Cytotoxic T-cell memory without antigen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-06

AUTHORS

L L Lau, B D Jamieson, T Somasundaram, R Ahmed

ABSTRACT

Memory is a hallmark of the immune system and ever since its recognition there has been considerable interest in understanding how immunity is maintained. The current model is that long-term memory is dependent on persistent antigenic stimulation. We report here results that challenge this view and provide evidence that antigen is not essential for the maintenance of CD8+ T-cell memory. We show that memory CD8+ cytotoxic T lymphocytes persist indefinitely in the absence of priming antigen, retain the memory phenotype (CD44hi), and provide protection against virus challenge. These findings suggest a re-evaluation of our current thinking on mechanisms involved in maintaining immunity and have implications towards designing effective vaccination strategies. More... »

PAGES

648-652

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/369648a0

DOI

http://dx.doi.org/10.1038/369648a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009618501

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7516038


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