Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-01

AUTHORS

Stephen M. Dilworth, Charlotte E. P. Brewster, Michael D. Jones, Luisa Lanfrancone, Guiliana Pelicci, Pier G. Pelicci

ABSTRACT

POLYOMA virus middle T-antigen converts normal fibroblasts to a fully transformed, tumorigenic phenotype1. It achieves this, at least in part, by binding and activating one of the non-receptor tyrosine kinases, pp60c-src, pp62c-yes or pp59c-fyn (reviewed in refs 2 and 3). As a result, middle T-antigen itself is phosphorylated on tyrosine residues4,5, one of which (Tyr 315) acts as a binding site for the SH2 domains of phosphatidylinositol-3'OH kinase 85K sub-unit6–8. Here we show that another tyrosine phosphorylation site in middle T-antigen (Tyr 250; refs 4, 5) acts as a binding region for the SH2 domain of the transforming protein Shc9. This results in Shc also becoming tyrosine-phosphorylated and binding to the SH2 domain of Grb2 (ref. 10). This probably stimulates p21ras activity through the mammalian homologue of the Drosophila guanine-nucleotide-exchange factor Sos (reviewed in ref. 11). We suggest that middle T-antigen transforms cells by acting as a functional homologue of an activated tyrosine kinase-associated growth-factor receptor. More... »

PAGES

87-90

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/367087a0

DOI

http://dx.doi.org/10.1038/367087a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002757816

