Rational design of potent sialidase-based inhibitors of influenza virus replication View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-06

AUTHORS

Mark von Itzstein, Wen-Yang Wu, Gaik B. Kok, Michael S. Pegg, Jeffrey C. Dyason, Betty Jin, Tho Van Phan, Mark L. Smythe, Hume F. White, Stuart W. Oliver, Peter M. Colman, Joseph N. Varghese, D. Michael Ryan, Jacqueline M. Woods, Richard C. Bethell, Vanessa J. Hotham, Janet M. Cameron, Charles R. Penn

ABSTRACT

Two potent inhibitors based on the crystal structure of influenza virus sialidase have been designed. These compounds are effective inhibitors not only of the enzyme, but also of the virus in cell culture and in animal models. The results provide an example of the power of rational, computer-assisted drug design, as well as indicating significant progress in the development of a new therapeutic or prophylactic treatment for influenza infection. More... »

PAGES

418-423

Journal

TITLE

Nature

ISSUE

6428

VOLUME

363

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/363418a0

    DOI

    http://dx.doi.org/10.1038/363418a0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1031791476

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8502295


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