The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-10-01

AUTHORS

Miguel Estevez, Liliana Attisano, Jeffrey L. Wrana, Patrice S. Albert, Joan Massagué, Donald L. Riddle

ABSTRACT

THE bone morphogenetic protein (BMP) family is a conserved group of signalling molecules within the transforming growth fact-or-β (TGF-β) superfamily1,2. This group, including theDrosophila decapentaplegic (dpp) protein and the mammalian BMPs, mediates cellular interactions and tissue differentiation during development3,4. Here we show that a homologue of human BMPs controls a developmental switch in the life cycle of the free-living soil nematode Caenorhabditis elegans. Starvation and overcrowding induce C. elegans to form a developmentally arrested, third-stage dauer larva5. The daf-4 gene, which acts to inhibit dauer larva formation and promote growth, encodes a receptor protein kinase similar to the daf-1, activin and TGF-β receptor serine/ threonine kinases. When expressed in monkey COS cells, thedaf-4receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family. More... »

PAGES

644-649

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

6447

VOLUME

365

Related Patents

  • Materials And Methods For Inducing Regulatory T Cells
  • Cdna Encoding A Bmp Type Ii Receptor
  • Bone Morphogenic Protein Receptor; For Diagnosis And Treatment Of Bone Disorders; For Detection Of Modulators Of Eceptor Binding Activity
  • Methods Of Antagonizing Op-1 Binding To A Cell Surface Receptor Utilizing Alk Polypeptides
  • Administering Dimeric Protein As Gastrointestinal Or Bone Tissue Specific Cell Differentiating Agent
  • Therapeutic And Diagnostic Tools For Impaired Glucose Tolerance Conditions
  • Cdna Encoding A Bmp Type Ii Receptor
  • Therapeutic And Diagnostic Tools For Impaired Glucose Tolerance Conditions
  • Use To Provide Nucleic Acids And Amino Acid Sequences For Osteogenic Protein (Op) Specific Binding Receptor Sequences To Develop Morphogen Receptor Binding Analogs Able To Mimic Receptor Binding For Use In Research, Diagnosis And Therapy
  • Injectable Calcium Phosphate Solid Rods And Pastes For Delivery Of Osteogenic Proteins
  • Therapeutic And Diagnostic Tools For Impaired Glucose Tolerance Conditions
  • Method For Identifying An Op-1 Analog Which Binds An Alk-1 Receptor
  • Use Of A Bmp Protein Receptor Complex For Screening Bone Metabolism Actives And Cells Co-Transfected With A Type Ii Bmp Receptor And Type I Bmp Receptor
  • Gastrointestinal Disorders; Antiulcer Agents
  • Therapeutic And Diagnostic Tools For Impaired Glucose Tolerance Conditions
  • Detecting Modulator Of Preferential Gene Expression; Obtain Cell From Human Or Nematode, Incubate Cells With Modulator, Monitor Cells For Decrease In Preferential Gene Expresssion
  • Detect Compound Which Binds To Bone Morphogenic Protein Receptors; Obtain Sample, Incubate With Binding Agent, Allow Binding, Detect Complex Formation Between Binding Agent And Receptors
  • Method For Predicting And/Or Preventing Preterm Labor
  • Methods Of Identifying Morphogen Receptor-Binding Analogs
  • Compositions For Maintaining The Integrity Of The Gastrointestinal Tract Luminal Lining In A Mammal, Including (1) Limiting Epithelial Cell Proliferation, (2) Inhibiting Ulcerative Lesion Formation, (3) Inhibiting Inflammation
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/365644a0

    DOI

    http://dx.doi.org/10.1038/365644a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1010736673