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7509037


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Vesicular Transport", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, Polyomavirus Transforming", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "GRB2 Adaptor Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphatidylinositol 3-Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphotransferases (Alcohol Group Acceptor)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins pp60(c-src)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Fibroblast Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Shc Signaling Adaptor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Src Homology 2 Domain-Containing, Transforming Protein 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tyrosine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Chemical Pathology, Royal Postgraduate Medical School, Du Cane Road, W12 ONN, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Department of Chemical Pathology, Royal Postgraduate Medical School, Du Cane Road, W12 ONN, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dilworth", 
        "givenName": "Stephen M.", 
        "id": "sg:person.01044712673.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044712673.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Chemical Pathology, Royal Postgraduate Medical School, Du Cane Road, W12 ONN, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Department of Chemical Pathology, Royal Postgraduate Medical School, Du Cane Road, W12 ONN, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brewster", 
        "givenName": "Charlotte E. P.", 
        "id": "sg:person.01332134345.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332134345.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Virology, Royal Postgraduate Medical School, Du Cane Road, W12 ONN, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.7445.2", 
          "name": [
            "Department of Virology, Royal Postgraduate Medical School, Du Cane Road, W12 ONN, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jones", 
        "givenName": "Michael D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto di Clinica Medica I, University of Perugia, Via Brunamonti, 06100, Perugia, Italy", 
          "id": "http://www.grid.ac/institutes/grid.9027.c", 
          "name": [
            "Istituto di Clinica Medica I, University of Perugia, Via Brunamonti, 06100, Perugia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lanfrancone", 
        "givenName": "Luisa", 
        "id": "sg:person.01074262331.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074262331.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto di Clinica Medica I, University of Perugia, Via Brunamonti, 06100, Perugia, Italy", 
          "id": "http://www.grid.ac/institutes/grid.9027.c", 
          "name": [
            "Istituto di Clinica Medica I, University of Perugia, Via Brunamonti, 06100, Perugia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pelicci", 
        "givenName": "Guiliana", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto di Clinica Medica I, University of Perugia, Via Brunamonti, 06100, Perugia, Italy", 
          "id": "http://www.grid.ac/institutes/grid.9027.c", 
          "name": [
            "Istituto di Clinica Medica I, University of Perugia, Via Brunamonti, 06100, Perugia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pelicci", 
        "givenName": "Pier G.", 
        "id": "sg:person.07544156027.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07544156027.35"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/292595a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020379194", 
          "https://doi.org/10.1038/292595a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/360689a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042782556", 
          "https://doi.org/10.1038/360689a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/227680a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010419937", 
          "https://doi.org/10.1038/227680a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/363015a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023945033", 
          "https://doi.org/10.1038/363015a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-01", 
    "datePublishedReg": "1994-01-01", 
    "description": "POLYOMA virus middle T-antigen converts normal fibroblasts to a fully transformed, tumorigenic phenotype1. It achieves this, at least in part, by binding and activating one of the non-receptor tyrosine kinases, pp60c-src, pp62c-yes or pp59c-fyn (reviewed in refs 2 and 3). As a result, middle T-antigen itself is phosphorylated on tyrosine residues4,5, one of which (Tyr 315) acts as a binding site for the SH2 domains of phosphatidylinositol-3'OH kinase 85K sub-unit6\u20138. Here we show that another tyrosine phosphorylation site in middle T-antigen (Tyr 250; refs 4, 5) acts as a binding region for the SH2 domain of the transforming protein Shc9. This results in Shc also becoming tyrosine-phosphorylated and binding to the SH2 domain of Grb2 (ref. 10). This probably stimulates p21ras activity through the mammalian homologue of the Drosophila guanine-nucleotide-exchange factor Sos (reviewed in ref. 11). We suggest that middle T-antigen transforms cells by acting as a functional homologue of an activated tyrosine kinase-associated growth-factor receptor.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/367087a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6458", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "367"
      }
    ], 
    "keywords": [
      "SH2 domain", 
      "exchange factor Sos", 
      "non-receptor tyrosine kinase", 
      "tyrosine phosphorylation sites", 
      "polyoma virus", 
      "mammalian homologue", 
      "functional homologue", 
      "pp60c-src", 
      "phosphorylation sites", 
      "growth factor receptor", 
      "tyrosine phosphorylation", 
      "p21ras activity", 
      "tyrosine kinase", 
      "Shc", 
      "homologues", 
      "normal fibroblasts", 
      "pp62c", 
      "Grb2", 
      "domain", 
      "kinase", 
      "phosphorylation", 
      "guanine", 
      "sites", 
      "virus", 
      "tyrosine", 
      "fibroblasts", 
      "cells", 
      "receptors", 
      "antigen", 
      "activity", 
      "region", 
      "transformation", 
      "SO", 
      "part", 
      "results", 
      "tumorigenic phenotype1", 
      "phenotype1", 
      "phosphatidylinositol-3'OH kinase 85K", 
      "kinase 85K", 
      "transforming protein Shc9", 
      "protein Shc9", 
      "Shc9", 
      "Drosophila guanine", 
      "factor Sos", 
      "tyrosine kinase-associated growth-factor receptor", 
      "kinase-associated growth-factor receptor"
    ], 
    "name": "Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc", 
    "pagination": "87-90", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002757816"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/367087a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7509037"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/367087a0", 
      "https://app.dimensions.ai/details/publication/pub.1002757816"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_252.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/367087a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/367087a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/367087a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/367087a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/367087a0'


 

This table displays all metadata directly associated to this object as RDF triples.

