Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-02

AUTHORS

Yvona Ward, Shashi Gupta, Peter Jensen, Markus Wartmann, Roger J. Davis, Kathleen Kelly

ABSTRACT

INTRACELLULAR signalling following mitogenic stimulation of quiescent cells involves the initiation of a phosphorylation cascade that leads to the rapid and reversible activation of the mitogen-activated protein (MAP) kinases ERK1 and ERK2 (refs 1,2). MAP kinase activation is mediated by dual phosphorylation within the motif Thr-Glu-Tyr by MAP kinase kinase (MEK)3. Following activation, the MAP kinases translocate into the nucleus where they phosphorylate several transduction targets, including transcription factors4–7. We have previously identified PAC1 as an immediate-early mitogen-inducible tyrosine phosphatase in nuclei of T cells8. Here we present several lines of evidence indicating that PAC1 is a physiologically relevant MAP kinase phosphatase. Recombinant PAC1 in vitro is a dual-specific Thr/Tyr phosphatase with stringent substrate specificity for MAP kinase. Constitutive expression of PAC1 in vivo leads to inhibition of MAP kinase activity normally stimulated by epidermal growth factor, phorbol myristyl acetate, or T-cell receptor crosslinking. The inactivation of MAP kinase by PAC1 results in inhibition of MAP kinase-regulated reporter gene expression. More... »

PAGES

651-654

Journal

TITLE

Nature

ISSUE

6464

VOLUME

367

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/367651a0

DOI

http://dx.doi.org/10.1038/367651a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015946646

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8107850


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Calmodulin-Dependent Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dual Specificity Phosphatase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutathione Transferase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Phosphatase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Tyrosine Phosphatases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ward", 
        "givenName": "Yvona", 
        "id": "sg:person.01034763247.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034763247.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gupta", 
        "givenName": "Shashi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jensen", 
        "givenName": "Peter", 
        "id": "sg:person.01017467302.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017467302.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wartmann", 
        "givenName": "Markus", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Davis", 
        "givenName": "Roger J.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kelly", 
        "givenName": "Kathleen", 
        "id": "sg:person.011405665312.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011405665312.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/227680a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010419937", 
          "https://doi.org/10.1038/227680a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/359644a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039608705", 
          "https://doi.org/10.1038/359644a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/358414a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052248806", 
          "https://doi.org/10.1038/358414a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-02", 
    "datePublishedReg": "1994-02-01", 
    "description": "INTRACELLULAR signalling following mitogenic stimulation of quiescent cells involves the initiation of a phosphorylation cascade that leads to the rapid and reversible activation of the mitogen-activated protein (MAP) kinases ERK1 and ERK2 (refs 1,2). MAP kinase activation is mediated by dual phosphorylation within the motif Thr-Glu-Tyr by MAP kinase kinase (MEK)3. Following activation, the MAP kinases translocate into the nucleus where they phosphorylate several transduction targets, including transcription factors4\u20137. We have previously identified PAC1 as an immediate-early mitogen-inducible tyrosine phosphatase in nuclei of T cells8. Here we present several lines of evidence indicating that PAC1 is a physiologically relevant MAP kinase phosphatase. Recombinant PAC1 in vitro is a dual-specific Thr/Tyr phosphatase with stringent substrate specificity for MAP kinase. Constitutive expression of PAC1 in vivo leads to inhibition of MAP kinase activity normally stimulated by epidermal growth factor, phorbol myristyl acetate, or T-cell receptor crosslinking. The inactivation of MAP kinase by PAC1 results in inhibition of MAP kinase-regulated reporter gene expression.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/367651a0", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6464", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "367"
      }
    ], 
    "keywords": [
      "mitogen-activated protein", 
      "MAP kinase activation", 
      "MAP kinase", 
      "kinase activation", 
      "stringent substrate specificity", 
      "MAP kinase kinase", 
      "MAP kinase phosphatase", 
      "reporter gene expression", 
      "MAP kinase activity", 
      "Tyr phosphatase", 
      "kinase phosphatase", 
      "dual phosphorylation", 
      "kinase kinase", 
      "phosphorylation cascade", 
      "tyrosine phosphatase", 
      "T-cell receptor crosslinking", 
      "epidermal growth factor", 
      "substrate specificity", 
      "kinase activity", 
      "gene expression", 
      "constitutive expression", 
      "Thr-Glu", 
      "quiescent cells", 
      "kinase", 
      "lines of evidence", 
      "phorbol myristyl", 
      "receptor crosslinking", 
      "mitogenic stimulation", 
      "phosphatase", 
      "growth factor", 
      "PAC1", 
      "reversible activation", 
      "activation", 
      "expression", 
      "ERK2", 
      "ERK1", 
      "cells8", 
      "phosphorylation", 
      "inhibition", 
      "protein", 
      "nucleus", 
      "mitogen", 
      "intracellular", 
      "Tyr", 
      "cascade", 
      "inactivation", 
      "myristyl", 
      "cells", 
      "vivo", 
      "target", 
      "specificity", 
      "lines", 
      "initiation", 
      "activity", 
      "stimulation", 
      "evidence", 
      "crosslinking", 
      "factors", 
      "control", 
      "results"
    ], 
    "name": "Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1", 
    "pagination": "651-654", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1015946646"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/367651a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8107850"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/367651a0", 
      "https://app.dimensions.ai/details/publication/pub.1015946646"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_218.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/367651a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/367651a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/367651a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/367651a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/367651a0'


