Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1993-05

AUTHORS

N Walworth, S Davey, D Beach

ABSTRACT

The dependence of cell-cycle progression on the integrity of the genome has been described as checkpoint control. A number of mutants of the fission yeast Schizosaccharomyces pombe, selected for their sensitivity to DNA damage caused by radiation (rad mutants) or to the DNA synthesis inhibitor hydroxyurea (hus mutants) have been classified as checkpoint mutants because they fail to arrest the cell cycle in response to DNA damage or incompletely replicated DNA. Coupling of the checkpoint pathways that monitor DNA repair and replication to control of the cell cycle is essential. In a search for components that interact with the cell-cycle regulatory kinase p34cdc2, we have identified a novel fission yeast protein kinase homologue which is involved in cell-cycle arrest when DNA damage has occurred or when unligated DNA is present. We have called the gene encoding this protein chk1 for checkpoint kinase. Multiple copies of chk1 partially rescue the ultraviolet sensitivity of rad1-1, a mutant deficient in checkpoint control. Identification of a gene involved in checkpoint control as a rescue of a cdc2 mutant links the rad1-dependent DNA-damage-sensing pathway and p34cdc2 activity. More... »

PAGES

368-371

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/363368a0

DOI

http://dx.doi.org/10.1038/363368a0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017961585

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8497322


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Amino Acid Sequence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CDC2 Protein Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Checkpoint Kinase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Damage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Endonucleases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fungal Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, Fungal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hydroxyurea", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Molecular Sequence Data", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Restriction Mapping", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Schizosaccharomyces", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Schizosaccharomyces pombe Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Walworth", 
        "givenName": "N", 
        "id": "sg:person.01227410254.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227410254.86"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Davey", 
        "givenName": "S", 
        "id": "sg:person.0744017556.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744017556.40"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Beach", 
        "givenName": "D", 
        "id": "sg:person.0657713656.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657713656.56"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90582-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009049825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/349808a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018874082", 
          "https://doi.org/10.1038/349808a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90266-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022241145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0076-6879(91)00126-h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024187255"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.6.11.2035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025334988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2660(08)60511-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030915580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(87)90458-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033265810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/344503a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036849203", 
          "https://doi.org/10.1038/344503a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(86)90546-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042688393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0968-0004(90)90235-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049027832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0968-0004(90)90235-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049027832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/359599a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051818534", 
          "https://doi.org/10.1038/359599a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(77)90173-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053412734"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(91)90583-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054549987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1703321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062501999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2683079", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062550422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05178.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076988949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1992.tb05179.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076988957"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1993-05", 
    "datePublishedReg": "1993-05-01", 
    "description": "The dependence of cell-cycle progression on the integrity of the genome has been described as checkpoint control. A number of mutants of the fission yeast Schizosaccharomyces pombe, selected for their sensitivity to DNA damage caused by radiation (rad mutants) or to the DNA synthesis inhibitor hydroxyurea (hus mutants) have been classified as checkpoint mutants because they fail to arrest the cell cycle in response to DNA damage or incompletely replicated DNA. Coupling of the checkpoint pathways that monitor DNA repair and replication to control of the cell cycle is essential. In a search for components that interact with the cell-cycle regulatory kinase p34cdc2, we have identified a novel fission yeast protein kinase homologue which is involved in cell-cycle arrest when DNA damage has occurred or when unligated DNA is present. We have called the gene encoding this protein chk1 for checkpoint kinase. Multiple copies of chk1 partially rescue the ultraviolet sensitivity of rad1-1, a mutant deficient in checkpoint control. Identification of a gene involved in checkpoint control as a rescue of a cdc2 mutant links the rad1-dependent DNA-damage-sensing pathway and p34cdc2 activity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/363368a0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1018957", 
        "issn": [
          "0090-0028", 
          "1476-4687"
        ], 
        "name": "Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6427", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "363"
      }
    ], 
    "name": "Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2", 
    "pagination": "368-371", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "5594b63a97f8579a2c66d12cdccb002dddadad12a37502e124d6555ce7a6ca9b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8497322"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0410462"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/363368a0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017961585"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/363368a0", 
      "https://app.dimensions.ai/details/publication/pub.1017961585"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T12:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/363368a0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/363368a0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/363368a0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/363368a0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/363368a0'


 

This table displays all metadata directly associated to this object as RDF triples.