254 TRIPLES      22 PREDICATES      100 URIs      88 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/367087a0 schema:about N0b4c65d76678483884374c7faa66609e
2 N20d87b1d88104847927eb060386740ff
3 N21eab784c396401596b5ee3156dccae7
4 N2d9ba558bd9e48c88d8d57106f5d8368
5 N378bb508c11c4ec2949dacfcca1bbfc6
6 N420b0dcefc4d473d87c823804f250a28
7 N4a58edf99bb249f29c1cb5c14f84dd95
8 N56b5ba478d21469fa25b0a29906d37e3
9 N6875a03ff4ee40049d6e2e25c685c3a3
10 N6a083c685c5c450eb250878339c51399
11 N6f65f5d2d688413cae0bbd3cb8f18110
12 N73ee8619e06545d892cfea218d137e4b
13 N7a4fd8a192174ec69b7c320861a8ca3f
14 N831ce26aebcc4f4ebffefd905d66179f
15 N8b551a7f9c1c4c178a16b9de18303a2a
16 N9ad1bcbfb13a4b26be13f478189fb3c2
17 N9d77949cda1f43d2b44348e33d56f08e
18 Na62c4e28fa2c43678f23f677e4c42b89
19 Nab9d90c6402940079bbeb0db9dd9ea3b
20 Nb8967a5a7e4e4461a27614eb10aa8fb7
21 Nc62eda140a7c4d76bc57d1edea0bb607
22 Ne85cd234cd074e1fa7c18103b7f6944b
23 Neadc717d8f2e4bd58b9deb1d5bb426de
24 anzsrc-for:06
25 anzsrc-for:0601
26 schema:author N0bd2fbc4532941619b9c6f5b2ed9b54f
27 schema:citation sg:pub.10.1038/227680a0
28 sg:pub.10.1038/292595a0
29 sg:pub.10.1038/360689a0
30 sg:pub.10.1038/363015a0
31 schema:datePublished 1994-01
32 schema:datePublishedReg 1994-01-01
33 schema:description POLYOMA virus middle T-antigen converts normal fibroblasts to a fully transformed, tumorigenic phenotype1. It achieves this, at least in part, by binding and activating one of the non-receptor tyrosine kinases, pp60c-src, pp62c-yes or pp59c-fyn (reviewed in refs 2 and 3). As a result, middle T-antigen itself is phosphorylated on tyrosine residues4,5, one of which (Tyr 315) acts as a binding site for the SH2 domains of phosphatidylinositol-3'OH kinase 85K sub-unit6–8. Here we show that another tyrosine phosphorylation site in middle T-antigen (Tyr 250; refs 4, 5) acts as a binding region for the SH2 domain of the transforming protein Shc9. This results in Shc also becoming tyrosine-phosphorylated and binding to the SH2 domain of Grb2 (ref. 10). This probably stimulates p21ras activity through the mammalian homologue of the Drosophila guanine-nucleotide-exchange factor Sos (reviewed in ref. 11). We suggest that middle T-antigen transforms cells by acting as a functional homologue of an activated tyrosine kinase-associated growth-factor receptor.
34 schema:genre article
35 schema:inLanguage en
36 schema:isAccessibleForFree false
37 schema:isPartOf Nb43916c697484a07af5a9731af85ba31
38 Nbd9fbf2b49504ce28090dbd5f8ac58cb
39 sg:journal.1018957
40 schema:keywords Drosophila guanine
41 Grb2
42 SH2 domain
43 SO
44 Shc
45 Shc9
46 activity
47 antigen
48 cells
49 domain
50 exchange factor Sos
51 factor Sos
52 fibroblasts
53 functional homologue
54 growth factor receptor
55 guanine
56 homologues
57 kinase
58 kinase 85K
59 kinase-associated growth-factor receptor
60 mammalian homologue
61 non-receptor tyrosine kinase
62 normal fibroblasts
63 p21ras activity
64 part
65 phenotype1
66 phosphatidylinositol-3'OH kinase 85K
67 phosphorylation
68 phosphorylation sites
69 polyoma virus
70 pp60c-src
71 pp62c
72 protein Shc9
73 receptors
74 region
75 results
76 sites
77 transformation
78 transforming protein Shc9
79 tumorigenic phenotype1
80 tyrosine
81 tyrosine kinase
82 tyrosine kinase-associated growth-factor receptor
83 tyrosine phosphorylation
84 tyrosine phosphorylation sites
85 virus
86 schema:name Transformation by polyoma virus middle T-antigen involves the binding and tyrosine phosphorylation of Shc
87 schema:pagination 87-90
88 schema:productId N050718e3c2334ce7a4a76afa5cb108d8
89 Nb894c0fc003a410b9c91ed7f3356706f
90 Nccb7013bdf1e4221bf21093d61994f50
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002757816
92 https://doi.org/10.1038/367087a0
93 schema:sdDatePublished 2022-01-01T18:06
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N9866b0095897425f9394ef627265928b
96 schema:url https://doi.org/10.1038/367087a0
