Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-11

AUTHORS

Hiroko Ohki-Hamazaki, Kei Watase, Kazutoshi Yamamoto, Hiroo Ogura, Mariko Yamano, Kazuyuki Yamada, Hiroshi Maeno, Junko Imaki, Sakae Kikuyama, Etsuko Wada, Keiji Wada

ABSTRACT

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism and behaviour1. They bind to G-protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors cloned so far include, gastrin-releasing peptide receptor (GRP-R)2,3, neuromedin B receptor (NMB-R)4,5, and bombesin receptor subtype-3 (BRS-3)6,7. However, despite the molecular characterization of BRS-3, determination of its function has been difficult as a result of its low affinity for bombesin and its lack of an identified natural ligand. We have generated BRS-3-deficient mice in an attempt to determine the in vivo function of the receptor. Mice lacking functional BRS-3 developed a mild obesity, associated with hypertension and impairment of glucose metabolism. They also exhibited reduced metabolic rate, increased feeding efficiency and subsequent hyperphagia. Our data suggest that BRS-3 is required for the regulation of endocrine processes and metabolism responsible for energy balance and adiposity. BRS-3-deficient mice provide a useful new model for the investigation of human obesity and associated diseases. More... »

PAGES

165-169

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/36568

DOI

http://dx.doi.org/10.1038/36568

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028396225

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9367152


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue, Brown", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Pressure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Body Weight", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Energy Metabolism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Deletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Targeting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose Tolerance Test", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hormones", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leptin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolic Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred ICR", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Motor Activity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Obesity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Bombesin", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Neurochemistry, Tokyo Institute of Psychiatry, 156, Setagaya, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.417113.1", 
          "name": [
            "Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan", 
            "Department of Neurochemistry, Tokyo Institute of Psychiatry, 156, Setagaya, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohki-Hamazaki", 
        "givenName": "Hiroko", 
        "id": "sg:person.01353745042.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353745042.84"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419280.6", 
          "name": [
            "Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watase", 
        "givenName": "Kei", 
        "id": "sg:person.01074465557.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074465557.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biology, School of Education, Waseda University, 169-50, Shinjuku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.5290.e", 
          "name": [
            "Department of Biology, School of Education, Waseda University, 169-50, Shinjuku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Kazutoshi", 
        "id": "sg:person.01202427225.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202427225.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Tsukuba Research Laboratories, Eisai Co. Ltd., 300-26, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.420377.5", 
          "name": [
            "Tsukuba Research Laboratories, Eisai Co. Ltd., 300-26, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ogura", 
        "givenName": "Hiroo", 
        "id": "sg:person.01226364701.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226364701.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Osaka Prefectural College of Health Sciences, 583, Habikino, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Osaka Prefectural College of Health Sciences, 583, Habikino, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamano", 
        "givenName": "Mariko", 
        "id": "sg:person.016530424405.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016530424405.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419280.6", 
          "name": [
            "Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamada", 
        "givenName": "Kazuyuki", 
        "id": "sg:person.015346225322.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015346225322.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419280.6", 
          "name": [
            "Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maeno", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01077575015.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077575015.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Anatomy, Nippon Medical School, 113, BunkyoJapan, Tokyo", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Anatomy, Nippon Medical School, 113, BunkyoJapan, Tokyo"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Imaki", 
        "givenName": "Junko", 
        "id": "sg:person.0726410022.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726410022.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biology, School of Education, Waseda University, 169-50, Shinjuku, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.5290.e", 
          "name": [
            "Department of Biology, School of Education, Waseda University, 169-50, Shinjuku, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kikuyama", 
