The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-11

AUTHORS

Mathias Müller, James Briscoe, Carl Laxton, Dmitry Guschin, Andrew Ziemiecki, Olli Silvennoinen, Ailsa G. Harpur, Giovanna Barbieri, Bruce A. Witthuhn, Chris Schindler, Sandra Pellegrini, Andrew F. Wilks, James N. Ihle, George R. Stark, lan M. Kerr

ABSTRACT

We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-α/β and -γ signal transduction pathways. The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-α pathway, and between JAK1 and JAK2 in the interferon-γ pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. More... »

PAGES

129-135

Journal

TITLE

Nature

ISSUE

6451

VOLUME

366

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/366129a0

DOI

http://dx.doi.org/10.1038/366129a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053037655

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8232552


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Complementation Test", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-Stimulated Gene Factor 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-Stimulated Gene Factor 3, gamma Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-beta", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Janus Kinase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Janus Kinase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "STAT1 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "TYK2 Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trans-Activators", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tyrosine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "M\u00fcller", 
        "givenName": "Mathias", 
        "id": "sg:person.016352165442.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016352165442.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Briscoe", 
        "givenName": "James", 
        "id": "sg:person.0726757017.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726757017.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Laxton", 
        "givenName": "Carl", 
        "id": "sg:person.0766770762.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766770762.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guschin", 
        "givenName": "Dmitry", 
        "id": "sg:person.01057647671.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057647671.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute for Clinical and Experimental Cancer Research, University of Berne, Tiefenaustrasse 120, 3004, Berne, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.5734.5", 
          "name": [
            "Institute for Clinical and Experimental Cancer Research, University of Berne, Tiefenaustrasse 120, 3004, Berne, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ziemiecki", 
        "givenName": "Andrew", 
        "id": "sg:person.0623364663.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623364663.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Pharmacology, New York University Medical Center, 10016, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.240324.3", 
          "name": [
            "Pharmacology, New York University Medical Center, 10016, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silvennoinen", 
        "givenName": "Olli", 
        "id": "sg:person.01164700021.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164700021.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, 3050, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.482095.2", 
          "name": [
            "Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, 3050, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Harpur", 
        "givenName": "Ailsa G.", 
        "id": "sg:person.01172752563.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172752563.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 INSERM 276, Institut Pasteur, 75724Cedex 15, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 INSERM 276, Institut Pasteur, 75724Cedex 15, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Barbieri", 
        "givenName": "Giovanna", 
        "id": "sg:person.01211310207.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211310207.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biochemistry, St Jude Children's Research Hospital, 322 North Lauderdale, 38101-0318, Memphis, Tennesee, USA", 
          "id": "http://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Biochemistry, St Jude Children's Research Hospital, 322 North Lauderdale, 38101-0318, Memphis, Tennesee, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Witthuhn", 
        "givenName": "Bruce A.", 
        "id": "sg:person.014716143024.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014716143024.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Columbia University Medical Center, 10032, New York, New York, USA", 
          "id": "http://www.grid.ac/institutes/grid.239585.0", 
          "name": [
            "Department of Medicine, Columbia University Medical Center, 10032, New York, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schindler", 