 

This table displays all metadata directly associated to this object as RDF triples.

225 TRIPLES      21 PREDICATES      104 URIs      93 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/367651a0 schema:about N07c056444a2b4ce88704d01c0d193938
2 N0905fa59a5824f4ba52c027d251e8c1c
3 N174ac251513844538d0bb7650da4bfe7
4 N4c4fd2a53fda46a7a564dc78652d106a
5 N6425d506dbf84186a6a7605ada9e98f8
6 N6cdbc83188f641a8b839fecbbf9fd850
7 N79e512e8ea5b4c9b8fa9b7dbd175c0be
8 N81f064a6ca44402d87de940926d6819d
9 N87db579cfa664487a615b00d6a13a8cf
10 Na407650d3a1a4a56b619d7f40e33d4e4
11 Nae19f65d0497456db9b40feb84d98ebe
12 Nbedafdda37e6416ca73ea4558aac3492
13 Nc41aae99f11749b08e9f53f85cce42c5
14 Nd539e29cd120487cae122ad802df8ddf
15 Nf5c0e2d1ec9142b0a7f7806cb5ddc745
16 anzsrc-for:06
17 anzsrc-for:0601
18 schema:author N30ad480b0e1d49b0af37cc90c6764b4c
19 schema:citation sg:pub.10.1038/227680a0
20 sg:pub.10.1038/358414a0
21 sg:pub.10.1038/359644a0
22 schema:datePublished 1994-02
23 schema:datePublishedReg 1994-02-01
24 schema:description INTRACELLULAR signalling following mitogenic stimulation of quiescent cells involves the initiation of a phosphorylation cascade that leads to the rapid and reversible activation of the mitogen-activated protein (MAP) kinases ERK1 and ERK2 (refs 1,2). MAP kinase activation is mediated by dual phosphorylation within the motif Thr-Glu-Tyr by MAP kinase kinase (MEK)3. Following activation, the MAP kinases translocate into the nucleus where they phosphorylate several transduction targets, including transcription factors4–7. We have previously identified PAC1 as an immediate-early mitogen-inducible tyrosine phosphatase in nuclei of T cells8. Here we present several lines of evidence indicating that PAC1 is a physiologically relevant MAP kinase phosphatase. Recombinant PAC1 in vitro is a dual-specific Thr/Tyr phosphatase with stringent substrate specificity for MAP kinase. Constitutive expression of PAC1 in vivo leads to inhibition of MAP kinase activity normally stimulated by epidermal growth factor, phorbol myristyl acetate, or T-cell receptor crosslinking. The inactivation of MAP kinase by PAC1 results in inhibition of MAP kinase-regulated reporter gene expression.
25 schema:genre article
26 schema:isAccessibleForFree true
27 schema:isPartOf N03c0851bcc4c4fbaa2a703eb57e9010e
28 N06f2cf4dcd0145b7a8caa441856dc696
29 sg:journal.1018957
30 schema:keywords ERK1
31 ERK2
32 MAP kinase
33 MAP kinase activation
34 MAP kinase activity
35 MAP kinase kinase
36 MAP kinase phosphatase
37 PAC1
38 T-cell receptor crosslinking
39 Thr-Glu
40 Tyr
41 Tyr phosphatase
42 activation
43 activity
44 cascade
45 cells
46 cells8
47 constitutive expression
48 control
49 crosslinking
50 dual phosphorylation
51 epidermal growth factor
52 evidence
53 expression
54 factors
55 gene expression
56 growth factor
57 inactivation
58 inhibition
59 initiation
60 intracellular
61 kinase
62 kinase activation
63 kinase activity
64 kinase kinase
65 kinase phosphatase
66 lines
67 lines of evidence
68 mitogen
69 mitogen-activated protein
70 mitogenic stimulation
71 myristyl
72 nucleus
73 phorbol myristyl
74 phosphatase
75 phosphorylation
76 phosphorylation cascade
77 protein
78 quiescent cells
79 receptor crosslinking
80 reporter gene expression
81 results
82 reversible activation
83 specificity
84 stimulation
85 stringent substrate specificity