        "givenName": "Sakae", 
        "id": "sg:person.01026512177.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026512177.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419280.6", 
          "name": [
            "Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wada", 
        "givenName": "Etsuko", 
        "id": "sg:person.0577551122.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577551122.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.419280.6", 
          "name": [
            "Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wada", 
        "givenName": "Keiji", 
        "id": "sg:person.0745404135.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745404135.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf02401419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011315753", 
          "https://doi.org/10.1007/bf02401419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1295-1311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052654931", 
          "https://doi.org/10.1038/nm1295-1311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-74781-6_3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035622667", 
          "https://doi.org/10.1007/978-3-642-74781-6_3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/364532a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053378436", 
          "https://doi.org/10.1038/364532a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0596-589", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001950089", 
          "https://doi.org/10.1038/nm0596-589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/326292a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050105118", 
          "https://doi.org/10.1038/326292a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm1195-1155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049565526", 
          "https://doi.org/10.1038/nm1195-1155"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-11", 
    "datePublishedReg": "1997-11-01", 
    "description": "Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism and behaviour1. They bind to G-protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors cloned so far include, gastrin-releasing peptide receptor (GRP-R)2,3, neuromedin B receptor (NMB-R)4,5, and bombesin receptor subtype-3 (BRS-3)6,7. However, despite the molecular characterization of BRS-3, determination of its function has been difficult as a result of its low affinity for bombesin and its lack of an identified natural ligand. We have generated BRS-3-deficient mice in an attempt to determine the in vivo function of the receptor. Mice lacking functional BRS-3 developed a mild obesity, associated with hypertension and impairment of glucose metabolism. They also exhibited reduced metabolic rate, increased feeding efficiency and subsequent hyperphagia. Our data suggest that BRS-3 is required for the regulation of endocrine processes and metabolism responsible for energy balance and adiposity. BRS-3-deficient mice provide a useful new model for the investigation of human obesity and associated diseases.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/36568", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6656", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "390"
      }
    ], 
    "keywords": [
      "BRS-3-deficient mice", 
      "bombesin receptor subtype-3", 
      "receptor subtype 3", 
      "BRS-3", 
      "subtype 3", 
      "peptide receptor", 
      "bombesin-like peptide receptors", 
      "gastrin-releasing peptide receptor", 
      "endocrine processes", 
      "smooth muscle contraction", 
      "central nervous system", 
      "neuromedin B receptor", 
      "mammalian bombesin-like peptides", 
      "bombesin-like peptides", 
      "protein-coupled receptors", 
      "mild obesity", 
      "gastrointestinal tract", 
      "subsequent hyperphagia", 
      "human obesity", 
      "glucose metabolism", 
      "nervous system", 
      "useful new model", 
      "metabolic defects", 
      "obesity", 
      "B receptor", 
      "mice", 
      "receptors", 
      "natural ligand", 
      "metabolism", 
      "metabolic rate", 
      "low affinity", 
      "cell surface", 
      "vivo function", 
      "hypertension", 
      "molecular characterization", 
      "adiposity", 
      "hyperphagia", 
      "exocrine", 
      "bombesin", 
      "disease", 
      "tract", 
      "impairment", 
      "contraction", 
      "NMB", 
      "energy balance", 
      "peptides", 
      "GRP", 
      "BRS", 
      "function", 
      "regulation", 
      "defects", 
      "rate", 
      "lack", 
      "effect", 
      "affinity", 
      "data", 
      "balance", 
      "investigation", 
      "ligands", 
      "results", 
      "attempt", 
      "behaviour1", 
      "model", 
      "process", 
      "characterization", 
      "determination", 
      "system", 
      "new model", 
      "surface", 
      "efficiency", 
      "functional BRS-3"
    ], 
    "name": "Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity", 
    "pagination": "165-169", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028396225"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/36568"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9367152"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/36568", 
      "https://app.dimensions.ai/details/publication/pub.1028396225"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_276.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/36568"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/36568'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/36568'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/36568'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/36568'


 

This table displays all metadata directly associated to this object as RDF triples.

