Ontology type: schema:ScholarlyArticle
1993-12
AUTHORSKe Shuai, Andrew Ziemiecki, Andrew F. Wilks, Ailsa G. Harpur, Henry B. Sadowski, Michael Z. Gilman, James E. Darnell
ABSTRACTBINDING of interferons IFN-α and IFN-γ to their cell surface receptors promptly induces tyrosine phosphorylation of latent cytoplasmic transcriptional activators1–4 (or Stat proteins, for signal transducers and activators of transcription). Interferon-α activates both Stat91 (Mr 91,000; ref. 1) and Statll3 (Mr 113,000; ref. 2) whereas IFN-γ activates only Stat91 (refs 3, 4). The activated proteins then move into the nucleus and directly activate genes induced by IFN-α and IFN-γ. Somatic cell genetics experiments have demonstrated a requirement for tyrosine kinase-2 (Tyk2) in the IFN-α response pathway5 and for Jak2 (ref. 6), a kinase with similar sequence7, in the IFN-γ response pathway. Here we investigate the tyrosine phosphorylation events on Stat and Jak proteins after treatment of cells with IFNs α and γ and with epidermal growth factor (EGF). Stat91 is phosphorylated on Tyr 701 after cells are treated with IFN-α and EGF, as it was after treatment with IFN-γ (ref. 8). We find that Jakl also becomes phosphorylated on tyrosine after cells are treated with these same three ligands, although each ligand is shown to activate at least one other differ-ent kinase. Jakl may therefore be the enzyme that phosphorylates Tyr701inStat91. More... »
PAGES580-583
http://scigraph.springernature.com/pub.10.1038/366580a0
DOIhttp://dx.doi.org/10.1038/366580a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1029168623
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/7504784
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Amino Acid Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "B-Lymphocytes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Base Sequence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Binding Sites",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epidermal Growth Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Glutathione Transferase",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Interferon-alpha",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Interferon-gamma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Janus Kinase 1",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Janus Kinase 2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Molecular Sequence Data",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphorylation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Phosphotyrosine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Protein-Tyrosine Kinases",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proto-Oncogene Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Recombinant Fusion Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Trans-Activators",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tumor Cells, Cultured",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Tyrosine",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, 10021\u20136399, New York, USA",
"id": "http://www.grid.ac/institutes/grid.134907.8",
"name": [
"Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, 10021\u20136399, New York, USA"
],
"type": "Organization"
},
"familyName": "Shuai",
"givenName": "Ke",
"id": "sg:person.0606405243.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0606405243.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute for Clinical and Experimental Cancer Research, University of Berne, Tiefenaustrasse 120, 3004, Berne, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5734.5",
"name": [
"Institute for Clinical and Experimental Cancer Research, University of Berne, Tiefenaustrasse 120, 3004, Berne, Switzerland"
],
"type": "Organization"
},
"familyName": "Ziemiecki",
"givenName": "Andrew",
"id": "sg:person.0623364663.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623364663.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ludwig Institute for Cancer Research, Royal Melbourne Hospital, 3050, Victoria, Australia",
"id": "http://www.grid.ac/institutes/grid.416153.4",
"name": [
"Ludwig Institute for Cancer Research, Royal Melbourne Hospital, 3050, Victoria, Australia"
],
"type": "Organization"
},
"familyName": "Wilks",
"givenName": "Andrew F.",
"id": "sg:person.0774515351.10",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774515351.10"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Ludwig Institute for Cancer Research, Royal Melbourne Hospital, 3050, Victoria, Australia",
"id": "http://www.grid.ac/institutes/grid.416153.4",
"name": [
"Ludwig Institute for Cancer Research, Royal Melbourne Hospital, 3050, Victoria, Australia"
],
"type": "Organization"
},
"familyName": "Harpur",
"givenName": "Ailsa G.",
"id": "sg:person.01172752563.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172752563.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cold Spring Harbor Laboratory, 11724, Cold Spring Harbor, New York, USA",