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8413626


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals, Genetically Modified", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Bone Morphogenetic Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Caenorhabditis elegans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Caenorhabditis elegans Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cell Line", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA Transposable Elements", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Growth", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Haplorhini", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Helminth Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Larva", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Binding", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Protein Serine-Threonine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptor Protein-Tyrosine Kinases", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Transforming Growth Factor beta", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Recombinant Proteins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Sequence Homology, Amino Acid", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, 65211, Columbia, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.134936.a", 
              "name": [
                "Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, 65211, Columbia, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Estevez", 
            "givenName": "Miguel", 
            "id": "sg:person.01023403264.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023403264.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Memorial Sloan-Kettering Cancer Center, Howard Hughes Medical Institute, Cell Biology and Genetics Program, 1275 York Avenue, 10021, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Memorial Sloan-Kettering Cancer Center, Howard Hughes Medical Institute, Cell Biology and Genetics Program, 1275 York Avenue, 10021, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Attisano", 
            "givenName": "Liliana", 
            "id": "sg:person.0626544736.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626544736.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Memorial Sloan-Kettering Cancer Center, Howard Hughes Medical Institute, Cell Biology and Genetics Program, 1275 York Avenue, 10021, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Memorial Sloan-Kettering Cancer Center, Howard Hughes Medical Institute, Cell Biology and Genetics Program, 1275 York Avenue, 10021, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wrana", 
            "givenName": "Jeffrey L.", 
            "id": "sg:person.01242174727.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242174727.43"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, 65211, Columbia, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.134936.a", 
              "name": [
                "Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, 65211, Columbia, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Albert", 
            "givenName": "Patrice S.", 
            "id": "sg:person.01114452650.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114452650.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Memorial Sloan-Kettering Cancer Center, Howard Hughes Medical Institute, Cell Biology and Genetics Program, 1275 York Avenue, 10021, New York, New York, USA", 
              "id": "http://www.grid.ac/institutes/grid.51462.34", 
              "name": [
                "Memorial Sloan-Kettering Cancer Center, Howard Hughes Medical Institute, Cell Biology and Genetics Program, 1275 York Avenue, 10021, New York, New York, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Massagu\u00e9", 
            "givenName": "Joan", 
            "id": "sg:person.0701107767.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701107767.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, 65211, Columbia, Missouri, USA", 
              "id": "http://www.grid.ac/institutes/grid.134936.a", 
              "name": [
                "Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, 65211, Columbia, Missouri, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Riddle", 
            "givenName": "Donald L.", 
            "id": "sg:person.0741240470.74", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741240470.74"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/361068a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051052317", 
              "https://doi.org/10.1038/361068a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/290668a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028873354", 
              "https://doi.org/10.1038/290668a0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1993-10-01", 
        "datePublishedReg": "1993-10-01", 