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N050718e3c2334ce7a4a76afa5cb108d8 schema:name doi
101 schema:value 10.1038/367087a0
102 rdf:type schema:PropertyValue
103 N0833620c11254ac0969c4664e7aca744 rdf:first sg:person.01332134345.80
104 rdf:rest Nbd23caa8eab24d2694cdc98a8a53e159
105 N0b4c65d76678483884374c7faa66609e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Amino Acid Sequence
107 rdf:type schema:DefinedTerm
108 N0bd2fbc4532941619b9c6f5b2ed9b54f rdf:first sg:person.01044712673.89
109 rdf:rest N0833620c11254ac0969c4664e7aca744
110 N20d87b1d88104847927eb060386740ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Molecular Sequence Data
112 rdf:type schema:DefinedTerm
113 N21eab784c396401596b5ee3156dccae7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Mutation
115 rdf:type schema:DefinedTerm
116 N2d9ba558bd9e48c88d8d57106f5d8368 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Cell Line
118 rdf:type schema:DefinedTerm
119 N378bb508c11c4ec2949dacfcca1bbfc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Proto-Oncogene Proteins pp60(c-src)
121 rdf:type schema:DefinedTerm
122 N420b0dcefc4d473d87c823804f250a28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Phosphatidylinositol 3-Kinases
124 rdf:type schema:DefinedTerm
125 N4993ec2d42c143358d7a4a3c708383ea rdf:first sg:person.07544156027.35
126 rdf:rest rdf:nil
127 N4a58edf99bb249f29c1cb5c14f84dd95 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Shc Signaling Adaptor Proteins
129 rdf:type schema:DefinedTerm
130 N56b5ba478d21469fa25b0a29906d37e3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Proteins
132 rdf:type schema:DefinedTerm
133 N6875a03ff4ee40049d6e2e25c685c3a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Transformation, Neoplastic
135 rdf:type schema:DefinedTerm
136 N6a083c685c5c450eb250878339c51399 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Tyrosine
138 rdf:type schema:DefinedTerm
139 N6f65f5d2d688413cae0bbd3cb8f18110 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Rats
141 rdf:type schema:DefinedTerm
142 N73ee8619e06545d892cfea218d137e4b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Phosphotransferases (Alcohol Group Acceptor)
144 rdf:type schema:DefinedTerm
145 N7a4fd8a192174ec69b7c320861a8ca3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Antigens, Polyomavirus Transforming
147 rdf:type schema:DefinedTerm
148 N831ce26aebcc4f4ebffefd905d66179f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Protein Binding
150 rdf:type schema:DefinedTerm
151 N8b551a7f9c1c4c178a16b9de18303a2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Adaptor Proteins, Signal Transducing
153 rdf:type schema:DefinedTerm
154 N9866b0095897425f9394ef627265928b schema:name Springer Nature - SN SciGraph project
155 rdf:type schema:Organization
156 N9ad1bcbfb13a4b26be13f478189fb3c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Phosphorylation
158 rdf:type schema:DefinedTerm
159 N9d77949cda1f43d2b44348e33d56f08e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Cell Transformation, Viral
161 rdf:type schema:DefinedTerm
162 Na62c4e28fa2c43678f23f677e4c42b89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Src Homology 2 Domain-Containing, Transforming Protein 1
164 rdf:type schema:DefinedTerm
165 Na6764614dd2c4468882727f5ee92b6fe schema:affiliation grid-institutes:grid.9027.c
166 schema:familyName Pelicci
167 schema:givenName Guiliana
168 rdf:type schema:Person
169 Nab9d90c6402940079bbeb0db9dd9ea3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Animals
171 rdf:type schema:DefinedTerm
172 Nac692cff969149c59502576089041ddf rdf:first sg:person.01074262331.21
173 rdf:rest Nb2438b9e8afc4fdea704add3590cec11
174 Nb2438b9e8afc4fdea704add3590cec11 rdf:first Na6764614dd2c4468882727f5ee92b6fe
175 rdf:rest N4993ec2d42c143358d7a4a3c708383ea
176 Nb43916c697484a07af5a9731af85ba31 schema:issueNumber 6458
177 rdf:type schema:PublicationIssue
178 Nb894c0fc003a410b9c91ed7f3356706f schema:name pubmed_id
179 schema:value 7509037
