Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-07

AUTHORS

Xian-Feng Zhang, Jeffrey Settleman, John Kyriakis, Erika Takeuchi-Suzuki, Stephen J. Elledge, Mark S. Marshall, Joseph T. Bruder, Ulf R. Rapp, Joseph Avruch

ABSTRACT

In higher eukaryotes, the Ras and Raf-1 proto-oncoproteins transduce growth and differentiation signals initiated by tyrosine kinases. The Ras polypeptide and the amino-terminal regulatory domain of Raf-1(residues 1–257) are shown to interact, directly in vitro and in a yeast expression system. Raf-1(1-257) binds GTP-Ras in preference to GDP-Ras, and inhibits Ras-GAP activity. Mutations in and around the Ras effector domain impair Ras binding to Raf-1(1-257) and Ras transforming activity in parallel. More... »

PAGES

308-313

Journal

TITLE

Nature

ISSUE

6435

VOLUME

364

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/364308a0

DOI

http://dx.doi.org/10.1038/364308a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021693984

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8332187


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Baculoviridae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Vectors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Moths", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oncogene Protein p21(ras)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Binding", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-raf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins p21(ras)", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recombinant Fusion Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Saccharomyces cerevisiae", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "the Department of Medicine, Harvard Medical School", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "The Diabetes Unit and Medical Services", 
            "the Department of Medicine, Harvard Medical School"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Xian-Feng", 
        "id": "sg:person.01203462023.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203462023.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Cancer Center, Massachusetts General Hospital East, 149 13th Street, 02129, Charlestown, Massachusetts, USA", 
          "id": "http://www.grid.ac/institutes/grid.32224.35", 
          "name": [
            "The Diabetes Unit and Medical Services", 
            "the Department of Medicine, Harvard Medical School", 
            "The Cancer Center, Massachusetts General Hospital East, 149 13th Street, 02129, Charlestown, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Settleman", 
        "givenName": "Jeffrey", 
        "id": "sg:person.07760537737.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07760537737.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "the Department of Medicine, Harvard Medical School", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "The Diabetes Unit and Medical Services", 
            "the Department of Medicine, Harvard Medical School"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kyriakis", 
        "givenName": "John", 
        "id": "sg:person.01243062072.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243062072.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "the Department of Medicine, Harvard Medical School", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "The Diabetes Unit and Medical Services", 
            "the Department of Medicine, Harvard Medical School"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takeuchi-Suzuki", 
        "givenName": "Erika", 
        "id": "sg:person.0660505504.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660505504.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Baylor College of Medicine, 1 Baylor Plaza, 77030, Houston, Texas, USA", 
          "id": "http://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "The Diabetes Unit and Medical Services", 
            "the Department of Medicine, Harvard Medical School", 
            "Department of Biochemistry, Baylor College of Medicine, 1 Baylor Plaza, 77030, Houston, Texas, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Elledge", 
        "givenName": "Stephen J.", 
        "id": "sg:person.01332255250.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332255250.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, Hematology-Oncology Section and Walther Oncology Center, Indiana University School of Medicine, 46202, Indianapolis, Indiana, USA", 
          "id": "http://www.grid.ac/institutes/grid.257413.6", 
          "name": [
            "The Diabetes Unit and Medical Services", 
            "the Department of Medicine, Harvard Medical School", 
            "Department of Medicine, Hematology-Oncology Section and Walther Oncology Center, Indiana University School of Medicine, 46202, Indianapolis, Indiana, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marshall", 
        "givenName": "Mark S.", 