        "givenName": "Chris", 
        "id": "sg:person.011156062132.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011156062132.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Unit\u00e9 INSERM 276, Institut Pasteur, 75724Cedex 15, Paris, France", 
          "id": "http://www.grid.ac/institutes/grid.428999.7", 
          "name": [
            "Unit\u00e9 INSERM 276, Institut Pasteur, 75724Cedex 15, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pellegrini", 
        "givenName": "Sandra", 
        "id": "sg:person.0673261331.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673261331.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, 3050, Victoria, Australia", 
          "id": "http://www.grid.ac/institutes/grid.482095.2", 
          "name": [
            "Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, 3050, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wilks", 
        "givenName": "Andrew F.", 
        "id": "sg:person.0774515351.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774515351.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Biochemistry, St Jude Children's Research Hospital, 322 North Lauderdale, 38101-0318, Memphis, Tennesee, USA", 
          "id": "http://www.grid.ac/institutes/grid.240871.8", 
          "name": [
            "Biochemistry, St Jude Children's Research Hospital, 322 North Lauderdale, 38101-0318, Memphis, Tennesee, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ihle", 
        "givenName": "James N.", 
        "id": "sg:person.01146753706.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146753706.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Research Institute, The Cleveland Clinic Foundation, 44195, Cleveland, Ohio, USA", 
          "id": "http://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Research Institute, The Cleveland Clinic Foundation, 44195, Cleveland, Ohio, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stark", 
        "givenName": "George R.", 
        "id": "sg:person.010237465232.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010237465232.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK", 
          "id": "http://www.grid.ac/institutes/grid.11485.39", 
          "name": [
            "Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kerr", 
        "givenName": "lan M.", 
        "id": "sg:person.016052245645.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016052245645.22"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/329840a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025629695", 
          "https://doi.org/10.1038/329840a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/366166a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003119860", 
          "https://doi.org/10.1038/366166a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1993-11", 
    "datePublishedReg": "1993-11-01", 
    "description": "We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-\u03b1/\u03b2 and -\u03b3 signal transduction pathways. The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-\u03b1 pathway, and between JAK1 and JAK2 in the interferon-\u03b3 pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/366129a0", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6451", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "366"
      }
    ], 
    "keywords": [
      "protein tyrosine kinase JAK1", 
      "tyrosine kinases Jak1", 
      "kinase JAK1", 
      "signal transduction pathways", 
      "interferon-receptor complex", 
      "TYK2 activity", 
      "signal transduction", 
      "transduction pathways", 
      "correct assembly", 
      "JAK1", 
      "receptor complex", 
      "interferon response", 
      "cell lines", 
      "complementation", 
      "mutants", 
      "transduction", 
      "kinase", 
      "JAK2", 
      "pathway", 
      "assembly", 
      "complexes", 
      "interferon", 
      "response", 
      "lines", 
      "activity", 
      "reciprocal interdependence", 
      "requirements", 
      "interdependence"
    ], 
    "name": "The protein tyrosine kinase JAK1 complements defects in interferon-\u03b1/\u03b2 and -\u03b3 signal transduction", 
    "pagination": "129-135", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053037655"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/366129a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8232552"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/366129a0", 
      "https://app.dimensions.ai/details/publication/pub.1053037655"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T15:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_256.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/366129a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/366129a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/366129a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/366129a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/366129a0'


