Mice lacking factor VII develop normally but suffer fatal perinatal bleeding View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-11

AUTHORS

Elliot D. Rosen, Joyce C. Y. Chan, Esohe Idusogie, Frédéric Clotman, George Vlasuk, Thomas Luther, Louise R. Jalbert, Sybille Albrecht, Liang Zhong, Ann Lissens, Luc Schoonjans, Lieve Moons, Désiré Collen, Francis J. Castellino, Peter Carmeliet

ABSTRACT

Blood coagulation in vivo is initiated by factor VII (FVII) binding to its cellular receptor tissue factor (TF). FVII is the only known ligand for TF, so it was expected that FVII-deficient embryos would have a similar phenotype to TF-deficient embryos, which have defective vitello-embryonic circulation and die around 9.5 days of gestation. Surprisingly, we find that FVII-deficient (FVII-/-) embryos developed normally. FVII-/- mice succumbed perinatally because of fatal haemorrhaging from normal blood vessels. At embryonic day 9.5, maternal-fetal transfer of FVII was undetectable and survival of embryos did not depend on TF-FVII-initiated fibrin formation. Thus, the TF-/- embryonic lethal and the FVII-/- survival-phenotypes suggest a role for TF during embryogenesis beyond fibrin formation. More... »

PAGES

290

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/36862

DOI

http://dx.doi.org/10.1038/36862

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028700542

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9384381


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/36862'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/36862'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/36862'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/36862'


 

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327 schema:name §Laboratory of Developmental Genetics, University of Louvain, B-1348 Louvain-la-Neuve, Belgium
328 rdf:type schema:Organization
 




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