        "description": "THE bone morphogenetic protein (BMP) family is a conserved group of signalling molecules within the transforming growth fact-or-\u03b2 (TGF-\u03b2) superfamily1,2. This group, including theDrosophila decapentaplegic (dpp) protein and the mammalian BMPs, mediates cellular interactions and tissue differentiation during development3,4. Here we show that a homologue of human BMPs controls a developmental switch in the life cycle of the free-living soil nematode Caenorhabditis elegans. Starvation and overcrowding induce C. elegans to form a developmentally arrested, third-stage dauer larva5. The daf-4 gene, which acts to inhibit dauer larva formation and promote growth, encodes a receptor protein kinase similar to the daf-1, activin and TGF-\u03b2 receptor serine/ threonine kinases. When expressed in monkey COS cells, thedaf-4receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family.", 
        "genre": "article", 
        "id": "sg:pub.10.1038/365644a0", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0028-0836", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6447", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "365"
          }
        ], 
        "keywords": [
          "C. elegans", 
          "bone morphogenetic protein (BMP) family", 
          "bone morphogenetic protein receptor", 
          "dauer larva formation", 
          "living soil nematode Caenorhabditis", 
          "serine/ threonine kinase", 
          "receptor protein kinase", 
          "monkey COS cells", 
          "soil nematode Caenorhabditis", 
          "morphogenetic protein receptor", 
          "larva formation", 
          "conserved group", 
          "nematode Caenorhabditis", 
          "threonine kinase", 
          "protein family", 
          "decapentaplegic protein", 
          "BMP family", 
          "DAF-1", 
          "protein kinase", 
          "developmental switch", 
          "BMP-4", 
          "COS cells", 
          "human BMP-2", 
          "larvae development", 
          "protein receptors", 
          "tissue differentiation", 
          "cellular interactions", 
          "human BMP", 
          "BMP-2", 
          "elegans", 
          "kinase", 
          "BMP", 
          "genes", 
          "life cycle", 
          "growth factor", 
          "Caenorhabditis", 
          "family", 
          "homologues", 
          "receptors", 
          "protein", 
          "starvation", 
          "differentiation", 
          "activin", 
          "cells", 
          "growth", 
          "molecules", 
          "growth facts", 
          "interaction", 
          "switch", 
          "cycle", 
          "formation", 
          "development", 
          "factors", 
          "group", 
          "fact"
        ], 
        "name": "The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development", 
        "pagination": "644-649", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1010736673"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/365644a0"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "8413626"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/365644a0", 
          "https://app.dimensions.ai/details/publication/pub.1010736673"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T20:46", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_229.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1038/365644a0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/365644a0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/365644a0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/365644a0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/365644a0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    258 TRIPLES      21 PREDICATES      106 URIs      95 LITERALS      30 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/365644a0 schema:about N1392afdc4d7a43058b1c972c87933179
    2 N25dd8507117d49efb06826018c36064e
    3 N2928efe031474d76819dff7f2de2224f
    4 N2bc975c9328e4fccb28958788c841e1d
    5 N3aa194fa38b14acfaa78477c950ee685
    6 N414f4bb2e5e54d309fa6b48405524bdd
    7 N53f55de1e51542fe94680f32e6ad7a3d
    8 N62a1dc090db74bb48f98fa9a05810d88
    9 N63a14de0906e4994b6b8f9ad10eccda1
    10 N68a0f016043e46cdad26518fb5643ea1
    11 N6ca8b4371e4a40519e3889540f0a4db8
    12 N93b9f50ff51e43b9bb6c31b162f81bd1
    13 N971e0f8ffbd3473fa43ce36b1b836da0
    14 N9779c658fd2f4f7baa7146491a029e0f
    15 Na3006fd6359c44639a36ef2f69769354
    16 Nb03fcd29fb434259a3d502305c39b8c4
    17 Nb83fafbfb9d94b29ab8cde5416723850
    18 Nc208e4d34e35442797a05cc7a6093283
    19 Ncfb534cf41ad4dce897343fc81bf0b85
    20 Ndf396e5a7a09426c8b624ef61336b975
    21 Neefff231059a4762a13ddf667f52ac8a
    22 Nf74d8066e50a42cda7abebf7241db45d
    23 Nffcbc30f48cd473cba472849440ac624
    24 anzsrc-for:06
    25 anzsrc-for:0601
    26 anzsrc-for:0604
    27 schema:author N1e762cacdbf24a63a4a5daa086f51797
    28 schema:citation sg:pub.10.1038/290668a0
    29 sg:pub.10.1038/361068a0
    30 schema:datePublished 1993-10-01
    31 schema:datePublishedReg 1993-10-01
    32 schema:description THE bone morphogenetic protein (BMP) family is a conserved group of signalling molecules within the transforming growth fact-or-β (TGF-β) superfamily1,2. This group, including theDrosophila decapentaplegic (dpp) protein and the mammalian BMPs, mediates cellular interactions and tissue differentiation during development3,4. Here we show that a homologue of human BMPs controls a developmental switch in the life cycle of the free-living soil nematode Caenorhabditis elegans. Starvation and overcrowding induce C. elegans to form a developmentally arrested, third-stage dauer larva5. The daf-4 gene, which acts to inhibit dauer larva formation and promote growth, encodes a receptor protein kinase similar to the daf-1, activin and TGF-β receptor serine/ threonine kinases. When expressed in monkey COS cells, thedaf-4receptor binds human BMP-2 and BMP-4. The daf-4 receptor is the first to be identified for any growth factor in the BMP family.