        "id": "sg:person.0650211612.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650211612.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, 21702, Frederick, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.418021.e", 
          "name": [
            "The Diabetes Unit and Medical Services", 
            "the Department of Medicine, Harvard Medical School", 
            "Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, 21702, Frederick, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruder", 
        "givenName": "Joseph T.", 
        "id": "sg:person.0745363570.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745363570.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, 21702, Frederick, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.418021.e", 
          "name": [
            "The Diabetes Unit and Medical Services", 
            "the Department of Medicine, Harvard Medical School", 
            "Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, 21702, Frederick, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rapp", 
        "givenName": "Ulf R.", 
        "id": "sg:person.0717475127.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717475127.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "the Department of Medicine, Harvard Medical School", 
          "id": "http://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "The Diabetes Unit and Medical Services", 
            "the Department of Medicine, Harvard Medical School"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Avruch", 
        "givenName": "Joseph", 
        "id": "sg:person.01074100404.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074100404.77"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/334715a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028437472", 
          "https://doi.org/10.1038/334715a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/349426a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033679127", 
          "https://doi.org/10.1038/349426a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/351069a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045337250", 
          "https://doi.org/10.1038/351069a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/358417a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000021328", 
          "https://doi.org/10.1038/358417a0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1993-07", 
    "datePublishedReg": "1993-07-01", 
    "description": "In higher eukaryotes, the Ras and Raf-1 proto-oncoproteins transduce growth and differentiation signals initiated by tyrosine kinases. The Ras polypeptide and the amino-terminal regulatory domain of Raf-1(residues 1\u2013257) are shown to interact, directly in vitro and in a yeast expression system. Raf-1(1-257) binds GTP-Ras in preference to GDP-Ras, and inhibits Ras-GAP activity. Mutations in and around the Ras effector domain impair Ras binding to Raf-1(1-257) and Ras transforming activity in parallel.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/364308a0", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0028-0836", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6435", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "364"
      }
    ], 
    "keywords": [
      "amino-terminal regulatory domain", 
      "regulatory domain", 
      "Ras GAP activity", 
      "oncogenic p21ras proteins", 
      "yeast expression system", 
      "higher eukaryotes", 
      "GDP-Ras", 
      "Raf-1", 
      "differentiation signals", 
      "GTP-Ras", 
      "ras polypeptides", 
      "p21ras proteins", 
      "expression system", 
      "tyrosine kinase", 
      "Raf", 
      "RA", 
      "eukaryotes", 
      "kinase", 
      "polypeptide", 
      "domain", 
      "protein", 
      "mutations", 
      "activity", 
      "vitro", 
      "growth", 
      "signals", 
      "preferences", 
      "parallel", 
      "system", 
      "Raf-1 proto-oncoproteins transduce growth", 
      "proto-oncoproteins transduce growth", 
      "transduce growth", 
      "Ras effector domain impair Ras", 
      "effector domain impair Ras", 
      "domain impair Ras", 
      "impair Ras"
    ], 
    "name": "Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1", 
    "pagination": "308-313", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021693984"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/364308a0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8332187"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/364308a0", 
      "https://app.dimensions.ai/details/publication/pub.1021693984"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_261.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/364308a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/364308a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/364308a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/364308a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/364308a0'


