Crystal structure of a yeast TBP/TATA-box complex View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-10

AUTHORS

Y Kim, J H Geiger, S Hahn, P B Sigler

ABSTRACT

The 2.5 A crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the concave surface of TBP by bending towards the major groove with unprecedented severity. This produces a wide open, underwound, shallow minor groove which forms a primarily hydrophobic interface with the entire under-surface of the TBP saddle. The severe bend and a positive writhe radically alter the trajectory of the flanking B-form DNA. More... »

PAGES

512-520

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/365512a0

DOI

http://dx.doi.org/10.1038/365512a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045509514

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8413604


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