331 TRIPLES      22 PREDICATES      126 URIs      111 LITERALS      28 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/36568 schema:about N13bc03ecddcb466f8fd9dba17075090f
2 N25716656ab084022bb602d559e656c11
3 N3479948cd0b0480aaceb87beadbfe673
4 N4d252e976e7a43fc87469e4243d18212
5 N5413debf13ca44e78f640e4f2103725c
6 N55831cf18dad4669b9e6bc9d02e93fe2
7 N82a7e606dc5a41faa1f7b845f9e7c834
8 N86e051ff4354481580f5ba713616355a
9 N873e996f7dcf4db59a86914dab0e3874
10 N92d1df01630c4216bf893e98d695913b
11 Na808ae41eb604405bd604de06d6ee6dd
12 Nb193397c9a434a8d8cf4d1fdb2bbc7f8
13 Nb4d6a567c1c64c00bbe786d298f919f8
14 Nbcdc103f36094a2c9d3718d73f3aafdd
15 Nd64a7001fb5e4997a7fb1f91b9beab40
16 Nda5a6ee4c1f34e6596daea4c3cd81675
17 Ne73e43e666364250a4923594d9aa9375
18 Ned12abc63ac742cca39c202506e1558a
19 Nf21827e65e9c4bc1a30544176757af2e
20 Nf21d531b3b3d4f419222bfa1d88a1e36
21 Nfdd8777d87f840adbe6091b5463b45e5
22 anzsrc-for:11
23 anzsrc-for:1115
24 schema:author N91a12e7d4633429b9089f6b48d8391cc
25 schema:citation sg:pub.10.1007/978-3-642-74781-6_3
26 sg:pub.10.1007/bf02401419
27 sg:pub.10.1038/326292a0
28 sg:pub.10.1038/364532a0
29 sg:pub.10.1038/nm0596-589
30 sg:pub.10.1038/nm1195-1155
31 sg:pub.10.1038/nm1295-1311
32 schema:datePublished 1997-11
33 schema:datePublishedReg 1997-11-01
34 schema:description Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism and behaviour1. They bind to G-protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors cloned so far include, gastrin-releasing peptide receptor (GRP-R)2,3, neuromedin B receptor (NMB-R)4,5, and bombesin receptor subtype-3 (BRS-3)6,7. However, despite the molecular characterization of BRS-3, determination of its function has been difficult as a result of its low affinity for bombesin and its lack of an identified natural ligand. We have generated BRS-3-deficient mice in an attempt to determine the in vivo function of the receptor. Mice lacking functional BRS-3 developed a mild obesity, associated with hypertension and impairment of glucose metabolism. They also exhibited reduced metabolic rate, increased feeding efficiency and subsequent hyperphagia. Our data suggest that BRS-3 is required for the regulation of endocrine processes and metabolism responsible for energy balance and adiposity. BRS-3-deficient mice provide a useful new model for the investigation of human obesity and associated diseases.
35 schema:genre article
36 schema:inLanguage en
37 schema:isAccessibleForFree false
38 schema:isPartOf N5dfd4d67a5fe481c87f55209eb8f8f9f
39 Nfdf18b86ec754cccaffcaec74da16aee
40 sg:journal.1018957
41 schema:keywords B receptor
42 BRS
43 BRS-3
44 BRS-3-deficient mice
45 GRP
46 NMB
47 adiposity
48 affinity
49 attempt
50 balance
51 behaviour1
52 bombesin
53 bombesin receptor subtype-3
54 bombesin-like peptide receptors
55 bombesin-like peptides
56 cell surface
57 central nervous system
58 characterization
59 contraction
60 data
61 defects
62 determination
63 disease
64 effect
65 efficiency
66 endocrine processes
67 energy balance
68 exocrine
69 function
70 functional BRS-3
71 gastrin-releasing peptide receptor
72 gastrointestinal tract
73 glucose metabolism
74 human obesity
75 hyperphagia
76 hypertension
77 impairment
78 investigation
79 lack
80 ligands
81 low affinity
82 mammalian bombesin-like peptides
83 metabolic defects
84 metabolic rate
85 metabolism
86 mice
87 mild obesity
88 model
89 molecular characterization
90 natural ligand
91 nervous system
92 neuromedin B receptor
93 new model
94 obesity
95 peptide receptor
96 peptides
97 process
98 protein-coupled receptors
99 rate
100 receptor subtype 3
101 receptors
102 regulation
103 results
104 smooth muscle contraction
105 subsequent hyperphagia
106 subtype 3
107 surface
108 system
