Molecular characterization of a peripheral receptor for cannabinoids View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-09

AUTHORS

S Munro, K L Thomas, M Abu-Shaar

ABSTRACT

The major active ingredient of marijuana, delta 9-tetrahydrocannabinol (delta 9-THC), has been used as a psychoactive agent for thousands of years. Marijuana, and delta 9-THC, also exert a wide range of other effects including analgesia, anti-inflammation, immunosuppression, anticonvulsion, alleviation of intraocular pressure in glaucoma, and attenuation of vomiting. The clinical application of cannabinoids has, however, been limited by their psychoactive effects, and this has led to interest in the biochemical bases of their action. Progress stemmed initially from the synthesis of potent derivatives of delta 9-THC, and more recently from the cloning of a gene encoding a G-protein-coupled receptor for cannabinoids. This receptor is expressed in the brain but not in the periphery, except for a low level in testes. It has been proposed that the nonpsychoactive effects of cannabinoids are either mediated centrally or through direct interaction with other, non-receptor proteins. Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen. More... »

PAGES

61-65

Journal

TITLE

Nature

ISSUE

6441

VOLUME

365

Related Patents

  • Hexahydro-Cyclooctyl Pyrazole Cannabinoid Modulators
  • Pyrazole Derivatives As Cannabinoid Receptor Modulators
  • Triazolopyridine Cannabinoid Receptor 1 Antagonists
  • Bicyclic Heterocycles As Cannabinoid-1 Receptor Modulators
  • Di-Azetidinyl Diamide As Monoacylglcerol Lipase Inhibitors
  • Classical Cannabinoid Metabolites And Methods Of Use Thereof
  • Heteroaromatic And Aromatic Piperazinyl Azetidinyl Amides As Monoacylglycerol Lipase Inhibitors
  • Use Of Novel Compounds For Ibd Treatment
  • Anandamide-Modified Nucleic Acid Molecules
  • Anti-Cancer Nanoparticle Compositions And Methods Of Use
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Methods, Kits And Pharmaceutical Compositions For Diagnosing, Delaying Onset Of, Preventing And/Or Treating Osteoporosis
  • Non-Endogenous, Constitutively Activated Known G Protein-Coupled Receptors
  • Pyrazolo[1,5-A] Pyrimidine Compounds As Cb1 Receptor Antagonist
  • Stilbenoid Derivatives And Their Uses
  • Pyrazolo[1,5-A] Pyrimidine Compounds As Cb1 Receptor Antagonist
  • Crystal Structure Of Monoacylglycerol Lipase (Mgll)
  • Reporter Gene Constructs For Pet
  • Methods Compositions And Articles Of Manufacture For Modulating Bone Growth
  • Alternative Crystal Form Of Monoacylglycerol Lipase (Mgll)
  • Cannabinoid 2 (Cb2) Receptor Gene Promoter And Unique Rna Transcripts In B Cells And Methods Of Use
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Piperidin-4-Yl-Azetidine Diamides As Monoacylglycerol Lipase Inhibitors
  • Cannabinoid Receptor Binding Agents, Compositions And Methods
  • 1h-Imidazole Derivatives Having Cb1 Agonistic, Cb1 Partial Agonistic Or Cb1-Antagonistic Activity
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Medicinal Composition Containing 1,3-Thiazine Derivative
  • Heterocyclic Modulators Of Cannabinoid Receptors
  • Inflammation Therapy
  • Heterocyclic Modulators Of Cannabinoid Receptors
  • Non-Endogenous, Constitutively Activated Known G Protein-Coupled Receptors
  • Hydrazone Modulators Of Cannabinoid Receptors