    33 schema:genre article
    34 schema:isAccessibleForFree false
    35 schema:isPartOf N294c9cb753704b008d8e2d6df1071d4c
    36 Nb856e29cf7ca49ff81dfd5626f2edbca
    37 sg:journal.1018957
    38 schema:keywords BMP
    39 BMP family
    40 BMP-2
    41 BMP-4
    42 C. elegans
    43 COS cells
    44 Caenorhabditis
    45 DAF-1
    46 activin
    47 bone morphogenetic protein (BMP) family
    48 bone morphogenetic protein receptor
    49 cells
    50 cellular interactions
    51 conserved group
    52 cycle
    53 dauer larva formation
    54 decapentaplegic protein
    55 development
    56 developmental switch
    57 differentiation
    58 elegans
    59 fact
    60 factors
    61 family
    62 formation
    63 genes
    64 group
    65 growth
    66 growth factor
    67 growth facts
    68 homologues
    69 human BMP
    70 human BMP-2
    71 interaction
    72 kinase
    73 larva formation
    74 larvae development
    75 life cycle
    76 living soil nematode Caenorhabditis
    77 molecules
    78 monkey COS cells
    79 morphogenetic protein receptor
    80 nematode Caenorhabditis
    81 protein
    82 protein family
    83 protein kinase
    84 protein receptors
    85 receptor protein kinase
    86 receptors
    87 serine/ threonine kinase
    88 soil nematode Caenorhabditis
    89 starvation
    90 switch
    91 threonine kinase
    92 tissue differentiation
    93 schema:name The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development
    94 schema:pagination 644-649
    95 schema:productId N28f3aafd4cf14fb6a4c7abb76e7b8e7b
    96 N79ffb90522ef4e85b5095746f70d35be
    97 N809c1b4a99a64735b1b6873a23746e19
    98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010736673
    99 https://doi.org/10.1038/365644a0
    100 schema:sdDatePublished 2022-11-24T20:46
    101 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    102 schema:sdPublisher Nfad50d78e3a24bbfa25461555729c602
    103 schema:url https://doi.org/10.1038/365644a0
    104 sgo:license sg:explorer/license/
    105 sgo:sdDataset articles
    106 rdf:type schema:ScholarlyArticle
    107 N1392afdc4d7a43058b1c972c87933179 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Caenorhabditis elegans
    109 rdf:type schema:DefinedTerm
    110 N1e762cacdbf24a63a4a5daa086f51797 rdf:first sg:person.01023403264.23
    111 rdf:rest Nc76b49db98cc44e79f4bb5c60b50be19
    112 N25dd8507117d49efb06826018c36064e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Sequence Homology, Amino Acid
    114 rdf:type schema:DefinedTerm
    115 N28f3aafd4cf14fb6a4c7abb76e7b8e7b schema:name dimensions_id
    116 schema:value pub.1010736673
    117 rdf:type schema:PropertyValue
    118 N2928efe031474d76819dff7f2de2224f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    119 schema:name Receptors, Transforming Growth Factor beta
    120 rdf:type schema:DefinedTerm
    121 N294c9cb753704b008d8e2d6df1071d4c schema:issueNumber 6447
    122 rdf:type schema:PublicationIssue
    123 N2bc975c9328e4fccb28958788c841e1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Protein Serine-Threonine Kinases
    125 rdf:type schema:DefinedTerm
    126 N35882090f306462babc82df101f4b7fe rdf:first sg:person.01114452650.45
    127 rdf:rest N3b1a41e4012543849849a072209cc927
    128 N3aa194fa38b14acfaa78477c950ee685 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Animals, Genetically Modified
    130 rdf:type schema:DefinedTerm
    131 N3b1a41e4012543849849a072209cc927 rdf:first sg:person.0701107767.38
    132 rdf:rest Nd1a8ad9af3d6427d98f53fdec54b704a
    133 N3e7598bfbdd1404b8503954c29187bd0 rdf:first sg:person.01242174727.43
    134 rdf:rest N35882090f306462babc82df101f4b7fe
    135 N414f4bb2e5e54d309fa6b48405524bdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    136 schema:name Larva
    137 rdf:type schema:DefinedTerm
    138 N53f55de1e51542fe94680f32e6ad7a3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Proteins
    140 rdf:type schema:DefinedTerm
    141 N62a1dc090db74bb48f98fa9a05810d88 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    142 schema:name Protein Binding
    143 rdf:type schema:DefinedTerm
    144 N63a14de0906e4994b6b8f9ad10eccda1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    145 schema:name Caenorhabditis elegans Proteins
    146 rdf:type schema:DefinedTerm
    147 N68a0f016043e46cdad26518fb5643ea1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name DNA Transposable Elements
    149 rdf:type schema:DefinedTerm
    150 N6ca8b4371e4a40519e3889540f0a4db8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Humans
    152 rdf:type schema:DefinedTerm
    153 N79ffb90522ef4e85b5095746f70d35be schema:name pubmed_id
    154 schema:value 8413626
    155 rdf:type schema:PropertyValue
    156 N809c1b4a99a64735b1b6873a23746e19 schema:name doi
    157 schema:value 10.1038/365644a0
    158 rdf:type schema:PropertyValue
    159 N93b9f50ff51e43b9bb6c31b162f81bd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Molecular Sequence Data