86 substrate specificity
87 target
88 tyrosine phosphatase
89 vivo
90 schema:name Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1
91 schema:pagination 651-654
92 schema:productId N47bc7cd6ba07457e8f9fa4b93449a298
93 N7d5cbd98b6164bf5a752ac4621919322
94 Na5fba67b95dc4e90b66bbc5849237322
95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015946646
96 https://doi.org/10.1038/367651a0
97 schema:sdDatePublished 2022-12-01T06:19
98 schema:sdLicense https://scigraph.springernature.com/explorer/license/
99 schema:sdPublisher N96d4b63301014feab6aa63f8ddb893df
100 schema:url https://doi.org/10.1038/367651a0
101 sgo:license sg:explorer/license/
102 sgo:sdDataset articles
103 rdf:type schema:ScholarlyArticle
104 N03c0851bcc4c4fbaa2a703eb57e9010e schema:issueNumber 6464
105 rdf:type schema:PublicationIssue
106 N06f2cf4dcd0145b7a8caa441856dc696 schema:volumeNumber 367
107 rdf:type schema:PublicationVolume
108 N07c056444a2b4ce88704d01c0d193938 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cell Line
110 rdf:type schema:DefinedTerm
111 N0905fa59a5824f4ba52c027d251e8c1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Protein-Tyrosine Kinases
113 rdf:type schema:DefinedTerm
114 N166937bd346d4693b4b49c409469a6dc schema:affiliation grid-institutes:grid.48336.3a
115 schema:familyName Davis
116 schema:givenName Roger J.
117 rdf:type schema:Person
118 N174ac251513844538d0bb7650da4bfe7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Recombinant Proteins
120 rdf:type schema:DefinedTerm
121 N1f5e60ce8f134aa094fe1286a9f889ad rdf:first N5447d7d5284141898f7165bafb04f5b3
122 rdf:rest N4c438b85b92b482c86e4a4563f9e8720
123 N30ad480b0e1d49b0af37cc90c6764b4c rdf:first sg:person.01034763247.45
124 rdf:rest N40504528ecf240678f311fd835978691
125 N40504528ecf240678f311fd835978691 rdf:first N7ecd4bae80bd479086d69beefe71d904
126 rdf:rest Nc8b629f848f2427eb9aaca8044b48525
127 N4577160c285a44c39d5e87a7efedb046 rdf:first sg:person.011405665312.33
128 rdf:rest rdf:nil
129 N47bc7cd6ba07457e8f9fa4b93449a298 schema:name pubmed_id
130 schema:value 8107850
131 rdf:type schema:PropertyValue
132 N4c438b85b92b482c86e4a4563f9e8720 rdf:first N166937bd346d4693b4b49c409469a6dc
133 rdf:rest N4577160c285a44c39d5e87a7efedb046
134 N4c4fd2a53fda46a7a564dc78652d106a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Calcium-Calmodulin-Dependent Protein Kinases
136 rdf:type schema:DefinedTerm
137 N5447d7d5284141898f7165bafb04f5b3 schema:affiliation grid-institutes:grid.48336.3a
138 schema:familyName Wartmann
139 schema:givenName Markus
140 rdf:type schema:Person
141 N6425d506dbf84186a6a7605ada9e98f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Dual Specificity Phosphatase 2
143 rdf:type schema:DefinedTerm
144 N6cdbc83188f641a8b839fecbbf9fd850 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Glutathione Transferase
146 rdf:type schema:DefinedTerm
147 N79e512e8ea5b4c9b8fa9b7dbd175c0be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Protein Phosphatase 2
149 rdf:type schema:DefinedTerm
150 N7d5cbd98b6164bf5a752ac4621919322 schema:name dimensions_id
151 schema:value pub.1015946646
152 rdf:type schema:PropertyValue
153 N7ecd4bae80bd479086d69beefe71d904 schema:affiliation grid-institutes:grid.48336.3a
154 schema:familyName Gupta
155 schema:givenName Shashi
156 rdf:type schema:Person