  • Oxopiperazine-Azetidine Amides And Oxodiazepine-Azetidine Amides As Monoacylglycerol Lipase Inhibitors
  • Amino-Pyrrolidine-Azetidine Diamides As Monoacylglycerol Lipase Inhibitors
  • N-Sulfonylpiperidine Cannabinoid Receptor 1 Antagonists
  • Anti-Cancer Nanoparticle Compositions And Methods Of Use
  • Alternative Crystal Form Of Monoacylglycerol Lipase (Mgll)
  • Heteroaromatic And Aromatic Piperazinyl Azetidinyl Amides As Monoacylglycerol Lipase Inhibitors
  • Pyridone Derivatives Having A Binding Activity To The Cannabinoid Type 2 Receptor
  • Triazolopyrimidine Cannabinoid Receptor 1 Antagonists
  • Crystalline Forms And Processes For The Preparation Of Cannabinoid Receptor Modulators
  • 1,3,5-Triazine-2-Amine Derivatives, Preparation Thereof And Diagnostic And Therapeutic Use Thereof
  • Bicyclic Heterocycles As Cannabinoid Receptor Modulators
  • Indole Or Benzimidazole Derivatives As Cb1 Inverse Agonists
  • Pyrazole Compounds Having Cannabinoid Receptor (Cb1) Antagonizing Activity
  • Hexahydro-Cyclooctyl Pyrazole Cannabinoid Modulators
  • Compounds Having Unique Cb1 Receptor Binding Selectivity And Methods For Their Production And Use
  • Bicyclic Heterocycles As Cannabinoid Receptor Modulators
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Hydrazone Modulators Of Cannabinoid Receptors
  • Cannabinoid 2 (Cb2) Receptor Gene Promoter And Unique Rna Transcripts In B Cells And Methods Of Use
  • Cannabinoid Receptor Modulators
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Benzochromene Derivatives For Use In Liquid Crystal Media And As Therapeutic Active Substances
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Hydrazone Modulators Of Cannabinoid Receptors
  • Bicyclic Heterocycles As Cannabinoid-1 Receptor Modulators
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Cannabinoid Receptor Modulators
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Di-Azetidinyl Diamide As Monoacylglycerol Lipase Inhibitors
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Pharmaceutical Compositions Comprising Cb1 Cannabinoid Receptor Antagonists And Potassium Channel Openers For The Treatment Of Obesity And Related Conditions
  • Pyridone Derivatives Having A Binding Activity To The Cannabinoid Type 2 Receptor
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Pyridone Derivatives Having Affinity For Cannabinoid 2-Type Receptor
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Bicyclic Heterocycles As Cannabinoid Receptor Modulators
  • Jnk Inhibitors For Use In Combination Therapy For Treating Or Managing Proliferative Disorders And Cancers
  • Bicyclic Heterocycles As Cannabinoind-1 Receptor Modulators
  • Bicyclic Heterocycles As Cannabinoid Receptor Modulators
  • Pyrimidine Derivatives And Their Use As Cb2 Modulators
  • Substituted 1-Benzyl-Cinnolin-4(1h)-One Derivatives, Preparation Thereof, And Therapeutic Use Thereof
  • Hexahydro-Cycloheptapyrazole Cannabinoid Modulators
  • Hexahydro-Cycloheptapyrazole Cannabinoid Modulators
  • Pyrazolo[1,5-A]Pyrimidine Compounds
  • Azetidinyl Diamides As Monoacylglycerol Lipase Inhibitors
  • Reporter Gene Constructs For Pet
  • Tetrahydroquinoline Cannabinoid Receptor Modulators
  • Oculoselective Drugs And Prodrugs
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/365061a0

    DOI

    http://dx.doi.org/10.1038/365061a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020160837

