An RNA motif that binds ATP View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-08

AUTHORS

M Sassanfar, J W Szostak

ABSTRACT

RNAs that contain specific high-affinity binding sites for small molecule ligands immobilized on a solid support are present at a frequency of roughly one in 10(10)-10(11) in pools of random sequence RNA molecules. Here we describe a new in vitro selection procedure designed to ensure the isolation of RNAs that bind the ligand of interest in solution as well as on a solid support. We have used this method to isolate a remarkably small RNA motif that binds ATP, a substrate in numerous biological reactions and the universal biological high-energy intermediate. The selected ATP-binding RNAs contain a consensus sequence, embedded in a common secondary structure. The binding properties of ATP analogues and modified RNAs show that the binding interaction is characterized by a large number of close contacts between the ATP and RNA, and by a change in the conformation of the RNA. More... »

PAGES

550-553

References to SciGraph publications

Journal

TITLE

Nature

ISSUE

6437

VOLUME

364

Author Affiliations

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/364550a0

    DOI

    http://dx.doi.org/10.1038/364550a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1012230197

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7687750


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