Ontology type: schema:ScholarlyArticle
1993-06-17
AUTHORSHendrik L. De Bondt, Jody Rosenblatt, Jarmila Jancarik, Heather D. Jones, David O. Morgan, Sung-Hou Kim
ABSTRACTCyclin-dependent kinase 2 (CDK2) is a member of a highly conserved family of protein klnases that regulate the eukaryotic cell cycle. The crystal structures of the human CDK2 apoenzyme and its Mg2+ATP complex have been determined to 2.4Å resolution. The structure is bi-lobate, like that of the cyclic AMP-dependent protein kinase, but contains a unique helix—loop segment that interferes with ATP and protein substrate binding and probably plays a key part in the regulation of all cyclin-dependent kinases. More... »
PAGES595-602
http://scigraph.springernature.com/pub.10.1038/363595a0
DOIhttp://dx.doi.org/10.1038/363595a0
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/8510751
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