Role for DNA methylation in genomic imprinting View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-12

AUTHORS

En Li, Caroline Beard, Rudolf Jaenisch

ABSTRACT

THE paternal and maternal genomes are not equivalent and both are required for mammalian development1,2. The difference between the parental genomes is believed to be due to gamete-specific differential modification, a process known as genomic imprinting. The study of transgene methylation has shown that methylation patterns can be inherited in a parent-of-origin-specific manner3–7, suggesting that DNA methylation may play a role in genomic imprinting. The functional significance of DNA methylation in genomic imprinting was strengthened by the recent finding that CpG islands (or sites) in three imprinted genes, H19, insulin-like growth factor 2 (Igf-2), and lgf-2 receptor (Igf-2r), are differentially methylated depending on their parental origin8–12. We have examined the expression of these three imprinted genes in mutant mice that are deficient in DNA methyltransferase activity13. We report here that expression of all three genes was affected in mutant embryos: the normally silent paternal allele of the HI9 gene was activated, whereas the normally active paternal allele of the Igf-2 gene and the active maternal allele of theIgf-2r gene were repressed. Our results demonstrate that a normal level of DNA methylation is required for controlling differential expression of the paternal and maternal alleles of imprinted genes. More... »

PAGES

362-365

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/366362a0

DOI

http://dx.doi.org/10.1038/366362a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020585492

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8247133


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