180 rdf:type schema:PropertyValue
181 Nb8967a5a7e4e4461a27614eb10aa8fb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name GRB2 Adaptor Protein
183 rdf:type schema:DefinedTerm
184 Nbd23caa8eab24d2694cdc98a8a53e159 rdf:first Nc19b0d4ae83d4dbfa21f2db72bc42411
185 rdf:rest Nac692cff969149c59502576089041ddf
186 Nbd9fbf2b49504ce28090dbd5f8ac58cb schema:volumeNumber 367
187 rdf:type schema:PublicationVolume
188 Nc19b0d4ae83d4dbfa21f2db72bc42411 schema:affiliation grid-institutes:grid.7445.2
189 schema:familyName Jones
190 schema:givenName Michael D.
191 rdf:type schema:Person
192 Nc62eda140a7c4d76bc57d1edea0bb607 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Adaptor Proteins, Vesicular Transport
194 rdf:type schema:DefinedTerm
195 Nccb7013bdf1e4221bf21093d61994f50 schema:name dimensions_id
196 schema:value pub.1002757816
197 rdf:type schema:PropertyValue
198 Ne85cd234cd074e1fa7c18103b7f6944b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Receptor Protein-Tyrosine Kinases
200 rdf:type schema:DefinedTerm
201 Neadc717d8f2e4bd58b9deb1d5bb426de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Receptors, Fibroblast Growth Factor
203 rdf:type schema:DefinedTerm
204 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
205 schema:name Biological Sciences
206 rdf:type schema:DefinedTerm
207 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
208 schema:name Biochemistry and Cell Biology
209 rdf:type schema:DefinedTerm
210 sg:journal.1018957 schema:issn 0028-0836
211 1476-4687
212 schema:name Nature
213 schema:publisher Springer Nature
214 rdf:type schema:Periodical
215 sg:person.01044712673.89 schema:affiliation grid-institutes:grid.7445.2
216 schema:familyName Dilworth
217 schema:givenName Stephen M.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044712673.89
219 rdf:type schema:Person
220 sg:person.01074262331.21 schema:affiliation grid-institutes:grid.9027.c
221 schema:familyName Lanfrancone
222 schema:givenName Luisa
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074262331.21
224 rdf:type schema:Person
225 sg:person.01332134345.80 schema:affiliation grid-institutes:grid.7445.2
226 schema:familyName Brewster
227 schema:givenName Charlotte E. P.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332134345.80
229 rdf:type schema:Person
230 sg:person.07544156027.35 schema:affiliation grid-institutes:grid.9027.c
231 schema:familyName Pelicci
232 schema:givenName Pier G.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07544156027.35
234 rdf:type schema:Person
235 sg:pub.10.1038/227680a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010419937
236 https://doi.org/10.1038/227680a0
237 rdf:type schema:CreativeWork
238 sg:pub.10.1038/292595a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020379194
239 https://doi.org/10.1038/292595a0
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/360689a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042782556
242 https://doi.org/10.1038/360689a0
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/363015a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023945033
245 https://doi.org/10.1038/363015a0
246 rdf:type schema:CreativeWork
247 grid-institutes:grid.7445.2 schema:alternateName Department of Chemical Pathology, Royal Postgraduate Medical School, Du Cane Road, W12 ONN, London, UK
248 Department of Virology, Royal Postgraduate Medical School, Du Cane Road, W12 ONN, London, UK
249 schema:name Department of Chemical Pathology, Royal Postgraduate Medical School, Du Cane Road, W12 ONN, London, UK
250 Department of Virology, Royal Postgraduate Medical School, Du Cane Road, W12 ONN, London, UK
251 rdf:type schema:Organization
252 grid-institutes:grid.9027.c schema:alternateName Istituto di Clinica Medica I, University of Perugia, Via Brunamonti, 06100, Perugia, Italy
253 schema:name Istituto di Clinica Medica I, University of Perugia, Via Brunamonti, 06100, Perugia, Italy
254 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...