Regulation of TFIIH ATPase and kinase activities by TFIIE during active initiation complex formation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-03

AUTHORS

Y Ohkuma, R G Roeder

ABSTRACT

The general transcription factor TFIIE, together with other general transcription factors, is essential for transcription initiation by RNA polymerase II. TFIIE stimulates the TFIIH-dependent kinase activity that phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II, and possesses a helicase activity. Here we show that human TFIIH has DNA-dependent ATPase activity and we characterize the stimulatory effect of TFIIE on both the ATPase and kinase activities. We demonstrate that extensive phosphorylation of RNA polymerase II occurs in a TFIIE-dependent manner in both the absence and presence of DNA but, in the latter case, only at a late stage of preinitiation complex assembly. We also show that TFIIH specifically phosphorylates three general transcription factors, human TFIID tau (TBP), TFIIE-alpha and TFIIF-alpha (RAP74). More... »

PAGES

160-163

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/368160a0

DOI

http://dx.doi.org/10.1038/368160a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022812854

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8166891


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