109 tract
110 useful new model
111 vivo function
112 schema:name Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity
113 schema:pagination 165-169
114 schema:productId N91c233ae369c4d9c941b9791a9ac2e7a
115 N95b42135df4c43eaa91f0aa47fa50a3b
116 N96a80fd2e04d46ef85df72a9763f51b4
117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028396225
118 https://doi.org/10.1038/36568
119 schema:sdDatePublished 2022-01-01T18:07
120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
121 schema:sdPublisher N503d68cee53142409fdc81a75f1997c8
122 schema:url https://doi.org/10.1038/36568
123 sgo:license sg:explorer/license/
124 sgo:sdDataset articles
125 rdf:type schema:ScholarlyArticle
126 N0299d610f92b473ca31de8b2200f5135 rdf:first sg:person.01077575015.15
127 rdf:rest N68dae492d920479295885c2669e5d4e1
128 N13bc03ecddcb466f8fd9dba17075090f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Glucose
130 rdf:type schema:DefinedTerm
131 N25716656ab084022bb602d559e656c11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Gene Deletion
133 rdf:type schema:DefinedTerm
134 N3479948cd0b0480aaceb87beadbfe673 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Female
136 rdf:type schema:DefinedTerm
137 N388212b381b148d9a2f36752891e161c rdf:first sg:person.01202427225.51
138 rdf:rest N8f3545abea2f410494921982a01cea60
139 N42b805ac72fd4c44b55ae72294cb3f1b rdf:first sg:person.01074465557.63
140 rdf:rest N388212b381b148d9a2f36752891e161c
141 N4d252e976e7a43fc87469e4243d18212 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Adipose Tissue, Brown
143 rdf:type schema:DefinedTerm
144 N503d68cee53142409fdc81a75f1997c8 schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N5413debf13ca44e78f640e4f2103725c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Metabolic Diseases
148 rdf:type schema:DefinedTerm
149 N55831cf18dad4669b9e6bc9d02e93fe2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Blood Pressure
151 rdf:type schema:DefinedTerm
152 N5dfd4d67a5fe481c87f55209eb8f8f9f schema:volumeNumber 390
153 rdf:type schema:PublicationVolume
154 N68dae492d920479295885c2669e5d4e1 rdf:first sg:person.0726410022.88
155 rdf:rest Nf4b40e9ab0f341f9a270f03d6ed2a95c
156 N7a9ee4a39fe74cf1b60c0693e15618e9 rdf:first sg:person.0745404135.33
157 rdf:rest rdf:nil
158 N82a7e606dc5a41faa1f7b845f9e7c834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Energy Metabolism
160 rdf:type schema:DefinedTerm
161 N86e051ff4354481580f5ba713616355a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Proteins
163 rdf:type schema:DefinedTerm
164 N873e996f7dcf4db59a86914dab0e3874 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Mice
166 rdf:type schema:DefinedTerm
167 N8f3545abea2f410494921982a01cea60 rdf:first sg:person.01226364701.01
168 rdf:rest Nc9fb3afdd5b848b7ad12c4d1a1bde120
169 N91a12e7d4633429b9089f6b48d8391cc rdf:first sg:person.01353745042.84
170 rdf:rest N42b805ac72fd4c44b55ae72294cb3f1b
171 N91c233ae369c4d9c941b9791a9ac2e7a schema:name pubmed_id
172 schema:value 9367152
173 rdf:type schema:PropertyValue
174 N92d1df01630c4216bf893e98d695913b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Glucose Tolerance Test
176 rdf:type schema:DefinedTerm
177 N95b42135df4c43eaa91f0aa47fa50a3b schema:name doi
178 schema:value 10.1038/36568
179 rdf:type schema:PropertyValue
180 N96a80fd2e04d46ef85df72a9763f51b4 schema:name dimensions_id
181 schema:value pub.1028396225
182 rdf:type schema:PropertyValue
183 N99a3b9f3847d416f990110359d14d304 rdf:first sg:person.015346225322.20
184 rdf:rest N0299d610f92b473ca31de8b2200f5135
185 Na808ae41eb604405bd604de06d6ee6dd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Heart Rate
187 rdf:type schema:DefinedTerm
188 Nb193397c9a434a8d8cf4d1fdb2bbc7f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Male
