Impaired immune and acute-phase responses in interleukin-6-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-03

AUTHORS

Manfred Kopf, Heinz Baumann, Giulia Freer, Marina Freudenberg, Marinus Lamers, Tadamitsu Kishimoto, Rolf Zinkernagel, Horst Bluethmann, Georges Köhler

ABSTRACT

lNTERLEUKIN-6 (IL-6) is a multifunctional cytokine that regulates various aspects of the immune response, acute-phase reaction and haematopoiesis (for reviews see refs 1, 2). In vitro, leukaemia inhibitory factor, oncostatin M, ciliary neurotrophic factor and interleukin-11 display overlapping activities with IL-6. This functional redundancy may be explained by the interactions of specific binding receptors with a common signal-transducing receptor (gp130) (for reviews see refs 3, 4). To elucidate the unique function of IL-6 in vivo, we have disrupted the IL-6 gene by homologous recombination. IL-6-deficient mice develop normally. They fail to control efficiently vaccinia virus and infection with Listeria monocytogenes, a facultative intracellular bacterium. The T-cell-dependent antibody response against vesicular stomatitis virus is impaired. Further, the inflammatory acute-phase response after tissue damage or infection is severely compromised, whereas it is only moderately affected after challenge with lipopolysaccharide. We conclude that IL-6 production induced by injury or infection is an important in vivo SOS signal which coordinates activities of liver cells, macrophages and lymphocytes. More... »

PAGES

339-342

Journal

TITLE

Nature

ISSUE

6469

VOLUME

368

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/368339a0

DOI

http://dx.doi.org/10.1038/368339a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032178521

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8127368


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