A role for the Ras signalling pathway in synaptic transmission and long-term memory View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-11

AUTHORS

Riccardo Brambilla, Nerina Gnesutta, Liliana Minichiello, Gail White, Alistair J. Roylance, Caroline E. Herron, Mark Ramsey, David P. Wolfer, Vincenzo Cestari, Clelia Rossi-Arnaud, Seth G. N. Grant, Paul F. Chapman, Hans-Peter Lipp, Emmapaola Sturani, iger Klein

ABSTRACT

Members of the Ras subfamily of small guanine-nucleotide-binding proteins are essential for controlling normal and malignant cell proliferation as well as cell differentiation. The neuronal-specific guanine-nucleotide-exchange factor, Ras-GRF/CDC25Mm, induces Ras signalling in response to Ca2+ influx and activation of G-protein-coupled receptors in vitro, suggesting that it plays a role in neurotransmission and plasticity in vivo. Here we report that mice lacking Ras-GRF are impaired in the process of memory consolidation, as revealed by emotional conditioning tasks that require the function of the amygdala; learning and short-term memory are intact. Electrophysiological measurements in the basolateral amygdala reveal that long-term plasticity is abnormal in mutant mice. In contrast, Ras-GRF mutants do not reveal major deficits in spatial learning tasks such as the Morris water maze, a test that requires hippocampal function. Consistent with apparently normal hippocampal functions, Ras-GRF mutants show normal NMDA (N-methyl-D-aspartate) receptor-dependent long-term potentiation in this structure. These results implicate Ras-GRF signalling via the Ras/MAP kinase pathway in synaptic events leading to formation of long-term memories. More... »

PAGES

281-286

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/36849

DOI

http://dx.doi.org/10.1038/36849

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014535875

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9384379


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