190 rdf:type schema:DefinedTerm
191 Nb4d6a567c1c64c00bbe786d298f919f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Gene Targeting
193 rdf:type schema:DefinedTerm
194 Nbcdc103f36094a2c9d3718d73f3aafdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Receptors, Bombesin
196 rdf:type schema:DefinedTerm
197 Nc9fb3afdd5b848b7ad12c4d1a1bde120 rdf:first sg:person.016530424405.75
198 rdf:rest N99a3b9f3847d416f990110359d14d304
199 Nd64a7001fb5e4997a7fb1f91b9beab40 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Mice, Inbred ICR
201 rdf:type schema:DefinedTerm
202 Nda5a6ee4c1f34e6596daea4c3cd81675 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Animals
204 rdf:type schema:DefinedTerm
205 Ne73e43e666364250a4923594d9aa9375 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Leptin
207 rdf:type schema:DefinedTerm
208 Ned12abc63ac742cca39c202506e1558a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Hormones
210 rdf:type schema:DefinedTerm
211 Ned8fcbf25a1845c6b28c37d935bab79c rdf:first sg:person.0577551122.97
212 rdf:rest N7a9ee4a39fe74cf1b60c0693e15618e9
213 Nf21827e65e9c4bc1a30544176757af2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Body Weight
215 rdf:type schema:DefinedTerm
216 Nf21d531b3b3d4f419222bfa1d88a1e36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Obesity
218 rdf:type schema:DefinedTerm
219 Nf4b40e9ab0f341f9a270f03d6ed2a95c rdf:first sg:person.01026512177.10
220 rdf:rest Ned8fcbf25a1845c6b28c37d935bab79c
221 Nfdd8777d87f840adbe6091b5463b45e5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Motor Activity
223 rdf:type schema:DefinedTerm
224 Nfdf18b86ec754cccaffcaec74da16aee schema:issueNumber 6656
225 rdf:type schema:PublicationIssue
226 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
227 schema:name Medical and Health Sciences
228 rdf:type schema:DefinedTerm
229 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
230 schema:name Pharmacology and Pharmaceutical Sciences
231 rdf:type schema:DefinedTerm
232 sg:journal.1018957 schema:issn 0028-0836
233 1476-4687
234 schema:name Nature
235 schema:publisher Springer Nature
236 rdf:type schema:Periodical
237 sg:person.01026512177.10 schema:affiliation grid-institutes:grid.5290.e
238 schema:familyName Kikuyama
239 schema:givenName Sakae
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01026512177.10
241 rdf:type schema:Person
242 sg:person.01074465557.63 schema:affiliation grid-institutes:grid.419280.6
243 schema:familyName Watase
244 schema:givenName Kei
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074465557.63
246 rdf:type schema:Person
247 sg:person.01077575015.15 schema:affiliation grid-institutes:grid.419280.6
248 schema:familyName Maeno
249 schema:givenName Hiroshi
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077575015.15
251 rdf:type schema:Person
252 sg:person.01202427225.51 schema:affiliation grid-institutes:grid.5290.e
253 schema:familyName Yamamoto
254 schema:givenName Kazutoshi
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202427225.51
256 rdf:type schema:Person
257 sg:person.01226364701.01 schema:affiliation grid-institutes:grid.420377.5
258 schema:familyName Ogura
259 schema:givenName Hiroo
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01226364701.01
261 rdf:type schema:Person
262 sg:person.01353745042.84 schema:affiliation grid-institutes:grid.417113.1
263 schema:familyName Ohki-Hamazaki
264 schema:givenName Hiroko
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353745042.84
266 rdf:type schema:Person
267 sg:person.015346225322.20 schema:affiliation grid-institutes:grid.419280.6
268 schema:familyName Yamada
269 schema:givenName Kazuyuki
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015346225322.20
