.86 schema:affiliation grid-institutes:grid.48336.3a
    216 schema:familyName Johnston
    217 schema:givenName James A.
    218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015231163517.86
    219 rdf:type schema:Person
    220 sg:person.0611511210.03 schema:affiliation grid-institutes:grid.48336.3a
    221 schema:familyName O'Shea
    222 schema:givenName John J.
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611511210.03
    224 rdf:type schema:Person
    225 sg:pub.10.1038/291335a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036146781
    226 https://doi.org/10.1038/291335a0
    227 rdf:type schema:CreativeWork
    228 sg:pub.10.1038/366129a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053037655
    229 https://doi.org/10.1038/366129a0
    230 rdf:type schema:CreativeWork
    231 sg:pub.10.1038/366166a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003119860
    232 https://doi.org/10.1038/366166a0
    233 rdf:type schema:CreativeWork
    234 sg:pub.10.1038/366583a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046404612
    235 https://doi.org/10.1038/366583a0
    236 rdf:type schema:CreativeWork
    237 sg:pub.10.1038/370153a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036067090
    238 https://doi.org/10.1038/370153a0
    239 rdf:type schema:CreativeWork
    240 grid-institutes:grid.48336.3a schema:alternateName Advanced BioSciences Laboratories Inc., National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA
    241 Biological Carcinogenesis and Development Program, PRI/DynCorp, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA
    242 Laboratory of Molecular Immunoregulation, Biological Response Modifier Program, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA
    243 Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA
    244 schema:name Advanced BioSciences Laboratories Inc., National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA
    245 Biological Carcinogenesis and Development Program, PRI/DynCorp, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA
    246 Laboratory of Molecular Immunoregulation, Biological Response Modifier Program, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA
    247 Leukocyte Cell Biology Section, Laboratory of Experimental Immunology, National Cancer Institute, FCRDC, 21702-1201, Frederick, Maryland, USA
    248 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...