A brain serine/threonine protein kinase activated by Cdc42 and Rac1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1994-01

AUTHORS

Edward Manser, Thomas Leung, Harfizah Salihuddin, Zhuo-shen Zhao, Louis Lim

ABSTRACT

A new brain serine/threonine protein kinase may be a target for the p21ras-related proteins Cdc42 and Rac1. The kinase sequence is related to that of the yeast protein STE20, implicated in pheromone-response pathways. The kinase complexes specifically with activated (GTP-bound) p21, inhibiting p21 GTPase activity and leading to kinase autophosphorylation and activation. Autophosphorylated kinase has a decreased affinity for Cdc42/Rac, freeing the p21 for further stimulatory activities or downregulation by GTPase-activating proteins. This bimolecular interaction provides a model for studying p21 regulation of mammalian phosphorylation signalling pathways. More... »

PAGES

40-46

Journal

TITLE

Nature

ISSUE

6458

VOLUME

367

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  • Serine Protein Kinase; Polypeptide
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/367040a0

    DOI

    http://dx.doi.org/10.1038/367040a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021411105

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8107774


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