271 rdf:type schema:Person
272 sg:person.016530424405.75 schema:affiliation grid-institutes:None
273 schema:familyName Yamano
274 schema:givenName Mariko
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016530424405.75
276 rdf:type schema:Person
277 sg:person.0577551122.97 schema:affiliation grid-institutes:grid.419280.6
278 schema:familyName Wada
279 schema:givenName Etsuko
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577551122.97
281 rdf:type schema:Person
282 sg:person.0726410022.88 schema:affiliation grid-institutes:grid.410821.e
283 schema:familyName Imaki
284 schema:givenName Junko
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726410022.88
286 rdf:type schema:Person
287 sg:person.0745404135.33 schema:affiliation grid-institutes:grid.419280.6
288 schema:familyName Wada
289 schema:givenName Keiji
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745404135.33
291 rdf:type schema:Person
292 sg:pub.10.1007/978-3-642-74781-6_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035622667
293 https://doi.org/10.1007/978-3-642-74781-6_3
294 rdf:type schema:CreativeWork
295 sg:pub.10.1007/bf02401419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011315753
296 https://doi.org/10.1007/bf02401419
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/326292a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050105118
299 https://doi.org/10.1038/326292a0
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/364532a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053378436
302 https://doi.org/10.1038/364532a0
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/nm0596-589 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001950089
305 https://doi.org/10.1038/nm0596-589
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/nm1195-1155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049565526
308 https://doi.org/10.1038/nm1195-1155
309 rdf:type schema:CreativeWork
310 sg:pub.10.1038/nm1295-1311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052654931
311 https://doi.org/10.1038/nm1295-1311
312 rdf:type schema:CreativeWork
313 grid-institutes:None schema:alternateName Osaka Prefectural College of Health Sciences, 583, Habikino, Osaka, Japan
314 schema:name Osaka Prefectural College of Health Sciences, 583, Habikino, Osaka, Japan
315 rdf:type schema:Organization
316 grid-institutes:grid.410821.e schema:alternateName Department of Anatomy, Nippon Medical School, 113, BunkyoJapan, Tokyo
317 schema:name Department of Anatomy, Nippon Medical School, 113, BunkyoJapan, Tokyo
318 rdf:type schema:Organization
319 grid-institutes:grid.417113.1 schema:alternateName Department of Neurochemistry, Tokyo Institute of Psychiatry, 156, Setagaya, Tokyo, Japan
320 schema:name Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan
321 Department of Neurochemistry, Tokyo Institute of Psychiatry, 156, Setagaya, Tokyo, Japan
322 rdf:type schema:Organization
323 grid-institutes:grid.419280.6 schema:alternateName Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan
324 schema:name Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 187, Kodaira, Tokyo, Japan
325 rdf:type schema:Organization
326 grid-institutes:grid.420377.5 schema:alternateName Tsukuba Research Laboratories, Eisai Co. Ltd., 300-26, Tsukuba, Ibaraki, Japan
327 schema:name Tsukuba Research Laboratories, Eisai Co. Ltd., 300-26, Tsukuba, Ibaraki, Japan
328 rdf:type schema:Organization
329 grid-institutes:grid.5290.e schema:alternateName Department of Biology, School of Education, Waseda University, 169-50, Shinjuku, Tokyo, Japan
330 schema:name Department of Biology, School of Education, Waseda University, 169-50, Shinjuku, Tokyo, Japan
331 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...