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7689702


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Pharmacology and Pharmaceutical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Amino Acid Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Arachidonic Acids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Base Sequence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Benzoxazines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Brain", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cannabinoids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cloning, Molecular", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "DNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endocannabinoids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fatty Acids, Unsaturated", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Macrophages", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Molecular Sequence Data", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Morpholines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Naphthalenes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polyunsaturated Alkamides", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Rats", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Cannabinoid", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Receptors, Drug", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Spleen", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Cells, Cultured", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "MRC Laboratory of Molecular Biology", 
              "id": "https://www.grid.ac/institutes/grid.42475.30", 
              "name": [
                "MRC Laboratory of Molecular Biology, Cambridge, UK."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Munro", 
            "givenName": "S", 
            "id": "sg:person.01000314607.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000314607.54"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Thomas", 
            "givenName": "K L", 
            "type": "Person"
          }, 
          {
            "familyName": "Abu-Shaar", 
            "givenName": "M", 
            "id": "sg:person.01256760474.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256760474.91"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1080/02791072.1992.10471635", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000663900"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(92)90214-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000759002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0024-3205(92)90214-a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000759002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.174.5.1049", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001181281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0074-7696(08)62453-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014490367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/20.4.909", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022013325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/18.19.5799", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023856334"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/329840a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025629695", 
              "https://doi.org/10.1038/329840a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2790129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026782215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2790129", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026782215"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/331624a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035701655", 
              "https://doi.org/10.1038/331624a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(93)90245-l", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045429287"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(92)90409-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048275723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(92)90409-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048275723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0166-2236(90)90124-s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049345230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0166-2236(90)90124-s", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049345230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(92)90428-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052241097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0006-8993(92)90428-c", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052241097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1021/jm00089a018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1055934654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1470919", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062484885"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076021092", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jlb.39.6.679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1079506448"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079676708", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079794146", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/j.1460-2075.1993.tb05814.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082785106"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1993-09", 