 

This table displays all metadata directly associated to this object as RDF triples.

316 TRIPLES      21 PREDICATES      81 URIs      71 LITERALS      32 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/366129a0 schema:about N00d2cdcb9838457c9dba7e985f40c38e
2 N019792162794417dab56fe18c2f3ca35
3 N01b73b0058ba4595bb66992e6727a13c
4 N0aa527c299c14c5b980e10ac9b5f22b9
5 N10122b3c35984eacb80149fab98463d8
6 N18893e7d8df64b459234fceca17e40c4
7 N1b8c4b2e46664a968cd678d1ba5cf83e
8 N1fbd06df3f1248d186a8b8698e7193aa
9 N2639d34095b74942b377612da531d88f
10 N2852147996cb4b429356eff232d325b9
11 N29a5f5118a5042eeb4d604c8bf29f1c4
12 N3aa02135a06d4f409d331417076c2ff7
13 N44b2b47dcaa74522a5f31fab08a818c3
14 N50c3c6a49da44d81a1f58810ef10d243
15 N573cdb79d41c4ad2b3b503429da030dd
16 N63c76868c7cd4451b28d0845e58ae1dd
17 N63e2b65691d847d69a22f642479522e5
18 N68ada4962c7b491488a7761d255857a6
19 N78d91ffa6bbd4f91b024b9cb0f029467
20 N7ff07c83090d4232bb3f333efda1fe43
21 Nbd660b31c3d14cf9b73799d4e4a9efa9
22 Ncdfdea7ca5b649a186b4164b4f289df9
23 Ndbe3eef3c09f469b9d7d10ac8d9121a0
24 Nf1fe77431548495ea3cdf7934910de74
25 Nf6da60edf69c477baf81cf87d199ac6a
26 anzsrc-for:06
27 anzsrc-for:0601
28 schema:author Na2186aee4d3a4347b0fad057c6cb3f56
29 schema:citation sg:pub.10.1038/329840a0
30 sg:pub.10.1038/366166a0
31 schema:datePublished 1993-11
32 schema:datePublishedReg 1993-11-01
33 schema:description We have produced a cell line which lacks the protein tyrosine kinase JAK1 and is completely defective in interferon response. Complementation of this mutant with JAK1 restored the response, establishing the requirement for JAK1 in both the interferon-α/β and -γ signal transduction pathways. The reciprocal interdependence between JAK1 and Tyk2 activities in the interferon-α pathway, and between JAK1 and JAK2 in the interferon-γ pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes.
34 schema:genre article
35 schema:isAccessibleForFree false
36 schema:isPartOf Nca1ab08df2c0447da29aaae57bde2b13
37 Ncad9aeaa660f4a8d8271d914cb0297cc
38 sg:journal.1018957
39 schema:keywords JAK1
40 JAK2
41 TYK2 activity
42 activity
43 assembly
44 cell lines
45 complementation
46 complexes
47 correct assembly
48 interdependence
49 interferon
50 interferon response
51 interferon-receptor complex
52 kinase
53 kinase JAK1
54 lines
55 mutants
56 pathway
57 protein tyrosine kinase JAK1
58 receptor complex
59 reciprocal interdependence
60 requirements
61 response
62 signal transduction
63 signal transduction pathways
64 transduction
65 transduction pathways
66 tyrosine kinases Jak1
67 schema:name The protein tyrosine kinase JAK1 complements defects in interferon-α/β and -γ signal transduction
68 schema:pagination 129-135
69 schema:productId N6be2853e2010484d9bee390a1b4e8034
70 Nbe0df0e08059494ea1101a16234205d1
71 Nc551753b7ee2436ca91cab71d7927b10
72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053037655
73 https://doi.org/10.1038/366129a0
74 schema:sdDatePublished 2022-09-02T15:48
75 schema:sdLicense https://scigraph.springernature.com/explorer/license/
76 schema:sdPublisher N046878d87241420384860a804cb9cf32
77 schema:url https://doi.org/10.1038/366129a0
78 sgo:license sg:explorer/license/
79 sgo:sdDataset articles
80 rdf:type schema:ScholarlyArticle
81 N00d2cdcb9838457c9dba7e985f40c38e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Genetic Complementation Test
83 rdf:type schema:DefinedTerm
84 N019792162794417dab56fe18c2f3ca35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Janus Kinase 2
86 rdf:type schema:DefinedTerm
87 N01b73b0058ba4595bb66992e6727a13c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Tyrosine
89 rdf:type schema:DefinedTerm
90 N0443c1b473644646a28e2c1c5e4828d0 rdf:first sg:person.0766770762.01
91 rdf:rest N30db29eca9c74f1e99481d9003449f52
92 N046878d87241420384860a804cb9cf32 schema:name Springer Nature - SN SciGraph project
93 rdf:type schema:Organization