 

This table displays all metadata directly associated to this object as RDF triples.

255 TRIPLES      22 PREDICATES      83 URIs      71 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/364308a0 schema:about N0add6ca915b0468db60ce3970cd06df3
2 N28e5d970f961454fb9e36ae7578801b0
3 N322808f60a7d424d956df31f2e6491af
4 N33948e524c754ee8b7cb61e297717c0e
5 N692154befc2c4d23aaa29bdbbb3fc9de
6 N84582601dbb64019b79804363cbf6e77
7 N8acee7d96f9d44adbd4ee02d1ca632d5
8 N92d6741166aa43aabe2ec51ed50139e4
9 N9a08b3a88da44fb5a493ebb751260c34
10 N9d7251a5f1064855894783af679e8fec
11 N9fbbbbffa9a8411ea964206abaff033f
12 Na36e6ef58e2e41699fa471499462ecec
13 Ncafe2f75423140dfaa8991d1445f00ef
14 Ndf806e91ea0a40239e04486c3dbfb830
15 Nee50925bf0854881a90bf03c6a1529df
16 Nf9ff90dea8ea48e7b09aeffde4e45975
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author Neaf470ea2b314dd0967fb8850654d0ec
20 schema:citation sg:pub.10.1038/334715a0
21 sg:pub.10.1038/349426a0
22 sg:pub.10.1038/351069a0
23 sg:pub.10.1038/358417a0
24 schema:datePublished 1993-07
25 schema:datePublishedReg 1993-07-01
26 schema:description In higher eukaryotes, the Ras and Raf-1 proto-oncoproteins transduce growth and differentiation signals initiated by tyrosine kinases. The Ras polypeptide and the amino-terminal regulatory domain of Raf-1(residues 1–257) are shown to interact, directly in vitro and in a yeast expression system. Raf-1(1-257) binds GTP-Ras in preference to GDP-Ras, and inhibits Ras-GAP activity. Mutations in and around the Ras effector domain impair Ras binding to Raf-1(1-257) and Ras transforming activity in parallel.
27 schema:genre article
28 schema:inLanguage en
29 schema:isAccessibleForFree false
30 schema:isPartOf N0e36a9f9c7464650a825ddd449961fea
31 N9b8d2984aa3349fbad879669e74bce55
32 sg:journal.1018957
33 schema:keywords GDP-Ras
34 GTP-Ras
35 RA
36 Raf
37 Raf-1
38 Raf-1 proto-oncoproteins transduce growth
39 Ras GAP activity
40 Ras effector domain impair Ras
41 activity
42 amino-terminal regulatory domain
43 differentiation signals
44 domain
45 domain impair Ras
46 effector domain impair Ras
47 eukaryotes
48 expression system
49 growth
50 higher eukaryotes
51 impair Ras
52 kinase
53 mutations
54 oncogenic p21ras proteins
55 p21ras proteins
56 parallel
57 polypeptide
58 preferences
59 protein
60 proto-oncoproteins transduce growth
61 ras polypeptides
62 regulatory domain
63 signals
64 system
65 transduce growth
66 tyrosine kinase
67 vitro
68 yeast expression system
69 schema:name Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
70 schema:pagination 308-313
71 schema:productId N3da8b3caf9ad48fe96220dea8edff1b3
72 N96ce3ae2256e4f0eb7962b7262fe07ad
73 Nb00b561e4b604302b6788e177ab3a6de
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021693984
75 https://doi.org/10.1038/364308a0
76 schema:sdDatePublished 2022-01-01T18:06
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher Nb858960f8756424fb5f15a094101a566
79 schema:url https://doi.org/10.1038/364308a0
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N011540055ef14139838632c25a3d3481 rdf:first sg:person.01243062072.45
84 rdf:rest N10b842e8874b422e9d457b0026ba59c7
85 N0add6ca915b0468db60ce3970cd06df3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Saccharomyces cerevisiae
87 rdf:type schema:DefinedTerm
88 N0e36a9f9c7464650a825ddd449961fea schema:issueNumber 6435
89 rdf:type schema:PublicationIssue
90 N10b842e8874b422e9d457b0026ba59c7 rdf:first sg:person.0660505504.89
91 rdf:rest Ndb0bcd59ca3044e3be290a6452f53e0b
92 N28e5d970f961454fb9e36ae7578801b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Proto-Oncogene Proteins
94 rdf:type schema:DefinedTerm
95 N322808f60a7d424d956df31f2e6491af schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Protein-Serine-Threonine Kinases
97 rdf:type schema:DefinedTerm
98 N33948e524c754ee8b7cb61e297717c0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Animals
100 rdf:type schema:DefinedTerm
101 N3857d3f35c7e46e8af2653a19367be14 rdf:first sg:person.0717475127.70
102 rdf:rest Nb19659100a5148c5bccbb1ebe23e53e5