    161 rdf:type schema:DefinedTerm
    162 N971e0f8ffbd3473fa43ce36b1b836da0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Growth
    164 rdf:type schema:DefinedTerm
    165 N9779c658fd2f4f7baa7146491a029e0f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name Helminth Proteins
    167 rdf:type schema:DefinedTerm
    168 Na3006fd6359c44639a36ef2f69769354 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Haplorhini
    170 rdf:type schema:DefinedTerm
    171 Nb03fcd29fb434259a3d502305c39b8c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Bone Morphogenetic Proteins
    173 rdf:type schema:DefinedTerm
    174 Nb83fafbfb9d94b29ab8cde5416723850 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name DNA
    176 rdf:type schema:DefinedTerm
    177 Nb856e29cf7ca49ff81dfd5626f2edbca schema:volumeNumber 365
    178 rdf:type schema:PublicationVolume
    179 Nc208e4d34e35442797a05cc7a6093283 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    180 schema:name Cell Line
    181 rdf:type schema:DefinedTerm
    182 Nc76b49db98cc44e79f4bb5c60b50be19 rdf:first sg:person.0626544736.34
    183 rdf:rest N3e7598bfbdd1404b8503954c29187bd0
    184 Ncfb534cf41ad4dce897343fc81bf0b85 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Animals
    186 rdf:type schema:DefinedTerm
    187 Nd1a8ad9af3d6427d98f53fdec54b704a rdf:first sg:person.0741240470.74
    188 rdf:rest rdf:nil
    189 Ndf396e5a7a09426c8b624ef61336b975 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    190 schema:name Recombinant Proteins
    191 rdf:type schema:DefinedTerm
    192 Neefff231059a4762a13ddf667f52ac8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    193 schema:name Receptor Protein-Tyrosine Kinases
    194 rdf:type schema:DefinedTerm
    195 Nf74d8066e50a42cda7abebf7241db45d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Base Sequence
    197 rdf:type schema:DefinedTerm
    198 Nfad50d78e3a24bbfa25461555729c602 schema:name Springer Nature - SN SciGraph project
    199 rdf:type schema:Organization
    200 Nffcbc30f48cd473cba472849440ac624 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    201 schema:name Amino Acid Sequence
    202 rdf:type schema:DefinedTerm
    203 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    204 schema:name Biological Sciences
    205 rdf:type schema:DefinedTerm
    206 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    207 schema:name Biochemistry and Cell Biology
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Genetics
    211 rdf:type schema:DefinedTerm
    212 sg:journal.1018957 schema:issn 0028-0836
    213 1476-4687
    214 schema:name Nature
    215 schema:publisher Springer Nature
    216 rdf:type schema:Periodical
    217 sg:person.01023403264.23 schema:affiliation grid-institutes:grid.134936.a
    218 schema:familyName Estevez
    219 schema:givenName Miguel
    220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023403264.23
    221 rdf:type schema:Person
    222 sg:person.01114452650.45 schema:affiliation grid-institutes:grid.134936.a
    223 schema:familyName Albert
    224 schema:givenName Patrice S.
    225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114452650.45
    226 rdf:type schema:Person
    227 sg:person.01242174727.43 schema:affiliation grid-institutes:grid.51462.34
    228 schema:familyName Wrana
    229 schema:givenName Jeffrey L.
    230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242174727.43
    231 rdf:type schema:Person
    232 sg:person.0626544736.34 schema:affiliation grid-institutes:grid.51462.34
    233 schema:familyName Attisano
    234 schema:givenName Liliana
    235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0626544736.34
    236 rdf:type schema:Person
    237 sg:person.0701107767.38 schema:affiliation grid-institutes:grid.51462.34
    238 schema:familyName Massagué
    239 schema:givenName Joan
    240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701107767.38
    241 rdf:type schema:Person
    242 sg:person.0741240470.74 schema:affiliation grid-institutes:grid.134936.a
    243 schema:familyName Riddle
    244 schema:givenName Donald L.
    245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0741240470.74
    246 rdf:type schema:Person
    247 sg:pub.10.1038/290668a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028873354
    248 https://doi.org/10.1038/290668a0
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1038/361068a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051052317
    251 https://doi.org/10.1038/361068a0
    252 rdf:type schema:CreativeWork
    253 grid-institutes:grid.134936.a schema:alternateName Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, 65211, Columbia, Missouri, USA
    254 schema:name Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, 65211, Columbia, Missouri, USA
    255 rdf:type schema:Organization
    256 grid-institutes:grid.51462.34 schema:alternateName Memorial Sloan-Kettering Cancer Center, Howard Hughes Medical Institute, Cell Biology and Genetics Program, 1275 York Avenue, 10021, New York, New York, USA
    257 schema:name Memorial Sloan-Kettering Cancer Center, Howard Hughes Medical Institute, Cell Biology and Genetics Program, 1275 York Avenue, 10021, New York, New York, USA
    258 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...