94 N0550621de8c448aa85893877da9e6b13 rdf:first sg:person.01146753706.54
95 rdf:rest Nb0548a50b70849f8aefb40bda75260be
96 N0aa527c299c14c5b980e10ac9b5f22b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Protein-Tyrosine Kinases
98 rdf:type schema:DefinedTerm
99 N10122b3c35984eacb80149fab98463d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Interferon-gamma
101 rdf:type schema:DefinedTerm
102 N18893e7d8df64b459234fceca17e40c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Phosphorylation
104 rdf:type schema:DefinedTerm
105 N1b8c4b2e46664a968cd678d1ba5cf83e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Proteins
107 rdf:type schema:DefinedTerm
108 N1fbd06df3f1248d186a8b8698e7193aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Interferon-alpha
110 rdf:type schema:DefinedTerm
111 N2639d34095b74942b377612da531d88f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Interferon-beta
113 rdf:type schema:DefinedTerm
114 N2852147996cb4b429356eff232d325b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Humans
116 rdf:type schema:DefinedTerm
117 N29a5f5118a5042eeb4d604c8bf29f1c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Signal Transduction
119 rdf:type schema:DefinedTerm
120 N30db29eca9c74f1e99481d9003449f52 rdf:first sg:person.01057647671.77
121 rdf:rest Ncb8fe604051a49468201166ef8b564f1
122 N3aa02135a06d4f409d331417076c2ff7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name STAT1 Transcription Factor
124 rdf:type schema:DefinedTerm
125 N44b2b47dcaa74522a5f31fab08a818c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Transcription Factors
127 rdf:type schema:DefinedTerm
128 N50c3c6a49da44d81a1f58810ef10d243 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Transcription, Genetic
130 rdf:type schema:DefinedTerm
131 N573cdb79d41c4ad2b3b503429da030dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Proto-Oncogene Proteins
133 rdf:type schema:DefinedTerm
134 N5d8c0fb1b5e54593a18c6013ef6a42a0 rdf:first sg:person.01164700021.08
135 rdf:rest N7be44f73dc124edfac31b4a5909e4ff5
136 N63c76868c7cd4451b28d0845e58ae1dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Animals
138 rdf:type schema:DefinedTerm
139 N63e2b65691d847d69a22f642479522e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Interferon-Stimulated Gene Factor 3, gamma Subunit
141 rdf:type schema:DefinedTerm
142 N687cb287e73b4f8fbf184e6b18da48a3 rdf:first sg:person.014716143024.04
143 rdf:rest Nc5ab5204e7f14714bde70c5432cd93c1
144 N68ada4962c7b491488a7761d255857a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name TYK2 Kinase
146 rdf:type schema:DefinedTerm
147 N6be2853e2010484d9bee390a1b4e8034 schema:name doi
148 schema:value 10.1038/366129a0
149 rdf:type schema:PropertyValue
150 N78d91ffa6bbd4f91b024b9cb0f029467 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Janus Kinase 1
152 rdf:type schema:DefinedTerm
153 N7be44f73dc124edfac31b4a5909e4ff5 rdf:first sg:person.01172752563.42
154 rdf:rest Ned37e803de3649f3983e92a444ab0f24
155 N7ff07c83090d4232bb3f333efda1fe43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name DNA-Binding Proteins
157 rdf:type schema:DefinedTerm
158 N803147bd4fb6418e874ac4ac3fb22bde rdf:first sg:person.016052245645.22
159 rdf:rest rdf:nil
160 N9f721eac977f4641a56dfae48f0e3bb3 rdf:first sg:person.0673261331.35
161 rdf:rest Nd6234b2b764e4a50b8d90fba48a45c47
162 Na2186aee4d3a4347b0fad057c6cb3f56 rdf:first sg:person.016352165442.14
163 rdf:rest Nbe8d3a4d99a24aa587df62a185d43f4f
164 Nb0548a50b70849f8aefb40bda75260be rdf:first sg:person.010237465232.81
165 rdf:rest N803147bd4fb6418e874ac4ac3fb22bde
166 Nbd660b31c3d14cf9b73799d4e4a9efa9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Trans-Activators
168 rdf:type schema:DefinedTerm
169 Nbe0df0e08059494ea1101a16234205d1 schema:name pubmed_id
170 schema:value 8232552
171 rdf:type schema:PropertyValue
172 Nbe8d3a4d99a24aa587df62a185d43f4f rdf:first sg:person.0726757017.83
173 rdf:rest N0443c1b473644646a28e2c1c5e4828d0