        "datePublishedReg": "1993-09-01", 
        "description": "The major active ingredient of marijuana, delta 9-tetrahydrocannabinol (delta 9-THC), has been used as a psychoactive agent for thousands of years. Marijuana, and delta 9-THC, also exert a wide range of other effects including analgesia, anti-inflammation, immunosuppression, anticonvulsion, alleviation of intraocular pressure in glaucoma, and attenuation of vomiting. The clinical application of cannabinoids has, however, been limited by their psychoactive effects, and this has led to interest in the biochemical bases of their action. Progress stemmed initially from the synthesis of potent derivatives of delta 9-THC, and more recently from the cloning of a gene encoding a G-protein-coupled receptor for cannabinoids. This receptor is expressed in the brain but not in the periphery, except for a low level in testes. It has been proposed that the nonpsychoactive effects of cannabinoids are either mediated centrally or through direct interaction with other, non-receptor proteins. Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/365061a0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1018957", 
            "issn": [
              "0090-0028", 
              "1476-4687"
            ], 
            "name": "Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "6441", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "365"
          }
        ], 
        "name": "Molecular characterization of a peripheral receptor for cannabinoids", 
        "pagination": "61-65", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "600f3d80bcc440b5bd679cd9609d3f1231e279f4da903132281af0fa0ec230ea"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "7689702"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0410462"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/365061a0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1020160837"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/365061a0", 
          "https://app.dimensions.ai/details/publication/pub.1020160837"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T17:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000424.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/365061a0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/365061a0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/365061a0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/365061a0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/365061a0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    235 TRIPLES      21 PREDICATES      73 URIs      45 LITERALS      33 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/365061a0 schema:about N072915f418cb4e5c915bf442bfa38c04
    2 N0de04078e2db4aeaa89998c7967849e6
    3 N1a114a5b99c84068add68355512d9727
    4 N23c0827c90e74d708ec1d0e5e0f7483a
    5 N29601fc59b0c4b609cf081013bea6413
    6 N2dbcde6d427c413996e6cc0be879a512
    7 N399c6a4373bf49e49b5bd0ef0437d5c1
    8 N3d48eb0359b64ec6a4220bcc2cb5b281
    9 N5bbfcfdba764463695089eea7e005d91
    10 N6f9c988065d8477aa59d668ff9cc6a2b
    11 N743550664a8b45cda5e2c47a15a01bec
    12 N7521dd8b14fe40bfab7adee9ece679af
    13 N76eaf0061fa0437aa49322e83ecce546
    14 N8a9911881ef2405b923b5c471a6ed291
    15 N8eceb21871364ea9870acececd6aef28
    16 Na8310a4f056e4390b26a0cb2cddc2a13
    17 Nc73046f9ef9a4eac99df30d2faf122bf
    18 Nce4560639d324965a6f34df11841c0b9
    19 Nd5fe39a17f2549278eedef5ef2ddf536
    20 Ndf4356463db04f3db4140b3f99ded008
    21 Ne456486956534d9e824bca3b31805710
    22 Neb5b1f18e3744c389fd3958d26b5853c
    23 Nf728733a3ab546e8a419739b148b243a
    24 Nf7bfd00febbf47158d0413453642e3e4
    25 anzsrc-for:11
    26 anzsrc-for:1115
    27 schema:author Na54f60630def43579fd254a04a6127f2
    28 schema:citation sg:pub.10.1038/329840a0
    29 sg:pub.10.1038/331624a0
    30 https://app.dimensions.ai/details/publication/pub.1076021092
    31 https://app.dimensions.ai/details/publication/pub.1079676708
    32 https://app.dimensions.ai/details/publication/pub.1079794146
    33 https://doi.org/10.1002/j.1460-2075.1993.tb05814.x
    34 https://doi.org/10.1002/jlb.39.6.679
    35 https://doi.org/10.1016/0006-8993(92)90428-c
    36 https://doi.org/10.1016/0024-3205(92)90214-a
    37 https://doi.org/10.1016/0092-8674(93)90245-l
    38 https://doi.org/10.1016/0166-2236(90)90124-s
    39 https://doi.org/10.1016/0306-4522(92)90409-u
    40 https://doi.org/10.1016/s0074-7696(08)62453-5
    41 https://doi.org/10.1021/jm00089a018
    42 https://doi.org/10.1042/bj2790129
    43 https://doi.org/10.1080/02791072.1992.10471635
    44 https://doi.org/10.1084/jem.174.5.1049
    45 https://doi.org/10.1093/nar/18.19.5799
    46 https://doi.org/10.1093/nar/20.4.909
    47 https://doi.org/10.1126/science.1470919
    48 schema:datePublished 1993-09
    49 schema:datePublishedReg 1993-09-01