202 TRIPLES      21 PREDICATES      63 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/363368a0 schema:about N19b6c02db76348a6985f068608637c33
2 N2a8e47d3a5b94fe592a1f3570d6f4537
3 N32a4ea03236140af9e839fa43b2b98eb
4 N3a3d21b284984c4ea5f6950fb9c51bf5
5 N46d4994a4fc341af9b5e065e7878aeb3
6 N4f282920742e4cb69f43314158a1bc51
7 N548f225616e349aaa66c3648055d76e4
8 N5ff10fca82d3498b8cfe009a829f950d
9 N6d553fded8e84357a250cf7d0a655246
10 N814a84d10c4c413ebbf9eb52c07e279a
11 N877df67ec7f54b51a22278adbdcc098f
12 N93f2fee35ad445c4a2518d49a0ac3ccb
13 N9f7fa165f40e43eda0136c297eaf6967
14 Nda9433997fe24d638d065da981095aae
15 Nea193d0e3498441ab248e29a27b83ae1
16 Nec24d6239949493e8782c1db5afe22a9
17 Nf476e74b0d7e4f93812407f2cfe7def3
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author Na3506efb11db4409926e6c29d523d94d
21 schema:citation sg:pub.10.1038/344503a0
22 sg:pub.10.1038/349808a0
23 sg:pub.10.1038/359599a0
24 https://doi.org/10.1002/j.1460-2075.1992.tb05178.x
25 https://doi.org/10.1002/j.1460-2075.1992.tb05179.x
26 https://doi.org/10.1016/0076-6879(91)00126-h
27 https://doi.org/10.1016/0092-8674(77)90173-8
28 https://doi.org/10.1016/0092-8674(86)90546-5
29 https://doi.org/10.1016/0092-8674(87)90458-2
30 https://doi.org/10.1016/0092-8674(91)90266-2
31 https://doi.org/10.1016/0092-8674(91)90582-j
32 https://doi.org/10.1016/0092-8674(91)90583-k
33 https://doi.org/10.1016/0968-0004(90)90235-4
34 https://doi.org/10.1016/s0065-2660(08)60511-8
35 https://doi.org/10.1101/gad.6.11.2035
36 https://doi.org/10.1126/science.1703321
37 https://doi.org/10.1126/science.2683079
38 schema:datePublished 1993-05
39 schema:datePublishedReg 1993-05-01
40 schema:description The dependence of cell-cycle progression on the integrity of the genome has been described as checkpoint control. A number of mutants of the fission yeast Schizosaccharomyces pombe, selected for their sensitivity to DNA damage caused by radiation (rad mutants) or to the DNA synthesis inhibitor hydroxyurea (hus mutants) have been classified as checkpoint mutants because they fail to arrest the cell cycle in response to DNA damage or incompletely replicated DNA. Coupling of the checkpoint pathways that monitor DNA repair and replication to control of the cell cycle is essential. In a search for components that interact with the cell-cycle regulatory kinase p34cdc2, we have identified a novel fission yeast protein kinase homologue which is involved in cell-cycle arrest when DNA damage has occurred or when unligated DNA is present. We have called the gene encoding this protein chk1 for checkpoint kinase. Multiple copies of chk1 partially rescue the ultraviolet sensitivity of rad1-1, a mutant deficient in checkpoint control. Identification of a gene involved in checkpoint control as a rescue of a cdc2 mutant links the rad1-dependent DNA-damage-sensing pathway and p34cdc2 activity.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree false
44 schema:isPartOf N2276fa6220ce4c32953772e07dbcce77
45 Nbcdf4004be7e48bcbfd73180ccc06a4f
46 sg:journal.1018957
47 schema:name Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2
48 schema:pagination 368-371
49 schema:productId N5563407db68b4c6c98c1f51ef0b6ab44
50 N5ec95b58f91e4f1fb70b464bc33d66fc
51 N674e7cc455e74d89a68cd29a24a78959
52 Na43e344f35264eb8a5e2879396927fd0
53 Nbe7b188322d3446bb8a62d7d16b8d047
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017961585
55 https://doi.org/10.1038/363368a0
56 schema:sdDatePublished 2019-04-10T12:58
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N10f1e24406c0457db619291da35626b5
59 schema:url http://www.nature.com/articles/363368a0
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N10f1e24406c0457db619291da35626b5 schema:name Springer Nature - SN SciGraph project
64 rdf:type schema:Organization
65 N19b6c02db76348a6985f068608637c33 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Endonucleases
67 rdf:type schema:DefinedTerm
68 N2276fa6220ce4c32953772e07dbcce77 schema:issueNumber 6427
69 rdf:type schema:PublicationIssue
70 N2a8e47d3a5b94fe592a1f3570d6f4537 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Protein Kinases
72 rdf:type schema:DefinedTerm
73 N32a4ea03236140af9e839fa43b2b98eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Mutation
75 rdf:type schema:DefinedTerm
76 N3a3d21b284984c4ea5f6950fb9c51bf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Amino Acid Sequence
78 rdf:type schema:DefinedTerm
79 N46d4994a4fc341af9b5e065e7878aeb3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Restriction Mapping
81 rdf:type schema:DefinedTerm
82 N4f282920742e4cb69f43314158a1bc51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Schizosaccharomyces pombe Proteins
84 rdf:type schema:DefinedTerm
85 N548f225616e349aaa66c3648055d76e4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Fungal Proteins
87 rdf:type schema:DefinedTerm
88 N5563407db68b4c6c98c1f51ef0b6ab44 schema:name readcube_id
89 schema:value 5594b63a97f8579a2c66d12cdccb002dddadad12a37502e124d6555ce7a6ca9b
90 rdf:type schema:PropertyValue
91 N5ec95b58f91e4f1fb70b464bc33d66fc schema:name nlm_unique_id
92 schema:value 0410462
93 rdf:type schema:PropertyValue
94 N5ff10fca82d3498b8cfe009a829f950d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Molecular Sequence Data
96 rdf:type schema:DefinedTerm
97 N674e7cc455e74d89a68cd29a24a78959 schema:name pubmed_id
98 schema:value 8497322
99 rdf:type schema:PropertyValue