174 Nc551753b7ee2436ca91cab71d7927b10 schema:name dimensions_id
175 schema:value pub.1053037655
176 rdf:type schema:PropertyValue
177 Nc5ab5204e7f14714bde70c5432cd93c1 rdf:first sg:person.011156062132.37
178 rdf:rest N9f721eac977f4641a56dfae48f0e3bb3
179 Nca1ab08df2c0447da29aaae57bde2b13 schema:volumeNumber 366
180 rdf:type schema:PublicationVolume
181 Ncad9aeaa660f4a8d8271d914cb0297cc schema:issueNumber 6451
182 rdf:type schema:PublicationIssue
183 Ncb8fe604051a49468201166ef8b564f1 rdf:first sg:person.0623364663.17
184 rdf:rest N5d8c0fb1b5e54593a18c6013ef6a42a0
185 Ncdfdea7ca5b649a186b4164b4f289df9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Mutation
187 rdf:type schema:DefinedTerm
188 Nd6234b2b764e4a50b8d90fba48a45c47 rdf:first sg:person.0774515351.10
189 rdf:rest N0550621de8c448aa85893877da9e6b13
190 Ndbe3eef3c09f469b9d7d10ac8d9121a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
191 schema:name Interferon-Stimulated Gene Factor 3
192 rdf:type schema:DefinedTerm
193 Ned37e803de3649f3983e92a444ab0f24 rdf:first sg:person.01211310207.70
194 rdf:rest N687cb287e73b4f8fbf184e6b18da48a3
195 Nf1fe77431548495ea3cdf7934910de74 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
196 schema:name Mice
197 rdf:type schema:DefinedTerm
198 Nf6da60edf69c477baf81cf87d199ac6a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
199 schema:name Cell Line
200 rdf:type schema:DefinedTerm
201 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
202 schema:name Biological Sciences
203 rdf:type schema:DefinedTerm
204 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
205 schema:name Biochemistry and Cell Biology
206 rdf:type schema:DefinedTerm
207 sg:journal.1018957 schema:issn 0028-0836
208 1476-4687
209 schema:name Nature
210 schema:publisher Springer Nature
211 rdf:type schema:Periodical
212 sg:person.010237465232.81 schema:affiliation grid-institutes:grid.239578.2
213 schema:familyName Stark
214 schema:givenName George R.
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010237465232.81
216 rdf:type schema:Person
217 sg:person.01057647671.77 schema:affiliation grid-institutes:grid.11485.39
218 schema:familyName Guschin
219 schema:givenName Dmitry
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01057647671.77
221 rdf:type schema:Person
222 sg:person.011156062132.37 schema:affiliation grid-institutes:grid.239585.0
223 schema:familyName Schindler
224 schema:givenName Chris
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011156062132.37
226 rdf:type schema:Person
227 sg:person.01146753706.54 schema:affiliation grid-institutes:grid.240871.8
228 schema:familyName Ihle
229 schema:givenName James N.
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146753706.54
231 rdf:type schema:Person
232 sg:person.01164700021.08 schema:affiliation grid-institutes:grid.240324.3
233 schema:familyName Silvennoinen
234 schema:givenName Olli
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164700021.08
236 rdf:type schema:Person
237 sg:person.01172752563.42 schema:affiliation grid-institutes:grid.482095.2
238 schema:familyName Harpur
239 schema:givenName Ailsa G.
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172752563.42
241 rdf:type schema:Person
242 sg:person.01211310207.70 schema:affiliation grid-institutes:grid.428999.7
243 schema:familyName Barbieri
244 schema:givenName Giovanna
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211310207.70
246 rdf:type schema:Person
247 sg:person.014716143024.04 schema:affiliation grid-institutes:grid.240871.8
248 schema:familyName Witthuhn
249 schema:givenName Bruce A.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014716143024.04
251 rdf:type schema:Person
252 sg:person.016052245645.22 schema:affiliation grid-institutes:grid.11485.39
253 schema:familyName Kerr
254 schema:givenName lan M.
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016052245645.22
256 rdf:type schema:Person