103 N3da8b3caf9ad48fe96220dea8edff1b3 schema:name pubmed_id
104 schema:value 8332187
105 rdf:type schema:PropertyValue
106 N4eb00c3c9cad4a4386815c725b07176e rdf:first sg:person.0650211612.35
107 rdf:rest N863b0f4e9c6047528058cd1bc6fce4ee
108 N692154befc2c4d23aaa29bdbbb3fc9de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Genetic Vectors
110 rdf:type schema:DefinedTerm
111 N84582601dbb64019b79804363cbf6e77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Signal Transduction
113 rdf:type schema:DefinedTerm
114 N863b0f4e9c6047528058cd1bc6fce4ee rdf:first sg:person.0745363570.59
115 rdf:rest N3857d3f35c7e46e8af2653a19367be14
116 N8acee7d96f9d44adbd4ee02d1ca632d5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Baculoviridae
118 rdf:type schema:DefinedTerm
119 N92d6741166aa43aabe2ec51ed50139e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Recombinant Fusion Proteins
121 rdf:type schema:DefinedTerm
122 N96ce3ae2256e4f0eb7962b7262fe07ad schema:name doi
123 schema:value 10.1038/364308a0
124 rdf:type schema:PropertyValue
125 N9a08b3a88da44fb5a493ebb751260c34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Oncogene Protein p21(ras)
127 rdf:type schema:DefinedTerm
128 N9a376b7b46144d908c68ddc86efe7bcb rdf:first sg:person.07760537737.93
129 rdf:rest N011540055ef14139838632c25a3d3481
130 N9b8d2984aa3349fbad879669e74bce55 schema:volumeNumber 364
131 rdf:type schema:PublicationVolume
132 N9d7251a5f1064855894783af679e8fec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Binding Sites
134 rdf:type schema:DefinedTerm
135 N9fbbbbffa9a8411ea964206abaff033f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Moths
137 rdf:type schema:DefinedTerm
138 Na36e6ef58e2e41699fa471499462ecec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Proto-Oncogene Proteins p21(ras)
140 rdf:type schema:DefinedTerm
141 Nb00b561e4b604302b6788e177ab3a6de schema:name dimensions_id
142 schema:value pub.1021693984
143 rdf:type schema:PropertyValue
144 Nb19659100a5148c5bccbb1ebe23e53e5 rdf:first sg:person.01074100404.77
145 rdf:rest rdf:nil
146 Nb858960f8756424fb5f15a094101a566 schema:name Springer Nature - SN SciGraph project
147 rdf:type schema:Organization
148 Ncafe2f75423140dfaa8991d1445f00ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Cells, Cultured
150 rdf:type schema:DefinedTerm
151 Ndb0bcd59ca3044e3be290a6452f53e0b rdf:first sg:person.01332255250.64
152 rdf:rest N4eb00c3c9cad4a4386815c725b07176e
153 Ndf806e91ea0a40239e04486c3dbfb830 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Protein Binding
155 rdf:type schema:DefinedTerm
156 Neaf470ea2b314dd0967fb8850654d0ec rdf:first sg:person.01203462023.55
157 rdf:rest N9a376b7b46144d908c68ddc86efe7bcb
158 Nee50925bf0854881a90bf03c6a1529df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Proto-Oncogene Proteins c-raf
160 rdf:type schema:DefinedTerm
161 Nf9ff90dea8ea48e7b09aeffde4e45975 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Mutation
163 rdf:type schema:DefinedTerm
164 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
165 schema:name Biological Sciences
166 rdf:type schema:DefinedTerm
167 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
168 schema:name Biochemistry and Cell Biology
169 rdf:type schema:DefinedTerm
170 sg:journal.1018957 schema:issn 0028-0836
171 1476-4687
172 schema:name Nature
173 schema:publisher Springer Nature
174 rdf:type schema:Periodical
175 sg:person.01074100404.77 schema:affiliation grid-institutes:grid.38142.3c
176 schema:familyName Avruch
177 schema:givenName Joseph
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074100404.77
179 rdf:type schema:Person
180 sg:person.01203462023.55 schema:affiliation grid-institutes:grid.38142.3c
181 schema:familyName Zhang
182 schema:givenName Xian-Feng
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01203462023.55
184 rdf:type schema:Person
185 sg:person.01243062072.45 schema:affiliation grid-institutes:grid.38142.3c
186 schema:familyName Kyriakis
187 schema:givenName John
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01243062072.45
189 rdf:type schema:Person