    50 schema:description The major active ingredient of marijuana, delta 9-tetrahydrocannabinol (delta 9-THC), has been used as a psychoactive agent for thousands of years. Marijuana, and delta 9-THC, also exert a wide range of other effects including analgesia, anti-inflammation, immunosuppression, anticonvulsion, alleviation of intraocular pressure in glaucoma, and attenuation of vomiting. The clinical application of cannabinoids has, however, been limited by their psychoactive effects, and this has led to interest in the biochemical bases of their action. Progress stemmed initially from the synthesis of potent derivatives of delta 9-THC, and more recently from the cloning of a gene encoding a G-protein-coupled receptor for cannabinoids. This receptor is expressed in the brain but not in the periphery, except for a low level in testes. It has been proposed that the nonpsychoactive effects of cannabinoids are either mediated centrally or through direct interaction with other, non-receptor proteins. Here we report the cloning of a receptor for cannabinoids that is not expressed in the brain but rather in macrophages in the marginal zone of spleen.
    51 schema:genre research_article
    52 schema:inLanguage en
    53 schema:isAccessibleForFree false
    54 schema:isPartOf N4420d47133a34d789f5b874ca9a9fc27
    55 Na3127687fd7848ee996a6c103dc21aa4
    56 sg:journal.1018957
    57 schema:name Molecular characterization of a peripheral receptor for cannabinoids
    58 schema:pagination 61-65
    59 schema:productId N4099c2c1b5234c54a40d66fe971a6047
    60 Nce8e101dc8984c34b1f9f20af4887dad
    61 Ned6dda6de1004440961b77848ed81d4e
    62 Nef361e97282b4943b3c06b71c3cb052b
    63 Nf1d82f60f7804163a896ec8874621ae8
    64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020160837
    65 https://doi.org/10.1038/365061a0
    66 schema:sdDatePublished 2019-04-10T17:19
    67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    68 schema:sdPublisher Nc1f054569cc149f9b2d47e28d6fbb6c4
    69 schema:url http://www.nature.com/articles/365061a0
    70 sgo:license sg:explorer/license/
    71 sgo:sdDataset articles
    72 rdf:type schema:ScholarlyArticle
    73 N072915f418cb4e5c915bf442bfa38c04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    74 schema:name Benzoxazines
    75 rdf:type schema:DefinedTerm
    76 N0de04078e2db4aeaa89998c7967849e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    77 schema:name Polyunsaturated Alkamides
    78 rdf:type schema:DefinedTerm
    79 N1a114a5b99c84068add68355512d9727 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Tumor Cells, Cultured
    81 rdf:type schema:DefinedTerm
    82 N23c0827c90e74d708ec1d0e5e0f7483a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Receptors, Cannabinoid
    84 rdf:type schema:DefinedTerm
    85 N29601fc59b0c4b609cf081013bea6413 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Endocannabinoids
    87 rdf:type schema:DefinedTerm
    88 N2dbcde6d427c413996e6cc0be879a512 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Macrophages
    90 rdf:type schema:DefinedTerm
    91 N399c6a4373bf49e49b5bd0ef0437d5c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    92 schema:name DNA
    93 rdf:type schema:DefinedTerm
    94 N3d48eb0359b64ec6a4220bcc2cb5b281 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    95 schema:name Humans
    96 rdf:type schema:DefinedTerm
    97 N4099c2c1b5234c54a40d66fe971a6047 schema:name dimensions_id
    98 schema:value pub.1020160837
    99 rdf:type schema:PropertyValue
    100 N4420d47133a34d789f5b874ca9a9fc27 schema:issueNumber 6441
    101 rdf:type schema:PublicationIssue
    102 N5bbfcfdba764463695089eea7e005d91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    103 schema:name Animals
    104 rdf:type schema:DefinedTerm
    105 N61abbc03a9af467880d6aaef748c29ac schema:familyName Thomas
    106 schema:givenName K L
    107 rdf:type schema:Person
    108 N6f9c988065d8477aa59d668ff9cc6a2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    109 schema:name Base Sequence
    110 rdf:type schema:DefinedTerm
    111 N743550664a8b45cda5e2c47a15a01bec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    112 schema:name Amino Acid Sequence
    113 rdf:type schema:DefinedTerm
    114 N7521dd8b14fe40bfab7adee9ece679af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Fatty Acids, Unsaturated
    116 rdf:type schema:DefinedTerm
    117 N76eaf0061fa0437aa49322e83ecce546 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name RNA
    119 rdf:type schema:DefinedTerm
    120 N77ced12b3efb433fa0785e4cc1bf4632 rdf:first N61abbc03a9af467880d6aaef748c29ac
    121 rdf:rest Nbc2f924b28634d79a5e68cb00452da4b
    122 N8a9911881ef2405b923b5c471a6ed291 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Cloning, Molecular
    124 rdf:type schema:DefinedTerm
    125 N8eceb21871364ea9870acececd6aef28 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Rats
    127 rdf:type schema:DefinedTerm
    128 Na3127687fd7848ee996a6c103dc21aa4 schema:volumeNumber 365
    129 rdf:type schema:PublicationVolume
    130 Na54f60630def43579fd254a04a6127f2 rdf:first sg:person.01000314607.54
    131 rdf:rest N77ced12b3efb433fa0785e4cc1bf4632
    132 Na8310a4f056e4390b26a0cb2cddc2a13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Naphthalenes
    134 rdf:type schema:DefinedTerm
    135 Nbc2f924b28634d79a5e68cb00452da4b rdf:first sg:person.01256760474.91
    136 rdf:rest rdf:nil
    137 Nc1f054569cc149f9b2d47e28d6fbb6c4 schema:name Springer Nature - SN SciGraph project
    138 rdf:type schema:Organization
    139 Nc73046f9ef9a4eac99df30d2faf122bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Molecular Sequence Data
    141 rdf:type schema:DefinedTerm
    142 Nce4560639d324965a6f34df11841c0b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Brain
    144 rdf:type schema:DefinedTerm