"id": "http://www.grid.ac/institutes/grid.225279.9",
"name": [
"Cold Spring Harbor Laboratory, 11724, Cold Spring Harbor, New York, USA"
],
"type": "Organization"
},
"familyName": "Sadowski",
"givenName": "Henry B.",
"id": "sg:person.0626730636.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626730636.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cold Spring Harbor Laboratory, 11724, Cold Spring Harbor, New York, USA",
"id": "http://www.grid.ac/institutes/grid.225279.9",
"name": [
"Cold Spring Harbor Laboratory, 11724, Cold Spring Harbor, New York, USA"
],
"type": "Organization"
},
"familyName": "Gilman",
"givenName": "Michael Z.",
"id": "sg:person.01205175467.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205175467.88"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, 10021\u20136399, New York, USA",
"id": "http://www.grid.ac/institutes/grid.134907.8",
"name": [
"Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, 10021\u20136399, New York, USA"
],
"type": "Organization"
},
"familyName": "Darnell",
"givenName": "James E.",
"id": "sg:person.01245015654.53",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245015654.53"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/362079a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045732118",
"https://doi.org/10.1038/362079a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/358646a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021461565",
"https://doi.org/10.1038/358646a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/366166a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003119860",
"https://doi.org/10.1038/366166a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/366129a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053037655",
"https://doi.org/10.1038/366129a0"
],
"type": "CreativeWork"
}
],
"datePublished": "1993-12",
"datePublishedReg": "1993-12-01",
"description": "BINDING of interferons IFN-\u03b1 and IFN-\u03b3 to their cell surface receptors promptly induces tyrosine phosphorylation of latent cytoplasmic transcriptional activators1\u20134 (or Stat proteins, for signal transducers and activators of transcription). Interferon-\u03b1 activates both Stat91 (Mr 91,000; ref. 1) and Statll3 (Mr 113,000; ref. 2) whereas IFN-\u03b3 activates only Stat91 (refs 3, 4). The activated proteins then move into the nucleus and directly activate genes induced by IFN-\u03b1 and IFN-\u03b3. Somatic cell genetics experiments have demonstrated a requirement for tyrosine kinase-2 (Tyk2) in the IFN-\u03b1 response pathway5 and for Jak2 (ref. 6), a kinase with similar sequence7, in the IFN-\u03b3 response pathway. Here we investigate the tyrosine phosphorylation events on Stat and Jak proteins after treatment of cells with IFNs \u03b1 and \u03b3 and with epidermal growth factor (EGF). Stat91 is phosphorylated on Tyr 701 after cells are treated with IFN-\u03b1 and EGF, as it was after treatment with IFN-\u03b3 (ref. 8). We find that Jakl also becomes phosphorylated on tyrosine after cells are treated with these same three ligands, although each ligand is shown to activate at least one other differ-ent kinase. Jakl may therefore be the enzyme that phosphorylates Tyr701inStat91.",
"genre": "article",
"id": "sg:pub.10.1038/366580a0",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6455",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "366"
}
],
"keywords": [
"epidermal growth factor",
"tyrosine phosphorylation",
"tyrosine phosphorylation events",
"tyrosine kinase 2",
"cell surface receptors",
"treatment of cells",
"phosphorylation events",
"genetic experiments",
"STAT proteins",
"JAK proteins",
"Tyr-701",
"response pathways",
"kinase 2",
"Stat91",
"surface receptors",
"protein",
"kinase",
"phosphorylation",
"growth factor",
"interferon IFN",
"cells",
"genes",
"IFN \u03b1",
"JAK",
"STAT",
"nucleus",
"JAK2",
"enzyme",
"tyrosine",
"pathway",
"binding",
"ligands",
"receptors",
"IFN",
"interferon",
"events",
"factors",
"treatment",
"experiments",
"requirements"
],
"name": "Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins",
"pagination": "580-583",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1029168623"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/366580a0"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"7504784"
]
}
],
"sameAs": [
"https://doi.org/10.1038/366580a0",
"https://app.dimensions.ai/details/publication/pub.1029168623"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:51",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_243.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/366580a0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/366580a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/366580a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/366580a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/366580a0'
This table displays all metadata directly associated to this object as RDF triples.
252 TRIPLES
21 PREDICATES
91 URIs
79 LITERALS
28 BLANK NODES