Ontology type: schema:ScholarlyArticle
1993-07
AUTHORSEnrico Martinoia, Erwin Grill, Roberto Tommasini, Klaus Kreuz, Nikolaus Amrhein
ABSTRACTPLANTS are exposed to many potentially phytotoxic foreign compounds, such as microbial toxins and agrochemicals (xenobiotics). Detoxification and elimination of these compounds within or from the cell is a prerequisite for their survival. Metabolism and detoxification of xenobiotics are remarkably similar in plants and animals and can generally be divided into three phases1,2. In the first phase, a foreign compound may be oxidized, reduced or hydrolysed to introduce or reveal a functional group. In a second step, the activated xenobiotic is conjugated to either glutathione, glucuronate (animals), or malonyl or glucosyl moieties (plants) by the respective transferases. In animals the third step, excretion of conjugated xenobiotics to the extracellular medium, is mediated by a specific ATPase1,3–5. In plants, instead of excretion, conjugates of xenobiotics appear to be stored in the large central vacuole6, but it is not known how they are transported into this organelle. We show here that glutathione S-conjugate uptake into the vacuole is mediated by a specific ATPase which is remarkably similar to the glutathione S-conjugate export pumps in the canalicular membrane of mammalian liver. More... »
PAGES247-249
http://scigraph.springernature.com/pub.10.1038/364247a0
DOIhttp://dx.doi.org/10.1038/364247a0
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1027245524
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Institute of Plant Sciences, Swiss Federal Institute of Technology, Sonneggstrasse 5, ETH-Z, CH-8092, Z\u00fcrich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5801.c",
"name": [
"Institute of Plant Sciences, Swiss Federal Institute of Technology, Sonneggstrasse 5, ETH-Z, CH-8092, Z\u00fcrich, Switzerland"
],
"type": "Organization"
},
"familyName": "Martinoia",
"givenName": "Enrico",
"id": "sg:person.01011612624.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011612624.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Plant Sciences, Swiss Federal Institute of Technology, Sonneggstrasse 5, ETH-Z, CH-8092, Z\u00fcrich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5801.c",
"name": [
"Institute of Plant Sciences, Swiss Federal Institute of Technology, Sonneggstrasse 5, ETH-Z, CH-8092, Z\u00fcrich, Switzerland"
],
"type": "Organization"
},
"familyName": "Grill",
"givenName": "Erwin",
"id": "sg:person.01237534662.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237534662.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Plant Sciences, Swiss Federal Institute of Technology, Sonneggstrasse 5, ETH-Z, CH-8092, Z\u00fcrich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5801.c",
"name": [
"Institute of Plant Sciences, Swiss Federal Institute of Technology, Sonneggstrasse 5, ETH-Z, CH-8092, Z\u00fcrich, Switzerland"
],
"type": "Organization"
},
"familyName": "Tommasini",
"givenName": "Roberto",
"id": "sg:person.01005772730.28",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005772730.28"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Plant Sciences, Swiss Federal Institute of Technology, Sonneggstrasse 5, ETH-Z, CH-8092, Z\u00fcrich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5801.c",
"name": [
"Institute of Plant Sciences, Swiss Federal Institute of Technology, Sonneggstrasse 5, ETH-Z, CH-8092, Z\u00fcrich, Switzerland"
],
"type": "Organization"
},
"familyName": "Kreuz",
"givenName": "Klaus",
"id": "sg:person.0667447462.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667447462.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Institute of Plant Sciences, Swiss Federal Institute of Technology, Sonneggstrasse 5, ETH-Z, CH-8092, Z\u00fcrich, Switzerland",
"id": "http://www.grid.ac/institutes/grid.5801.c",
"name": [
"Institute of Plant Sciences, Swiss Federal Institute of Technology, Sonneggstrasse 5, ETH-Z, CH-8092, Z\u00fcrich, Switzerland"
],
"type": "Organization"
},
"familyName": "Amrhein",
"givenName": "Nikolaus",
"id": "sg:person.0663624415.92",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0663624415.92"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/346362a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052799411",
"https://doi.org/10.1038/346362a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00197903",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046112909",
"https://doi.org/10.1007/bf00197903"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-3-662-09838-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1109712290",
"https://doi.org/10.1007/978-3-662-09838-7"
],
"type": "CreativeWork"
}
],
"datePublished": "1993-07",
"datePublishedReg": "1993-07-01",
"description": "PLANTS are exposed to many potentially phytotoxic foreign compounds, such as microbial toxins and agrochemicals (xenobiotics). Detoxification and elimination of these compounds within or from the cell is a prerequisite for their survival. Metabolism and detoxification of xenobiotics are remarkably similar in plants and animals and can generally be divided into three phases1,2. In the first phase, a foreign compound may be oxidized, reduced or hydrolysed to introduce or reveal a functional group. In a second step, the activated xenobiotic is conjugated to either glutathione, glucuronate (animals), or malonyl or glucosyl moieties (plants) by the respective transferases. In animals the third step, excretion of conjugated xenobiotics to the extracellular medium, is mediated by a specific ATPase1,3\u20135. In plants, instead of excretion, conjugates of xenobiotics appear to be stored in the large central vacuole6, but it is not known how they are transported into this organelle. We show here that glutathione S-conjugate uptake into the vacuole is mediated by a specific ATPase which is remarkably similar to the glutathione S-conjugate export pumps in the canalicular membrane of mammalian liver.",
"genre": "article",
"id": "sg:pub.10.1038/364247a0",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1018957",
"issn": [
"0028-0836",
"1476-4687"
],
"name": "Nature",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6434",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "364"
}
],
"keywords": [
"glutathione S",
"detoxification of xenobiotics",
"ATP-dependent glutathione S",
"vacuolar membrane",
"foreign compounds",
"specific ATPase",
"mammalian liver",
"microbial toxins",
"conjugated xenobiotics",
"extracellular medium",
"plants",
"xenobiotics",
"canalicular membrane",
"detoxification",
"membrane",
"export pump",
"respective transferases",
"organelles",
"vacuoles",
"ATPase",
"animals",
"transferase",
"malonyl",
"metabolism",
"cells",
"toxin",
"agrochemicals",
"glutathione",
"uptake",
"glucuronate",
"export",
"functional groups",
"compounds",
"survival",
"step",
"prerequisite",
"moiety",
"liver",
"medium",
"pump",
"conjugates",
"third step",
"second step",
"elimination",
"excretion",
"first phase",
"group",
"phase"
],
"name": "ATP-dependent glutathione S-conjugate 'export' pump in the vacuolar membrane of plants",
"pagination": "247-249",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1027245524"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/364247a0"
]
}
],
"sameAs": [
"https://doi.org/10.1038/364247a0",
"https://app.dimensions.ai/details/publication/pub.1027245524"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T16:52",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_252.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/364247a0"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/364247a0'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/364247a0'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/364247a0'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/364247a0'
This table displays all metadata directly associated to this object as RDF triples.
145 TRIPLES
21 PREDICATES
76 URIs
65 LITERALS
6 BLANK NODES