    145 Nce8e101dc8984c34b1f9f20af4887dad schema:name nlm_unique_id
    146 schema:value 0410462
    147 rdf:type schema:PropertyValue
    148 Nd5fe39a17f2549278eedef5ef2ddf536 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Amides
    150 rdf:type schema:DefinedTerm
    151 Ndf4356463db04f3db4140b3f99ded008 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Arachidonic Acids
    153 rdf:type schema:DefinedTerm
    154 Ne456486956534d9e824bca3b31805710 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Receptors, Drug
    156 rdf:type schema:DefinedTerm
    157 Neb5b1f18e3744c389fd3958d26b5853c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    158 schema:name Morpholines
    159 rdf:type schema:DefinedTerm
    160 Ned6dda6de1004440961b77848ed81d4e schema:name doi
    161 schema:value 10.1038/365061a0
    162 rdf:type schema:PropertyValue
    163 Nef361e97282b4943b3c06b71c3cb052b schema:name pubmed_id
    164 schema:value 7689702
    165 rdf:type schema:PropertyValue
    166 Nf1d82f60f7804163a896ec8874621ae8 schema:name readcube_id
    167 schema:value 600f3d80bcc440b5bd679cd9609d3f1231e279f4da903132281af0fa0ec230ea
    168 rdf:type schema:PropertyValue
    169 Nf728733a3ab546e8a419739b148b243a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Cannabinoids
    171 rdf:type schema:DefinedTerm
    172 Nf7bfd00febbf47158d0413453642e3e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Spleen
    174 rdf:type schema:DefinedTerm
    175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Medical and Health Sciences
    177 rdf:type schema:DefinedTerm
    178 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
    179 schema:name Pharmacology and Pharmaceutical Sciences
    180 rdf:type schema:DefinedTerm
    181 sg:journal.1018957 schema:issn 0090-0028
    182 1476-4687
    183 schema:name Nature
    184 rdf:type schema:Periodical
    185 sg:person.01000314607.54 schema:affiliation https://www.grid.ac/institutes/grid.42475.30
    186 schema:familyName Munro
    187 schema:givenName S
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000314607.54
    189 rdf:type schema:Person
    190 sg:person.01256760474.91 schema:familyName Abu-Shaar
    191 schema:givenName M
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256760474.91
    193 rdf:type schema:Person
    194 sg:pub.10.1038/329840a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025629695
    195 https://doi.org/10.1038/329840a0
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1038/331624a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035701655
    198 https://doi.org/10.1038/331624a0
    199 rdf:type schema:CreativeWork
    200 https://app.dimensions.ai/details/publication/pub.1076021092 schema:CreativeWork
    201 https://app.dimensions.ai/details/publication/pub.1079676708 schema:CreativeWork
    202 https://app.dimensions.ai/details/publication/pub.1079794146 schema:CreativeWork
    203 https://doi.org/10.1002/j.1460-2075.1993.tb05814.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1082785106
    204 rdf:type schema:CreativeWork
    205 https://doi.org/10.1002/jlb.39.6.679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079506448
    206 rdf:type schema:CreativeWork
    207 https://doi.org/10.1016/0006-8993(92)90428-c schema:sameAs https://app.dimensions.ai/details/publication/pub.1052241097
    208 rdf:type schema:CreativeWork
    209 https://doi.org/10.1016/0024-3205(92)90214-a schema:sameAs https://app.dimensions.ai/details/publication/pub.1000759002
    210 rdf:type schema:CreativeWork
    211 https://doi.org/10.1016/0092-8674(93)90245-l schema:sameAs https://app.dimensions.ai/details/publication/pub.1045429287
    212 rdf:type schema:CreativeWork
    213 https://doi.org/10.1016/0166-2236(90)90124-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1049345230
    214 rdf:type schema:CreativeWork
    215 https://doi.org/10.1016/0306-4522(92)90409-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1048275723
    216 rdf:type schema:CreativeWork
    217 https://doi.org/10.1016/s0074-7696(08)62453-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014490367
    218 rdf:type schema:CreativeWork
    219 https://doi.org/10.1021/jm00089a018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055934654
    220 rdf:type schema:CreativeWork
    221 https://doi.org/10.1042/bj2790129 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026782215
    222 rdf:type schema:CreativeWork
    223 https://doi.org/10.1080/02791072.1992.10471635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000663900
    224 rdf:type schema:CreativeWork
    225 https://doi.org/10.1084/jem.174.5.1049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001181281
    226 rdf:type schema:CreativeWork
    227 https://doi.org/10.1093/nar/18.19.5799 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023856334
    228 rdf:type schema:CreativeWork
    229 https://doi.org/10.1093/nar/20.4.909 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022013325
    230 rdf:type schema:CreativeWork
    231 https://doi.org/10.1126/science.1470919 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062484885
    232 rdf:type schema:CreativeWork
    233 https://www.grid.ac/institutes/grid.42475.30 schema:alternateName MRC Laboratory of Molecular Biology
    234 schema:name MRC Laboratory of Molecular Biology, Cambridge, UK.
    235 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...