257 sg:person.016352165442.14 schema:affiliation grid-institutes:grid.11485.39
258 schema:familyName Müller
259 schema:givenName Mathias
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016352165442.14
261 rdf:type schema:Person
262 sg:person.0623364663.17 schema:affiliation grid-institutes:grid.5734.5
263 schema:familyName Ziemiecki
264 schema:givenName Andrew
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623364663.17
266 rdf:type schema:Person
267 sg:person.0673261331.35 schema:affiliation grid-institutes:grid.428999.7
268 schema:familyName Pellegrini
269 schema:givenName Sandra
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673261331.35
271 rdf:type schema:Person
272 sg:person.0726757017.83 schema:affiliation grid-institutes:grid.11485.39
273 schema:familyName Briscoe
274 schema:givenName James
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726757017.83
276 rdf:type schema:Person
277 sg:person.0766770762.01 schema:affiliation grid-institutes:grid.11485.39
278 schema:familyName Laxton
279 schema:givenName Carl
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766770762.01
281 rdf:type schema:Person
282 sg:person.0774515351.10 schema:affiliation grid-institutes:grid.482095.2
283 schema:familyName Wilks
284 schema:givenName Andrew F.
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774515351.10
286 rdf:type schema:Person
287 sg:pub.10.1038/329840a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025629695
288 https://doi.org/10.1038/329840a0
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/366166a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003119860
291 https://doi.org/10.1038/366166a0
292 rdf:type schema:CreativeWork
293 grid-institutes:grid.11485.39 schema:alternateName Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK
294 schema:name Imperial Cancer Research Fund Laboratories, 44 Lincoln's Inn Fields, PO Box 123, WC2A 3PX, London, UK
295 rdf:type schema:Organization
296 grid-institutes:grid.239578.2 schema:alternateName Research Institute, The Cleveland Clinic Foundation, 44195, Cleveland, Ohio, USA
297 schema:name Research Institute, The Cleveland Clinic Foundation, 44195, Cleveland, Ohio, USA
298 rdf:type schema:Organization
299 grid-institutes:grid.239585.0 schema:alternateName Department of Medicine, Columbia University Medical Center, 10032, New York, New York, USA
300 schema:name Department of Medicine, Columbia University Medical Center, 10032, New York, New York, USA
301 rdf:type schema:Organization
302 grid-institutes:grid.240324.3 schema:alternateName Pharmacology, New York University Medical Center, 10016, New York, New York, USA
303 schema:name Pharmacology, New York University Medical Center, 10016, New York, New York, USA
304 rdf:type schema:Organization
305 grid-institutes:grid.240871.8 schema:alternateName Biochemistry, St Jude Children's Research Hospital, 322 North Lauderdale, 38101-0318, Memphis, Tennesee, USA
306 schema:name Biochemistry, St Jude Children's Research Hospital, 322 North Lauderdale, 38101-0318, Memphis, Tennesee, USA
307 rdf:type schema:Organization
308 grid-institutes:grid.428999.7 schema:alternateName Unité INSERM 276, Institut Pasteur, 75724Cedex 15, Paris, France
309 schema:name Unité INSERM 276, Institut Pasteur, 75724Cedex 15, Paris, France
310 rdf:type schema:Organization
311 grid-institutes:grid.482095.2 schema:alternateName Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, 3050, Victoria, Australia
312 schema:name Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, 3050, Victoria, Australia
313 rdf:type schema:Organization
314 grid-institutes:grid.5734.5 schema:alternateName Institute for Clinical and Experimental Cancer Research, University of Berne, Tiefenaustrasse 120, 3004, Berne, Switzerland
315 schema:name Institute for Clinical and Experimental Cancer Research, University of Berne, Tiefenaustrasse 120, 3004, Berne, Switzerland
316 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...