100 N6d553fded8e84357a250cf7d0a655246 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name DNA, Fungal
102 rdf:type schema:DefinedTerm
103 N814a84d10c4c413ebbf9eb52c07e279a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Checkpoint Kinase 1
105 rdf:type schema:DefinedTerm
106 N877df67ec7f54b51a22278adbdcc098f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name DNA-Binding Proteins
108 rdf:type schema:DefinedTerm
109 N93f2fee35ad445c4a2518d49a0ac3ccb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Hydroxyurea
111 rdf:type schema:DefinedTerm
112 N9c4835deaf6c405ca4d262aeef1fd001 rdf:first sg:person.0744017556.40
113 rdf:rest Nb14c39261eb548f09063f803a6ac1b8a
114 N9f7fa165f40e43eda0136c297eaf6967 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Genes, Fungal
116 rdf:type schema:DefinedTerm
117 Na3506efb11db4409926e6c29d523d94d rdf:first sg:person.01227410254.86
118 rdf:rest N9c4835deaf6c405ca4d262aeef1fd001
119 Na43e344f35264eb8a5e2879396927fd0 schema:name doi
120 schema:value 10.1038/363368a0
121 rdf:type schema:PropertyValue
122 Nb14c39261eb548f09063f803a6ac1b8a rdf:first sg:person.0657713656.56
123 rdf:rest rdf:nil
124 Nbcdf4004be7e48bcbfd73180ccc06a4f schema:volumeNumber 363
125 rdf:type schema:PublicationVolume
126 Nbe7b188322d3446bb8a62d7d16b8d047 schema:name dimensions_id
127 schema:value pub.1017961585
128 rdf:type schema:PropertyValue
129 Nd5e98d51d05b464da3df63cf9090bdcb schema:name Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, New York 11724.
130 rdf:type schema:Organization
131 Nda9433997fe24d638d065da981095aae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Cell Cycle
133 rdf:type schema:DefinedTerm
134 Nea193d0e3498441ab248e29a27b83ae1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name CDC2 Protein Kinase
136 rdf:type schema:DefinedTerm
137 Nec24d6239949493e8782c1db5afe22a9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name DNA Damage
139 rdf:type schema:DefinedTerm
140 Nf476e74b0d7e4f93812407f2cfe7def3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Schizosaccharomyces
142 rdf:type schema:DefinedTerm
143 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
144 schema:name Biological Sciences
145 rdf:type schema:DefinedTerm
146 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
147 schema:name Biochemistry and Cell Biology
148 rdf:type schema:DefinedTerm
149 sg:journal.1018957 schema:issn 0090-0028
150 1476-4687
151 schema:name Nature
152 rdf:type schema:Periodical
153 sg:person.01227410254.86 schema:affiliation Nd5e98d51d05b464da3df63cf9090bdcb
154 schema:familyName Walworth
155 schema:givenName N
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227410254.86
157 rdf:type schema:Person
158 sg:person.0657713656.56 schema:familyName Beach
159 schema:givenName D
160 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657713656.56
161 rdf:type schema:Person
162 sg:person.0744017556.40 schema:familyName Davey
163 schema:givenName S
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744017556.40
165 rdf:type schema:Person
166 sg:pub.10.1038/344503a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036849203
167 https://doi.org/10.1038/344503a0
168 rdf:type schema:CreativeWork
169 sg:pub.10.1038/349808a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018874082
170 https://doi.org/10.1038/349808a0
171 rdf:type schema:CreativeWork
172 sg:pub.10.1038/359599a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051818534
173 https://doi.org/10.1038/359599a0
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1002/j.1460-2075.1992.tb05178.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1076988949
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1002/j.1460-2075.1992.tb05179.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1076988957
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/0076-6879(91)00126-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1024187255
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/0092-8674(77)90173-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053412734
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/0092-8674(86)90546-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042688393
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/0092-8674(87)90458-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033265810
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/0092-8674(91)90266-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022241145
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1016/0092-8674(91)90582-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1009049825
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1016/0092-8674(91)90583-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1054549987
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1016/0968-0004(90)90235-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049027832
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1016/s0065-2660(08)60511-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030915580
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1101/gad.6.11.2035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025334988
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1126/science.1703321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062501999
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1126/science.2683079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062550422
202 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...