Lethal effect of the anti-Fas antibody in mice View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-08

AUTHORS

J Ogasawara, R Watanabe-Fukunaga, M Adachi, A Matsuzawa, T Kasugai, Y Kitamura, N Itoh, T Suda, S Nagata

ABSTRACT

During mammalian development, many cells are programmed to die most mediated by apoptosis. The Fas antigen coded by the structural gene for mouse lymphoproliferation mutation (lpr), is a cell surface protein belonging to the tumour necrosis factor/nerve growth factor receptor family, and mediates apoptosis. The Fas antigen messenger RNA is expressed in the thymus, liver, heart, lung and ovary. We prepared a monoclonal antibody against mouse Fas antigen, which immunoprecipitated the antigen (M(r) 45K) and had cytolytic activity against cell lines expressing mouse Fas antigen. We report here that staining of mouse thymocytes with the antibody indicated that thymocytes from the wild-type and lprcg mice expressed the Fas antigen, whereas little expression of the Fas antigen was found in lpr mice. Intraperitoneal administration of the anti-Fas antibody into mice rapidly killed the wild-type mice but neither lpr nor lprcg mice. Biochemical, histological and electron microscope analyses indicated severe damage of the liver by apoptosis. These findings suggest that the Fas antigen is important in programmed cell death in the liver, and may be involved in fulminant hepatitis in some cases. More... »

PAGES

806-809

Journal

TITLE

Nature

ISSUE

6440

VOLUME

364

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/364806a0

DOI

http://dx.doi.org/10.1038/364806a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050650199

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7689176


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