190 sg:person.01332255250.64 schema:affiliation grid-institutes:grid.39382.33
191 schema:familyName Elledge
192 schema:givenName Stephen J.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332255250.64
194 rdf:type schema:Person
195 sg:person.0650211612.35 schema:affiliation grid-institutes:grid.257413.6
196 schema:familyName Marshall
197 schema:givenName Mark S.
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0650211612.35
199 rdf:type schema:Person
200 sg:person.0660505504.89 schema:affiliation grid-institutes:grid.38142.3c
201 schema:familyName Takeuchi-Suzuki
202 schema:givenName Erika
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0660505504.89
204 rdf:type schema:Person
205 sg:person.0717475127.70 schema:affiliation grid-institutes:grid.418021.e
206 schema:familyName Rapp
207 schema:givenName Ulf R.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717475127.70
209 rdf:type schema:Person
210 sg:person.0745363570.59 schema:affiliation grid-institutes:grid.418021.e
211 schema:familyName Bruder
212 schema:givenName Joseph T.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745363570.59
214 rdf:type schema:Person
215 sg:person.07760537737.93 schema:affiliation grid-institutes:grid.32224.35
216 schema:familyName Settleman
217 schema:givenName Jeffrey
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07760537737.93
219 rdf:type schema:Person
220 sg:pub.10.1038/334715a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028437472
221 https://doi.org/10.1038/334715a0
222 rdf:type schema:CreativeWork
223 sg:pub.10.1038/349426a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033679127
224 https://doi.org/10.1038/349426a0
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/351069a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045337250
227 https://doi.org/10.1038/351069a0
228 rdf:type schema:CreativeWork
229 sg:pub.10.1038/358417a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000021328
230 https://doi.org/10.1038/358417a0
231 rdf:type schema:CreativeWork
232 grid-institutes:grid.257413.6 schema:alternateName Department of Medicine, Hematology-Oncology Section and Walther Oncology Center, Indiana University School of Medicine, 46202, Indianapolis, Indiana, USA
233 schema:name Department of Medicine, Hematology-Oncology Section and Walther Oncology Center, Indiana University School of Medicine, 46202, Indianapolis, Indiana, USA
234 The Diabetes Unit and Medical Services
235 the Department of Medicine, Harvard Medical School
236 rdf:type schema:Organization
237 grid-institutes:grid.32224.35 schema:alternateName The Cancer Center, Massachusetts General Hospital East, 149 13th Street, 02129, Charlestown, Massachusetts, USA
238 schema:name The Cancer Center, Massachusetts General Hospital East, 149 13th Street, 02129, Charlestown, Massachusetts, USA
239 The Diabetes Unit and Medical Services
240 the Department of Medicine, Harvard Medical School
241 rdf:type schema:Organization
242 grid-institutes:grid.38142.3c schema:alternateName the Department of Medicine, Harvard Medical School
243 schema:name The Diabetes Unit and Medical Services
244 the Department of Medicine, Harvard Medical School
245 rdf:type schema:Organization
246 grid-institutes:grid.39382.33 schema:alternateName Department of Biochemistry, Baylor College of Medicine, 1 Baylor Plaza, 77030, Houston, Texas, USA
247 schema:name Department of Biochemistry, Baylor College of Medicine, 1 Baylor Plaza, 77030, Houston, Texas, USA
248 The Diabetes Unit and Medical Services
249 the Department of Medicine, Harvard Medical School
250 rdf:type schema:Organization
251 grid-institutes:grid.418021.e schema:alternateName Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, 21702, Frederick, Maryland, USA
252 schema:name Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick Cancer Research and Development Center, 21702, Frederick, Maryland, USA
253 The Diabetes Unit and Medical Services
254 the Department of Medicine, Harvard Medical School
255 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...