157 N81f064a6ca44402d87de940926d6819d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Recombinant Fusion Proteins
159 rdf:type schema:DefinedTerm
160 N87db579cfa664487a615b00d6a13a8cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Mitogen-Activated Protein Kinase 1
162 rdf:type schema:DefinedTerm
163 N96d4b63301014feab6aa63f8ddb893df schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 Na407650d3a1a4a56b619d7f40e33d4e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Protein Serine-Threonine Kinases
167 rdf:type schema:DefinedTerm
168 Na5fba67b95dc4e90b66bbc5849237322 schema:name doi
169 schema:value 10.1038/367651a0
170 rdf:type schema:PropertyValue
171 Nae19f65d0497456db9b40feb84d98ebe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Mitogens
173 rdf:type schema:DefinedTerm
174 Nbedafdda37e6416ca73ea4558aac3492 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Protein Tyrosine Phosphatases
176 rdf:type schema:DefinedTerm
177 Nc41aae99f11749b08e9f53f85cce42c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Mitogen-Activated Protein Kinases
179 rdf:type schema:DefinedTerm
180 Nc8b629f848f2427eb9aaca8044b48525 rdf:first sg:person.01017467302.91
181 rdf:rest N1f5e60ce8f134aa094fe1286a9f889ad
182 Nd539e29cd120487cae122ad802df8ddf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Mitogen-Activated Protein Kinase 3
184 rdf:type schema:DefinedTerm
185 Nf5c0e2d1ec9142b0a7f7806cb5ddc745 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Enzyme Activation
187 rdf:type schema:DefinedTerm
188 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
189 schema:name Biological Sciences
190 rdf:type schema:DefinedTerm
191 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
192 schema:name Biochemistry and Cell Biology
193 rdf:type schema:DefinedTerm
194 sg:journal.1018957 schema:issn 0028-0836
195 1476-4687
196 schema:name Nature
197 schema:publisher Springer Nature
198 rdf:type schema:Periodical
199 sg:person.01017467302.91 schema:affiliation grid-institutes:grid.48336.3a
200 schema:familyName Jensen
201 schema:givenName Peter
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017467302.91
203 rdf:type schema:Person
204 sg:person.01034763247.45 schema:affiliation grid-institutes:grid.48336.3a
205 schema:familyName Ward
206 schema:givenName Yvona
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01034763247.45
208 rdf:type schema:Person
209 sg:person.011405665312.33 schema:affiliation grid-institutes:grid.48336.3a
210 schema:familyName Kelly
211 schema:givenName Kathleen
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011405665312.33
213 rdf:type schema:Person
214 sg:pub.10.1038/227680a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010419937
215 https://doi.org/10.1038/227680a0
216 rdf:type schema:CreativeWork
217 sg:pub.10.1038/358414a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052248806
218 https://doi.org/10.1038/358414a0
219 rdf:type schema:CreativeWork
220 sg:pub.10.1038/359644a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039608705
221 https://doi.org/10.1038/359644a0
222 rdf:type schema:CreativeWork
223 grid-institutes:grid.48336.3a schema:alternateName Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA
224 schema:name Laboratory of Pathology, National Cancer Institute, Building 10, Room 2A-33, 20892, Bethesda, Maryland, USA
225 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...