Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-06

AUTHORS

Frederic J. de Sauvage, Philip E. Hass, Susan D. Spencer, Beth E. Malloy, Austin L. Gurney, Steven A. Spencer, Walter C. Darbonne, William J. Henzel, Suzy C. Wong, Wun-Jing Kuang, Karl J. Oles, Bruce Hultgren, Lawrence A. Solberg, David V. Goeddel, Dan L. Eaton

ABSTRACT

Physiological platelet synthesis is thought to require the humoral activities of meg-CSF and thrombopoietin, which respectively promote proliferation and maturation of megakaryocytic cells. A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned. This protein binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily. The isolated Mpl ligand shares homology with erythropoietin and stimulates both megakaryocytopoiesis and thrombopoiesis. More... »

PAGES

533-538

Journal

TITLE

Nature

ISSUE

6481

VOLUME

369

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/369533a0

    DOI

    http://dx.doi.org/10.1038/369533a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1013050793

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8202154


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